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8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Platinum Compound Étude non communiquée | Lupus · Sclérose en plaques | À vérifier | Phase 1 | Actif | This phase Ib trial studies the side effects of nivolumab and to see how w… À vérifier | ClinicalTrials.gov 2026-09-12 | Détail |
| Aminophylline NCT05552404 · Postdural Puncture Headache Relief With Aminophylline and SPGB | Sclérose en plaques | À vérifier | Phase 4 | COMPLETED | This safety study is the first in a series of studies testing the applicat… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| Aminophylline NCT01530464 · GQ01 — The Safety Evaluation of Aminophylline and Ambrisentan When Administered… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | This safety study is the first in a series of studies testing the applicat… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| Aminophylline (250mg IV +/- a second dose of 250mg IV) NCT00312273 · Aminophylline in Bradyasystolic Cardiac Arrest | Sclérose en plaques | À vérifier | Phase 2 | COMPLETED | The purpose of this study is to evaluate the effect of aminophylline in pa… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| Beta Adrenergic Sweat Test NCT04274413 · CFTR Related Pancreatitis Study | Sclérose en plaques | À vérifier | Non applicable | WITHDRAWN | The main causes of acute recurrent pancreatitis (ARP) or chronic pancreati… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| BiPAP NCT03296579 · Non-invasive Ventilation vs. Standard Therapy for Children Hospitalized With an… | Sclérose en plaques | Immunomodulation | Non applicable | UNKNOWN | Acute asthma produces greatly increased work of breathing and increased ox… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| Compound Ipratropium Bromide Solution(C1) for Inhalation NCT04101500 · Effect of Compound Sodium Chlorate and Aminophylline Tablets on Chronic Obstruct… | Sclérose en plaques | À vérifier | Phase 4 | UNKNOWN | Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| Doxapram Hydrochloride NCT03894189 · The Effect of Doxapram Versus Theophylline on Diaphragmatic Function | Sclérose en plaques | Immunomodulation | Non applicable | UNKNOWN | Doxapram is licensed for drug-induced post-anesthesia respiratory depressi… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| Montelukast or Salmeterol or Theophylline or Steroid NCT03269318 · PRISTINE - Personalised Approach to Improve aSThma prescrIbing iN childrEn | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Phase 4 | TERMINATED | Asthma is one of the most common chronic diseases affecting children in th… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| Theophylline NCT02001935 · Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms a… | Sclérose en plaques | À vérifier | Non applicable | COMPLETED | To evaluate the effect of multiple doses of BIIL 284 BS on the pharmacokin… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| Theophylline and Bambuterol NCT01566565 · The Safety Evaluation of Drug Combinations Against High Altitude Pulmonary Hyper… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | This is a Phase I, three period, two sequence, open-label, randomized, cro… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| Theophylline Anhydrous Oral Tablet NCT04257851 · Is Theophylline More Effective Than Sumatriptan in the Treatment of Post-dural P… | Sclérose en plaques | À vérifier | Phase 4 | COMPLETED | Objectives: To compare the safety and efficacy of oral theophylline versus… À vérifier | ClinicalTrials.gov 2026-09-11 23:42:39 | Détail |
| A Multiple Dose Study to Investigate Safety, Tolerability and Pharmac… NCT04667013 · NCT04667013 | Sclérose latérale amyotrophique | À vérifier | Phase 1 | NOT_YET_RECRUITING | The purpose of this study is to assess the safety, tolerability and pharma… À vérifier | ClinicalTrials.gov 2026-09-11 23:41:59 | Détail |
| Colchicine 0.5 MG Oral Tablet NCT07813858 · CO-ALSII — Colchicine Effect on Amyotrophic Lateral Sclerosis Patients | Sclérose latérale amyotrophique | Ralentissement de la progression | Phase 2 | NOT_YET_RECRUITING | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-09-11 23:41:59 | Détail |
| Fecal microbiota transplantation NCT03766321 · FETR-ALS — Fecal Microbiota Transplantation Effect on Amyotrophic Lateral Sclero… | Sclérose latérale amyotrophique | Ralentissement de la progression | Non applicable | COMPLETED | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-09-11 23:41:59 | Détail |
| HK-001 NCT03651349 · To Determine the Maximum Tolerated Dose (MTD) of HK-001 in Healthy Volunteers | Sclérose latérale amyotrophique | À vérifier | Phase 1 | ACTIVE_NOT_RECRUITING | Eligible subjects will receive either different dosages of HK-001 or place… À vérifier | ClinicalTrials.gov 2026-09-11 23:41:59 | Détail |
| Multi-site direct current stimulation (DCS) NCT06649955 · CALM — Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study | Sclérose latérale amyotrophique | À vérifier | Non applicable | RECRUITING | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-09-11 23:41:59 | Détail |
| Tazbentetol NCT07325591 · Efficacy and Safety of Tazbentetol in ALS Participants | Sclérose latérale amyotrophique | À vérifier | Phase 2/3 | NOT_YET_RECRUITING | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-09-11 23:41:59 | Détail |
| TRCN-1023 NCT07674667 · FUNCtion ALS: Aiming to Restore UNC13A Function in People Living With ALS | Sclérose latérale amyotrophique | À vérifier | Phase 1/2 | RECRUITING | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-09-11 23:41:59 | Détail |
| WVE-004 10 mg Q12W NCT05683860 · Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated… | Sclérose latérale amyotrophique | À vérifier | Phase 1/2 | TERMINATED | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-09-11 23:41:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of testosterone-augmented multimodal exercise intervention in… Whole-body Electrical Muscle Stimulation Exercise · PMID 41988780 | Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Spinal cord injury (SCI) leads to profound muscle atrophy, aerobic deconditioning, and metabolic dysfunction. Exercise-… | The Journal of clinical endocrinology and metabolism 2026-09-20 04:37:05 | Source |
| Feasibility and acceptability of whole-body electromyostimulation in… Whole-body Electrical Muscle Stimulation Exercise · PMID 42464389 | Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Evidence on the effectiveness of electromyostimulation (EMS) has been reported in pulmonary rehabilitation, but the ben… | Pilot and feasibility studies 2026-09-20 04:37:05 | Source |
| Vestibular contributions adapt to the balance strategies adopted duri… Whole-body Electrical Muscle Stimulation Exercise · PMID 42616645 | Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Vestibular contributions during walking are not uniform, but vary with gait phase, muscle group, and balance demands. M… | Journal of neurophysiology 2026-09-20 04:37:05 | Source |
| Clinical efficacy of abdominal moxibustion at the Zhongji (CV3) in co… Yangyin Roujin Decoction · PMID 42015783 | Myopathies | Neuroprotection · Traitement symptomatique | Publication | PubMed | Voir la publication source To investigate the clinical effect of abdominal moxibustion at the Zhongji (CV3) combined with Yiqi Tonglin Yangyin dec… | Journal of traditional Chinese medicine = Chung i tsa… 2026-09-20 04:37:03 | Source |
| Yiqi Huoxue Yangyin Decoction Ameliorates Diabetic Nephropathy by Tar… Yangyin Roujin Decoction · PMID 42713045 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source This study aimed to investigate the protective effects and underlying mechanisms of Yiqi Huoxue Yangyin Decoction (YHY)… | Diabetes, metabolic syndrome and obesity : targets and… 2026-09-20 04:37:03 | Source |
| Yiqi Huoxue Yangyin Decoction attenuates diabetic nephropathy in mice… Yangyin Roujin Decoction · PMID 42016924 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source Diabetic nephropathy (DN) is a major complication of diabetes with limited therapeutic options. Yiqi Huoxue Yangyin Dec… | Frontiers in pharmacology 2026-09-20 04:37:03 | Source |
| Barcoded oligonucleotide system (BOLT) for targeted organ delivery. Immunotherapy · PMID 42733790 | Cancer | À vérifier | Publication | PubMed | Voir la publication source The therapeutic potential of oligonucleotides (oligos) is limited by insufficient delivery to extrahepatic tissues. In… | Bioactive materials 2026-09-20 04:36:56 | Source |
| Dual metabolic checkpoint blockade a 3D-Printed metalloplatform remod… Immunotherapy · PMID 42724565 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source The immunosuppressive tumor microenvironment limits the efficacy of therapies that target metabolism. Here we show a st… | Bioactive materials 2026-09-20 04:36:56 | Source |
| Oligosaccharide adjuvant-deferred antigen endocytosis promotes cross-… Immunotherapy · PMID 42751513 | Cancer | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Antigen cross-presentation by dendritic cells (DCs) is essential for inducing cytotoxic immune responses, which are cru… | Bioactive materials 2026-09-20 04:36:56 | Source |
| Feasibility and safety of early discharge after robot-assisted uro-on… Digital care pathway for hypertension · PMID 42671715 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Early discharge after robot-assisted uro-oncologic surgery remains limited by concerns regarding patient safety and the… | Journal of robotic surgery 2026-09-20 04:36:49 | Source |
| HomeSafe: Postpartum Hypertensive Care Enabled by Electronic Health R… Digital care pathway for hypertension · PMID 41707683 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source The objective is to present stepwise refinements to , an Epic-tethered, population-health-coordinated postpartum pathwa… | American journal of perinatology 2026-09-20 04:36:49 | Source |
| Nutraceutical and functional food: efficacy against metabolic disorde… Digital care pathway for hypertension · PMID 42603698 | Hypertension artérielle | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source The growing global emphasis on health consciousness has significantly increased demand for traditional and complementar… | Journal of advanced research 2026-09-20 04:36:49 | Source |
| Community-engaged design of a virtual diabetes prevention program int… Asynchronous communication with nurse · PMID 42288862 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source The Diabetes Prevention Program (DPP) is an evidence-based approach to prevent Type 2 Diabetes (T2D), the leading cause… | BMC health services research 2026-09-20 04:36:48 | Source |
| Evolving Lung Cancer Navigator Practice Through Targeted Professional… Asynchronous communication with nurse · PMID 42463006 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Lung cancer remains the leading cause of cancer deaths worldwide, and it has persistent disparities in detection, treat… | Chest 2026-09-20 04:36:48 | Source |
| Mass casualty training for prehospital and emergency providers in Kig… Asynchronous communication with nurse · PMID 42751142 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source A mass casualty incident (MCI) occurs when the number of patients exceeds available healthcare resources, placing signi… | African journal of emergency medicine : Revue africain… 2026-09-20 04:36:48 | Source |
| Innovating a Teach-Back Model for Community Health Workers Led Health… Health Literacy Project · PMID 40194526 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source From 2021 to 2023, the City of Albuquerque, the University of New Mexico (UNM) Office for Community Health, the UNM Hos… | Health literacy research and practice 2026-09-20 04:36:34 | Source |
| Carotid intima-media thickness may be an early biomarker for cardiova… Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy · PMID 41026111 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source To assess early signs of atherosclerosis following long-term treatment with the ketogenic diet therapy due to concerns… | Epilepsia open 2026-09-20 04:36:33 | Source |
| Impact of low-carbohydrate diet on health status: an umbrella review. Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy · PMID 39385794 | Cancer | À vérifier | Publication | PubMed | Voir la publication source The prevalence of diet-related non-communicable diseases has increased. A low-carbohydrate diet (LCDs) is one of the mo… | Frontiers in nutrition 2026-09-20 04:36:33 | Source |
| The effect of anti-seizure medications on lipid values in adults with… Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy · PMID 37244221 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Certain anti-seizure medications (ASMs) adversely impact lipid values. Here, we explored the impact of ASMs on lipid va… | Epilepsy & behavior : E&B 2026-09-20 04:36:33 | Source |
| Possible role of locus coeruleus neuronal loss in age-related memory… The Role of the Locus Coeruleus in Age-related Distractibility · PMID 37694113 | Maladie d’Alzheimer | Immunomodulation | Publication | PubMed | Voir la publication source Aging is associated with a decline in cognitive abilities, including memory and attention. It is generally accepted tha… | Frontiers in neuroscience 2026-09-20 04:36:30 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||