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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Accelerated intermittent theta-burst stimulation (iTBS) rTMS to right… NCT07701785 · Superior Parietal iTBS for PD-MCI | Maladie de Parkinson | À vérifier | Non applicable | RECRUITING | The goal of this study is to determine the whether a short-term, high-dose… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:22 | Détail |
| CoQ10 NCT00076492 · NINDS Parkinson's Disease Neuroprotection Trial of CoQ10 and GPI 1485 | Maladie de Parkinson | Neuroprotection · Ralentissement de la progression | Phase 2 | COMPLETED | The goal of this study is to assess the impact of CoQ10 and GPI 1485 on th… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:22 | Détail |
| 150% of their routine home dopaminergic medications dose right in the… NCT06586320 · Quantification of Parkinson's Disease Patients as a Biomarker for Classification… | Maladie de Parkinson | À vérifier | Non applicable | ENROLLING_BY_INVITATION | This is a three-armed open investigational study that aims to differentiat… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:21 | Détail |
| Algorithm-guided group NCT07505394 · PREVENT-ICD — Efficacy of a Prediction Model-based Algorithm to PREVENT Drug-ind… | Maladie de Parkinson | Traitement symptomatique | Non applicable | RECRUITING | Impulse control disorders and related behaviors (ICDRBs) are characterized… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:21 | Détail |
| CREXONT ER NCT07138560 · BOOST-PD A Naturalistic Study on IPX-203 for Parkinson's Disease | Maladie de Parkinson | Traitement symptomatique | Phase 4 | RECRUITING | The purpose of this study is to evaluate the effect of IPX203 (Crexont®) -… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:21 | Détail |
| cultured allogeneic adult umbilical cord or placental derived mesench… NCT05152394 · Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchy… | Maladie de Parkinson | Thérapie cellulaire | Phase 1 | RECRUITING | This trial will study the safety and efficacy of intranasal instillation o… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:21 | Détail |
| Deep Brain Stimulation management NCT02119611 · Deep Brain Stimulation Therapy in Movement Disorders | Maladie de Parkinson | À vérifier | Non applicable | RECRUITING | Background: \- In deep brain stimulation (DBS), a device called a neurosti… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:21 | Détail |
| MT101-5 NCT06175767 · A Study to Evaluate the Safety, Tolerability and Efficacy of MT101-5 in Subjects… | Maladie de Parkinson | À vérifier | Phase 2 | NOT_YET_RECRUITING | A Phase IIa, Randomized, Multicenter, Double-Blind, Placebo-Controlled Stu… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:21 | Détail |
| Summit RC+S NCT04675398 · Adaptive Deep Brain Stimulation to Improve Motor and Gait Functions in Parkinson… | Maladie de Parkinson | À vérifier | Non applicable | ACTIVE_NOT_RECRUITING | This is a single-center phase I clinical study aiming to improve gait func… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:21 | Détail |
| Technology-based Rehabilitation NCT05399043 · Experience of Use and Biopsychosocial Effects of Robotic and Virtual Reality Dev… | Maladie de Parkinson | Traitement symptomatique | Non applicable | COMPLETED | The implementation of virtual reality (VR) and robotic devices in neuromot… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:21 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | ACTIVE_NOT_RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:15 | Détail |
| bbT369 NCT05169489 · A Study of bbT369 in Relapsed and/or Refractory B Cell Non-Hodgkin's Lymphoma (N… | Sclérose en plaques | Immunomodulation | Phase 1 | TERMINATED | This non-randomized, open label, multi-site, first-in-human, Phase 1/2 stu… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:14 | Détail |
| C-CAR168 NCT07854483 · C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy,… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire · Thérapie génique | Phase 1 | NOT_YET_RECRUITING | This Phase 2, multicenter, open-label study will evaluate the safety and e… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:14 | Détail |
| Oxaliplatin, Cytosine Arabinoside, Dexamethasone With Rituxan (ROAD) NCT00166439 · Trial of Oxaliplatin, Cytosine Arabinoside, Dexamethasone With Rituxan (ROAD) in… | Sclérose en plaques | Immunomodulation | Phase 2 | COMPLETED | The goals of this protocol are to determine the effect of oxaliplatin, cyt… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:14 | Détail |
| Part A NCT00291928 · HuMax-CD20 in Active Rheumatoid Arthritis, Phase I/II | Sclérose en plaques | Immunomodulation | Phase 2 | COMPLETED | The purpose of this trial is primarily to investigate the safety profile o… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:14 | Détail |
| CART Infusion NCT07441525 · UCAR-T Targeting CD19/BCMA in Subjects With Autoantibody-Mediated Autoimmune Ben… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | This is a single-arm, open-label, investigator-initiated trial (IIT) desig… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:13 | Détail |
| Phase 1 Dose Level 1 NCT06839456 · Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infectio… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire · Thérapie génique | Phase 1/2 | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant (HS… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:13 | Détail |
| Second generation CAR-T cells NCT02965092 · CD19 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patient… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1/2 | UNKNOWN | This is a single arm, open-label, phase 1/2 study to evaluate the safety a… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:13 | Détail |
| TBI-2001 NCT05963217 · Study of TBI-2001(Autologous CD19 Specific Chimeric Antigen Receptor (CAR) Gene-… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | This is a Phase 1/1b, open-label, dose-escalation study to evaluate the sa… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:13 | Détail |
| Ocrelizumab NCT04877457 · CELLO — Ocrelizumab for Preventing Clinical Multiple Sclerosis in Individuals Wi… | Sclérose en plaques | Ralentissement de la progression | Phase 4 | TERMINATED | A study to evaluate the efficacy and safety of fenebrutinib on disability… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:05 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||