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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| ADCT-701 NCT06041516 · A First-in-Human Phase I Trial With Antibody Drug Conjugate ADCT-701 in Neuroend… | Cancer | À vérifier | Phase 1 | RECRUITING | Background: Neuroendocrine neoplasms (NENs) are rare cancers in the gastro… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:52 | Détail |
| AdHER2DC vaccine NCT06253494 · Pembrolizumab, Lenvatinib and IL-15 Superagonist N-803 in Combination With HER2… | Cancer | Immunomodulation | Phase 1/2 | RECRUITING | Background: Endometrial cancer (EC) of the uterus is becoming more common… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:52 | Détail |
| Breast MRI Screening NCT07878377 · SAFE-MRI — Screening and the Future of Enhanced MRI for Early Breast Cancer Dete… | Cancer | À vérifier | Non applicable | NOT_YET_RECRUITING | This study aims to recruit women aged 45 years in the Netherlands to parti… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:52 | Détail |
| Histotripsie — HistoSonics Edison System NCT07873606 · histo-pancreas — Histotripsy x Pancreatic Cancer | Cancer | À vérifier | Non applicable | RECRUITING | Ultrasons focalisés produisant une cavitation contrôlée et une destruction… HOPE4LIVER a rapporté un succès technique dans 95 % des tumeurs évaluées et des complications majeures liées à la procé… | ClinicalTrials.gov 2026-10-18 04:36:52 | Détail |
| Intrathecal Resiniferatoxin NCT00804154 · Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer | Cancer | Traitement symptomatique | Phase 1 | RECRUITING | This study will examine the safety of giving the experimental drug, resini… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:52 | Détail |
| Nivo800 NCT07460765 · Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Sq… | Cancer | À vérifier | Phase 1 | RECRUITING | The goal of this Phase 1 clinical trial is to evaluate the safety and feas… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:52 | Détail |
| Panitumumab-IRDye800 NCT07493447 · Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detec… | Cancer | À vérifier | Phase 1 | RECRUITING | This pilot clinical study evaluates the safety and imaging performance of… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:52 | Détail |
| rhIL-15 NCT06995872 · Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Child… | Cancer | À vérifier | Phase 1 | RECRUITING | Background: Neuroblastoma is a type of cancer that causes tumors in nerves… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:52 | Détail |
| Serplulimab Combined With Chemotherapy NCT06576921 · Efficacy and Safety of Serplulimab Combined With Chemotherapy as Neoadjuvant Tre… | Cancer | Thérapie génique | Phase 2 | ACTIVE_NOT_RECRUITING | This is a multicenter, Open-label, randomized, phase 2 trial to investigat… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:52 | Détail |
| ZL-1310 NCT06179069 · A Study of ZL-1310 in Subjects With Small Cell Lung Cancer | Cancer | À vérifier | Phase 1 | RECRUITING | The purpose of this study is to evaluate the efficacy and safety of ZL-131… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:52 | Détail |
| BR1019A NCT06220773 · A Study to Evaluate the Efficacy and Safety of BR1019A and BR1019B Combination T… | Hypertension artérielle | À vérifier | Phase 3 | RECRUITING | The objective of this clinical study is to Evaluate the Efficacy and Safet… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:47 | Détail |
| Brachiobasilic arteriovenous fistula followed by basilic vein superfi… NCT07879027 · Incidence of Venous Hypertension in Side-to-Side Versus End-to-Side Brachiobasil… | Hypertension artérielle | À vérifier | Non applicable | COMPLETED | The study aimed to compare the incidence of postoperative venous hypertens… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:47 | Détail |
| Metformin NCT07589387 · HTN2 — Hypertension Treatment in Nigeria: Hypertension Diabetes Integration Stud… | Hypertension artérielle | À vérifier | Non applicable | RECRUITING | The goal of this clinical trial is to Evaluating Metformin Efficacy and Sa… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:47 | Détail |
| qMT-MRI to detect fibrosis. NCT04508049 · A Study to Evaluate Renal Fibrosis Using MRI Techniques | Hypertension artérielle | À vérifier | Non applicable | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate whether or not an MRI technique (… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:47 | Détail |
| Blood sampling, questionnaire and phone call NCT07067112 · SIIM-reg — Suppressive Functions of Regulatory T Cells in Migraine | Migraine | Immunomodulation · Traitement symptomatique | Non applicable | RECRUITING | Migraine is a frequent, disabling condition, of great social and economica… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:36 | Détail |
| Eptinezumab NCT04965675 · PROSPECT-2 — A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic… | Migraine | Traitement symptomatique | Phase 3 | RECRUITING | Most individuals with mild traumatic brain injury (mTBI) experience post-t… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:36 | Détail |
| Erenumab Dose 1 NCT03836040 · OASIS(EM) — Efficacy and Safety of Erenumab in Pediatric Participants With Episo… | Migraine | À vérifier | Phase 3 | ACTIVE_NOT_RECRUITING | This study will evaluate the efficacy and safety of erenumab in migraine p… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:36 | Détail |
| Transcranial Direct Current Therapy (tDCS) NCT05780450 · Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-1… | Migraine | Traitement symptomatique | Non applicable | RECRUITING | This study aims to verify the efficacy/effectiveness of treatment with tra… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:36 | Détail |
| Xeomin NCT07018713 · MINT-C — A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections… | Migraine | À vérifier | Phase 3 | ACTIVE_NOT_RECRUITING | In this clinical trial, participants with chronic migraine will receive in… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:36 | Détail |
| Xeomin NCT07018700 · MINT-E — A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections… | Migraine | À vérifier | Phase 3 | ACTIVE_NOT_RECRUITING | In this clinical trial, participants with chronic migraine will receive in… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:36 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||