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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| The molecular mechanisms of platelets in tumor invasion and metastasi… Tumor Microenvironment · PMID 42578461 | Cancer | Ralentissement de la progression · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Platelets, traditionally recognized for their role in hemostasis, are now understood to actively contribute to tumor pr… | Cancer biology & therapy 2026-08-16 13:14:46 | Source |
| Point/Counterpoint: Dordaviprone for diffuse midline glioma - A landm… ONC201 · PMID 42172613 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Diffuse midline glioma (DMG) remains one of the most aggressive and uniformly fatal brain tumors, with a median overall… | Neuro-oncology 2026-08-16 13:14:41 | Source |
| Dysregulation of Human ClpP Using Small Molecules with Piperazine-Bas… ONC201 · PMID 42418817 | Cancer | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source Diffuse intrinsic pontine glioma (DIPG) is a dismal pediatric brainstem tumor with a median survival of approximately 1… | Journal of medicinal chemistry 2026-08-16 13:14:40 | Source |
| Fewer breast cancers during post-treatment surveillance among patient… MRI in Ductal Carcinoma in Situ (DCIS) · PMID 42593550 | Cancer | À vérifier | Publication | PubMed | Voir la publication source The role of contrast-based imaging (CBI) at diagnosis in early breast cancer remains debated. More sensitive baseline s… | Breast cancer research and treatment 2026-08-16 13:14:40 | Source |
| Peak Uptake Value on Positron Emission Mammography Addresses Biopsy S… MRI in Ductal Carcinoma in Situ (DCIS) · PMID 42596586 | Cancer | À vérifier | Publication | PubMed | Voir la publication source To evaluate peak uptake value (PUVmax) derived from positron emission mammography (PEM) as a functional biomarker for i… | The British journal of radiology 2026-08-16 13:14:40 | Source |
| Pathologic characterization of non-mass enhancement lesions of the br… MRI in Ductal Carcinoma in Situ (DCIS) · PMID 42556743 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Breast MRI is widely used for screening high-risk patients and for assessing the extent of disease in patients with bre… | Human pathology 2026-08-16 13:14:39 | Source |
| EGFR signaling upregulates surface expression of the GluN2B-containin… BIBX 1382 · PMID 26204818 | Cancer | À vérifier | Publication | PubMed | Voir la publication source N-methyl-d-aspartate receptors (NMDARs) have been known to be regulated by various receptor tyrosine kinases. Activatio… | Neuroscience 2026-08-16 13:14:38 | Source |
| Desmoid Fibromatosis of the Gastric Wall Mimicking Needle Tract Seedi… Positron Emission Tomography · PMID 42058264 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is widely used for the pathological diagnosis of pancreatic d… | DEN open 2026-08-16 13:14:37 | Source |
| Ulcerative Esophagitis With Marked Eosinophilic Infiltration and Fluo… Positron Emission Tomography · PMID 42416861 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Esophagitis with marked eosinophilic infiltration, including eosinophilic esophagitis (EoE), can rarely present with ul… | DEN open 2026-08-16 13:14:37 | Source |
| Assessment of response to neoadjuvant radiochemotherapy with F-18 FLT… Fluorothymidine F-18 · PMID 25503812 | Cancer | À vérifier | Publication | PubMed | Voir la publication source The comparison of 2-deoxy-2-[18F]fluoro-D-glucose (F-18 FDG) and 3'-deoxy-3'-[18F]fluorothymidine (F-18 FLT) imaging in… | Annals of nuclear medicine 2026-08-16 13:14:36 | Source |
| Distinct clinical, molecular, and treatment response profiles in prim… hydroxyurea · PMID 42237068 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Myelofibrosis (MF) includes primary myelofibrosis (PMF) and secondary myelofibrosis (SMF) evolving from essential throm… | Hematology (Amsterdam, Netherlands) 2026-08-16 13:14:34 | Source |
| Thrombotic burden and longitudinal outcomes in Thai patients with pol… hydroxyurea · PMID 42262970 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Polycythemia vera (PV) is a myeloproliferative neoplasm frequently complicated by thromboembolic events. However, data… | Annals of medicine 2026-08-16 13:14:34 | Source |
| Tubular dysfunction in stable adult sickle cell patients in Kinshasa:… hydroxyurea · PMID 42544603 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Renal complications of sickle cell disease (SCD) often begin with tubular dysfunction (TD), yet this entity remains ins… | Renal failure 2026-08-16 13:14:34 | Source |
| Autonomous radiotherapy planning via agentic orchestration using a mu… radiation therapy · PMID 42466075 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Radiation therapy (RT) treatment planning requires iterative, multi-day optimization workflows in which subjective plan… | Machine learning. Health 2026-08-16 13:14:32 | Source |
| Immunogenicity of neoantigens from hepatocellular carcinoma patients… radiation therapy · PMID 41851965 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source In some cancers, patients responding to immune checkpoint inhibitors (ICI) usually harbor tumors with a higher tumor mu… | Oncoimmunology 2026-08-16 13:14:32 | Source |
| Local delivery of SBRT and IL-12 to murine PDAC tumors modulates hema… radiation therapy · PMID 42246474 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Standard of care radiotherapy and chemotherapy have shown limited efficacy in pancreatic ductal adenocarcinoma (PDAC).… | Oncoimmunology 2026-08-16 13:14:32 | Source |
| Ivonescimab combined with chemotherapy for the treatment of metastati… paclitaxel albumin-stabilized nanoparticle formulation · PMID 42012232 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source The prognosis for patients with recurrent or metastatic cervical cancer (r/mCC) remains challenging, with a 5-y surviva… | Human vaccines & immunotherapeutics 2026-08-16 13:14:28 | Source |
| The colloidal stability of albumin-based drug delivery systems has a… paclitaxel albumin-stabilized nanoparticle formulation · PMID 41556287 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Human serum albumin (HSA) has attracted significant attention in drug delivery since the approval of Abraxane in 2005.… | Drug delivery 2026-08-16 13:14:28 | Source |
| Multimodality imaging features of primary mammary angiosarcoma: a cas… 18F-FDG · PMID 42569372 | Cancer · Épilepsie · Épilepsie | Thérapie génique | Publication | PubMed | Voir la publication source Primary angiosarcoma of the breast is an uncommon and aggressive vascular malignancy that typically affects young women… | Radiology case reports 2026-08-16 13:14:27 | Source |
| Unveiling the unexpected: Skeletal sarcoidosis with an extraosseous s… 18F-FDG · PMID 42491317 | Cancer · Épilepsie · Épilepsie | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Sarcoidosis is a chronic granulomatous, multisystem disease of uncertain etiology that affects various organ systems, a… | Radiology case reports 2026-08-16 13:14:27 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||