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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of Stromal Cell-Derived Factor 1 on Osteoblast Activity Durin… Plerixafor · PMID 42594265 | Cancer | À vérifier | Publication | PubMed | Voir la publication source This study aimed to clarify the relationship between stromal cell‑derived factor 1 (SDF‑1) and osteoblast-related respo… | Clinical and experimental dental research 2026-08-16 13:15:30 | Source |
| PAMD-Ch17, a Polymeric Analog of Plerixafor, Induces Mitochondrial Dy… Plerixafor · PMID 41893624 | Cancer | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source PAMD-Ch17 is a polymer composed of the CXCR4 inhibitor AMD3100/Plerixafor with a cholesterol modification. In previous… | Molecular cancer therapeutics 2026-08-16 13:15:30 | Source |
| 3D computed tomography airway geometry for predicting bronchoscopic a… Radial Probe Endobronchial Ultrasound · PMID 42291365 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Bronchoscopic diagnosis of peripheral pulmonary nodules (PPNs) using radial probe endobronchial ultrasound (rEBUS) has… | Translational lung cancer research 2026-08-16 13:15:28 | Source |
| A multimodal bronchoscopic approach for diagnosing peripheral ground-… Bronchoscopy · PMID 42566914 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Ground-glass nodules (GGNs) remain challenging to diagnose using endobronchial ultrasound-guided transbronchial biopsy… | Annals of medicine 2026-08-16 13:15:27 | Source |
| Landscape of the upper and lower airway microbiota in children with c… Bronchoscopy · PMID 42388029 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Community-acquired pneumonia (CAP) is one of the most common causes of death in children. Obtaining lower airway sample… | Virulence 2026-08-16 13:15:27 | Source |
| Low, plasma level‑informed native curcumin concentrations fail to ind… Turmeric · PMID 41858052 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Curcumin, a dietary polyphenol derived from turmeric, has been widely studied for its anti-cancer properties, yet its e… | Pharmaceutical biology 2026-08-16 13:15:27 | Source |
| Rarely reported cases of hepatotoxicity associated with turmeric- and… Turmeric · PMID 42364655 | Cancer | À vérifier | Publication | PubMed | Voir la publication source The United States Pharmacopeia (USP) Dietary Supplement Admission Evaluation and Labeling Expert Committee (DSAEL EC) r… | Pharmaceutical biology 2026-08-16 13:15:27 | Source |
| Remimazolam for sedation in flexible bronchoscopy: A systematic revie… Bronchoscopy · PMID 42313074 | Cancer | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Remimazolam is a novel benzodiazepine increasingly used for procedural sedation and general anaesthesia. Its role in cl… | Pulmonology 2026-08-16 13:15:27 | Source |
| Optimal dose window, formulation efficacy, and molecular mechanisms o… Turmeric · PMID 42447971 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Approximately 25% of the global adult population is affected by metabolic dysfunction-associated steatotic liver diseas… | Journal of ethnopharmacology 2026-08-16 13:15:26 | Source |
| The sex hormone system in carriers of BRCA1/2 mutations: a case-contr… Breast Imaging Studies in Women at High Genetic Risk of Breast Cancer: Menstrual Cycle Study ·… | Cancer | À vérifier | Publication | PubMed | Voir la publication source Penetrance for breast cancer, ovarian cancer, or both in carriers of BRCA1/BRCA2 mutations is disproportionately high.… | The Lancet. Oncology 2026-08-16 13:15:25 | Source |
| Addition of pulsed electric field ablation to SBRT for lung tumors: e… Stereotactic Body Radiation Therapy (SBRT) · PMID 41783980 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Treatment indications for oligometastatic/oligoprogressive lung tumors are growing. Safety and lack of detrimental effe… | Lung cancer management 2026-08-16 13:15:24 | Source |
| Workflow and dosimetric results for direct-to-unit single-fraction ad… Stereotactic Body Radiation Therapy (SBRT) · PMID 42592074 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Direct-to-unit (DTU) workflows coupled with online adaptive radiation therapy can streamline stereotactic body radiatio… | Clinical and translational radiation oncology 2026-08-16 13:15:24 | Source |
| Sphingosine-1-Phosphate Receptor 3 Confers Tumor Metastasis in Lung C… AZD9291 · PMID 42039707 | Cancer | Ralentissement de la progression · Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source The third-generation EGFR tyrosine kinase inhibitor (TKI) osimertinib (AZD9291) has significantly improved the survival… | MedComm 2026-08-16 13:15:22 | Source |
| A fast method for the quantification of bortezomib in serum and rat n… bortezomib · PMID 42526316 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Bortezomib is a proteasome inhibitor used to treat cancers such as Multiple Myeloma and Mantle Cell Lymphoma. Due to it… | Journal of pharmaceutical and biomedical analysis 2026-08-16 13:15:18 | Source |
| Proliferative glomerulonephritis with monoclonal IgG3 deposits: A cas… bortezomib · PMID 42519182 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) caused by IgG3-dominant is rare and i… | Journal of translational autoimmunity 2026-08-16 13:15:18 | Source |
| Selinexor combined bortezomib, lenalidomide, and dexamethasone for ne… bortezomib · PMID 42544613 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source This study aimed to evaluate the efficacy and safety of selinexor combined with bortezomib, lenalidomide, and dexametha… | Annals of medicine 2026-08-16 13:15:18 | Source |
| Preclinical evaluation of zirconium-89 labeled anti-Trop2 antibody-dr… Sacituzumab govitecan-hziy · PMID 39878898 | Cancer | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Trophoblast cell-surface antigen 2 (Trop2) is overexpressed in various solid tumors and contributes to tumor progressio… | European journal of nuclear medicine and molecular ima… 2026-08-16 13:15:14 | Source |
| Deferred Cytoreductive Nephrectomy With Partial Hepatectomy for Giant… Cabozantinib · PMID 42558954 | Cancer · Lupus · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Deferred cytoreductive nephrectomy may improve the prognosis of patients with metastatic renal cell carcinoma (RCC). Ho… | IJU case reports 2026-08-16 13:15:11 | Source |
| Efficacy and safety of cabozantinib plus nivolumab in advanced non-cl… Cabozantinib · PMID 42366526 | Cancer · Lupus · Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Non-clear cell renal cell carcinoma (nccRCC) represents a biologically heterogeneous group of tumors for which optimal… | Oncoimmunology 2026-08-16 13:15:11 | Source |
| Treatment of Human Glioblastoma Multiforme in NRG Mice by Convection-… Panitumumab · PMID 42276782 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source The effectiveness and safety of Auger electron (AE)-emitting epidermal growth factor receptor (EGFR)-targeted panitumum… | Journal of nuclear medicine : official publication, So… 2026-08-16 13:15:10 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||