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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Validation and refinement of the AJCC 8th edition ypStage in esophage… Survival Prediction After Neoadjuvant Chemoimmunotherapy and Esophagectomy for Esophageal Squa… | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source The AJCC 8th edition post-neoadjuvant pathologic stage (ypStage) shows limited prognostic discrimination in esophageal… | International journal of surgery (London, England) 2026-08-16 13:17:09 | Source |
| The dynamic evolution of circulating tumor cells during glecirasib tr… JAB 21822 · PMID 42384131 | Cancer | Ralentissement de la progression · Thérapie cellulaire | Publication | PubMed | Voir la publication source The Kirsten rat sarcoma viral oncogene homolog (KRAS) is one of the most frequently mutated oncogenes and is associated… | Human cell 2026-08-16 13:17:08 | Source |
| Biomimetic co-delivery nanoplatform overcomes CAF- and TAM-induced im… Vismodegib · PMID 42436866 | Cancer | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Immune checkpoint blockade (ICB) has emerged as a cornerstone therapy for triple-negative breast cancer (TNBC); however… | International journal of pharmaceutics: X 2026-08-16 13:17:04 | Source |
| Comparative safety analysis of Hedgehog inhibitor preparations: insig… Vismodegib · PMID 39934996 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Vismodegib and sonidegib are currently the only Hedgehog inhibitors (HHIs) approved by the U.S. Food and Drug Administr… | Expert opinion on drug safety 2026-08-16 13:17:04 | Source |
| Impact of gamma irradiation and ethylene oxide sterilisation on the s… Vismodegib · PMID 42250781 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Terminal sterilisation is a critical process for pharmaceutical products intended for parenteral or invasive administra… | European journal of pharmaceutical sciences : official… 2026-08-16 13:17:04 | Source |
| Adult onset Still's disease-The evidence that anti-interleukin-1 trea… Anakinra (Kineret®) · PMID 28757235 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source The literature contains many reports of the use of commercially available anti-IL-1 agents (anakinra/Kineret, canakinum… | Seminars in arthritis and rheumatism 2026-08-16 13:17:03 | Source |
| Expedited Desensitization to Canakinumab. Anakinra (Kineret®) · PMID 32612876 | Cancer | Immunomodulation · Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Interleukin-1 (IL-1) antagonists have been successful in the management of monogenic auto-inflammatory diseases, notabl… | Allergy & rhinology (Providence, R.I.) 2026-08-16 13:17:03 | Source |
| IL (Interleukin)-1 Receptor Antagonist Increases Ang (Angiotensin [1-… Anakinra (Kineret®) · PMID 32275191 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source IL (Interleukin)-1 antagonism decreases blood pressure in obese individuals. The underlying mechanisms are unknown. Bas… | Hypertension (Dallas, Tex. : 1979) 2026-08-16 13:17:03 | Source |
| Low-dose dasatinib in second-line therapy or beyond for the treatment… Nilotinib followed by treatment-free · PMID 42394986 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Dasatinib is a favorable option for patients with chronic-phase chronic myeloid leukemia (CML-CP) who have an inadequat… | Frontiers in pharmacology 2026-08-16 13:17:02 | Source |
| Treatment-Free Remission and Immune Profiling after Frontline Second-… Nilotinib followed by treatment-free · PMID 42314090 | Cancer | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Treatment-free remission (TFR) is a major therapeutic goal in chronic myeloid leukemia (CML). This study analyzed 5-yea… | Blood advances 2026-08-16 13:17:02 | Source |
| Unraveling clinical and biological predictors of successful treatment… Nilotinib followed by treatment-free · PMID 42369955 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Tyrosine Kinase Inhibitors (TKIs) have revolutionized the management of Chronic Myeloid Leukemia (CML), making treatmen… | Pakistan journal of medical sciences 2026-08-16 13:17:02 | Source |
| G-quadruplex DNA reprograms the photochemistry of CX-5461 toward radi… Pidnarulex · PMID 42578368 | Cancer | À vérifier | Publication | PubMed | Voir la publication source CX-5461 (pidnarulex) is the most clinically advanced small-molecule ligand associated with G-quadruplex (G4) targeting… | Nucleic acids research 2026-08-16 13:17:01 | Source |
| High-throughput combination screening of Pidnarulex and other G-quadr… Pidnarulex · PMID 41130416 | Cancer | Thérapie cellulaire | Publication | PubMed | Voir la publication source G-quadruplexes (G4s) are four-stranded nucleic acid structures that regulate key cellular processes and represent promi… | SLAS discovery : advancing life sciences R & D 2026-08-16 13:17:01 | Source |
| Lysosomal membrane permeabilization enhances the anticancer effects o… Pidnarulex · PMID 40528705 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Lysosomes contribute to the development of drug resistance through various mechanisms that include drug sequestration a… | Autophagy 2026-08-16 13:17:01 | Source |
| Cost-effectiveness of pembrolizumab plus chemotherapy vs cemiplimab p… Cemiplimab · PMID 41861397 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Recent clinical guidelines recommend pembrolizumab plus chemotherapy and cemiplimab plus chemotherapy as key first-line… | Journal of medical economics 2026-08-16 13:16:58 | Source |
| Economic evaluation of added neoadjuvant cemiplimab to upfront wide l… Cemiplimab · PMID 42438454 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Cutaneous squamous cell carcinoma occurs with increasing incidence in the aging United States population and, depending… | JID innovations : skin science from molecules to popul… 2026-08-16 13:16:58 | Source |
| Predictions and cross-center validation of IDH status and 1p/19q stat… Magnetic Resonance Imaging · PMID 42518518 | Accident vasculaire cérébral · Cancer · Sclérose en plaques · Cancer… | À vérifier | Publication | PubMed | Voir la publication source This study developed and validated a non-invasive multi-metabolite magnetic resonance spectroscopy framework for preope… | Magnetic resonance letters 2026-08-16 13:16:58 | Source |
| Real-World Response of Cemiplimab Immunotherapy for Treating Locally… Cemiplimab · PMID 42577731 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Cemiplimab has been licensed for use in the United Kingdom as the sole immunotherapy agent for first-line use in advanc… | Journal of skin cancer 2026-08-16 13:16:58 | Source |
| ESHRE recommendations on Good Practice in the IVF laboratory†. Biopsy Procedure · PMID 42405499 | Cancer · Sclérose en plaques · Cancer · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source What is the current good practice in the IVF laboratory, based on the best available evidence in the literature, if ava… | Human reproduction (Oxford, England) 2026-08-16 13:16:57 | Source |
| Pancreatic Metastasis of Clear Cell Renal Cell Carcinoma: Challenges… Biopsy Procedure · PMID 42449514 | Cancer · Sclérose en plaques · Cancer · Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source The objective of this study is to investigate the value of conventional ultrasound, contrast-enhanced ultrasound (CEUS)… | Cancer medicine 2026-08-16 13:16:57 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||