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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Unveiling the hidden: diagnosing isolated myeloid sarcoma through asc… Bone Marrow Aspiration/Biopsy · PMID 41601314 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source Isolated myeloid sarcoma, defined as an extramedullary manifestation of acute myeloid leukemia with essentially normal… | Laboratory medicine 2026-08-16 13:18:05 | Source |
| A Phase 1/1b Study of the All-Oral Regimen CC-486 and Venetoclax in A… CC-486 (5-azacitidine) · PMID 42498285 | Cancer | Traitement symptomatique · Thérapie cellulaire | Publication | PubMed | Voir la publication source Venetoclax with azacitidine is the standard of care for newly diagnosed AML patients who are unfit for intensive induct… | Blood advances 2026-08-16 13:18:02 | Source |
| Effects of the HDAC6/8 Inhibitor MC1568, Alone and in Combination Wit… Romidepsin · PMID 42415217 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Fungal infections pose a severe health risk, particularly in immunocompromised individuals, with Candida species being… | MicrobiologyOpen 2026-08-16 13:18:02 | Source |
| Maintenance Therapy in Acute Myeloid Leukemia: Current Perspectives a… CC-486 (5-azacitidine) · PMID 42346269 | Cancer | Thérapie cellulaire | Publication | PubMed | Voir la publication source The management of acute myeloid leukemia (AML) remains characterized by high relapse rates despite advances in inductio… | Current oncology (Toronto, Ont.) 2026-08-16 13:18:02 | Source |
| Romidepsin inhibits NRF2 and enhances the efficacy of adagrasib by in… Romidepsin · PMID 42114191 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source KRAS-mutant tumors remain a major challenge in cancer therapy. Although current targeted drugs show initial promise, th… | Bioorganic chemistry 2026-08-16 13:18:02 | Source |
| SOHO State of the Art Updates and Next Questions | Beyond Romidepsin:… Romidepsin · PMID 42414110 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Peripheral T-cell lymphomas (PTCLs) represent heterogeneous aggressive non-Hodgkin lymphomas with dismal outcomes in th… | Clinical lymphoma, myeloma & leukemia 2026-08-16 13:18:02 | Source |
| SWOG 1918: A phase II/III randomized study of R-miniCHOP with or with… CC-486 (5-azacitidine) · PMID 34686472 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Diffuse large B cell lymphoma (DLBCL) is an aggressive but potentially curable malignancy; however, cure is highly depe… | Journal of geriatric oncology 2026-08-16 13:18:02 | Source |
| Crystal Violet Staining for Colitis-associated Neoplasia-guided Delin… Biopsy · PMID 42597446 | Cancer · Sclérose en plaques · Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Ulcerative colitis-associated neoplasia (UCAN) is often difficult to delineate because chronic inflammatory changes obs… | DEN open 2026-08-16 13:18:01 | Source |
| Discovery of DA1 as PARP inhibitor for the treatment of BRCA-proficie… olaparib · PMID 42531674 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Currently, PARP inhibitors (PARPis) have been primarily utilized to treat breast cancer susceptibility gene (BRCA)-mut… | Bioorganic & medicinal chemistry 2026-08-16 13:18:00 | Source |
| A phase Ib/II and pharmacokinetic study of EP0057 (formerly CRLX101)… EP0057 · PMID 33390325 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source EP0057 (formerly CRLX101) is an investigational nanoparticle-drug conjugate (NDC) of a cyclodextrin-based polymer backb… | Gynecologic oncology 2026-08-16 13:17:57 | Source |
| Clinical Outcomes and Effectiveness of CRLX101 for Solid Tumors: A Sy… EP0057 · PMID 38415437 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source While it has been demonstrated that delivery of cytotoxic chemotherapy using nanoparticles greatly improves patient dru… | Current medicinal chemistry 2026-08-16 13:17:57 | Source |
| A dual-channel electron expressway triggers piezocatalytic ferroptosi… temozolomide (TMZ) · PMID 42114378 | Cancer | Remyélinisation indirecte / réparation · Thérapie génique | Publication | PubMed | Voir la publication source Glioblastoma (GBM) remains clinically challenging due to its pronounced resistance to conventional chemotherapy. Ferrop… | Biomaterials 2026-08-16 13:17:55 | Source |
| Rewiring cell death and evading repair: Evolution of temozolomide and… temozolomide (TMZ) · PMID 42314466 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor, characterized by a universally dism… | European journal of medicinal chemistry 2026-08-16 13:17:55 | Source |
| Integrative transcriptomics, machine learning, and molecular docking… silevertinib in combination with temozolomide · PMID 42413331 | Cancer | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Glioblastoma presents a significant challenge for drug development due to its complex immunosuppressive microenvironmen… | Computational biology and chemistry 2026-08-16 13:17:53 | Source |
| Selective inhibition of ELFN2-containing PP1 hinders autophagy and en… silevertinib in combination with temozolomide · PMID 42276409 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Glioblastoma (GBM) frequently develops resistance to temozolomide (TMZ), a process critically mediated by pro-survival… | Cancer letters 2026-08-16 13:17:53 | Source |
| Trichodermin exhibits potent anti-glioblastoma activity by inducing c… silevertinib in combination with temozolomide · PMID 42474259 | Cancer | Thérapie cellulaire | Publication | PubMed | Voir la publication source Trichodermin, a sesquiterpene antibiotic from species, shows anticancer potential. In this study, anti-glioblastoma act… | Journal of enzyme inhibition and medicinal chemistry 2026-08-16 13:17:53 | Source |
| Detective flow imaging contrast-enhanced EUS in solid pancreatic lesi… EUS-DFI in Solid Pancreatic Lesions · PMID 39318752 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Detective flow imaging EUS (DFI-EUS) is a new technology that detects fine vessels and low-flow velocity without contra… | Endoscopic ultrasound 2026-08-16 13:17:52 | Source |
| Early Integrated Neuropsychological Care for Patients with Brain Meta… Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases · PMID… | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source Decline of quality of life (QOL) and cognitive function is common for brain metastases patients receiving radiotherapy… | International journal of radiation oncology, biology,… 2026-08-16 13:17:50 | Source |
| Longitudinal changes of neurocognitive function and ALPS-index in pat… Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases · PMID… | Cancer | À vérifier | Publication | PubMed | Voir la publication source BACKGROUND: Neurocognitive decline is common after brain radiotherapy (RT), but underlying mechanisms remain unclear. A… | Journal of neuro-oncology 2026-08-16 13:17:50 | Source |
| Transcranial Magnetic Stimulation for the Treatment of Chemo Brain. Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases · PMID… | Migraine · Cancer | À vérifier | Publication | PubMed | Voir la publication source This pilot feasibility study aimed to evaluate the effects of transcranial magnetic stimulation (TMS) on chemotherapy-r… | Sensors (Basel, Switzerland) 2026-08-16 13:17:50 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||