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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Contrast-enhanced ultrasound as a problem-solving tool and irreversib… Irreversible Electroporation (IRE) · PMID 42305363 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Interventional ultrasound (IUS) supported by contrast-enhanced ultrasound (CEUS) enables accurate real-time characteriz… | Radiology case reports 2026-08-16 13:20:09 | Source |
| Oncologic and functional outcomes of novel focal therapy methods for… Irreversible Electroporation (IRE) · PMID 42489172 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Focal therapy has emerged as a potential treatment option that may provide similar oncological outcomes with fewer comp… | Current opinion in urology 2026-08-16 13:20:09 | Source |
| Prostate imaging after focal ablation scoring after irreversible elec… Irreversible Electroporation (IRE) · PMID 42172740 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Detecting recurrence after focal therapy for prostate cancer is challenging due to treatment-induced MRI changes and un… | European journal of radiology 2026-08-16 13:20:09 | Source |
| Lessons from Exceptional Responders with High-Grade Brain Tumors Trea… Standard-of-care surgery · PMID 41868199 | Cancer | À vérifier | Publication | PubMed | Voir la publication source High-grade gliomas are associated with dismal outcomes and have devastating neurologic sequelae. Standard-of-care surge… | Journal of immunotherapy and precision oncology 2026-08-16 13:20:05 | Source |
| Niacin Modulates Immune Responses in a Phase I Dose-Escalation Clinic… Standard-of-care surgery · PMID 41632924 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Glioblastoma, a highly aggressive and uniformly lethal brain tumor, resists current treatments and immunotherapies by c… | Neurology(R) neuroimmunology & neuroinflammation 2026-08-16 13:20:05 | Source |
| [F]FDG-PET/CT's change in total lesion glycolysis can accurately iden… Standard-of-care surgery · PMID 41145919 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Ultra-short immunotherapy may spare cutaneous squamous cell carcinoma (CSCC) patients from mutilating surgery, but earl… | European journal of nuclear medicine and molecular ima… 2026-08-16 13:20:05 | Source |
| Spotlight on cabozantinib for previously untreated advanced renal cel… Cabozantinib S-malate · PMID 30288108 | Cancer | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source In the past few years, new drugs made their appearance in the first-line setting of treatment for metastatic renal cell… | Cancer management and research 2026-08-16 13:20:04 | Source |
| Update on International Medical Taxonomies of Biomarkers and Their Ap… Cabozantinib S-malate · PMID 35328215 | Cancer | Neuroprotection · Thérapie génique | Publication | PubMed | Voir la publication source Biomarkers (BMs) are medical signs which can be precisely measured and reproduced. Mainly, BMs provide information on t… | Diagnostics (Basel, Switzerland) 2026-08-16 13:20:04 | Source |
| Investigational Use of Real-World Data as a Hybrid Control in Pancrea… Atezolizumab and Recombinant Human Hyaluronidase · PMID 39707623 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Enrolling adequate numbers of patients into the control arm of randomized controlled trials (RCTs) often presents barri… | Clinical pharmacology and therapeutics 2026-08-16 13:20:01 | Source |
| Analysis of the efficacy and safety of the IVD/EM maintenance regimen… Vincristine · PMID 42475939 | Cancer · Insuffisance cardiaque · Sclérose en plaques | Ralentissement de la progression · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source To analyze the efficacy and safety of ifosfamide + vincristine + dexamethasone/etoposide + mitoxantrone (IVD/EM) regime… | Leukemia research 2026-08-16 13:19:57 | Source |
| Interim Positron Emission Tomography-Guided Dose-Adapted Residual Sit… Vincristine · PMID 42440462 | Cancer · Insuffisance cardiaque · Sclérose en plaques | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source Optimal management of diffuse large B-cell lymphoma (DLBCL) patients achieving partial remission (Deauville 5-point sca… | Advances in radiation oncology 2026-08-16 13:19:57 | Source |
| A dual green chromatographic platform for bioanalytical quantificatio… Bendamustine · PMID 42218001 | Cancer · Sclérose en plaques · Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Multiple myeloma (MM) is a hematological malignancy associated with high morbidity and mortality. The BBD salvage regim… | Analytica chimica acta 2026-08-16 13:19:56 | Source |
| Comparative pathogenesis and management of orbital/conjunctival and g… Bendamustine · PMID 41819216 | Cancer · Sclérose en plaques · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of indolent extranodal B-cell non-Hodgkin lymphoma. Orbi… | Survey of ophthalmology 2026-08-16 13:19:56 | Source |
| Follicular Lymphoma Arising in an Ileal Neobladder Presenting as a La… Bendamustine · PMID 42591708 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source Secondary malignancies arising in intestinal segments used for urinary diversion are rare, and reports of malignant lym… | IJU case reports 2026-08-16 13:19:56 | Source |
| A retrospective study of the efficacy and safety of rituximab biosimi… Rituximab biosimilar · PMID 42216069 | Cancer | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Rituximab (RTX) is a monoclonal antibody that targets CD20 and is recommended by the KDIGO guidelines as a first-line t… | BMC pharmacology & toxicology 2026-08-16 13:19:55 | Source |
| Comparative efficacy of tarlatamab and second-line therapies in exten… Amrubicin · PMID 42229339 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source In the phase 3 DeLLphi-304 trial, tarlatamab demonstrated significant clinical benefit over second-line (2L) standard-o… | Lung cancer (Amsterdam, Netherlands) 2026-08-16 13:19:55 | Source |
| Cost-efficiency modeling of conversion to biosimilar rituximab-based… Rituximab biosimilar · PMID 41941177 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Rituximab-pvvr (Ruxience), -abbs (Truxima), and -arrx (Riabni) are biologic therapies approved by the United States Foo… | Journal of medical economics 2026-08-16 13:19:55 | Source |
| Development of a simplified population pharmacokinetic-pharmacodynami… Amrubicin · PMID 42517921 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Amrubicin is an important chemotherapeutic agent for small cell lung cancer; however, severe neutropenia is a major dos… | Cancer chemotherapy and pharmacology 2026-08-16 13:19:55 | Source |
| Safety and effectiveness of rituximab biosimilar (Rituximab-GP2013) v… Rituximab biosimilar · PMID 42520483 | Cancer | À vérifier | Publication | PubMed | Voir la publication source To compare the effectiveness, safety, and retention of rituximab biosimilar (RTX-GP2013) and RTX-originator in RTX-naiv… | Clinics (Sao Paulo, Brazil) 2026-08-16 13:19:55 | Source |
| Wild-Type Sarcomatoid Carcinoma as Acquired Resistance to Tarlatamab… Amrubicin · PMID 42519408 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source EGFR tyrosine kinase inhibitors are the standard treatment for -mutated lung cancer, but acquired resistance frequently… | JTO clinical and research reports 2026-08-16 13:19:55 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||