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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Current perspectives on the pathogenesis of multiple sclerosis: A min… Risk Factors in Early Multiple Sclerosis · PMID 42365629 | Sclérose en plaques | Remyélinisation indirecte / réparation · Neuroprotection · Ralentissement de la… | Publication | PubMed | Voir la publication source Multiple sclerosis (MS) is a chronic immune-mediated demyelinating disease of the central nervous system characterized… | Endocrine regulations 2026-07-08 15:42:38 | Source |
| Diagnostic Value of Neurofilament Light Chain and Glial Fibrillary Ac… Risk Factors in Early Multiple Sclerosis · PMID 42405663 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Headache is one of the most frequent reasons for emergency department (ED) visits, and distinguishing primary from seco… | European journal of neurology 2026-07-08 15:42:38 | Source |
| Comparisons of Respiratory Function and Cardiorespiratory Responses I… Systematic exercise training · PMID 41977107 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source : Regular aerobic exercise during childhood promotes critical physiological adaptations in the cardiovascular and respi… | Journal of clinical medicine 2026-07-08 15:42:37 | Source |
| The angiotensin-converting enzyme I/D polymorphism does not impact tr… Systematic exercise training · PMID 37880303 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Systematic exercise training effectively improves exercise capacity in patients with coronary artery disease (CAD), but… | Scientific reports 2026-07-08 15:42:37 | Source |
| Ginseng glycopeptides from Panax ginseng: Process optimization, struc… Ginseng · PMID 42413671 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source An efficient enzymatic hydrolysis process for preparing ginseng glycopeptides was optimized using response surface meth… | International journal of biological macromolecules 2026-07-08 15:42:35 | Source |
| Procyanidin B2 alleviates triphenyl phosphate-induced colon injury th… Ginseng · PMID 42413335 | Sclérose en plaques | Neuroprotection · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Procyanidin B2 (PCB2), a natural dietary polyphenol with anti-inflammatory and antioxidant properties, demonstrates pot… | Ecotoxicology and environmental safety 2026-07-08 15:42:35 | Source |
| Does physical activity timing differentially correlate with symptoms… Aerobic Exercise in Persons With Multiple Sclerosis With Restless Legs Syndrome · PMID 36049405 | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The present study examined the associations among physical activity during different times of the day(i.e., morning, mi… | Sleep medicine 2026-07-08 14:04:35 | Source |
| Effect of exergaming in people with restless legs syndrome with multi… Aerobic Exercise in Persons With Multiple Sclerosis With Restless Legs Syndrome · PMID 36603295 | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Restless legs syndrome (RLS) is a sensory-motor disorder characterized by an uncomfortable sensation in the lower extre… | Multiple sclerosis and related disorders 2026-07-08 14:04:35 | Source |
| CSF galanin and noradrenaline downregulation by psilocybin therapy in… Psilocybin · PMID 42414566 | Maladie d’Alzheimer · Cancer · Migraine · Maladie de Parkinson · Sclé… | À vérifier | Publication | PubMed | Voir la publication source Psilocybin is a rapid-acting antidepressant, but its mechanism of action in major depressive disorder remains unclear.… | Neuropsychopharmacology : official publication of the… 2026-07-08 12:07:05 | Source |
| α-Adrenergic receptor modulates 5-HT-mediated behavioral effects of M… Psilocybin · PMID 42414551 | Maladie d’Alzheimer · Cancer · Migraine · Maladie de Parkinson · Sclé… | À vérifier | Publication | PubMed | Voir la publication source Classic serotonergic psychedelics such as psilocybin act as agonists at cortical serotonin (5-HT) 2A receptors (5-HTR),… | Molecular psychiatry 2026-07-08 12:07:05 | Source |
| Apoptosis and motor deficits in SPG76 hereditary spastic paraplegia:… Olesoxime · PMID 41620148 | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source SPG76 is a complicated form of hereditary spastic paraplegia (HSP) associated with mutations in the CAPN1 gene. The enc… | Pharmacological research 2026-07-08 12:07:04 | Source |
| Safety and efficacy of apitegromab in nonambulatory type 2 or type 3… Olesoxime · PMID 40818473 | Sclérose latérale amyotrophique | Traitement symptomatique | Publication | PubMed | Voir la publication source Approved spinal muscular atrophy therapies greatly improve clinical outcomes; however, substantial motor function defic… | The Lancet. Neurology 2026-07-08 12:07:04 | Source |
| Cholesterol in amyotrophic lateral sclerosis: a bystander, a biomarke… ALS patients genetic characterization · PMID 42405014 | Sclérose latérale amyotrophique | Ralentissement de la progression | Publication | PubMed | Voir la publication source Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron los… | Atherosclerosis plus 2026-07-08 12:07:03 | Source |
| Striatal neuron dysfunction in C9ORF72-FTD/ALS is driven by AIS and p… ALS patients genetic characterization · PMID 42412610 | Sclérose latérale amyotrophique | Neuroprotection · Thérapie cellulaire | Publication | PubMed | Voir la publication source Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) form a neurodegenerative spectrum characterized b… | Cell reports 2026-07-08 12:07:03 | Source |
| Complement inhibitor therapy in atypical hemolytic uremic syndrome (a… eculizumab · PMID 42399762 | Myasthénie · Sclérose en plaques · Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Eculizumab, a humanized monoclonal antibody, inhibits activation of complement component C5. For patients with atypical… | BMC nephrology 2026-07-08 12:07:02 | Source |
| Digitally Coded, Screen-Printed Flexible Metasurfaces for Tunable Ele… Custom Mask Interface · PMID 42117227 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source We describe a strategy for fabricating programmable metasurfaces with binary spatial material coding on flexible polyet… | ACS applied materials & interfaces 2026-07-08 12:07:02 | Source |
| A case report of atypical hemolytic uremic syndrome with a CFH mutati… eculizumab · PMID 42410819 | Myasthénie · Sclérose en plaques · Myasthénie | Traitement symptomatique | Publication | PubMed | Voir la publication source Atypical hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy (TMA) characterized by microangiopathic… | Medicine 2026-07-08 12:07:01 | Source |
| Baseline peak VO₂ and treatment effect consistency of perioperative r… Inspiratory muscle training · PMID 42410367 | Myasthénie | À vérifier | Publication | PubMed | Voir la publication source In the PORT trial (Perioperative Rehabilitation in Patients Undergoing Elective Cardiac Valve Surgery: A Randomised Con… | BMC anesthesiology 2026-07-08 12:07:00 | Source |
| Inspiratory muscle training as part of multimodal prehabilitation imp… Inspiratory muscle training · PMID 42414962 | Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Older adults awaiting major surgery often present with reduced physical fitness and respiratory muscle weakness, which… | BMC geriatrics 2026-07-08 12:07:00 | Source |
| Disparities in deworming coverage between children with and without d… COVID-19 Pandemic and Parents of Disabled Children · PMID 42264499 | Myopathies | Ralentissement de la progression | Publication | PubMed | Voir la publication source Children with disabilities experience lower school enrolment rates and may be systematically excluded from school-based… | BMJ global health 2026-07-08 12:06:58 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||