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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ginsenoside Rg1 attenuates platelet activation under shear stress via… Ginseng · PMID 42418135 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Ginsenoside Rg1, a key bioactive component of Panax ginseng, is recognized for its cardiovascular protective effects, y… | Journal of thrombosis and thrombolysis 2026-07-08 20:14:05 | Source |
| HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis vi… GNbAC1 · PMID 36769337 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Schizophrenia is a severe neuropsychiatric disorder affecting about 1% of individuals worldwide. Increased innate immun… | International journal of molecular sciences 2026-07-08 20:14:05 | Source |
| Inhibition, biochemical activities, and control efficacy of fluopyram… Ginseng · PMID 42417719 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source To tackle the QoI fungicide resistance of Alternaria spp. (the causal agent of ginseng Alternaria leaf and stem blight… | Plant disease 2026-07-08 20:14:05 | Source |
| Nose-to-brain delivery of riluzole-loaded nanoemulsion in a controlle… Riluzole · PMID 42391660 | Maladie de Parkinson · Sclérose latérale amyotrophique · Maladie de P… | Neuroprotection · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Traumatic brain injury (TBI) triggers oxidative stress, neuroinflammation, and functional impairments, yet effective br… | Colloids and surfaces. B, Biointerfaces 2026-07-08 15:43:18 | Source |
| Recent advances in universal chimeric antigen receptor T cell therapy. UCAR T-cell · PMID 40883768 | Myasthénie | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source While chimeric antigen receptor (CAR) T cell therapy is highly effective for hematological malignancies, its widespread… | Journal of hematology & oncology 2026-07-08 15:43:11 | Source |
| Universal CAR-T Cell Therapy for Cancer Treatment: Advances and Chall… UCAR T-cell · PMID 41179303 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source This review aims to explore the development, challenges, and future directions of UCAR cell therapy as a scalable alter… | Oncology research 2026-07-08 15:43:11 | Source |
| Feasibility and behavioral impact of a wearable-supported digital hea… test of walk · PMID 42416388 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source This proof-of-concept study examined whether wearable devices integrated with the Welloop mobile application and a ligh… | Digital health 2026-07-08 15:43:04 | Source |
| Five-Year Outcomes of Paclitaxel-Coated Balloons in Patients with Dia… test of walk · PMID 42416524 | Myopathies | Thérapie génique | Publication | PubMed | Voir la publication source Long-term outcomes of paclitaxel-coated drug-coated balloons (DCBs) in patients with diabetes mellitus (DM) and infrain… | Vascular health and risk management 2026-07-08 15:43:04 | Source |
| About a case of diffuse endometrial squamous metaplasia after resecto… Leuprorelin (GF) · PMID 20436347 | Cancer | À vérifier | Publication | PubMed | Voir la publication source We report a case of diffuse endometrial squamous metaplasia found after in a resectoscopic myomectomy specimen. A 35-ye… | Applied immunohistochemistry & molecular morphology :… 2026-07-08 15:43:01 | Source |
| Case Report: Conversion therapy for initially unresectable intrahepat… fluorouracil · PMID 42415870 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Intrahepatic Cholangiocarcinoma (ICC) is a highly malignant tumor originating from the intrahepatic biliary epithelium,… | Frontiers in oncology 2026-07-08 15:42:56 | Source |
| Gastric Cancer Treated with 5-Fluorouracil following Discontinuation… fluorouracil · PMID 42416521 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Drug-induced acute pancreatitis (DIAP) is a rare cause of acute pancreatitis, accounting for approximately 3-5% of case… | Case reports in oncology 2026-07-08 15:42:56 | Source |
| Anti-seizure medication in Germany over 25 years: trends in prices an… Brivaracetam (ucb34714) · PMID 42398365 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source To analyse trends in the prices and prescription volumes of anti-seizure medications (ASMs) in Germany from 2000 to 202… | Epilepsy & behavior : E&B 2026-07-08 15:42:53 | Source |
| Brivaracetam as viable monotherapy option for focal and generalized e… Brivaracetam (ucb34714) · PMID 42400971 | Épilepsie | Traitement symptomatique | Publication | PubMed | Voir la publication source Antiseizure monotherapy is the gold standard of early epilepsy care. We investigated whether Brivaracetam (BRV), a high… | Epilepsy & behavior : E&B 2026-07-08 15:42:53 | Source |
| A survey on treatment satisfaction with leuprorelin acetate in girls… GnRH, gonadorelin acetate · PMID 42415823 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Central precocious puberty (CPP) is often treated with gonadotropin-releasing hormone (GnRH) analogs to manage compromi… | Clinical pediatric endocrinology : case reports and cl… 2026-07-08 15:42:52 | Source |
| Single-nuclei RNA sequencing reveals heterogeneity within developing… GnRH, gonadorelin acetate · PMID 42415515 | Maladie d’Alzheimer | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Gonadotropin-releasing hormone (GnRH) is a central regulator of vertebrate reproduction regulating pituitary gonadotrop… | Journal of neuroendocrinology 2026-07-08 15:42:52 | Source |
| Clinical Characterization of Enzyme and Transporter Precipitants to E… Digoxin · PMID 42399716 | Épilepsie · Sclérose latérale amyotrophique · Sclérose latérale amyot… | À vérifier | Publication | PubMed | Voir la publication source Orforglipron is an orally administered, small-molecule glucagon-like peptide-1 receptor agonist in clinical development… | Clinical pharmacology and therapeutics 2026-07-08 15:42:51 | Source |
| Comparative effectiveness of 200mcg versus 400mcg misoprostol dosing… Digoxin · PMID 42401255 | Épilepsie · Sclérose latérale amyotrophique · Sclérose latérale amyot… | À vérifier | Publication | PubMed | Voir la publication source To assess efficacy and adverse outcomes of misoprostol 200mcg versus 400mcg every three hours buccal or vaginal for med… | Contraception 2026-07-08 15:42:51 | Source |
| EphB1-Mediated Transient Blood-Brain Barrier Opening Facilitates a Fe… Donepezil · PMID 42406553 | Maladie d’Alzheimer | Remyélinisation indirecte / réparation · Immunomodulation | Publication | PubMed | Voir la publication source The treatment of Alzheimer's disease (AD) is severely hampered by the blood-brain barrier (BBB), which limits the deliv… | Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026-07-08 15:42:49 | Source |
| Post Hoc Subgroup Analysis by Disease Severity in a Non-Inferiority T… Donepezil · PMID 42411945 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source The efficacy of cholinesterase inhibitors varies depending on the severity of Alzheimer disease. We examined the effect… | Alzheimer disease and associated disorders 2026-07-08 15:42:49 | Source |
| Impact of an exercise program on physical, emotional, and social aspe… Changes in Movement, Fitness, and Quality of Life in People With Parkinson's Disease After Dif… | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source We evaluated changes in different domains of quality of life (QL) for persons with Parkinson's disease after a program… | Movement disorders : official journal of the Movement… 2026-07-08 15:42:44 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||