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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
9643 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4897
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| CD19 PD-1/CD28 CAR-T Plus Low Dose Decitabine NCT04850560 · Sequential Low-dose Decitabine With PD-1/CD28 CD19 CAR-T in Relapsed or Refracto… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | UNKNOWN | To evaluate the efficacy and safety of CD19 PD-1/CD28-CAR-T sequential low… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:13 | Détail |
| Fast Dual CAR-T Injection NCT04877080 · CD19 and BCMA Targeted Fast Dual CAR-T for CD19+ Refractory/Relapsed B-NHL | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | WITHDRAWN | This is a single arm, open-label, single-center prospective study to deter… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:13 | Détail |
| MB-CART2019.1 NCT07288879 · DALY II Japan/MB-CART2019.1 for DLBCL | Sclérose en plaques | Immunomodulation | Phase 2 | RECRUITING | DALY II Japan is a phase II, multi-center, single arm study to evaluate th… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:12 | Détail |
| Rituximab NCT01609023 · CaLLypso — A Study of Rituximab (MabThera) in Combination With Chemotherapy in P… | Sclérose en plaques | Immunomodulation | À vérifier | COMPLETED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:12 | Détail |
| Rituximab NCT00004179 · Combination Chemotherapy With or Without Rituximab in Treating Patients With Rel… | Sclérose en plaques | À vérifier | Phase 3 | COMPLETED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:12 | Détail |
| C-CAR168 NCT07729826 · C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy,… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire · Thérapie génique | Phase 2 | NOT_YET_RECRUITING | This Phase 2, multicenter, open-label study will evaluate the safety and e… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:11 | Détail |
| Aminophylline NCT06196853 · Prevention of Cisplatin-induced Nephrotoxicity | Sclérose en plaques | À vérifier | Phase 2/3 | NOT_YET_RECRUITING | This safety study is the first in a series of studies testing the applicat… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| Aminophylline-Dexmedetomidine NCT06125665 · Aminophylline on Perioperative Lung Mechanics in COPD Morbidly Obese Patients Un… | Sclérose en plaques | À vérifier | Non applicable | UNKNOWN | The aim of this study is to evaluate the usefulness of adding aminophyllin… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| Empirical therapy group NCT03319121 · The Evaluation of Effectiveness Between Empirical and Guided Therapy for Unexpla… | Sclérose en plaques | Traitement symptomatique | Phase 2/3 | COMPLETED | This is a prospective randomised clinical trial performed in a single cent… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| Intravesical Aminophylline NCT07617948 · Intravesical Aminophylline for Urgent Ureteral Stenting in Acute Calculous Anuria | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Phase 2 | RECRUITING | Acute calculous anuria is a urological emergency caused by ureteral stone… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| IV Aminophylline NCT03997006 · RCT — Is Aminophylline More Effective Than Neostigmine/Atropine Mixture in the T… | Sclérose en plaques | À vérifier | Phase 4 | COMPLETED | Objectives: To compare the safety and efficacy of IV aminophylline versus… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| Lebrikizumab NCT01875003 · A Study of Lebrikizumab in Adolescent Participants With Uncontrolled Asthma Who… | Sclérose en plaques | À vérifier | Phase 3 | TERMINATED | This randomized, multicenter, double-blind, placebo-controlled, parallel-g… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| Tamsulosin NCT07623876 · TAM-AMIN-UAS — Tamsulosin and Intraureteral Aminophylline for Ureteral Access Du… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This multicenter randomized controlled trial will evaluate whether preoper… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| MK0476; montelukast sodium/Duration of Treatment: 16 weeks NCT00157937 · A Study to Compare Effectiveness of Montelukast Sodium With Comparator in Mild t… | Sclérose en plaques | À vérifier | Phase 4 | COMPLETED | Subjects have 8-week with montelukast sodium or comparator drug administra… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:06 | Détail |
| Single Dose Theophylline NCT05853601 · TheoPHyLNNe — Theophylline Prophylaxis During Hypothermia to Limit Neonatal Neph… | Sclérose en plaques | À vérifier | Phase 1/2 | ACTIVE_NOT_RECRUITING | Acute kidney injury is a significant complication for infants who experien… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:06 | Détail |
| Dapagliflozin 10 mg/day (oral) NCT05374291 · The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal… | Maladie rénale chronique | À vérifier | Phase 3 | ACTIVE_NOT_RECRUITING | Rationale: Sodium glucose co transporter 2 (SGLT2) inhibitors are a relati… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:53 | Détail |
| isolated Ultrafiltration (iso-UF) NCT05642156 · ISO-UF — Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultra… | Maladie rénale chronique | À vérifier | Non applicable | RECRUITING | Patients treated with hemodialysis (HD) bear increased risk of cardiovascu… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:50 | Détail |
| AI-Guided Relaxation Platform NCT07522944 · AI-Guided Personalized Relaxation for Hemodialysis Patients | Maladie rénale chronique | Traitement symptomatique | Non applicable | COMPLETED | Patients undergoing maintenance hemodialysis frequently experience impaire… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:49 | Détail |
| BMS-986553 NCT07873931 · A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases | Maladie rénale chronique | Immunomodulation | Phase 1 | NOT_YET_RECRUITING | The purpose of this study is to evaluate the safety and tolerability of BM… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:49 | Détail |
| Clazakizumab NCT07783802 · CLARITY-CRP — A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP… | Maladie rénale chronique | Immunomodulation | Phase 2 | RECRUITING | The purpose of this study is to measure the change in high-sensitivity C-r… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:49 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4725
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| K7 and K Potassium Channels in Thalamocortical Function and Their The… Effects of Antiepileptic Drugs on Brain Excitability · PMID 42261627 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Potassium (K) channels are one of the key regulators of neuronal excitability and network stability. Among all the pota… | Archiv der Pharmazie 2026-07-08 12:06:42 | Source |
| Lateral Habenula 5-HT₂A Receptors Mediate Social Deficits in a Valpro… Effects of Antiepileptic Drugs on Brain Excitability · PMID 42277370 | Épilepsie | Traitement symptomatique | Publication | PubMed | Voir la publication source Autism Spectrum Disorder (ASD) is characterized by social deficits, yet underlying neural mechanisms remain poorly unde… | Molecular neurobiology 2026-07-08 12:06:42 | Source |
| Progress report on new antiepileptic drugs: a summary of the Ninth Ei… BIA 2-093 · PMID 19008076 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source The Ninth Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT IX, took place in Sitges, Barcelona from the 15th to… | Epilepsy research 2026-07-08 12:06:42 | Source |
| Diagnostic performance of [18F]FDG PET/CT in large vessel vasculitis… 18F-FDG · PMID 42411928 | Cancer · Épilepsie · Épilepsie | Immunomodulation | Publication | PubMed | Voir la publication source Large vessel vasculitis (LVV), encompassing giant cell arteritis (GCA), Takayasu arteritis (TAK) and polymyalgia rheuma… | The quarterly journal of nuclear medicine and molecula… 2026-07-08 12:06:41 | Source |
| Divergent Radiomolecular Phenotype of Spindle Cell Lipoma: Inten… 18F-FDG · PMID 42411770 | Cancer | À vérifier | Publication | PubMed | Voir la publication source A 68-year-old man with gastric cancer underwent 18F-fluorodeoxyglucose (FDG) PET/CT, which revealed an incidental subcu… | Clinical nuclear medicine 2026-07-08 12:06:41 | Source |
| Intermittent theta burst stimulation enhances the efficacy of brain-c… Intermittent theta burst stimulation · PMID 42404120 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source "BCI illiteracy," characterized by insufficient -rhythm Event-Related Desynchronization (ERD) in approximately 40% of s… | Frontiers in neurology 2026-07-08 12:06:40 | Source |
| Subchronic comparative assessment of graded ferrous sulfate doses on… 0.9% NaCl · PMID 42376110 | Maladie d’Alzheimer | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Iron is a necessary trace element in the human body. However, excessive concentration can promote the overproduction of… | Open veterinary journal 2026-07-08 12:06:39 | Source |
| Sustainable soil improvement strategies for coral islands: Synergisti… 0.9% NaCl · PMID 42379437 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source The sustainable development of coral islands is constrained by bottleneck issues such as poor water retention and nutri… | International journal of biological macromolecules 2026-07-08 12:06:39 | Source |
| Minaxolone: an evaluation with and without premedication. Allopregnanolone injection (intravenous solution) · PMID 7270828 | Maladie d’Alzheimer | Traitement symptomatique | Publication | PubMed | Voir la publication source Minaxolone, a water-soluble steroid intravenous anaesthetic, has been used in clinical trials for induction and mainten… | Anaesthesia 2026-07-08 12:06:38 | Source |
| Continuous theta burst stimulation to the frontal pole durably decrea… Continuous theta burst stimulation · PMID 42379239 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source The frontal pole is a transdiagnostic target for affective disorders, perhaps through its connectivity with affective r… | International review of psychiatry (Abingdon, England) 2026-07-08 12:06:37 | Source |
| Role of the Upper Motor Neuron in the Generation of Fasciculations in… Continuous theta burst stimulation · PMID 42407013 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source The origin of fasciculation potentials (FPs) in the early stages of amyotrophic lateral sclerosis (ALS) remains a subje… | Neurology 2026-07-08 12:06:37 | Source |
| Extrapontine Myelinolysis and Reversible Parkinsonism After Hyponatre… Levodopa/carbidopa solution for SC administration · PMID 30055367 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Osmotic demyelination syndrome commonly follows rapid correction of hyponatremia. Although pons is a common location, e… | World neurosurgery 2026-07-08 12:06:36 | Source |
| Foslevodopa/Foscarbidopa: A New Subcutaneous Treatment for Parkinson'… Levodopa/carbidopa solution for SC administration · PMID 33772855 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source The aim was to demonstrate that continuous s.c. infusion of a soluble levodopa (LD)/carbidopa (CD) phosphate prodrug co… | Annals of neurology 2026-07-08 12:06:36 | Source |
| Between Surgery and Science: Patient Journeys in Deep Brain Stimulati… Determining Patterns In Trial Experiences of Parkinson's Disease Patients · PMID 41910515 | Maladie de Parkinson | Thérapie génique | Publication | PubMed | Voir la publication source For the past 25 years, local field potential (LFP) recordings from externalized deep brain stimulation (DBS) leads have… | Neuromodulation : journal of the International Neuromo… 2026-07-08 12:06:35 | Source |
| Technology Acceptance of 2 mHealth Apps During an Observational Techn… Determining Patterns In Trial Experiences of Parkinson's Disease Patients · PMID 42061832 | Maladie de Parkinson | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Mobile health (mHealth) apps are useful tools for research and disease management. However, implementation of mHealth a… | JMIR human factors 2026-07-08 12:06:35 | Source |
| The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in… ACP-103 · PMID 37627285 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Almost 25% of schizophrenia patients suffer from obsessive-compulsive symptoms (OCS) considered a transdiagnostic clini… | Biomolecules 2026-07-08 12:06:34 | Source |
| Unlocking the potential of lumateperone and novel anti-psychotics for… ACP-103 · PMID 40161932 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Schizophrenia is a devastating chronic mental health illness which includes a complex set of symptoms like hallucinatio… | BioImpacts : BI 2026-07-08 12:06:34 | Source |
| A Qualitative Study of Lived Treatment Experiences and Preferences of… Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis · PMID 42247185 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Relapsing-remitting multiple sclerosis (RRMS) requires prolonged use of disease-modifying therapies (DMTs), often perce… | Neurology and therapy 2026-07-08 12:06:33 | Source |
| Complex emotion recognition in neurological and neurodevelopmental co… Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis · PMID 42176442 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Social cognition deficits are prevalent but under-recognised in neurological and neurodevelopmental disorders. Complex… | Acta psychologica 2026-07-08 12:06:33 | Source |
| Assessing Progression Independent of Relapse Activity in Multiple Scl… Ambulation Study in Multiple Sclerosis · PMID 42405485 | Sclérose en plaques | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source The objective of this study was to investigate the ability of patient-reported/administered outcomes to capture disabil… | Annals of neurology 2026-07-08 12:06:32 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||