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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
9643 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4897
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| CD19 PD-1/CD28 CAR-T Plus Low Dose Decitabine NCT04850560 · Sequential Low-dose Decitabine With PD-1/CD28 CD19 CAR-T in Relapsed or Refracto… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | UNKNOWN | To evaluate the efficacy and safety of CD19 PD-1/CD28-CAR-T sequential low… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:13 | Détail |
| Fast Dual CAR-T Injection NCT04877080 · CD19 and BCMA Targeted Fast Dual CAR-T for CD19+ Refractory/Relapsed B-NHL | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | WITHDRAWN | This is a single arm, open-label, single-center prospective study to deter… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:13 | Détail |
| MB-CART2019.1 NCT07288879 · DALY II Japan/MB-CART2019.1 for DLBCL | Sclérose en plaques | Immunomodulation | Phase 2 | RECRUITING | DALY II Japan is a phase II, multi-center, single arm study to evaluate th… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:12 | Détail |
| Rituximab NCT01609023 · CaLLypso — A Study of Rituximab (MabThera) in Combination With Chemotherapy in P… | Sclérose en plaques | Immunomodulation | À vérifier | COMPLETED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:12 | Détail |
| Rituximab NCT00004179 · Combination Chemotherapy With or Without Rituximab in Treating Patients With Rel… | Sclérose en plaques | À vérifier | Phase 3 | COMPLETED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:12 | Détail |
| C-CAR168 NCT07729826 · C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy,… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire · Thérapie génique | Phase 2 | NOT_YET_RECRUITING | This Phase 2, multicenter, open-label study will evaluate the safety and e… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:11 | Détail |
| Aminophylline NCT06196853 · Prevention of Cisplatin-induced Nephrotoxicity | Sclérose en plaques | À vérifier | Phase 2/3 | NOT_YET_RECRUITING | This safety study is the first in a series of studies testing the applicat… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| Aminophylline-Dexmedetomidine NCT06125665 · Aminophylline on Perioperative Lung Mechanics in COPD Morbidly Obese Patients Un… | Sclérose en plaques | À vérifier | Non applicable | UNKNOWN | The aim of this study is to evaluate the usefulness of adding aminophyllin… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| Empirical therapy group NCT03319121 · The Evaluation of Effectiveness Between Empirical and Guided Therapy for Unexpla… | Sclérose en plaques | Traitement symptomatique | Phase 2/3 | COMPLETED | This is a prospective randomised clinical trial performed in a single cent… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| Intravesical Aminophylline NCT07617948 · Intravesical Aminophylline for Urgent Ureteral Stenting in Acute Calculous Anuria | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Phase 2 | RECRUITING | Acute calculous anuria is a urological emergency caused by ureteral stone… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| IV Aminophylline NCT03997006 · RCT — Is Aminophylline More Effective Than Neostigmine/Atropine Mixture in the T… | Sclérose en plaques | À vérifier | Phase 4 | COMPLETED | Objectives: To compare the safety and efficacy of IV aminophylline versus… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| Lebrikizumab NCT01875003 · A Study of Lebrikizumab in Adolescent Participants With Uncontrolled Asthma Who… | Sclérose en plaques | À vérifier | Phase 3 | TERMINATED | This randomized, multicenter, double-blind, placebo-controlled, parallel-g… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| Tamsulosin NCT07623876 · TAM-AMIN-UAS — Tamsulosin and Intraureteral Aminophylline for Ureteral Access Du… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This multicenter randomized controlled trial will evaluate whether preoper… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:07 | Détail |
| MK0476; montelukast sodium/Duration of Treatment: 16 weeks NCT00157937 · A Study to Compare Effectiveness of Montelukast Sodium With Comparator in Mild t… | Sclérose en plaques | À vérifier | Phase 4 | COMPLETED | Subjects have 8-week with montelukast sodium or comparator drug administra… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:06 | Détail |
| Single Dose Theophylline NCT05853601 · TheoPHyLNNe — Theophylline Prophylaxis During Hypothermia to Limit Neonatal Neph… | Sclérose en plaques | À vérifier | Phase 1/2 | ACTIVE_NOT_RECRUITING | Acute kidney injury is a significant complication for infants who experien… À vérifier | ClinicalTrials.gov 2026-10-18 04:38:06 | Détail |
| Dapagliflozin 10 mg/day (oral) NCT05374291 · The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal… | Maladie rénale chronique | À vérifier | Phase 3 | ACTIVE_NOT_RECRUITING | Rationale: Sodium glucose co transporter 2 (SGLT2) inhibitors are a relati… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:53 | Détail |
| isolated Ultrafiltration (iso-UF) NCT05642156 · ISO-UF — Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultra… | Maladie rénale chronique | À vérifier | Non applicable | RECRUITING | Patients treated with hemodialysis (HD) bear increased risk of cardiovascu… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:50 | Détail |
| AI-Guided Relaxation Platform NCT07522944 · AI-Guided Personalized Relaxation for Hemodialysis Patients | Maladie rénale chronique | Traitement symptomatique | Non applicable | COMPLETED | Patients undergoing maintenance hemodialysis frequently experience impaire… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:49 | Détail |
| BMS-986553 NCT07873931 · A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases | Maladie rénale chronique | Immunomodulation | Phase 1 | NOT_YET_RECRUITING | The purpose of this study is to evaluate the safety and tolerability of BM… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:49 | Détail |
| Clazakizumab NCT07783802 · CLARITY-CRP — A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP… | Maladie rénale chronique | Immunomodulation | Phase 2 | RECRUITING | The purpose of this study is to measure the change in high-sensitivity C-r… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:49 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4725
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Long-term neuromuscular alterations during botulinum toxin treatment… Botulinum toxin type A · PMID 42394961 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source To evaluate early and long-term neuromuscular and clinical effects of botulinum toxin type A (BoNTA) in women with chro… | Clinical neurophysiology practice 2026-07-08 12:06:55 | Source |
| Pilot RCT comparing low-dose naltrexone, gabapentin and placebo to re… Low-Dose Naltrexone, 4.5mg · PMID 38408060 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source To estimate the effects on pain of two medications (low-dose naltrexone and gabapentin) compared to placebo among peopl… | PloS one 2026-07-08 12:06:53 | Source |
| Pilot trial of low-dose naltrexone and quality of life in multiple sc… Low-Dose Naltrexone, 4.5mg · PMID 20695007 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source To evaluate the efficacy of 4.5mg nightly naltrexone on the quality of life of multiple sclerosis (MS) patients. This s… | Annals of neurology 2026-07-08 12:06:53 | Source |
| Agomelatine for Sjögren's syndrome: a study on its therapeutic effect… Hydroxychloroquine · PMID 42406252 | Lupus | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Sjogren's Syndrome (SS) is an autoimmune disease characterized mainly by xerostomia (dry mouth), xerophthalmia (dry eye… | Inflammopharmacology 2026-07-08 12:06:52 | Source |
| Targeting lysosomes with a novel chloroquine derivative induces irrev… Hydroxychloroquine · PMID 42410967 | Cancer | Remyélinisation indirecte / réparation · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Pancreatic ductal adenocarcinoma (PDAC) exhibits profound therapy resistance driven by lysosome-dependent nutrient recy… | Autophagy 2026-07-08 12:06:52 | Source |
| Influenza vaccine uptake in juvenile idiopathic arthritis during the… Vaccination Perception in Inflammatory Conditions - Flu, Pneumonia and COVID-19 · PMID 41094677 | Lupus | Immunomodulation | Publication | PubMed | Voir la publication source Children with rheumatic diseases are at risk for contracting severe influenza and COVID-19 and are thus targeted for th… | Pediatric rheumatology online journal 2026-07-08 12:06:51 | Source |
| Mesenchymal Stromal Cells Improve Postoperative Cardiac Dysmaturation… MSC treatment · PMID 42396758 | Lupus | Neuroprotection · Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Mesenchymal stromal cells (MSCs) are known to protect tissues from inflammation and oxidative stress. This study aimed… | Journal of the American Heart Association 2026-07-08 12:06:50 | Source |
| Evaluation of [18F]MFPBG: a novel automatically radiolabeled probe fo… Positron Emission Tomography · PMID 42414788 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Cardiac sympathetic nerve imaging is critical for sudden death risk stratification in heart failure patients. Conventio… | EJNMMI research 2026-07-08 12:06:49 | Source |
| Radioluminescence microscopy of tumor organoids enabled by a reconfig… Positron Emission Tomography · PMID 42414758 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source This study aims to construct and implement an experimental radioluminescence microscopy (RLM) setup using a standard li… | EJNMMI research 2026-07-08 12:06:49 | Source |
| Assessing Bone Marrow Activity with []FLT PET in Patients with Essent… Fluorothymidine F-18 · PMID 35341409 | Cancer | À vérifier | Publication | PubMed | Voir la publication source This study aims to assess the value of FLT-PET as a non-invasive tool to differentiate between patients with ET and Pre… | Technology in cancer research & treatment 2026-07-08 12:06:48 | Source |
| Quantification of uptake in pelvis F-18 FLT PET-CT images using a 3D… Fluorothymidine F-18 · PMID 34982836 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source The purpose of this work was to develop and validate a deep convolutional neural network (CNN) approach for the automat… | Medical physics 2026-07-08 12:06:48 | Source |
| Chitosan/β-cyclodextrin nanocarriers enhance 5-fluorouracil efficacy… fluorouracil · PMID 42414363 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Globally, colorectal cancer continues to be a major cause of cancer-related death. Clinical application of 5‑fluorourac… | Scientific reports 2026-07-08 12:06:46 | Source |
| The Landmark Series: Neoadjuvant Therapy for Patients with Resectable… fluorouracil · PMID 42414817 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Neoadjuvant therapy is a cornerstone of treatment for resectable gastroesophageal junction (GEJ) tumors. Despite substa… | Annals of surgical oncology 2026-07-08 12:06:46 | Source |
| CBCT based online daily adaptive treatment improves target coverage w… radiation therapy · PMID 42415083 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source The precise application of stereotactic body radiation therapy (SBRT) for prostate cancer is challenged by prostate mot… | Radiation oncology (London, England) 2026-07-08 12:06:45 | Source |
| Comparative outcomes of proton and photon therapy in the management o… radiation therapy · PMID 42414660 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive sarcomas often arising in the spine, characterized by… | European spine journal : official publication of the E… 2026-07-08 12:06:45 | Source |
| Association Between Geriatric Nutritional Risk Index and Gemcitabine… paclitaxel albumin-stabilized nanoparticle formulation · PMID 42373239 | Cancer | À vérifier | Publication | PubMed | Voir la publication source This retrospective study evaluated the impact of Geriatric Nutritional Risk Index (GNRI) group on time to treatment fai… | Anticancer research 2026-07-08 12:06:44 | Source |
| Nab-paclitaxel or Paclitaxel Treatment for Relapsed Small Cell Lung C… paclitaxel albumin-stabilized nanoparticle formulation · PMID 42373285 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Relapsed small cell lung cancer (SCLC) treatment has limited evidence-based options. Solvent-based paclitaxel (PTX) and… | Anticancer research 2026-07-08 12:06:44 | Source |
| Responsive stimulation of the thalamus for idiopathic generalized epi… RNS® System · PMID 42233958 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source This study was undertaken to evaluate the safety and effectiveness of responsive thalamic stimulation as adjunctive the… | Epilepsia 2026-07-08 12:06:44 | Source |
| Thalamocortical seizure onset patterns in drug-resistant focal epilep… RNS® System · PMID 42396599 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Drug-resistant epilepsy affects tens of millions of people worldwide and is associated with considerable morbidity and… | Brain communications 2026-07-08 12:06:44 | Source |
| A review of the efficacy and safety of eslicarbazepine acetate in the… BIA 2-093 · PMID 26136845 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Eslicarbazepine acetate is a is a once-daily antiepileptic drug (AED) that was approved in 2009 by the European Medicin… | Therapeutic advances in neurological disorders 2026-07-08 12:06:42 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||