Vue transversale globale
Toutes les maladies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
Filtrer toute la vue
Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
· 36 visibles sur cette page
dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Role of the Upper Motor Neuron in the Generation of Fasciculations in… Continuous theta burst stimulation · PMID 42407013 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source The origin of fasciculation potentials (FPs) in the early stages of amyotrophic lateral sclerosis (ALS) remains a subje… | Neurology 2026-07-08 12:06:37 | Source |
| Extrapontine Myelinolysis and Reversible Parkinsonism After Hyponatre… Levodopa/carbidopa solution for SC administration · PMID 30055367 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Osmotic demyelination syndrome commonly follows rapid correction of hyponatremia. Although pons is a common location, e… | World neurosurgery 2026-07-08 12:06:36 | Source |
| Foslevodopa/Foscarbidopa: A New Subcutaneous Treatment for Parkinson'… Levodopa/carbidopa solution for SC administration · PMID 33772855 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source The aim was to demonstrate that continuous s.c. infusion of a soluble levodopa (LD)/carbidopa (CD) phosphate prodrug co… | Annals of neurology 2026-07-08 12:06:36 | Source |
| Between Surgery and Science: Patient Journeys in Deep Brain Stimulati… Determining Patterns In Trial Experiences of Parkinson's Disease Patients · PMID 41910515 | Maladie de Parkinson | Thérapie génique | Publication | PubMed | Voir la publication source For the past 25 years, local field potential (LFP) recordings from externalized deep brain stimulation (DBS) leads have… | Neuromodulation : journal of the International Neuromo… 2026-07-08 12:06:35 | Source |
| Technology Acceptance of 2 mHealth Apps During an Observational Techn… Determining Patterns In Trial Experiences of Parkinson's Disease Patients · PMID 42061832 | Maladie de Parkinson | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Mobile health (mHealth) apps are useful tools for research and disease management. However, implementation of mHealth a… | JMIR human factors 2026-07-08 12:06:35 | Source |
| The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in… ACP-103 · PMID 37627285 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Almost 25% of schizophrenia patients suffer from obsessive-compulsive symptoms (OCS) considered a transdiagnostic clini… | Biomolecules 2026-07-08 12:06:34 | Source |
| Unlocking the potential of lumateperone and novel anti-psychotics for… ACP-103 · PMID 40161932 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Schizophrenia is a devastating chronic mental health illness which includes a complex set of symptoms like hallucinatio… | BioImpacts : BI 2026-07-08 12:06:34 | Source |
| A Qualitative Study of Lived Treatment Experiences and Preferences of… Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis · PMID 42247185 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Relapsing-remitting multiple sclerosis (RRMS) requires prolonged use of disease-modifying therapies (DMTs), often perce… | Neurology and therapy 2026-07-08 12:06:33 | Source |
| Complex emotion recognition in neurological and neurodevelopmental co… Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis · PMID 42176442 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Social cognition deficits are prevalent but under-recognised in neurological and neurodevelopmental disorders. Complex… | Acta psychologica 2026-07-08 12:06:33 | Source |
| Assessing Progression Independent of Relapse Activity in Multiple Scl… Ambulation Study in Multiple Sclerosis · PMID 42405485 | Sclérose en plaques | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source The objective of this study was to investigate the ability of patient-reported/administered outcomes to capture disabil… | Annals of neurology 2026-07-08 12:06:32 | Source |
| Comparative effects of pilates-based interventions on functional mobi… Ambulation Study in Multiple Sclerosis · PMID 42400084 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Pilates-based exercise has gained attention as a non-pharmacological rehabilitation strategy for people with multiple s… | BMC sports science, medicine & rehabilitation 2026-07-08 12:06:32 | Source |
| Commentary: The effects of postponing BCG vaccination on the risk of… Bacille Calmette-Guerin vaccine · PMID 42282960 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Frontiers in immunology 2026-07-08 12:06:31 | Source |
| Single cell transcriptomics reveals dendritic cell subsets in bovine… Bacille Calmette-Guerin vaccine · PMID 42023217 | Sclérose en plaques | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Bovine tuberculosis (bTB), caused by (), remains an ongoing global issue for human and animal health. The Bacille Calme… | Frontiers in immunology 2026-07-08 12:06:31 | Source |
| Effects of Drugs for the Treatment of Multiple Sclerosis in Severe Ac… Fingolimod · PMID 42381150 | Sclérose en plaques | Remyélinisation · Neuroprotection · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Multiple sclerosis (MS) is an immune-mediated and demyelinating disease affecting oligodendrocytes, leading to neurodeg… | Current neuropharmacology 2026-07-08 12:06:30 | Source |
| Impact of multiple sclerosis disease-modifying therapies on chronic l… Fingolimod · PMID 42384032 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Chronic lesion tissue expansion (CLTE) reflects slow, concentric growth of established multiple sclerosis (MS) lesions… | Multiple sclerosis (Houndmills, Basingstoke, England) 2026-07-08 12:06:30 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||