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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Quantification of uptake in pelvis F-18 FLT PET-CT images using a 3D… Fluorothymidine F-18 · PMID 34982836 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source The purpose of this work was to develop and validate a deep convolutional neural network (CNN) approach for the automat… | Medical physics 2026-07-08 12:06:48 | Source |
| Chitosan/β-cyclodextrin nanocarriers enhance 5-fluorouracil efficacy… fluorouracil · PMID 42414363 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Globally, colorectal cancer continues to be a major cause of cancer-related death. Clinical application of 5‑fluorourac… | Scientific reports 2026-07-08 12:06:46 | Source |
| The Landmark Series: Neoadjuvant Therapy for Patients with Resectable… fluorouracil · PMID 42414817 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Neoadjuvant therapy is a cornerstone of treatment for resectable gastroesophageal junction (GEJ) tumors. Despite substa… | Annals of surgical oncology 2026-07-08 12:06:46 | Source |
| CBCT based online daily adaptive treatment improves target coverage w… radiation therapy · PMID 42415083 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source The precise application of stereotactic body radiation therapy (SBRT) for prostate cancer is challenged by prostate mot… | Radiation oncology (London, England) 2026-07-08 12:06:45 | Source |
| Comparative outcomes of proton and photon therapy in the management o… radiation therapy · PMID 42414660 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive sarcomas often arising in the spine, characterized by… | European spine journal : official publication of the E… 2026-07-08 12:06:45 | Source |
| Association Between Geriatric Nutritional Risk Index and Gemcitabine… paclitaxel albumin-stabilized nanoparticle formulation · PMID 42373239 | Cancer | À vérifier | Publication | PubMed | Voir la publication source This retrospective study evaluated the impact of Geriatric Nutritional Risk Index (GNRI) group on time to treatment fai… | Anticancer research 2026-07-08 12:06:44 | Source |
| Nab-paclitaxel or Paclitaxel Treatment for Relapsed Small Cell Lung C… paclitaxel albumin-stabilized nanoparticle formulation · PMID 42373285 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Relapsed small cell lung cancer (SCLC) treatment has limited evidence-based options. Solvent-based paclitaxel (PTX) and… | Anticancer research 2026-07-08 12:06:44 | Source |
| Responsive stimulation of the thalamus for idiopathic generalized epi… RNS® System · PMID 42233958 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source This study was undertaken to evaluate the safety and effectiveness of responsive thalamic stimulation as adjunctive the… | Epilepsia 2026-07-08 12:06:44 | Source |
| Thalamocortical seizure onset patterns in drug-resistant focal epilep… RNS® System · PMID 42396599 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Drug-resistant epilepsy affects tens of millions of people worldwide and is associated with considerable morbidity and… | Brain communications 2026-07-08 12:06:44 | Source |
| A review of the efficacy and safety of eslicarbazepine acetate in the… BIA 2-093 · PMID 26136845 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Eslicarbazepine acetate is a is a once-daily antiepileptic drug (AED) that was approved in 2009 by the European Medicin… | Therapeutic advances in neurological disorders 2026-07-08 12:06:42 | Source |
| K7 and K Potassium Channels in Thalamocortical Function and Their The… Effects of Antiepileptic Drugs on Brain Excitability · PMID 42261627 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Potassium (K) channels are one of the key regulators of neuronal excitability and network stability. Among all the pota… | Archiv der Pharmazie 2026-07-08 12:06:42 | Source |
| Lateral Habenula 5-HT₂A Receptors Mediate Social Deficits in a Valpro… Effects of Antiepileptic Drugs on Brain Excitability · PMID 42277370 | Épilepsie | Traitement symptomatique | Publication | PubMed | Voir la publication source Autism Spectrum Disorder (ASD) is characterized by social deficits, yet underlying neural mechanisms remain poorly unde… | Molecular neurobiology 2026-07-08 12:06:42 | Source |
| Progress report on new antiepileptic drugs: a summary of the Ninth Ei… BIA 2-093 · PMID 19008076 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source The Ninth Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT IX, took place in Sitges, Barcelona from the 15th to… | Epilepsy research 2026-07-08 12:06:42 | Source |
| Diagnostic performance of [18F]FDG PET/CT in large vessel vasculitis… 18F-FDG · PMID 42411928 | Cancer · Épilepsie · Épilepsie | Immunomodulation | Publication | PubMed | Voir la publication source Large vessel vasculitis (LVV), encompassing giant cell arteritis (GCA), Takayasu arteritis (TAK) and polymyalgia rheuma… | The quarterly journal of nuclear medicine and molecula… 2026-07-08 12:06:41 | Source |
| Divergent Radiomolecular Phenotype of Spindle Cell Lipoma: Inten… 18F-FDG · PMID 42411770 | Cancer | À vérifier | Publication | PubMed | Voir la publication source A 68-year-old man with gastric cancer underwent 18F-fluorodeoxyglucose (FDG) PET/CT, which revealed an incidental subcu… | Clinical nuclear medicine 2026-07-08 12:06:41 | Source |
| Intermittent theta burst stimulation enhances the efficacy of brain-c… Intermittent theta burst stimulation · PMID 42404120 | Maladie d’Alzheimer · Myopathies · Maladie de Parkinson · Maladie d’A… | À vérifier | Publication | PubMed | Voir la publication source "BCI illiteracy," characterized by insufficient -rhythm Event-Related Desynchronization (ERD) in approximately 40% of s… | Frontiers in neurology 2026-07-08 12:06:40 | Source |
| Subchronic comparative assessment of graded ferrous sulfate doses on… 0.9% NaCl · PMID 42376110 | Maladie d’Alzheimer | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Iron is a necessary trace element in the human body. However, excessive concentration can promote the overproduction of… | Open veterinary journal 2026-07-08 12:06:39 | Source |
| Sustainable soil improvement strategies for coral islands: Synergisti… 0.9% NaCl · PMID 42379437 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source The sustainable development of coral islands is constrained by bottleneck issues such as poor water retention and nutri… | International journal of biological macromolecules 2026-07-08 12:06:39 | Source |
| Minaxolone: an evaluation with and without premedication. Allopregnanolone injection (intravenous solution) · PMID 7270828 | Maladie d’Alzheimer | Traitement symptomatique | Publication | PubMed | Voir la publication source Minaxolone, a water-soluble steroid intravenous anaesthetic, has been used in clinical trials for induction and mainten… | Anaesthesia 2026-07-08 12:06:38 | Source |
| Continuous theta burst stimulation to the frontal pole durably decrea… Continuous theta burst stimulation · PMID 42379239 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source The frontal pole is a transdiagnostic target for affective disorders, perhaps through its connectivity with affective r… | International review of psychiatry (Abingdon, England) 2026-07-08 12:06:37 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||