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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Sustainable gold nanoparticles using Jania rubens, targeted therapeut… Doxorubicin · PMID 42436223 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Gold nanoparticles (AuNPs) are highly versatile nanomaterials due to their exceptional physicochemical and biological p… | Scientific reports 2026-07-12 19:41:50 | Source |
| Durable benefit in a crowded frontline landscape: final results for n… Cabozantinib · PMID 42436771 | Cancer · Lupus · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Translational andrology and urology 2026-07-12 19:41:48 | Source |
| The ITALIC-RCC: A Randomized Trial on Clinical and Humoral Impact of… Cabozantinib · PMID 42433301 | Cancer · Lupus · Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Immunotherapy-based combinations have improved overall survival (OS) in metastatic renal cell carcinoma (mRCC), but rec… | European urology open science 2026-07-12 19:41:48 | Source |
| Durable Response to Sotorasib Plus Panitumumab in NRAS G12C-Mutated,… Panitumumab · PMID 42428178 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Oncogenic Rat sarcoma (RAS) mutations are common drivers of solid tumors, yet for decades they were regarded as "undrug… | Cureus 2026-07-12 19:41:47 | Source |
| Recent advances in fluorescent probes for guided surgery of head and… Panitumumab · PMID 42433441 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Head and neck squamous cell carcinoma (HNSCC) rank as the sixth most common cancer worldwide. Traditional treatments in… | RSC advances 2026-07-12 19:41:47 | Source |
| Developments in Pharmacotherapy for Acromegaly: Current and Emerging… Octreotide Acetate · PMID 41964795 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Pituitary surgery is the primary therapy for most patients with acromegaly. Medical therapy has an important, albeit ad… | Drugs 2026-07-12 19:41:45 | Source |
| Effect of octreotide-deoxycholate hydrophobic ion pairing solid dispe… Octreotide Acetate · PMID 41905700 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Oral delivery of peptide drugs (BCS Class III) is limited by gastrointestinal instability, low permeability, and poor s… | International journal of pharmaceutics 2026-07-12 19:41:45 | Source |
| Identification of FOXK1 and SEMA7A as key genes associated with mA-re… Decitabine · PMID 42432759 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Diabetic retinopathy (DR), a serious microvascular complication of diabetes, has a complex pathogenic mechanism that is… | Hereditas 2026-07-12 19:41:44 | Source |
| Ten-day decitabine vs "3+7" in patients with AML aged ≥60 years: long… Decitabine · PMID 42436879 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Blood neoplasia 2026-07-12 19:41:44 | Source |
| A cloud model and data envelopment analysis-enhanced FMEA framework f… 3D-printed non-coplanar template · PMID 41579140 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Failure mode and effects analysis (FMEA) is a widely used proactive tool for risk assessment in radiotherapy. With the… | Medical physics 2026-07-12 19:41:42 | Source |
| A rapid semi-automated trajectory planning method for non-coplanar in… 3D-printed non-coplanar template · PMID 42337636 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source Precise spatial distribution of interstitial needles is critical for 3D-printing-assisted brachytherapy in cervical can… | Radiation oncology (London, England) 2026-07-12 19:41:42 | Source |
| Aptamer Circuit-Engineered Bio-Nanovesicles With Self-Promoted Tumor-… Doxorubicin Hydrochloride · PMID 42415536 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Targeted delivery of chemodrugs to tumor sites is highly desirable for efficient chemotherapy. Extracellular vesicles (… | Small methods 2026-07-12 19:41:41 | Source |
| Ensemble Machine Learning- and Deep Learning-Driven Identification an… Doxorubicin Hydrochloride · PMID 42353251 | Cancer · Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Dipeptidyl peptidase-4 (DPP-4) is a key therapeutic target for type 2 diabetes (T2D). Several synthetic anti-DPP-4 drug… | International journal of molecular sciences 2026-07-12 19:41:41 | Source |
| Dermatomyositis With Necrotizing Vasculitis, Pulmonary Arterial Hyper… Cyclophosphamide · PMID 42437258 | Hypertension artérielle | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Dermatomyositis is a rare autoimmune inflammatory disease with a highly heterogeneous clinical presentation and potenti… | Cureus 2026-07-12 19:41:40 | Source |
| Detection of occult non-mass enhancement in bloody nipple discharge u… MRI in Ductal Carcinoma in Situ (DCIS) · PMID 42422274 | Cancer | À vérifier | Publication | PubMed | Voir la publication source A 66-year-old woman presented with right bloody nipple discharge (BND). Initial evaluation, including palpation, mammog… | Oxford medical case reports 2026-07-12 19:41:36 | Source |
| Isolated Cardiac Sarcoidosis With Marfan Syndrome Following Cardiovas… Positron Emission Tomography · PMID 42437246 | Insuffisance cardiaque | Immunomodulation | Publication | PubMed | Voir la publication source A 55-year-old male patient with Marfan syndrome presented with exertional dyspnea. The patient had undergone aortic val… | Cureus 2026-07-12 19:41:34 | Source |
| Cancer history and second cancer risk in polycythemia vera and essent… hydroxyurea · PMID 42436123 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Patients with myeloproliferative neoplasms (MPN), including polycythemia vera (PV) and essential thrombocythemia (ET),… | Blood cancer journal 2026-07-12 19:41:32 | Source |
| S-phase targeted treatment triggers caspase-dependent lytic immunogen… hydroxyurea · PMID 42432251 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Immunogenic cell death (ICD) is a type of cell death that can enhance anti-tumour immune responses of chemotherapies an… | Cell death and differentiation 2026-07-12 19:41:32 | Source |
| Antimetabolites synergize with non-genotoxic antibody drug conjugate… fluorouracil · PMID 42436858 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Hematopoietic stem cell transplantation (HSCT) of genetically engineered cells is a promising treatment modality for mo… | Molecular therapy. Advances 2026-07-12 19:41:31 | Source |
| PDLIM4 increases sphingolipid accumulation to promote cancer stem cel… fluorouracil · PMID 42436219 | Cancer | Thérapie cellulaire | Publication | PubMed | Voir la publication source The prognosis for advanced colorectal cancer (CRC) remains poor, and 5-fluorouracil (5-FU)-based chemotherapy is the pr… | Communications biology 2026-07-12 19:41:31 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||