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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Response to "Nanoformulated fingolimod for spinal cord injury: promis… Fingolimod · PMID 42443564 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Spinal cord 2026-07-14 16:01:09 | Source |
| Feasibility and sensitivity of a multimodal digital endpoint panel fo… Speech Analysis in ALS Patients · PMID 42405987 | Sclérose latérale amyotrophique | Ralentissement de la progression | Publication | PubMed | Voir la publication source : The use of digital technology may improve monitoring of amyotrophic lateral sclerosis (ALS) but a multimodal approach… | Amyotrophic lateral sclerosis & frontotemporal degener… 2026-07-12 19:43:05 | Source |
| Neural decoding of speech using deep neural ensembles. Real World Testing of a Brain-Computer Interface · PMID 42282632 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Speech brain-computer interfaces (BCIs) can restore rapid communication to people with paralysis, but decoding errors s… | bioRxiv : the preprint server for biology 2026-07-12 19:43:05 | Source |
| Reproducible testing for embedded BCIs: a demultiplexing PCB and acqu… Real World Testing of a Brain-Computer Interface · PMID 42256671 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Validating machine learning models for Brain-Computer Interfaces (BCIs) on resource-constrained edge devices is challen… | HardwareX 2026-07-12 19:43:05 | Source |
| Anchoring ALS Prognosis: Neurofilament Light Chain Outperforms Inflam… Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS) · PMID 42207242 | Sclérose latérale amyotrophique | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder with marked biologica… | Molecular neurobiology 2026-07-12 19:43:03 | Source |
| From Environment to Symptoms: Mapping Premorbid Risk Factors onto Cli… Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS) · PMID 41830966 | Hypertension artérielle · Sclérose latérale amyotrophique | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with multifactorial causes, including ge… | Neurology and therapy 2026-07-12 19:43:03 | Source |
| Multimodal analysis of cell-free DNA identifies epigenetic biomarkers… Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS) · PMID 42222887 | Sclérose latérale amyotrophique | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source The role of the epigenome in age-related neurodegenerative disorders remains understudied. Here, we analyzed circulatin… | The Journal of clinical investigation 2026-07-12 19:43:03 | Source |
| Prospective Validation of the New PLS Diagnostic Criteria From PLS Na… Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS) · PMID 41772409 | Sclérose latérale amyotrophique | Traitement symptomatique | Publication | PubMed | Voir la publication source Primary lateral sclerosis (PLS) is an ultrarare upper motor neuron syndrome with a prognosis unique from classical ALS.… | Muscle & nerve 2026-07-12 19:43:03 | Source |
| Determinants of Repetitive Transcranial Magnetic Stimulation Efficacy… Sham rTMS of the brain · PMID 42428110 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Repetitive Transcranial Magnetic Stimulation (rTMS) is a promising treatment for tobacco use disorder (TUD). Although a… | medRxiv : the preprint server for health sciences 2026-07-12 19:42:56 | Source |
| Ischemic Conditioning Enhances Corticomotor Excitability, Strength, a… Sham rTMS of the brain · PMID 42435025 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source This study aimed to evaluate the corticomotor mechanisms and short-term motor effects of ischemic conditioning (IC) app… | Neuromodulation : journal of the International Neuromo… 2026-07-12 19:42:56 | Source |
| Psilocybin-assisted therapy in treatment-resistant depression: rapid… Psilocybin · PMID 42433813 | Maladie d’Alzheimer · Cancer · Migraine · Maladie de Parkinson · Sclé… | Traitement symptomatique | Publication | PubMed | Voir la publication source Treatment-resistant depression (TRD) remains a major clinical challenge and is typically defined as the persistence of… | Annals of medicine and surgery (2012) 2026-07-12 19:42:55 | Source |
| Psychedelics produce enduring enhancement of reward responsiveness in… Psilocybin · PMID 42432161 | Maladie d’Alzheimer · Cancer · Migraine · Maladie de Parkinson · Sclé… | Traitement symptomatique | Publication | PubMed | Voir la publication source Anhedonia, the blunted responsiveness to previously rewarding stimuli, is a core symptom of several psychiatric disorde… | Neuropsychopharmacology : official publication of the… 2026-07-12 19:42:55 | Source |
| A multimodal biomarker strategy to enhance diagnostic precision in ne… The Ontario Neurodegenerative Disease Research Initiative · PMID 42157002 | Maladie de Parkinson | Thérapie génique | Publication | PubMed | Voir la publication source Differential diagnosis of neurodegenerative parkinsonian syndromes is complicated by overlapping clinical features and… | Nature medicine 2026-07-12 19:42:52 | Source |
| Application of a clinical scale for predicting Aβ-positivity in a mul… The Ontario Neurodegenerative Disease Research Initiative · PMID 42275797 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Clinical Amyloid positivity Prediction Score (CAPS) is a clinical tool developed on a small Canadian cohort with clinic… | Journal of the neurological sciences 2026-07-12 19:42:52 | Source |
| Multi-omics-guided diagnosis and treatment of toxoplasma retinochoroi… Prednisone · PMID 42436394 | Cancer · Insuffisance cardiaque · Lupus · Myasthénie · Myopathies · S… | Immunomodulation | Publication | PubMed | Voir la publication source Toxoplasma retinochoroiditis is challenging to diagnose and treat, especially in immunocompromised or co-infected indiv… | BMC ophthalmology 2026-07-12 19:42:50 | Source |
| The effects of spinal stabilization exercises in patients with myasth… The Effect of Spinal Stabilization Exercises in Patients With Myasthenia Gravis · PMID 34978954 | Myasthénie | Traitement symptomatique | Publication | PubMed | Voir la publication source The effects of spinal stabilization exercises (SSE) on fatigue, muscle strength, respiratory functions, functional capa… | Disability and rehabilitation 2026-07-12 19:42:49 | Source |
| Clinical characteristics, cerebellar MR spectroscopy and response to… 3, 4-Diaminopyridine · PMID 41065930 | Myasthénie | Traitement symptomatique | Publication | PubMed | Voir la publication source The clinical and genetic heterogeneity of hereditary ataxias presents a significant diagnostic challenge, particularly… | Journal of neurology 2026-07-12 19:42:48 | Source |
| The impact of experimental variables in twitch tension recording on t… 3, 4-Diaminopyridine · PMID 40803653 | Myasthénie | À vérifier | Publication | PubMed | Voir la publication source Electrophysiological investigations have previously demonstrated that snake venom phospholipase A (PLA) neurotoxins suc… | Toxicon : official journal of the International Societ… 2026-07-12 19:42:48 | Source |
| Kidney Survival in Children With Steroid-Resistant Nephrotic Syndrome… Rituximab · PMID 42437162 | Maladie rénale chronique | Thérapie génique | Publication | PubMed | Voir la publication source Kidney outcomes in children with steroid-resistant nephrotic syndrome (SRNS) following rituximab remain unclear. We con… | Kidney international reports 2026-07-12 19:42:44 | Source |
| CD8+ T Cells in Acute Lymphoblastic Leukemia Show a Progenitor-exhaus… Control Group · PMID 42437313 | Accident vasculaire cérébral · Myasthénie · Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Exhausted T cells are phenotypically and functionally heterogeneous, from progenitor- to terminally-exhausted T cells.… | Iranian journal of allergy, asthma, and immunology 2026-07-12 19:42:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||