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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Allosteric potentiation of GABA receptor promotes survival and matura… Ganaxolone · PMID 42213674 | Épilepsie · Sclérose en plaques · Sclérose en plaques · Épilepsie | Remyélinisation | Publication | PubMed | Voir la publication source Oligodendrocytes (OLs) and their precursor cells (OPCs) express specific receptors to GABA; however, the direct functio… | American journal of physiology. Cell physiology 2026-07-14 16:02:34 | Source |
| Comprehensive evaluation of neurosteroid monotherapy and neurosteroid… Ganaxolone · PMID 42190906 | Épilepsie · Sclérose en plaques · Sclérose en plaques · Épilepsie | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Children are especially vulnerable to the neurotoxic effects of nerve agents, which can cause lasting neuronal dysfunct… | Neuropharmacology 2026-07-14 16:02:34 | Source |
| [Approach to brain effect research: exploring the connection among "a… Acupuncture intervention · PMID 42443088 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source The classical statement, "feeling comfortable when acupoint is pressed" in (' ) is regarded as the origin of acupoint t… | Zhongguo zhen jiu = Chinese acupuncture & moxibustion 2026-07-14 16:02:31 | Source |
| [Effect of eye acupuncture on mitophagy in neurons of ischemic cortic… Acupuncture intervention · PMID 42443081 | Épilepsie | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source To observe the effects of eye acupuncture on neurological deficits and mitophagy in neurons of ischemic cortical brain… | Zhongguo zhen jiu = Chinese acupuncture & moxibustion 2026-07-14 16:02:31 | Source |
| Effect of Low-Dose Rivaroxaban Plus Aspirin on 18F-FDG PET/CT-Detecta… 18F-FDG · PMID 42439277 | Cancer · Épilepsie · Épilepsie | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Aspirin plus low-dose rivaroxaban reduces cardiovascular events in stable atherosclerosis; its effect on arterial infla… | European heart journal. Cardiovascular Imaging 2026-07-14 16:02:22 | Source |
| Prostatic incidental uptake on PET/CT: an updated systematic review a… 18F-FDG · PMID 42440426 | Cancer · Épilepsie · Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Prostatic incidental uptake (PIU) may have clinical relevance, and progress in molecular imaging is likely to increase… | Frontiers in oncology 2026-07-14 16:02:22 | Source |
| Baseline Conceptual-Semantic Impairment Predicts Longitudinal Treatme… Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia · PMID 38283767 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source An individual's diagnostic subtype may fail to predict the efficacy of a given type of treatment for anomia. Classifica… | Aphasiology 2026-07-14 16:02:21 | Source |
| Long-Term maintenance of anomia treatment effects in primary progress… Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia · PMID 29380657 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source This study examined the maintenance of anomia treatment effects in primary progressive aphasia (PPA). Following baselin… | Neuropsychological rehabilitation 2026-07-14 16:02:21 | Source |
| Hearing Rehabilitation in Veterans With Severe Hearing Loss: Challeng… Hearing aids · PMID 42426936 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source There is increased recognition of the importance of hearing ability in social connectedness and healthy aging. Hearing… | Ear and hearing 2026-07-14 16:02:20 | Source |
| Single-cell analysis reveals impaired Müller glia-mediated intercellu… Hearing aids · PMID 42426189 | Maladie d’Alzheimer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Usher syndrome type 1, caused by pathogenic variants in the USH1C gene, leads to congenital deafness and progressive re… | Cellular and molecular life sciences : CMLS 2026-07-14 16:02:20 | Source |
| Ge-Gen Decoction Modulates the HSP90/AKT Signaling Pathway and the NL… Ibuprofen · PMID 42438818 | Maladie d’Alzheimer | Immunomodulation | Publication | PubMed | Voir la publication source Ge-Gen Decoction (GGD) is a traditional Chinese medicinal formula composed of seven herbs (including , and ), commonly… | Journal of pain research 2026-07-14 16:02:19 | Source |
| Ketamine-induced cystitis: Lessons from a case of recreational use. Ibuprofen · PMID 42431377 | Maladie d’Alzheimer | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source To describe a case of ketamine-induced cystitis (KIC) in a middle-aged patient using ketamine recreationally, highlight… | Journal of the American Pharmacists Association : JAPhA 2026-07-14 16:02:19 | Source |
| FK962 protects retinal ganglion cell under hypoxia/reoxygenation: Pos… FK962 · PMID 39284507 | Maladie d’Alzheimer | Neuroprotection | Publication | PubMed | Voir la publication source Loss of retinal ganglion cells (RGCs) is the cause of visual impairment and blindness in glaucoma. Previously, our stud… | Experimental eye research 2026-07-14 16:02:18 | Source |
| In Silico Ocular Pharmacokinetic Modeling: Delivery of Topical FK962… FK962 · PMID 28598703 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source To establish the in silico ocular pharmacokinetic modeling for eye drops, and to simulate the dose regimen for FK962 in… | Journal of ocular pharmacology and therapeutics : the… 2026-07-14 16:02:18 | Source |
| Alterations of homotopic functional connectivity and correlates with… Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease · PMID 42133147 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Identifying individuals with mild cognitive impairment (MCI) who are at risk of progressing to Alzheimer's disease (AD)… | Brain imaging and behavior 2026-07-14 16:02:17 | Source |
| Longitudinal Alterations in Sleep EEG Biomarkers of Memory Consolidat… Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease · PMID 42182430 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source The precise coordination of slow oscillations (SO) and sleep spindles during non-rapid eye movement (NREM) sleep suppor… | bioRxiv : the preprint server for biology 2026-07-14 16:02:17 | Source |
| Evaluating ATR expression and the effects of renin-angiotensin system… Telmisartan · PMID 42441801 | Maladie d’Alzheimer · Hypertension artérielle · Hypertension artériel… | À vérifier | Publication | PubMed | Voir la publication source The renin-angiotensin-aldosterone system (RAAS) has been shown to be dysregulated in dementia, with elevated levels of… | Brain research 2026-07-14 16:02:15 | Source |
| Optimizing a carbon source based on water temperature to reduce abund… Telmisartan · PMID 42440415 | Maladie d’Alzheimer · Hypertension artérielle · Hypertension artériel… | À vérifier | Publication | PubMed | Voir la publication source Biofloc technology (BFT) does not recognize bioactive molecules, which significantly impact shrimp intestinal microbiot… | Frontiers in systems biology 2026-07-14 16:02:15 | Source |
| Behavioral Effects of Renin-Angiotensin System Modulators in a Roteno… Perindopril · PMID 42317891 | Maladie de Parkinson | Neuroprotection | Publication | PubMed | Voir la publication source Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor dysfunction r… | Cureus 2026-07-14 16:02:14 | Source |
| Facilitatory effects of LY404187, a positive allosteric modulator of… Perindopril · PMID 42314242 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source The present study aimed to investigate the effects of the systemic administration of LY404187, a positive allosteric mo… | Archives of oral biology 2026-07-14 16:02:14 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||