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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Virtual reality approaches for enhancing postural stability and mobil… Nintendo Wii Fit + Conventional Therapy · PMID 40269386 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source The elderly population is growing rapidly, with a significant portion facing challenges related to balance and mobility… | JPMA. The Journal of the Pakistan Medical Association 2026-07-10 00:14:04 | Source |
| Mechanistically resolved prediction of compound hepatotoxicity using… Tolebrutinib · PMID 42418948 | Sclérose en plaques | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source Drug-induced liver injury remains a major cause of clinical trial attrition and postmarketing drug withdrawals, reflect… | Drug metabolism and disposition: the biological fate o… 2026-07-10 00:13:55 | Source |
| Fingolimod Acutely Facilitates the Activation of TRKB in a BDNF-depen… Fingolimod · PMID 42420746 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Fingolimod (FNG) is a sphingosine-1-phosphate receptor agonist currently prescribed for the treatment of remitting-rela… | Cellular and molecular neurobiology 2026-07-10 00:13:44 | Source |
| Associations Between Neurological Diseases and Dioxin Exposure Origin… A Study of Brain Aging in Vietnam War Veterans · PMID 42198545 | Maladie d’Alzheimer · Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Now, half a century after the Vietnam War, Agent Orange exposure during the war is increasingly discussed as a risk fac… | Toxics 2026-07-08 21:51:04 | Source |
| Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers. A Study of Brain Aging in Vietnam War Veterans · PMID 42371653 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Traumatic brain injury (TBI) is a risk factor for dementia and is known to impact levels of several Alzheimer disease (… | JAMA neurology 2026-07-08 21:51:04 | Source |
| Long-term independent use of an intracortical brain-computer interfac… Brain Computer Interface Keyboard · PMID 42297978 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Brain-computer interfaces (BCIs) can provide naturalistic communication and digital access to people with severe paraly… | Nature medicine 2026-07-08 21:23:26 | Source |
| Noninvasive decoding of typed sentences from human brain activity. Brain Computer Interface Keyboard · PMID 42374156 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Modern neuroprostheses can now restore communication in patients who have lost the ability to speak or move. However, i… | Nature neuroscience 2026-07-08 21:23:26 | Source |
| Long-term eculizumab treatment failure in C3 glomerulonephritis: two… eculizumab · PMID 42415834 | Myasthénie | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source C3 glomerulonephritis (C3GN) is a rare kidney disease driven by dysregulation of the alternative complement pathway. We… | Clinical kidney journal 2026-07-08 21:23:19 | Source |
| CFTR modulator monotherapy for people with cystic fibrosis with class… Ataluren · PMID 42095711 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Cystic fibrosis (CF) is a common, life-shortening genetic condition caused by a variant in the cystic fibrosis transmem… | The Cochrane database of systematic reviews 2026-07-08 21:23:16 | Source |
| Ion-Channel-Mediated Drug Repurposing Opportunities Validated by Sing… Ataluren · PMID 42074061 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Colorectal cancer (CRC) remains a leading cause of cancer mortality, yet no systematic effort has linked druggable CRC… | International journal of molecular sciences 2026-07-08 21:23:16 | Source |
| Comparison of temporal and stride characteristics in myotonic dystrop… Investigating Exercise in Myotonic Dystrophy Type 2 (DM2) · PMID 27004657 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source We analyzed temporal and stride characteristics in patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2) while… | Gait & posture 2026-07-08 21:23:15 | Source |
| PDE5A variation is associated with tadalafil response in men with dia… Tadalafil · PMID 42407102 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | The journal of sexual medicine 2026-07-08 21:23:14 | Source |
| Selective targeting phosphodiesterase-5 (PDE5): clinical progress, de… Tadalafil · PMID 42390922 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source PDE5 is a subfamily member of the phosphodiesterase (PDE) superfamily. It is encoded by a single PDE5A gene, and its pr… | Journal of enzyme inhibition and medicinal chemistry 2026-07-08 21:23:14 | Source |
| CD19-CAR-DNT cells (RJMty19) in patients with relapsed or refractory… RJMty19 (CD19-CAR-DNT cells) · PMID 38444429 | Lupus | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Current approved chimeric antigen receptor (CAR) T-cell products are autologous cell therapies that are costly and poor… | EClinicalMedicine 2026-07-08 21:23:02 | Source |
| Clinical use of trastuzumab combined with different chemotherapy regi… Teysuno (S1) in combination with epirubicin and oxaliplatin · PMID 30214596 | Cancer | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source It is generally acknowledged that gastric cancer requires comprehensive treatment approaches to be adopted. For patient… | Oncology letters 2026-07-08 21:22:59 | Source |
| Enigmatic Case of Adult-Onset Langerhans Cell Histiocytosis with Aggr… hydroxyurea · PMID 42405367 | Cancer | Traitement symptomatique | Publication | PubMed | Voir la publication source Langerhans cell histiocytosis (LCH) is a rare hematologic neoplasm predominantly affecting children, with adult-onset c… | Journal of Brown hospital medicine 2026-07-08 21:22:53 | Source |
| Hydroxyurea Promotes Brain Development in Children with Sickle Cell A… hydroxyurea · PMID 42413789 | Cancer | Neuroprotection | Publication | PubMed | Voir la publication source Sickle cell anemia (SCA) is associated with chronic anemia and cerebrovascular dysfunction, leading to progressive brai… | Brain research bulletin 2026-07-08 21:22:53 | Source |
| AI-surrogate structure and dose correlation for left anterior descend… radiation therapy · PMID 42418215 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source The left anterior descending (LAD) coronary artery is a critical organ-at-risk in thoracic radiotherapy. In thoracic st… | Journal of applied clinical medical physics 2026-07-08 21:22:52 | Source |
| Same-day Hyaluronic Acid rectal spacer for TRUS-guided HDR Prostate B… radiation therapy · PMID 42418218 | Cancer | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Rectal spacers are widely used to reduce rectal dose in prostate radiotherapy. However, their use during transrectal ul… | Journal of applied clinical medical physics 2026-07-08 21:22:52 | Source |
| Long-Term Inhaled Cannabis Therapy for Chronic Low Back Pain: A Five-… Antiepileptic drug (1 to 3 only) · PMID 42351683 | Épilepsie | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Chronic low back pain (CLBP) affects approximately 20% of the global population and is a leading cause of years lived w… | Biomedicines 2026-07-08 21:22:48 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||