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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Metabolic Mechanisms of Modified Lingguizhugan Decoction in Obesity a… Atorvastatin · PMID 42445565 | Accident vasculaire cérébral · Lupus · Lupus | Thérapie génique | Publication | PubMed | Voir la publication source Obesity and related metabolic disorders, including metabolic dysfunction-associated fatty liver disease, dyslipidemia,… | Obesity science & practice 2026-07-14 21:30:16 | Source |
| IL-1α Expands SLC2A1highSPP1highIFNlow Myeloid Cells to Drive Immune… Anti-CD19-CD3E-CAR-T cells · PMID 42446924 | Lupus | Ralentissement de la progression · Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Head and neck squamous cell carcinomas (HNSCC) are preceded by potentially malignant precursor lesions, highlighting th… | Cancer research 2026-07-14 21:30:14 | Source |
| PDE5a Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Media… Anti-CD19-CD3E-CAR-T cells · PMID 42446922 | Cancer | Remyélinisation indirecte / réparation · Ralentissement de la progression · Thé… | Publication | PubMed | Voir la publication source Non-canonical metabolic functions of signaling molecules contribute to cancer plasticity and metastatic progression. He… | Cancer research 2026-07-14 21:30:14 | Source |
| Efficacy and safety of mitoxantrone hydrochloride liposome/ thiotepa/… Fludarabine · PMID 42446104 | Cancer · Lupus · Myasthénie · Myopathies · Sclérose en plaques | Ralentissement de la progression · Thérapie cellulaire | Publication | PubMed | Voir la publication source To investigate the efficacy and safety of MTBF as conditioning regimen for salvage allogeneic hematopoietic stem cell t… | Cell transplantation 2026-07-14 21:30:10 | Source |
| Application Timing-Dependent Impact of Donor Source on Outcomes After… Cyclophosphamide · PMID 42446167 | Cancer · Épilepsie · Insuffisance cardiaque · Lupus · Myasthénie · My… | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is usually performed as a curative treatment for adult T… | Hematological oncology 2026-07-14 21:30:08 | Source |
| Salvage ultra-low-dose radiotherapy for conjunctival mantle cell lymp… Cyclophosphamide · PMID 42445702 | Cancer · Épilepsie · Insuffisance cardiaque · Lupus · Myasthénie · My… | À vérifier | Publication | PubMed | Voir la publication source Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma with variable responses to frontline chemothera… | Reports of practical oncology and radiotherapy : journ… 2026-07-14 21:30:08 | Source |
| Long-term pulmonary function decline after stereotactic body radiatio… Stereotactic Body Radiation Therapy (SBRT) · PMID 42445710 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Stereotactic body radiation therapy (SBRT) is widely used for early-stage lung cancer and inoperable cases due to its h… | Reports of practical oncology and radiotherapy : journ… 2026-07-14 21:29:59 | Source |
| Sustained Disease Control of High-Risk Metastatic Renal Epithelioid A… Cabozantinib · PMID 42445892 | Cancer · Lupus · Sclérose en plaques | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source Renal epithelioid angiomyolipoma (EAML) is a rare perivascular epithelioid cell tumor with malignant potential. Radiolo… | Case reports in oncology 2026-07-14 21:29:54 | Source |
| Low-Dose Chidamide Maintenance Therapy After Hematopoietic Stem Cell… Chidamide · PMID 42446114 | Cancer | Thérapie cellulaire | Publication | PubMed | Voir la publication source Post-transplant relapse remains a major challenge in T-ALL, with limited effective salvage options. We report on eight… | Hematological oncology 2026-07-14 21:29:50 | Source |
| A comprehensive review of C-, F-, and I-labeled radiotracers targetin… Positron Emission Tomography · PMID 42446559 | Cancer · Sclérose en plaques | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Cyclooxygenase-2 (COX-2), an inducible enzyme pivotal to prostaglandin biosynthesis from arachidonic acid, is aberrantl… | Medicinal chemistry research : an international journa… 2026-07-14 21:29:43 | Source |
| Vitrectomy Status Alters Early Intravitreal Drug Distribution: An Ex… Positron Emission Tomography · PMID 42446480 | Cancer · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source We aimed to evaluate the ex-vivo early-phase spatial drug distribution of intravitreally applied bevacizumab and vancom… | Investigative ophthalmology & visual science 2026-07-14 21:29:43 | Source |
| Design, Synthesis and Antitumor Activity Evaluation in Vitro of Novel… fluorouracil · PMID 42446688 | Cancer | À vérifier | Publication | PubMed | Voir la publication source In the search for novel, highly effective antitumor agents, a series of novel 1,6-naphthyridine derivatives were design… | Medicinal chemistry research : an international journa… 2026-07-14 21:29:40 | Source |
| Identification of , , , and as lactylation-related prognostic markers… fluorouracil · PMID 42445420 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Lactylation, a protein modification driven by lactate produced during glycolysis, has been implicated in tumorigenesis… | Translational cancer research 2026-07-14 21:29:40 | Source |
| Bevacizumab and Platinum Choice in Pembrolizumab-Treated Advanced Cer… carboplatin · PMID 42446878 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Pembrolizumab plus chemotherapy, with or without bevacizumab, improves overall survival (OS) in advanced cervical cance… | JAMA network open 2026-07-14 21:29:39 | Source |
| Effects of dose heterogeneity on response and toxicity after Y-SIRT f… radiation therapy · PMID 42446581 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Yttrium-90 (Y) selective internal radiation therapy (SIRT) is an established treatment for hepatocellular carcinoma (HC… | European journal of nuclear medicine and molecular ima… 2026-07-14 21:29:39 | Source |
| Efficacy of poloxamer Р188 in restoring the metabolic profile in myel… carboplatin · PMID 42446256 | Cancer · Maladie de Parkinson · Sclérose en plaques · Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Modern diagnostics in oncohematology is based on highly informative "gold standards" such as bone marrow biopsy, immuno… | Biomeditsinskaia khimiia 2026-07-14 21:29:39 | Source |
| Neoadjuvant nedaplatin and paclitaxel regimen with concurrent radioth… paclitaxel albumin-stabilized nanoparticle formulation · PMID 42446091 | Cancer | À vérifier | Publication | PubMed | Voir la publication source To evaluate the efficacy and safety of neoadjuvant concurrent chemoradiotherapy (CCRT) utilizing nedaplatin and paclita… | Future oncology (London, England) 2026-07-14 21:29:38 | Source |
| Evaluation of insulin, leptin, ghrelin, and adiponectin levels in typ… Metformin · PMID 42446258 | Cancer · Épilepsie · Hypertension artérielle · Myopathies · Maladie d… | À vérifier | Publication | PubMed | Voir la publication source Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder, which is commonly related to reduced insulin responsiv… | Biomeditsinskaia khimiia 2026-07-14 21:29:33 | Source |
| Pharmacist-led management of suspected drug-provoked seizures and seq… Levetiracetam &/or sodium valproate · PMID 42445248 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Drug-provoked seizures constitute a clinically significant yet frequently underappreciated complication of pharmacother… | Frontiers in pharmacology 2026-07-14 21:29:32 | Source |
| Rewiring reward in addiction: a systematic review of human evidence f… Neurosurgical Outcome Network · PMID 42446584 | Épilepsie | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Neurosurgical modulation of reward circuitry has been explored for severe, treatment-refractory substance use disorders… | Acta neurochirurgica 2026-07-14 21:29:31 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||