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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Pilot feasibility study of intraprocedural transcranial Doppler monit… Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation · PMID 42422222 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Utility of flow diverter (FD) surface modification (SM) in reducing thromboembolism of cerebral aneurysm treatment rema… | Frontiers in neurology 2026-07-14 16:03:48 | Source |
| The relationship between cerebellar functional connectivity alteratio… Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation · PMID 42360506 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Altered cerebellar resting-state functional connectivity (FC) may contribute to hand motor impairment in People with Mu… | Journal of neurology 2026-07-14 16:03:48 | Source |
| Ultrasound-guided platelet-rich plasma myofascial injection for chron… GenPHSat injection (Efficacy) · PMID 42443868 | Myopathies | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Retrospective cohort study to evaluate the efficacy and safety of ultrasound-guided myofascial platelet-rich plasma (PR… | BMC musculoskeletal disorders 2026-07-14 16:03:47 | Source |
| EXPRESS: Comparing the Efficacy of Transmucosal and Subcutaneous Gluc… GenPHSat injection (Safety) · PMID 42444066 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source ObjectivesTo evaluate the efficacy of two different formulations of glucagon given by three different routes (subcutane… | Journal of feline medicine and surgery 2026-07-14 16:03:46 | Source |
| EXPRESS: Ultrasound Enhances Glymphatic-Associated Solute Transport v… GenPHSat injection (Safety) · PMID 42444063 | Maladie d’Alzheimer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Glymphatic dysfunction impairs Aβ clearance and contributes to Alzheimer's disease (AD) progression. Low-intensity tran… | Journal of cerebral blood flow and metabolism : offici… 2026-07-14 16:03:46 | Source |
| Insulin Regulates CD36-Dependent Fatty Acid Uptake but Not Mitochondr… Glutamine · PMID 42444333 | Myopathies | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source Sertoli cells (SCs) provide essential metabolic support for spermatogenesis, including lactate production for developin… | Andrology 2026-07-14 16:03:43 | Source |
| [Effect of electroacupuncture on chronic pain in patients with knee o… Glutamine · PMID 42443077 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source To observe the clinical therapeutic effect of electroacupuncture (EA) on chronic pain in patients with knee osteoarthri… | Zhongguo zhen jiu = Chinese acupuncture & moxibustion 2026-07-14 16:03:43 | Source |
| Does creatine supplementation improve strength and power in physicall… Creatine Monohydrate · PMID 42390589 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source This study aimed to assess the impact of four weeks of creatine monohydrate supplementation on strength and power perfo… | European journal of applied physiology 2026-07-14 16:03:42 | Source |
| Exercise-Induced Rhabdomyolysis With Markedly Elevated Creatine Kinas… Creatine Monohydrate · PMID 42396376 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Exercise-induced rhabdomyolysis results from skeletal muscle injury after strenuous or unaccustomed exertion. Acute kid… | Case reports in nephrology 2026-07-14 16:03:42 | Source |
| Increased intra-abdominal pressure linked to worse long-term prognosi… Organ Dysfunction Associated With Intra Abdominal Pressures in Liver Transplantation · PMID 40… | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source To investigate the prognostic value of intra-abdominal pressure (IAP) among patients with orthotopic liver transplantat… | BMC gastroenterology 2026-07-14 16:03:40 | Source |
| Intra-abdominal hypertension, fluid balance, and adverse outcomes aft… Organ Dysfunction Associated With Intra Abdominal Pressures in Liver Transplantation · PMID 33… | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Intra-abdominal hypertension (IAH) is frequently encountered in critically ill surgical patients. We aimed to evaluate… | Journal of critical care 2026-07-14 16:03:40 | Source |
| Acute trazodone administration reduces behavioral and physiological i… Behavioral Interventions for Controlling Oral Behaviors · PMID 42441254 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Travel-induced stress and anxiety are prevalent in dogs resulting in behavioral changes that can negatively affect the… | Frontiers in veterinary science 2026-07-14 16:03:35 | Source |
| Development of zein-based nanoparticles for oral co-delivery of insul… Behavioral Interventions for Controlling Oral Behaviors · PMID 42442575 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Oral delivery of peptide-based therapeutics remains a major challenge due to enzymatic degradation and poor intestinal… | International journal of biological macromolecules 2026-07-14 16:03:35 | Source |
| Immune-Related Adverse Events From Checkpoint Inhibitors: An Evidence… IvIg · PMID 42442518 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Immune checkpoint inhibitors (ICIs) improve cancer outcomes but can cause immune‑related adverse events (irAEs) in any… | Critical reviews in oncology/hematology 2026-07-14 16:03:35 | Source |
| Intravenous Immunoglobulin-Resistant Kawasaki Disease: Diagnosis, Mec… IvIg · PMID 42442680 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD), also referred to as IVIG-refractory KD or refractory… | European journal of pharmacology 2026-07-14 16:03:35 | Source |
| Occult Necrotizing Fasciitis Presenting as a Severe Hyperosmolar Hype… Chronic Corticosteroid Therapy · PMID 42434630 | Myopathies | À vérifier | Publication | PubMed | Voir la publication source Necrotizing fasciitis is a rapidly progressive and life-threatening soft tissue infection in which early diagnosis rema… | Cureus 2026-07-14 16:03:32 | Source |
| Leukocyte Telomere Length and Cross-Sectional and Longitudinal Variat… MRI · PMID 42444504 | Épilepsie · Migraine · Myopathies · Sclérose en plaques · Sclérose la… | À vérifier | Publication | PubMed | Voir la publication source Telomere length (TL) has emerged as a candidate predictor for biological aging and age-associated conditions, yet its r… | Brain and behavior 2026-07-14 16:03:25 | Source |
| Standardized Acquisition of Fetal Cardiac Cine MRI: A Practical Guide. MRI · PMID 42444472 | Épilepsie · Migraine · Myopathies · Sclérose en plaques · Sclérose la… | Thérapie génique | Publication | PubMed | Voir la publication source Fetal ultrasound is the primary screening modality for routine prenatal examinations, but its effectiveness can be infl… | Circulation. Cardiovascular imaging 2026-07-14 16:03:25 | Source |
| Central adiposity is associated with poorer functional capacity in wo… test of walk · PMID 42443640 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source To investigate the associations of waist circumference (WC) and calf circumference (CC) with functional performance in… | Rheumatology international 2026-07-14 16:03:23 | Source |
| Effects of Pulmonary Rehabilitation Nursing on Pulmonary Function and… test of walk · PMID 42444418 | Myopathies | Traitement symptomatique | Publication | PubMed | Voir la publication source Chronic obstructive pulmonary disease (COPD) is associated with persistent airflow limitation, reduced exercise toleran… | Nursing in critical care 2026-07-14 16:03:23 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||