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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of a Lidocaine-Loaded Alginate/CMC/PEO Electrospun Nanofiber… Lidocaine (drug) · PMID 42075660 | Migraine | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source : Postoperative pain and intra-abdominal adhesions are common complications following surgery. Pain delays early mobili… | Medicina (Kaunas, Lithuania) 2026-08-16 19:24:37 | Source |
| The Anaesthetic Efficacy of Tetracaine and Oxymetazoline Compared Wit… Lidocaine (drug) · PMID 39286961 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Nasal anaesthetic-decongestant sprays are commonly used prior to nasal instrumentation, such as flexible and rigid nasa… | Clinical otolaryngology : official journal of ENT-UK ;… 2026-08-16 19:24:37 | Source |
| Functional characterization of cutinase genes NsCut1-NsCut4 in and th… Glycerol Tributyrate · PMID 40265120 | Migraine | Neuroprotection | Publication | PubMed | Voir la publication source Fishscale bamboo rhombic-spot, caused by , poses a significant threat to in Sichuan province. Based on genomic analysis… | Frontiers in plant science 2026-08-16 19:24:34 | Source |
| Optical Fiber Surface Plasmon Resonance Sensor for Glyceryl Tributyra… Glycerol Tributyrate · PMID 38656893 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Glycerol tributyrate as a low-density lipoprotein plays a crucial role in drug development and food safety. In this wor… | Analytical chemistry 2026-08-16 19:24:34 | Source |
| Synergistic Modification of Polylactic Acid Fibrous Membranes with Im… Glycerol Tributyrate · PMID 40254794 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Reusable and biodegradable facemasks with enhanced antibacterial and mechanical functions are considered sustainable pe… | ACS applied materials & interfaces 2026-08-16 19:24:34 | Source |
| Efficacy of acupuncture therapies for polycystic ovary syndrome: a ne… fire needling combined with filiform needling · PMID 42591356 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Polycystic ovary syndrome (PCOS) is a prevalent gynecological disorder that significantly impairs quality of life and r… | Frontiers in medicine 2026-08-16 19:24:33 | Source |
| Refractory Periungual Warts Treated with Filiform Fire Needle Combine… fire needling combined with filiform needling · PMID 42226748 | Migraine | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Periungual warts, caused by Human Papillomavirus (HPV) infection, are a therapeutic challenge due to their proximity to… | Clinical, cosmetic and investigational dermatology 2026-08-16 19:24:33 | Source |
| ['s experience in treatment of knee osteoarthritis with 's filiform f… fire needling combined with filiform needling · PMID 41987451 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source This paper introduces the clinical experience of Professor in treatment of knee osteoarthritis (KOA) using "'s filiform… | Zhongguo zhen jiu = Chinese acupuncture & moxibustion 2026-08-16 19:24:33 | Source |
| Investigating the effects of chlorogenic acid on novel object recogni… Ketamine · PMID 42571303 | Épilepsie · Migraine · Migraine · Épilepsie | Neuroprotection · Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Schizophrenia is a severe neuropsychiatric disorder characterized by positive, negative, cognitive, mood-related, and m… | IBRO neuroscience reports 2026-08-16 19:24:32 | Source |
| Ketamine preserves perineuronal nets in chronic stressed mice brain t… Ketamine · PMID 42571376 | Épilepsie · Migraine · Migraine · Épilepsie | Immunomodulation | Publication | PubMed | Voir la publication source Deeper understanding of ketamine's mechanism of action would contribute to the discovery of novel therapeutic targets w… | IBRO neuroscience reports 2026-08-16 19:24:32 | Source |
| Pediatric Acupuncture Safety: A Scoping Review. filiform needling · PMID 42179706 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Previous research studies have indicated that acupuncture may be a promising treatment for several pediatric conditions… | Global advances in integrative medicine and health 2026-08-16 19:24:32 | Source |
| Substance use and mental health outcomes among gay and bisexual men i… Ketamine · PMID 42494974 | Épilepsie · Migraine · Migraine · Épilepsie | Traitement symptomatique | Publication | PubMed | Voir la publication source This study investigated the prevalence of substance use among gay and bisexual men in South Korea and examined its asso… | Addictive behaviors reports 2026-08-16 19:24:32 | Source |
| [Long-term clinical effect of fire needling on knee osteoarthritis]. filiform needling · PMID 42116777 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source To observe the long-term clinical efficacy and safety of fire needling in the treatment of knee osteoarthritis. Sixty p… | Zhongguo zhen jiu = Chinese acupuncture & moxibustion 2026-08-16 19:24:32 | Source |
| Ditan Decoction alleviates glutamate excitotoxicity in an Aβ-induced… ditan · PMID 42320774 | Maladie d’Alzheimer | Neuroprotection | Publication | PubMed | Voir la publication source Alzheimer's disease (AD), as the most prevalent form of dementia among the elders, poses a major global health challeng… | Journal of ethnopharmacology 2026-08-16 19:24:28 | Source |
| Impact of antiviral treatment and initiation time on mother-to-child… ditan · PMID 42003011 | Migraine | À vérifier | Publication | PubMed | Voir la publication source To further reduce mother-to-child transmission (MTCT), this study aims to explore the factors influencing MTCT rate in… | Virulence 2026-08-16 19:24:28 | Source |
| Impact of midwife-led continuous support during childbirth on materna… ditan · PMID 42373140 | Migraine | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source To evaluate the association between integrated midwife-led continuous labor support with postpartum care and maternal a… | The journal of maternal-fetal & neonatal medicine : th… 2026-08-16 19:24:28 | Source |
| Effectiveness and safety of sumatriptan 85 mg/naproxen sodium 500 mg… combination of sumatriptan and naproxen · PMID 42591283 | Migraine | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source This prospective multicenter observational study, designed by the Greek Research Alliance for the Study of Headache and… | Frontiers in neurology 2026-08-16 19:24:27 | Source |
| CGRP: the immune system's double agent - context-dependent roles in i… anti-CGRP monoclonal antibodies · PMID 42488654 | Migraine · Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Calcitonin gene-related peptide (CGRP) is traditionally recognized as a key mediator of nociception and vasodilation. H… | Frontiers in immunology 2026-08-16 19:24:26 | Source |
| Perceived comfort with migraine treatments and control of migraine sy… gepants · PMID 42517716 | Migraine | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source This study was conducted to identify patient characteristics and medication factors associated with perceived comfort w… | Headache 2026-08-16 19:24:26 | Source |
| STS101 nasal powder as a new treatment option for acute migraine with… gepants · PMID 42217235 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Although effective acute migraine therapies are available, unmet treatment needs such as nausea, vomiting, or delayed g… | Expert review of neurotherapeutics 2026-08-16 19:24:26 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||