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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| An evaluation of memantine ER + donepezil for the treatment of Alzhei… memantine ER · PMID 30244611 | Maladie d’Alzheimer | Traitement symptomatique | Publication | PubMed | Voir la publication source Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide and carries an immense societal burden.… | Expert opinion on pharmacotherapy 2026-08-08 00:57:30 | Source |
| Memantine ER Maintains Patient Response in Moderate to Severe Alzheim… memantine ER · PMID 29771687 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Memantine extended release (ER) significantly outperformed placebo on co-primary endpoints of Clinician's Interview-bas… | Alzheimer disease and associated disorders 2026-08-08 00:57:30 | Source |
| Impact assessment of effective rounds of mass drug administration aga… Lighting Intervention Therapy · PMID 42566425 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Schistosomiasis (SCH) and Soil-transmitted helminthiasis (STH) remain major neglected tropical diseases across sub-Saha… | PLoS neglected tropical diseases 2026-08-08 00:57:28 | Source |
| Nurses' experiences implementing clinical practice guidelines for det… Lighting Intervention Therapy · PMID 42564409 | Hypertension artérielle · Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Chronic kidney disease (CKD) is an emerging public health concern in Eswatini, with increasing prevalence among individ… | Health SA = SA Gesondheid 2026-08-08 00:57:28 | Source |
| Large-scale analysis demonstrates the influence of CYP2C19 genotype o… escitalopram · PMID 42552300 | Maladie d’Alzheimer · Sclérose latérale amyotrophique · Sclérose laté… | À vérifier | Publication | PubMed | Voir la publication source We evaluated the effect of CYP2C19 genotype on SSRI response in 114,627 research participants. We graded metabolizer st… | The pharmacogenomics journal 2026-08-08 00:57:24 | Source |
| Sertraline and Escitalopram But Not Other Antidepressants Increase Ac… escitalopram · PMID 42553268 | Maladie d’Alzheimer · Sclérose latérale amyotrophique · Sclérose laté… | À vérifier | Publication | PubMed | Voir la publication source Abstract. Depression is a pervasive mental health disorder that has been extensively studied, but effective treatment r… | Annals of neurosciences 2026-08-08 00:57:24 | Source |
| Adaptive genetic trade-offs govern the enantioselective degradation a… Ibuprofen · PMID 42561690 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Ibuprofen (IBU), a prevalent chiral pharmaceutical, was a common emerging contaminant in municipal wastewater. The mech… | Journal of hazardous materials 2026-08-08 00:57:21 | Source |
| Crosslinked gelatin pastilles prepared via maillard reaction as oral… Ibuprofen · PMID 42551677 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Ionic liquid pharmaceuticals (ILP) represent a new class of pharmaceuticals that can circumvent the issues of low aqueo… | International journal of biological macromolecules 2026-08-08 00:57:21 | Source |
| Health and disability assessment in individuals with hearing loss: a… Hearing aids · PMID 42561300 | Maladie d’Alzheimer | Ralentissement de la progression | Publication | PubMed | Voir la publication source To assess the self-perception of health and disability of individuals with bilateral hearing loss (HL) before and after… | CoDAS 2026-08-08 00:57:21 | Source |
| Precision correction of the GJB2 c.235delC mutation by prime editing… Hearing aids · PMID 42562992 | Maladie d’Alzheimer | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Hereditary hearing loss, predominantly attributed to mutations in the GJB2 gene, constitutes a significant global healt… | Gene therapy 2026-08-08 00:57:21 | Source |
| Cognitive training and promoting a healthy lifestyle in isolated REM… Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease · PMID 42555286 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal phase of Lewy body diseases and linked… | Alzheimer's & dementia : the journal of the Alzheimer'… 2026-08-08 00:57:19 | Source |
| Drug-associated psoriasis: a pharmacovigilance study based on the FAE… Telmisartan · PMID 42558881 | Maladie d’Alzheimer · Hypertension artérielle · Hypertension artériel… | Immunomodulation | Publication | PubMed | Voir la publication source Drug-induced psoriasis has been increasingly recognized, but the spectrum of potential triggering medications remains i… | Frontiers in pharmacology 2026-08-08 00:57:17 | Source |
| Telmisartan, P-glycoprotein inhibition, and bleeding risk in DOAC-tre… Telmisartan · PMID 42557440 | Maladie d’Alzheimer · Hypertension artérielle · Hypertension artériel… | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Hypertension research : official journal of the Japane… 2026-08-08 00:57:17 | Source |
| Adherence and Healthcare Costs Associated with Single-vs Free-Pill Co… Perindopril · PMID 42566123 | Hypertension artérielle | À vérifier | Publication | PubMed | Voir la publication source Short-term studies have demonstrated that single-pill combinations (SPCs) improve adherence, reduce hypertension-relate… | American journal of cardiovascular drugs : drugs, devi… 2026-08-08 00:57:16 | Source |
| Digital pharmacoepidemiology of angiotensin-converting enzyme inhibit… Perindopril · PMID 42564536 | Hypertension artérielle | Thérapie génique | Publication | PubMed | Voir la publication source Hypertension remains one of the leading causes of cardiovascular morbidity and mortality; however, patient adherence to… | Frontiers in pharmacology 2026-08-08 00:57:16 | Source |
| Efficacy of sequential aerobic exercise and cognitive training in old… The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial · PMID 42524288 | Maladie d’Alzheimer | Thérapie génique | Publication | PubMed | Voir la publication source Multi-component interventions may be critical for reducing Alzheimer's disease (AD) risk since AD pathogenesis is multi… | Aging and health research 2026-08-08 00:57:11 | Source |
| Cognitive Impairment Associated with Chemotherapy: Neuroimmunological… Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention · PMID 42512539 | Cancer | Remyélinisation indirecte / réparation · Neuroprotection · Immunomodulation · T… | Publication | PubMed | Voir la publication source Chemotherapy is a treatment designed to contain or eradicate neoplastic cells; however, patients may experience various… | Brain sciences 2026-08-08 00:57:09 | Source |
| Sedentary Behavior and Physical Activity in Individuals With Bipolar… Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention · PMID 42545207 | Maladie d’Alzheimer | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Higher time in sedentary behavior and insufficient physical activity are very common in bipolar disorder (BD). Whereas… | Bipolar disorders 2026-08-08 00:57:09 | Source |
| Daturaolone from L. Inhibits acetylcholinesterase and monoamine oxida… Donepezil · PMID 42555879 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Daturaolone is an amyrin-type triterpenoid isolated from L. which was evaluated in the current study as a multitarget i… | Natural product research 2026-08-08 00:57:05 | Source |
| Valorization of 2-aminoethoxydiphenyl borate as a neurotherapeutic ag… Donepezil · PMID 42541674 | Maladie d’Alzheimer | Neuroprotection · Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source In Alzheimer's disease (AD), amyloid beta (Aβ) plaques and hyperphosphorylated tau tangles drive neurodegeneration and… | Inflammopharmacology 2026-08-08 00:57:05 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||