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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Brain Tumor Imaging with Iopamidol CEST MRI: In Vivo Detection and Va… Gadoteridol · PMID 41889470 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Several diamagnetic CEST (chemical exchange saturation transfer) molecules have been proposed as a potential alternativ… | Chemical & biomedical imaging 2026-08-13 14:19:38 | Source |
| Mn(II)-Tagged DOTA-Modified Sugar-Based Biopolymers as Gadolinium-Fre… Gadoteridol · PMID 42198224 | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source : Paramagnetic manganese (Mn(II)) has emerged as a promising alternative to gadolinium-based contrast agents (GBCAs) du… | Pharmaceutics 2026-08-13 14:19:38 | Source |
| Optimizing the ferumoxytol dose for vascular suppression in brachial… Ferumoxytol infusion · PMID 40961975 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Magnetic resonance neurography (MRN) enables visualization of peripheral nerves using T2-weighted, fat-suppressed seque… | Physics in medicine and biology 2026-08-13 14:19:37 | Source |
| USPIO enhanced MR imaging in CNS tumors (UMIC): a study protocol. Ferumoxytol infusion · PMID 42267547 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Tumor-associated macrophages (TAMs) are key drivers of brain tumor progression and therapy resistance. Clinically appli… | Nanomedicine (London, England) 2026-08-13 14:19:37 | Source |
| Subcutaneous Ocrelizumab in Patients With Multiple Sclerosis: Results… OCR SC · PMID 40245351 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source IV-administered ocrelizumab (OCR) is approved for the treatment of relapsing and primary progressive multiple sclerosis… | Neurology 2026-08-13 14:19:36 | Source |
| AQP4-IgG-positive myelitis occurring in a patient with small cell lun… Methylprednisolone · PMID 42591078 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Acute myelopathy in patients with small cell lung cancer (SCLC) is often attributed to metastatic spinal cord involveme… | Frontiers in oncology 2026-08-13 14:19:32 | Source |
| Recent advances in the medical management of thyroid eye disease. Methylprednisolone · PMID 42590938 | Cancer · Lupus · Myopathies · Maladie de Parkinson · Sclérose en plaq… | Immunomodulation | Publication | PubMed | Voir la publication source Thyroid eye disease (TED) is a debilitating autoimmune disorder that can cause facial disfigurement, impair vision and… | Current opinion in endocrinology, diabetes, and obesity 2026-08-13 14:19:32 | Source |
| Characterization of adverse reactions to two antihistamine drugs: A d… Antihistamine · PMID 42585211 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Antihistamines like azelastine and levocabastine are key in treating allergies, including allergic rhinitis, conjunctiv… | PloS one 2026-08-13 14:19:31 | Source |
| Objective Sleep Assessment in Systemic Mastocytosis: Polysomnographic… Antihistamine · PMID 42590170 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source : Systemic mastocytosis (SM) is a rare clonal mast cell disorder associated with mediator-related symptoms and a broad… | Journal of clinical medicine 2026-08-13 14:19:31 | Source |
| Intermittent Theta Burst Stimulation Improves Sleep in Autism Spectru… Sham · PMID 42590803 | Migraine · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Overlapping network architecture supports functional integration and multifunctional regional engagement in the brain,… | CNS neuroscience & therapeutics 2026-08-13 14:19:28 | Source |
| Role of Hypoxia-Inducible Factor-1α in Regulating Muscle Degeneration… Sham · PMID 42590923 | Migraine · Sclérose en plaques | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Secondary muscle degeneration after a rotator cuff tear (RCT) critically affects clinical outcomes. Vascular compromise… | The American journal of sports medicine 2026-08-13 14:19:28 | Source |
| The impact of fluoxetine on the aversive effects of lysergic acid die… paroxetine · PMID 42574097 | Migraine · Sclérose en plaques · Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Serotonergic antidepressant history can reduce the subjective effects, including therapeutic efficacy, of a number of p… | Experimental and clinical psychopharmacology 2026-08-13 14:19:25 | Source |
| Xiaoyao San exerts antidepressant effects via the gut microbiota-brai… paroxetine · PMID 42580208 | Migraine · Sclérose en plaques · Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Depression is characterized by a dysregulated brain-gut axis. Xiaoyao San (XYS), a classic Traditional Chinese Medicine… | Journal of pharmaceutical and biomedical analysis 2026-08-13 14:19:25 | Source |
| Bacterial Outer Membrane Vesicle-Based Versatile In Situ Nanovaccine… Early Highly Effective Therapies Group · PMID 42590861 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Radiofrequency ablation (RFA) is the primary curative therapy for early hepatocellular carcinoma (HCC). However, incomp… | Advanced healthcare materials 2026-08-13 14:19:16 | Source |
| Beyond Weight Loss: Gut Microenvironment Modulation to Enhance Cardio… Escalation Therapies Group · PMID 42590012 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Glucagon-like peptide-1 receptor agonists and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1… | Journal of clinical medicine 2026-08-13 14:19:16 | Source |
| Mentalisation-Based Treatment (MBT) in youth at Clinical High-Risk fo… Early Highly Effective Therapies Group · PMID 42586730 | Sclérose en plaques | Ralentissement de la progression · Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Psychoses are among the most severe disorders in children and adolescents, representing the second leading cause of yea… | BMJ open 2026-08-13 14:19:16 | Source |
| Time-Dependent Bias and Prognostic Confounding in Exposure-Response A… Escalation Therapies Group · PMID 42587360 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Exposure-response (E-R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration-gu… | Clinical pharmacology and therapeutics 2026-08-13 14:19:16 | Source |
| Antitumor Effects of L. subsp. in a Mammary Tumor Model: Regulation o… Other treatment · PMID 42588430 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Estrogen receptor-positive breast cancer remains difficult to treat, driving the search for new therapeutic agents. L.,… | Molecules (Basel, Switzerland) 2026-08-13 14:19:09 | Source |
| Discrepancy Between Eligibility and Practice: A 14-Year Nationwide St… Other treatment · PMID 42588674 | Cancer | À vérifier | Publication | PubMed | Voir la publication source The 2026 Barcelona Clinic Liver Cancer (BCLC) update recommends surgical resection for a single hepatocellular carcinom… | Cancers 2026-08-13 14:19:09 | Source |
| Safety, pharmacodynamics, and pharmacokinetics of oral cannabigerol i… No Drug · PMID 42575778 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Cannabigerol (CBG) is a minor cannabinoid that has been considered as a potential therapeutic, yet basic acute pharmaco… | The Journal of pharmacology and experimental therapeut… 2026-08-13 14:19:08 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||