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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Immunoglobulin Superfamily Protein BTNL9 Functions as a Non-Canonical… Etoposide · PMID 42589257 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Butyrophilin-like 9 (BTNL9), a member of the immunoglobulin superfamily containing a bZIP-like domain, has a poorly def… | International journal of molecular sciences 2026-08-13 14:22:06 | Source |
| Case report: Lichenoid eruption under immunotherapy with MK-4830 and… MK-4830 · PMID 39193329 | Cancer | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, yet they can induce immune-related adverse ev… | Frontiers in pharmacology 2026-08-13 14:22:05 | Source |
| KEYSTEP-008: phase II trial of pembrolizumab-based combination in MSI… MK-4830 · PMID 37701986 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Robust clinical activity has been observed with the immune checkpoint inhibitor pembrolizumab in patients with microsat… | Future oncology (London, England) 2026-08-13 14:22:05 | Source |
| Integrating Mediterranean Diet Education and Sustainability in Primar… Agricultural Health Study Follow-up · PMID 42588028 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source : School-based programmes may play an important role in promoting healthier and more sustainable dietary habits from ea… | Nutrients 2026-08-13 14:22:04 | Source |
| Post-intervention durability of standalone digital behavior change in… Agricultural Health Study Follow-up · PMID 42577435 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Standalone digital behavior change interventions (DBCIs) are increasingly used to promote physical activity (PA), but t… | Frontiers in public health 2026-08-13 14:22:04 | Source |
| Direct Substantia Nigra Deep Brain Stimulation in Parkinson's Disease… Deep Brain Stimulation · PMID 42586498 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source The substantia nigra (SN) is an emerging deep brain stimulation (DBS) target for Parkinson's disease (PD). However, its… | Brain stimulation 2026-08-13 14:22:03 | Source |
| Molecular Mechanisms of Foreign Body Responses to Neural Electrodes a… Deep Brain Stimulation · PMID 42589408 | Épilepsie · Myopathies · Maladie de Parkinson · Épilepsie · Maladie d… | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Long-term implantable neural electrodes underpin brain-machine interfaces, deep brain stimulation, epilepsy monitoring,… | International journal of molecular sciences 2026-08-13 14:22:03 | Source |
| Closing the Loop With Cortical Sensing: The Development of Adaptive D… Medtronic Activa Tremor Control System · PMID 34955714 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Deep Brain Stimulation (DBS) is an important tool in the treatment of pharmacologically resistant neurological movement… | Frontiers in neuroscience 2026-08-13 14:22:02 | Source |
| Neurostimulation systems for deep brain stimulation: in vitro evaluat… Medtronic Activa Tremor Control System · PMID 11891968 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source To assess magnetic resonance imaging (MRI)-related heating for a neurostimulation system (Activa Tremor Control System,… | Journal of magnetic resonance imaging : JMRI 2026-08-13 14:22:02 | Source |
| DECIDER-2: Prospective randomized multicenter phase III trial of deci… ATRA · PMID 42563153 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of t… | BMC cancer 2026-08-13 14:22:01 | Source |
| Systemic administration of all-trans retinoic acid modulated circulat… ATRA · PMID 42582022 | Cancer | Remyélinisation indirecte / réparation · Immunomodulation | Publication | PubMed | Voir la publication source Musculoskeletal trauma is exceedingly common and experiences a high incidence of complications, including bone non-unio… | Frontiers in immunology 2026-08-13 14:22:01 | Source |
| Concordance of pathologic response assessment between local and centr… Vibostolimab · PMID 42190314 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Substudy 02C of the phase I-II KEYMAKER-U02 study was designed to evaluate neoadjuvant pembrolizumab as monotherapy and… | ESMO open 2026-08-13 14:22:00 | Source |
| No RFS benefit found from adding vibostolimab to pembrolizumab in pat… Vibostolimab · PMID 42316576 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Cancer 2026-08-13 14:22:00 | Source |
| LITESPARK-012: pembrolizumab plus lenvatinib with or without belzutif… Quavonlimab · PMID 37882432 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Combination treatment with immunotherapy agents and/or vascular endothelial growth factor tyrosine kinase inhibitors ar… | Future oncology (London, England) 2026-08-13 14:21:59 | Source |
| Novel pembrolizumab-based treatments as first-line therapy in advance… Quavonlimab · PMID 41115468 | Maladie de Parkinson | Ralentissement de la progression | Publication | PubMed | Voir la publication source First-line triplet therapy may expand clinical benefit for advanced clear-cell renal cell carcinoma (ccRCC). The phase… | Annals of oncology : official journal of the European… 2026-08-13 14:21:59 | Source |
| Effects of N-carbamylglutamate on down yield and quality and thyroid… Amino acid supplement · PMID 42341506 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source The efficiency of goose down production depends on improvements in both yield and quality, and thyroid function plays a… | Poultry science 2026-08-13 14:21:58 | Source |
| Preparation and Properties of Fruit Shell Cellulose Nanoparticle Mate… Amino acid supplement · PMID 42181979 | Maladie de Parkinson | Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Histidine deficiency has been associated with oxidative stress, inflammation, and metabolic diseases, compared with ins… | International journal of food science 2026-08-13 14:21:58 | Source |
| Randomized controlled trial evaluating synbiotic supplementation as a… Daily Amino Acid Supplementation for People With Parkinson's Disease · PMID 40434674 | Maladie de Parkinson | Neuroprotection · Ralentissement de la progression · Immunomodulation · Traitem… | Publication | PubMed | Voir la publication source Neuroinflammatory mechanisms have been closely related to the microbiota-gut-brain axis and could lead to degeneration… | Inflammopharmacology 2026-08-13 14:21:57 | Source |
| Safety and efficacy of continuous subcutaneous levodopa-carbidopa inf… Daily Amino Acid Supplementation for People With Parkinson's Disease · PMID 38499015 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Conventional oral levodopa therapy for the treatment of Parkinson's disease can be associated with variations in plasma… | The Lancet. Neurology 2026-08-13 14:21:57 | Source |
| Add-on safinamide and amantadine in Filipino Parkinson's disease pati… Safinamide · PMID 42550256 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source To describe and compare short-term motor fluctuation-related outcomes among ambulatory Filipino patients with Parkinson… | Journal of neural transmission (Vienna, Austria : 1996) 2026-08-13 14:21:56 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||