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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Fractures in Parkinson's Disease: Pathophysiology, Prevention, and Or… Home-Based Exercise Programs for Fall Prevention in Parkinson Disease · PMID 41133050 | Maladie de Parkinson | Ralentissement de la progression | Publication | PubMed | Voir la publication source Fractures are an important comorbidity in Parkinson's disease (PD), which can result in disability, mortality, and high… | Cureus 2026-08-13 14:22:19 | Source |
| Prediction of benefit from docetaxel chemotherapy for HR-positive bre… Docetaxel · PMID 42585966 | Cancer | Thérapie génique | Publication | PubMed | Voir la publication source Adjuvant chemotherapy for hormone receptor-positive (HR+) breast cancer relies on taxanes, but existing tests do not id… | Breast (Edinburgh, Scotland) 2026-08-13 14:22:18 | Source |
| UNCX/SIN3A-Mediated H4K8 decrotonylation suppresses FOXO3 to drive TN… Docetaxel · PMID 42586287 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Triple-negative breast cancer (TNBC) remains a clinically challenging subtype characterized by aggressive behavior and… | Cellular signalling 2026-08-13 14:22:18 | Source |
| Correction: TROPION-Lung10: a phase 3 study of datopotamab deruxtecan… Rilvegostomig · PMID 41756332 | Cancer | À vérifier | Publication | PubMed | Voir la publication source [This corrects the article DOI: 10.3389/fonc.2025.1721624.]. | Frontiers in oncology 2026-08-13 14:22:17 | Source |
| Rilvegostomig for Metastatic Non-Small-Cell Lung Cancer: A First-In-H… Rilvegostomig · PMID 42574065 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Rilvegostomig, an anti-PD-1/TIGIT bispecific antibody, was evaluated in this first-in-human, multicenter, phase I/II, o… | Clinical cancer research : an official journal of the… 2026-08-13 14:22:17 | Source |
| Dynamic HER2 reassessment and precision sequencing after trastuzumab… Trastuzumab deruxtecan · PMID 42583014 | Cancer | Ralentissement de la progression | Publication | PubMed | Voir la publication source Human epidermal growth factor receptor 2 (HER2)-targeted therapy has transformed the treatment of HER2-positive advance… | ESMO gastrointestinal oncology 2026-08-13 14:22:16 | Source |
| Small Triple-Negative and HER2-Positive Early Breast Cancer: Upfront… Trastuzumab deruxtecan · PMID 42588641 | Cancer | À vérifier | Publication | PubMed | Voir la publication source Breast cancer (BC) can be treated by combinations of surgery, radiotherapy, chemotherapy, endocrine therapy and targete… | Cancers 2026-08-13 14:22:16 | Source |
| Implantation of Deep Brain Stimulator Through Polyetheretherketone (P… Deep Brain Stimulation (DBS) · PMID 42584182 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Polyetheretherketone (PEEK) is a commonly used material for cranioplasties due to its advantages over other materials a… | The Journal of craniofacial surgery 2026-08-13 14:22:15 | Source |
| Imaging the neuroimmune response to alcohol exposure in adolescent ba… DPA-714 Metabolite Analysis · PMID 28944558 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source The effects of acute alcohol exposure to the central nervous system are hypothesized to involve the innate immune syste… | Addiction biology 2026-08-13 14:22:14 | Source |
| Impact of Endothelial 18-kDa Translocator Protein on the Quantificati… DPA-714 Metabolite Analysis · PMID 28775204 | Maladie de Parkinson | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source F-DPA-714 is a second-generation tracer for PET imaging of the 18-kDa translocator protein (TSPO), a marker of neuroinf… | Journal of nuclear medicine : official publication, So… 2026-08-13 14:22:14 | Source |
| 18F-DPA-714 PET/MRI reveals early and widespread neuroinflammation in… DPA-714-PET/MRI · PMID 41623402 | Maladie de Parkinson | Immunomodulation | Publication | PubMed | Voir la publication source Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disorder caused by prion proteins, with microglial activat… | BMJ neurology open 2026-08-13 14:22:13 | Source |
| Neuroinflammation in GAD65 Antibody-Associated Epilepsy Measured Usin… DPA-714-PET/MRI · PMID 41572577 | Maladie de Parkinson | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody-associated epi… | Annals of clinical and translational neurology 2026-08-13 14:22:13 | Source |
| Pharmaceutical and pharmacokinetic evaluation of a newly formulated m… Levodopa/Carbidopa (Sinemet) · PMID 36778908 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Levodopa is routinely co-administered with carbidopa in the management of Parkinson's disease. Although the aforementio… | ADMET & DMPK 2026-08-13 14:22:12 | Source |
| The effect of levodopa or levodopa-carbidopa (sinemet) on fracture he… Levodopa/Carbidopa (Sinemet) · PMID 16891938 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Levodopa (L-dopa) and L-dopa/carbidopa were evaluated to determine their effectiveness in the stimulation of bone heali… | Journal of orthopaedic trauma 2026-08-13 14:22:12 | Source |
| Nicotinamide Riboside Enhances Mitochondrial Bioenergetics and Dopami… NAD Supplementation in Parkinson's Disease · PMID 42370283 | Maladie de Parkinson | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source Parkinson's disease (PD) is characterized by progressive degeneration of (SNc) dopaminergic (DA) neurons and the develo… | Research square 2026-08-13 14:22:09 | Source |
| The NAD-brain pharmacokinetic study of NAD augmentation in blood and… NAD Supplementation in Parkinson's Disease · PMID 41858901 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Nicotinamide adenine dinucleotide (NAD) augmentation therapy (NAD-AT) is increasingly explored in clinical trials acros… | iScience 2026-08-13 14:22:09 | Source |
| Factors affecting the performance of a novel artificial intelligence-… Oxygen-15 Water · PMID 40248500 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source AI-QCT is an FDA-cleared novel artificial intelligence-guided method that utilizes features from coronary computed tomo… | European heart journal. Imaging methods and practice 2026-08-13 14:22:08 | Source |
| The future of PET imaging: Looking forward to more choices and increa… Oxygen-15 Water · PMID 38342511 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Journal of nuclear cardiology : official publication o… 2026-08-13 14:22:08 | Source |
| The free plasma amyloid Aβ/Aβ ratio predicts conversion to dementia f… 15-0 H20 · PMID 38423192 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Blood-based biomarkers are a non-invasive solution to predict the risk of conversion of mild cognitive impairment (MCI)… | Neurobiology of disease 2026-08-13 14:22:07 | Source |
| Amphiphilic Semisynthetic Triterpenoids Impair Survival Pathways and… Etoposide · PMID 42589221 | Cancer | Remyélinisation indirecte / réparation | Publication | PubMed | Voir la publication source High-risk neuroblastoma (HR-NB) remains a major clinical challenge due to the emergence of therapy resistance. In this… | International journal of molecular sciences 2026-08-13 14:22:06 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||