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Toutes les maladies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Metal nanocrystals and nanoclusters with paracetamol passivation and… Paracetamol (acetaminophen) · PMID 42483226 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Paracetamol (acetaminophen), being a well-used pharmaceutical drug, has several harmful health effects due to its overc… | Nanoscale advances 2026-08-16 19:25:47 | Source |
| Paracetamol-induced hepatic injury following intentional self-poisoni… Paracetamol (acetaminophen) · PMID 42573610 | Migraine | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Paracetamol (acetaminophen) overdose is a common cause of drug-induced hepatocellular injury and represents an importan… | Naunyn-Schmiedeberg's archives of pharmacology 2026-08-16 19:25:47 | Source |
| Knowledge About and the Use of Oral Nonsteroidal Anti-inflammatory Dr… NSAID (Nonsteroidal anti-inflammatory drugs) · PMID 38073919 | Migraine | Immunomodulation | Publication | PubMed | Voir la publication source The aims were to evaluate rheumatic disorder patients' knowledge of the side effects of nonsteroidal anti-inflammatory… | Cureus 2026-08-16 19:25:46 | Source |
| Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Use Is Associated With… NSAID (Nonsteroidal anti-inflammatory drugs) · PMID 41293358 | Migraine | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Background and objective Many patients across the United States suffer from migraines, which can be extremely painful a… | Cureus 2026-08-16 19:25:46 | Source |
| NSAID (nonsteroidal anti-inflammatory drugs) Induced Stevens Johnson… NSAID (Nonsteroidal anti-inflammatory drugs) · PMID 38469333 | Migraine | Immunomodulation | Publication | PubMed | Voir la publication source Stevens-Johnson Syndrome (SJS) is a severe and rare adverse drug reaction associated with significant morbidity and mor… | Toxicology reports 2026-08-16 19:25:46 | Source |
| Current Clinical Evidence on Nose-to-Brain Drug Delivery. triptans · PMID 42580438 | Maladie d’Alzheimer · Migraine · Maladie de Parkinson · Sclérose en p… | Traitement symptomatique | Publication | PubMed | Voir la publication source Intranasal delivery is increasingly recognised as a promising strategy for direct drug transport to the brain via the n… | Drug discovery today 2026-08-16 19:25:45 | Source |
| Efficacy analysis of combined nerve combing and decompression for occ… triptans · PMID 42003361 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medicat… | Annals of medicine 2026-08-16 19:25:45 | Source |
| A full-spectrum aqueous extract of black cardamom () improves focus/a… Caffeine (200 mg) · PMID 42027681 | Migraine | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Interest is increasing in natural, plant-based, food-grade nootropics that deliver sustained cognitive benefits without… | Frontiers in neuroscience 2026-08-16 19:25:42 | Source |
| Design and rationale of TROCADERO: A TRial Of Caffeine to Alleviate D… Caffeine (200 mg) · PMID 26385029 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Ticagrelor treatment has the side effect of increased incidence of dyspnea. Adenosine-induced dyspnea is augmented by t… | American heart journal 2026-08-16 19:25:42 | Source |
| A scheme to tackle the dilemma from hepatoma cells under doxorubicin-… Metoclopramide · PMID 42482449 | Migraine | À vérifier | Publication | PubMed | Voir la publication source The aim of this study was to investigate key target(s), mechanism(s) from hepatoma cells in harsh doxorubicin-resistant… | Artificial cells, nanomedicine, and biotechnology 2026-08-16 19:25:39 | Source |
| Comprehensive MRI analysis of olfactory bulb morphology and olfactory… Understanding the Pathophysiology of Migraine Pain · PMID 42162730 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source This study aimed to provide a comprehensive MRI-based assessment of olfactory bulb (OB) morphology and olfactory sulcus… | Neuroscience 2026-08-16 19:25:39 | Source |
| Pharmaceutical policy and off-label prescribing in pregnancy: A popul… Metoclopramide · PMID 42281148 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Nausea and vomiting in pregnancy is highly prevalent and can significantly impact pregnant women's quality of life. Des… | Acta obstetricia et gynecologica Scandinavica 2026-08-16 19:25:39 | Source |
| Receptor-Targeted Antiemetic Strategies in Cats: A Systematic Review… Metoclopramide · PMID 42599757 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Emesis is a common adverse effect in cats receiving alpha-2 adrenergic agonists and opioids and may compromise perioper… | Veterinary medicine and science 2026-08-16 19:25:39 | Source |
| The influence of chronotype on pain: a systematic review and meta-ana… Understanding the Pathophysiology of Migraine Pain · PMID 42153471 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Sleep and circadian rhythms play critical roles in pain regulation, yet the influence of chronotype remains underexplor… | Pain 2026-08-16 19:25:39 | Source |
| [Migraine in men: biological, psychosocial and clinical characteristi… Understanding the Pathophysiology of Migraine Pain · PMID 41995752 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Migraine affects 15% of the global population, with men being 2-3 times less frequently affected than women and are mar… | Schmerz (Berlin, Germany) 2026-08-16 19:25:39 | Source |
| Anti-inflammatory drugs disrupt granulosa cell homeostasis in vitro a… Ketoprofen · PMID 42308573 | Migraine | Immunomodulation | Publication | PubMed | Voir la publication source Granulosa cells (GCs) play a crucial role in maintaining follicular homeostasis and supporting the acquisition of oocyt… | Theriogenology 2026-08-16 19:25:38 | Source |
| Membrane-mediated mechanisms of NSAID-induced cardiotoxicity independ… Ketoprofen · PMID 42336296 | Migraine | Immunomodulation | Publication | PubMed | Voir la publication source Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with cardiovascular adverse events that are not fully exp… | Toxicology and applied pharmacology 2026-08-16 19:25:38 | Source |
| Benzodiazepines use in Morocco: A nation wide consumption database st… Clorazepate Dipotassium · PMID 31759283 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Although information exists regarding the rate of benzodiazepines (BZDs) use in different countries, little information… | Asian journal of psychiatry 2026-08-16 19:25:35 | Source |
| Effect of Clomethiazole Vs. Clorazepate on Hepatic Fat and Serum Tran… Clorazepate Dipotassium · PMID 36562601 | Migraine | Neuroprotection | Publication | PubMed | Voir la publication source Alcohol-associated liver disease (ALD) is a global health problem caused, among other factors, by oxidative stress from… | Alcohol and alcoholism (Oxford, Oxfordshire) 2026-08-16 19:25:35 | Source |
| Preclinical characterization of MTX-101: a novel bispecific CD8 Treg… MTX101 · PMID 39559361 | Migraine | Immunomodulation | Publication | PubMed | Voir la publication source Regulatory CD8 T cells (CD8 Treg) are responsible for the selective killing of self-reactive and pathogenic CD4 T cells… | Frontiers in immunology 2026-08-16 19:25:32 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||