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Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
8666 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4050
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19-CAR-T cells NCT06420154 · The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an investigator-initiated trial to evaluate the safety and efficac… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ASP2802 NCT06248086 · A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell L… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | TERMINATED | CAR-T cell therapy is a type of treatment for people with certain lymphoma… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Bexxar NCT00434629 · Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Ce… | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | Patients with B-cell lymphoma who relapse after autologous transplant tend… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CD19/CD22 CAR-T NCT04499573 · Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B… | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and efficiency of auto… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| cemacabtagene ansegedleucel NCT06500273 · ALPHA3 — Consolidation of First-Line MRD+ Remission With Cema-cel in Patients Wi… | Sclérose en plaques | À vérifier | Phase 2 | RECRUITING | This is a randomized, open-label study in adult patients who have complete… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Deplet… NCT03810196 · CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Non applicable | RECRUITING | The major morbidities of allogeneic hematopoietic stem cell transplant wit… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| KYV-101, an autologous fully-human anti-CD19 CAR T-cell immunotherapy NCT06590545 · IDEAL — Anti-CD 19 CAR-T Cell Therapy in Patients With ANCA Vasculitis | Sclérose en plaques | Thérapie cellulaire | Phase 1/2 | NOT_YET_RECRUITING | The goal of this phase I/II clinical trial is to investigate anti-CD 19 ch… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rapcabtagene autoleucel (YTB323) NCT07443137 · CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study) | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | NOT_YET_RECRUITING | This is an open-label, multi-center, non-confirmatory study to assess the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| rondecabtagene autoleucel NCT07188558 · PiNACLE-H2H — A Study to Investigate Ronde-cel Versus Investigator's Choice CD19… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 3 | RECRUITING | This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| TC011 single-arm NCT07360288 · TC011_FL_201 — Efficacy and Safety of TC011 in Relapsed or Refractory Follicular… | Sclérose en plaques | Thérapie cellulaire | Phase 2 | NOT_YET_RECRUITING | This Phase II, multi-center, single-arm, open-label study evaluates the ef… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| ThisCART19A with Dose Level 1 NCT05691153 · ThisCART19A for B-NHL Relapsed After Auto-CAR T | Sclérose en plaques | Thérapie cellulaire | Phase 1 | UNKNOWN | This is a phase 1, single-center, dose selection study to evaluate the eff… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:27 | Détail |
| Rituximab NCT03636503 · Rituximab + Immunotherapy in Follicular Lymphoma | Sclérose en plaques | À vérifier | Phase 1 | TERMINATED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Rituximab NCT00006669 · Rituximab Followed by Combination Chemotherapy in Treating Patients With Refract… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| SCT400 plus CHOP NCT02772822 · A Study Comparing the Efficiency and Safety of S-CHOP(Cyclophosphamide, Hydroxyd… | Sclérose en plaques | Immunomodulation | Phase 3 | UNKNOWN | The primary objective of the study is to assess the efficiency of SCT400 p… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:26 | Détail |
| Armored and GPC3-targeted autologous CAR T-cell NCT06590246 · A Study to Evaluate C-CAR031 in Glypican-3 (GPC3)+ Advanced/Recurrent Hepatocell… | Sclérose en plaques | À vérifier | Phase 1/2 | RECRUITING | This single-arm, open-label multicenter Phase I/II study will evaluate the… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT05155189 · A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| C-CAR031 NCT07444281 · An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Ad… | Sclérose en plaques | À vérifier | Phase 1 | RECRUITING | A study that aimed to assess the safety and anti-tumor activity of CCAR031… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| CD19/CD20-directed Chimeric Antigen Receptor T Cells NCT05149391 · A Study of C-CAR039 in Subjects With Relapsed and/or Refractory B Cell Non-Hodgk… | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | This is a single-center, open-label study to evaluate the safety and effic… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04317885 · A Study Evaluating Safety and Efficacy of C-CAR039 Treatment in NHL Subjects | Sclérose en plaques | À vérifier | Phase 1 | COMPLETED | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
| Prizloncabtagene Autoleucel NCT04693676 · A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Ly… | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | The trial is a single arm, single-center, non-randomized phase I clinical… À vérifier | ClinicalTrials.gov 2026-09-20 04:37:25 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4595
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Contribution of intravenous medication diluent fluid composition on t… Dextrose 5% in water · PMID 40689261 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Intravenous solutions such as dextrose 5% in water and 0.9% sodium chloride (normal saline) differ in electrolyte compo… | SAGE open medicine 2026-08-16 19:26:07 | Source |
| Enteral free water vs. parenteral dextrose 5% in water for the treatm… Dextrose 5% in water · PMID 37638970 | Migraine | Thérapie génique | Publication | PubMed | Voir la publication source Effective treatment options for patients with hypernatremia are limited. Free water administration (parenterally or ent… | Journal of anesthesia 2026-08-16 19:26:07 | Source |
| Management of Recurrent Laryngeal Nerve Injury During Radiofrequency… Dextrose 5% in water · PMID 35415225 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | AACE clinical case reports 2026-08-16 19:26:07 | Source |
| Could an intraoperative lidocaine intravenous infusion enhance patien… Lidocaine Intravenous Infusion · PMID 36367408 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Minerva anestesiologica 2026-08-16 19:26:06 | Source |
| Early Postoperative Analgesic Evaluation of Intravenous Lidocaine Inf… Lidocaine Intravenous Infusion · PMID 41472096 | Migraine | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Combined intraperitoneal and incisional block provides effective perioperative analgesia but is limited in clinical pra… | Veterinary sciences 2026-08-16 19:26:06 | Source |
| Evaluation of continuous intravenous lidocaine on brain relaxation, i… Lidocaine Intravenous Infusion · PMID 36086723 | Migraine | Immunomodulation | Publication | PubMed | Voir la publication source In craniotomy tumor removal, brain relaxation after dura opening is essential. Lidocaine is known to have analgesic and… | Medicine 2026-08-16 19:26:06 | Source |
| Middle Meningeal Artery Embolization With n-Butyl Cyanoacrylate in Pa… embolization of middle meningeal arteries · PMID 42295790 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Middle meningeal artery embolization (MMAE) is a minimally invasive adjunctive treatment for chronic subdural hematoma… | JAMA neurology 2026-08-16 19:26:03 | Source |
| Development of a transdermal sumatriptan formulation with iontophores… Sumatriptan · PMID 42312369 | Migraine | Thérapie génique | Publication | PubMed | Voir la publication source A transdermal iontophoretic formulation for sumatriptan was approved by the U.S. FDA in 2013 for patients who cannot ta… | Drug development and industrial pharmacy 2026-08-16 19:25:59 | Source |
| A mild photothermal-mediated neuroimmunomodulatory composite hydrogel… Substance P · PMID 42518658 | Migraine | Remyélinisation indirecte / réparation · Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source The peripheral sensory nervous system plays a crucial role in the repair of bone injuries. However, the excessive accum… | Bioactive materials 2026-08-16 19:25:58 | Source |
| Da-Jian-Zhong decoction restores the gut-brain balance in diarrhea-pr… Substance P · PMID 42498089 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Da-Jian-Zhong decoction (DJZD), a Chinese medicinal formula, exhibits therapeutic effects in the clinical management of… | Journal of ethnopharmacology 2026-08-16 19:25:58 | Source |
| Neuroimmune circuits in respiratory pathophysiology: decoding molecul… Substance P · PMID 41601146 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source The lung is a uniquely innervated barrier organ with dynamic neuroimmune interactions that critically regulate respirat… | Annals of medicine 2026-08-16 19:25:58 | Source |
| Nomogram prediction model for the clinical efficacy of flunarizine hy… Flunarizine Hydrochloride · PMID 41980299 | Migraine | Neuroprotection · Thérapie génique | Publication | PubMed | Voir la publication source This study aimed to develop and validate a nomogram model integrating 5-Hydroxytryptamine (5-HT) and oxidative stress m… | Clinics (Sao Paulo, Brazil) 2026-08-16 19:25:57 | Source |
| Efficacy of Acupuncture in the Treatment of Residual Pain After Osteo… Fu's Subcutaneous Needling · PMID 42483105 | Migraine | Ralentissement de la progression · Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source Osteoporotic vertebral compression fractures (OVCF) are common fractures in the elderly and have reached epidemic propo… | Journal of pain research 2026-08-16 19:25:56 | Source |
| Fu's subcutaneous needling therapy significantly enhances pain relief… Fu's Subcutaneous Needling · PMID 41177207 | Migraine | Remyélinisation indirecte / réparation · Immunomodulation · Traitement symptoma… | Publication | PubMed | Voir la publication source Mitochondrial autophagy is linked to neuropathic pain. This study explores how Fu's subcutaneous needling (FSN) affects… | Biomedical journal 2026-08-16 19:25:56 | Source |
| More than just numbers: the expanding burden of non-communicable dise… Fu's Subcutaneous Needling · PMID 42542110 | Cancer | Remyélinisation indirecte / réparation · Ralentissement de la progression · Imm… | Publication | PubMed | Voir la publication source Non-communicable diseases (NCDs) account for a major share of global mortality and disability, while their development… | Biomedical journal 2026-08-16 19:25:56 | Source |
| A multimodal evaluation of transcranial photobiomodulation in mild co… Sham breathing device · PMID 42231857 | Maladie d’Alzheimer | Remyélinisation indirecte / réparation · Immunomodulation | Publication | PubMed | Voir la publication source BackgroundMild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease and related dementias (ADRD), repre… | Journal of Alzheimer's disease : JAD 2026-08-16 19:25:52 | Source |
| Impact of respiratory muscle training on sleep disordered breathing i… Sham breathing device · PMID 42595897 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Sub-analysis of a randomised controlled trial. Respiratory muscle training (RMT) in people with tetraplegia yields mark… | Spinal cord 2026-08-16 19:25:52 | Source |
| Modulating autonomic nervous system activity with transcutaneous auri… Sham breathing device · PMID 42465725 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Cardiovascular dysautonomia is a debilitating non-motor symptom of Parkinson's disease (PD) that limits exercise capaci… | Frontiers in neuroscience 2026-08-16 19:25:52 | Source |
| Partial rebreathing is not effective for early treatment of migraine… Partial Rebreathing Device · PMID 41272403 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Evaluate the efficacy and safety of a novel partial rebreathing device for early treatment of acute attacks of migraine… | Headache 2026-08-16 19:25:51 | Source |
| From watershed to lagoon: Occurrence and ecological risk of paracetam… Paracetamol (acetaminophen) · PMID 42570042 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Pharmaceutical contamination in tropical coastal lagoons remains poorly characterized despite increasing anthropogenic… | Environmental science and pollution research internati… 2026-08-16 19:25:47 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||