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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Prospective, randomised, parallel-group, open-label study to evaluate… IMU-838 · PMID 36396307 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Globally, there is a scarcity of effective treatments for SARS-CoV-2 infections (causing COVID-19). Repurposing existin… | BMJ open 2026-08-16 13:00:26 | Source |
| Temelimab versus placebo in patients with post-COVID condition. Temelimab 54 mg/kg · PMID 42409185 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source More than 400 million individuals are estimated to have been affected by post-COVID condition or long COVID. This condi… | Brain, behavior, and immunity 2026-08-16 13:00:20 | Source |
| Real-World, Long-Term Outcomes with Cladribine Tablets Versus Other O… Teriflunomide HMR1726 · PMID 42321508 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, often associated with significant dis… | Neurology and therapy 2026-08-16 13:00:16 | Source |
| Bruton's Tyrosine Kinase Inhibitors in Multiple Sclerosis. Tolebrutinib · PMID 42126690 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Multiple sclerosis (MS) is a chronic, inflammatory disorder of the central nervous system (CNS) characterized by overla… | Drugs 2026-08-16 13:00:12 | Source |
| Dampening of Microglial Activation With Nasal Foralumab Administratio… Foralumab · PMID 40359013 | Maladie d’Alzheimer | Immunomodulation | Publication | PubMed | Voir la publication source A 78-year-old man with moderate Alzheimer disease (AD) dementia was treated with nasal-foralumab, a fully human anti-CD… | Clinical nuclear medicine 2026-08-16 13:00:09 | Source |
| CNM-Au8 in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Tri… CNM-Au8 · PMID 40067821 | Sclérose latérale amyotrophique | Remyélinisation indirecte / réparation · Neuroprotection · Ralentissement de la… | Publication | PubMed | Voir la publication source Bioenergetic failure has been proposed as a driver of amyotrophic lateral sclerosis (ALS). CNM-Au8 is a suspension of g… | JAMA 2026-08-16 12:59:57 | Source |
| Nonendoscopic Detection of Barrett's Esophagus on Patients Without Ga… EsoGuard · PMID 40748349 | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Upper endoscopy (EGD) is generally recommended in those with chronic gastroesophageal reflux disease (GERD). To evaluat… | The American journal of gastroenterology 2026-08-16 12:59:49 | Source |
| Comparison of epcoritamab, lenalidomide, and rituximab versus usual c… Rituximab · PMID 42415230 | Cancer · Lupus · Myasthénie · Sclérose en plaques · Myasthénie · Lupu… | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Patients with relapsed/refractory follicular lymphoma (R/R FL) often experience multiple disease recurrences with progr… | Oncoimmunology 2026-08-16 12:59:44 | Source |
| Proteinuria selectivity index as a predictor of remission and rituxim… Rituximab · PMID 42535733 | Cancer · Lupus · Myasthénie · Sclérose en plaques · Myasthénie · Lupu… | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source The protein selectivity index (PSI) has been proposed as a prognostic marker in nephrotic syndrome, but its prognostic… | Renal failure 2026-08-16 12:59:44 | Source |
| Rituximab remodels the circulating immune landscape in pemphigus vulg… Rituximab · PMID 42602981 | Cancer · Lupus · Myasthénie · Sclérose en plaques · Myasthénie · Lupu… | Immunomodulation | Publication | PubMed | Voir la publication source (PV) is a severe autoimmune blistering disease characterized by pathogenic autoantibodies primarily targeting desmoglei… | Journal of translational autoimmunity 2026-08-16 12:59:44 | Source |
| Longitudinal evolution of JC virus serological index in multiple scle… Risk Factors in Early Multiple Sclerosis · PMID 42229340 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source The anti-JC virus (JCV) antibody index is an established biomarker for estimating the risk of progressive multifocal le… | Clinical neurology and neurosurgery 2026-08-16 12:59:43 | Source |
| Ozanimod: A Review in Relapsing Forms of Multiple Sclerosis. Zeposia · PMID 39368032 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Ozanimod (Zeposia), an orally administered sphingosine 1-phosphate (S1P) receptor modulator (S1PRM) that is selective f… | CNS drugs 2026-08-16 12:59:42 | Source |
| Deciphering the PgLEA2-50 interactome: implications for abiotic stres… Ginseng · PMID 41645041 | Sclérose en plaques | Neuroprotection | Publication | PubMed | Voir la publication source Ginseng's prolonged development renders it susceptible to environmental stresses. Late embryogenesis abundant (LEA) pro… | Plant signaling & behavior 2026-08-16 12:59:41 | Source |
| Integrating multi-omics and network pharmacology in a systems approac… Ginseng · PMID 42497599 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Panax ginseng C.A. Mey. is traditionally utilized to "tonify Qi and replenish Blood," particularly in managing anemia-l… | Journal of ethnopharmacology 2026-08-16 12:59:41 | Source |
| UHPLC/Q-TOF-MS-based blood-component profiling and multi-omics analys… Ginseng · PMID 42385329 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Diabetic kidney disease (DKD) is a common microvascular complication of diabetes, with no definitive treatment currentl… | Journal of pharmaceutical and biomedical analysis 2026-08-16 12:59:41 | Source |
| HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through… GNbAC1 · PMID 35062349 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source An increasing number of studies have begun considering human endogenous retroviruses () as potential pathogenic phenome… | Viruses 2026-08-16 12:59:40 | Source |
| Chinese herbal medicine Xiangsu Hewei Granules in treating non-erosiv… Control Group · PMID 42372807 | Accident vasculaire cérébral · Myasthénie · Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Xiangsu Hewei Granules are an herbal preparation that has shown potential for controlling symptoms of nonerosive gastro… | Journal of ethnopharmacology 2026-08-16 12:59:39 | Source |
| Comparative efficacy of percutaneous vertebroplasty combined with min… Control Group · PMID 42480043 | Accident vasculaire cérébral · Myasthénie · Sclérose en plaques | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source The study aimed to assess the comparative efficacy of percutaneous vertebroplasty (PVP) combined with minimally invasiv… | The Libyan journal of medicine 2026-08-16 12:59:39 | Source |
| Unveiling the skin-protective material basis of Coreopsis tinctoria N… Control Group · PMID 42508546 | Accident vasculaire cérébral · Myasthénie · Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Coreopsis tinctoria Nutt. (commonly known as Kunlun snow chrysanthemum) is a traditional medicinal and edible plant dis… | Journal of ethnopharmacology 2026-08-16 12:59:39 | Source |
| Brain iron deposition mediates cognitive impairment in COPD: A possib… MRI · PMID 42464739 | Cancer · Épilepsie · Migraine · Myopathies · Sclérose en plaques · Sc… | Immunomodulation | Publication | PubMed | Voir la publication source Cognitive impairment is a relatively prevalent comorbidity in chronic obstructive pulmonary disease (COPD), yet its neu… | Pulmonology 2026-08-16 12:59:38 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||