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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Safety of Remibrutinib in Chronic Spontaneous Urticaria: A Pooled Ana… Remibrutinib · PMID 42242425 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Remibrutinib, an oral, highly selective Bruton's tyrosine kinase inhibitor, showed sustained efficacy in phase 3 REMIX… | The journal of allergy and clinical immunology. In pra… 2026-08-16 13:01:21 | Source |
| Solar urticaria successfully treated with remibrutinib. Remibrutinib · PMID 42173244 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | The journal of allergy and clinical immunology. In pra… 2026-08-16 13:01:21 | Source |
| Successful treatment of pure red cell aplasia with Orelabrutinib foll… Orelabrutinib · PMID 42385585 | Sclérose en plaques · Sclérose latérale amyotrophique · Sclérose en p… | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Pure red cell aplasia (PRCA) is a severe complication following major ABO-incompatible hematopoietic stem cell transpla… | Transfusion and apheresis science : official journal o… 2026-08-16 13:01:21 | Source |
| A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and… Frexalimab · PMID 42203212 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin-producin… | Diabetes, obesity & metabolism 2026-08-16 13:01:20 | Source |
| Inhibition of CD40L with Frexalimab in Multiple Sclerosis. Frexalimab · PMID 38354138 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source The CD40-CD40L costimulatory pathway regulates adaptive and innate immune responses and has been implicated in the path… | The New England journal of medicine 2026-08-16 13:01:20 | Source |
| Psychometric validation of PROMIS-Fatigue-MS-8a and MSIS-29v2 questio… Frexalimab · PMID 41780470 | Sclérose en plaques | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source There are limited psychometric studies conducted using the Patient-Reported Outcomes Measurement Information System Adu… | Multiple sclerosis and related disorders 2026-08-16 13:01:20 | Source |
| Immunoglobulin dynamics and infection risk with ofatumumab versus ocr… Ofatumumab · PMID 42413316 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source To evaluate the impact of ofatumumab versus ocrelizumab on immunoglobulin levels in people with multiple sclerosis (pwM… | Multiple sclerosis and related disorders 2026-08-16 13:01:17 | Source |
| Narrative analysis and clinical meta-synthesis of YouTube storytellin… Risk Perception in Multiple Sclerosis · PMID 41546548 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source In the digital era, people with multiple sclerosis (MS) turn to platforms like YouTube (YT) for information and support… | Journal of health psychology 2026-08-16 13:01:16 | Source |
| Comparative effectiveness of ocrelizumab in subgroups of patients wit… Ocrelizumab (US) · PMID 42161588 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, is a high-efficacy therapy for multiple sclerosis (MS). Pat… | Journal of neurology, neurosurgery, and psychiatry 2026-08-16 13:01:14 | Source |
| Early Versus Delayed Treatment with Ocrelizumab: A Multicenter, Real-… Ocrelizumab (US) · PMID 42217095 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Growing evidence suggests that first-line (1L) treatment with high-efficacy disease-modifying therapies (HE-DMTs) may h… | Neurology and therapy 2026-08-16 13:01:14 | Source |
| Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the… GLP-1 · PMID 42503322 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Mulberry leaf (Morus alba L.) has long been used in traditional Chinese medicine for treating "Xiaoke" (diabetes), as d… | Journal of ethnopharmacology 2026-08-16 13:01:14 | Source |
| Peptide LKLKLL is a more effective component of which regulate glucol… GLP-1 · PMID 42473065 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source The ability of (AKK) to ameliorate metabolic dysfunction has attracted increasing attention as a potential strategy for… | Gut microbes 2026-08-16 13:01:14 | Source |
| reduces kynurenine levels and alleviates obesity and related metaboli… GLP-1 · PMID 42434935 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Next-generation probiotics derived from gut commensals show promise for metabolic disease intervention, yet effective a… | Gut microbes 2026-08-16 13:01:14 | Source |
| Metabolic characteristic changes in local tissues after high-intensit… dimethyl fumarate · PMID 41846319 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source To investigate the changes in the metabolome of fibroid tissue after high-intensity focused ultrasound (HIFU) treatment… | International journal of hyperthermia : the official j… 2026-08-16 13:01:11 | Source |
| Neuroprotective effects of glucotropaeolin as the major glucosinolate… dimethyl fumarate · PMID 42327485 | Sclérose en plaques | Remyélinisation · Neuroprotection · Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Multiple sclerosis (MS) is a neurodegenerative disease characterized by inflammation and myelin damage. Glucosinolates,… | Biochemistry and biophysics reports 2026-08-16 13:01:11 | Source |
| Genetic Risk in Multiple Sclerosis: Susceptibility, Modifiers and Unr… Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility · PMID 425… | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Multiple sclerosis (MS) is a chronic, immune-mediated disorder of the central nervous system (CNS) characterised by inf… | Neurology and therapy 2026-08-16 13:01:09 | Source |
| Interplay between genetic and environmental risk factors in multiple… Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility · PMID 418… | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Genome-wide association studies have identified >230 genetic variants associated with susceptibility to multiple sclero… | Brain : a journal of neurology 2026-08-16 13:01:09 | Source |
| The elusive link: EBV in MS. Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility · PMID 425… | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source The link between the risk of developing Multiple Sclerosis (MS) and Epstein-Barr virus (EBV) infection has been confirm… | Expert review of clinical immunology 2026-08-16 13:01:08 | Source |
| Age-related differences in motor learning, sensorimotor neurochemistr… Transcranial Magnetic Stimulation (TMS) · PMID 42372614 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Age-related declines in motor learning are commonly attributed to changes in sensorimotor neurophysiology. However, dir… | Neurobiology of aging 2026-08-16 13:01:06 | Source |
| Mechanisms of taVNS-induced working memory enhancement: a multimodal… Transcranial Magnetic Stimulation (TMS) · PMID 42153185 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a promising neuromodulation technique for enhan… | Cognitive neurodynamics 2026-08-16 13:01:06 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||