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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Evolution of Brain Volume Loss Rates in Early Stages of Multiple Scle… Avonex · PMID 33727311 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source To describe the dynamics of brain volume loss (BVL) at different stages of relapsing-remitting multiple sclerosis (RRMS… | Neurology(R) neuroimmunology & neuroinflammation 2026-08-16 13:02:44 | Source |
| Dimethyl fumarate modulates the regulatory T cell response in the mes… Tecfidera · PMID 38765015 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Dimethyl fumarate (DMF, Tecfidera) is an oral drug utilized to treat relapsing-remitting multiple sclerosis (MS). DMF t… | Frontiers in immunology 2026-08-16 13:02:40 | Source |
| Periconceptional nonsteroidal anti-inflammatory drug use, folic acid… Tecfidera · PMID 34346174 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source Use of nonsteroidal anti-inflammatory drugs (NSAIDs) during pregnancy may increase risk for neural tube defects (NTDs),… | Birth defects research 2026-08-16 13:02:40 | Source |
| Does desloratadine alter the serum levels of montelukast when adminis… Desloratadine given orally · PMID 23918211 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source The aim of this study was to investigate the serum levels of montelukast when administered alone or in combination with… | The Laryngoscope 2026-08-16 13:02:36 | Source |
| Interventions for idiopathic steroid-resistant nephrotic syndrome in… Dexamethasone given orally · PMID 40337980 | Hypertension artérielle | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Nephrotic syndrome is a condition in which the glomeruli of the kidney leak large amounts of protein from the blood int… | The Cochrane database of systematic reviews 2026-08-16 13:02:35 | Source |
| A prospective, randomized trial of intravenous prochlorperazine versu… Diphenhydramine IV · PMID 20045576 | Migraine | Traitement symptomatique | Publication | PubMed | Voir la publication source Intravenous (IV) prochlorperazine with diphenhydramine is superior to subcutaneous sumatriptan in the treatment of migr… | Annals of emergency medicine 2026-08-16 13:02:34 | Source |
| Methylprednisolone for acute type A aortic dissection patients underg… Methylprednisolone IV · PMID 39395565 | Sclérose en plaques | Immunomodulation | Publication | PubMed | Voir la publication source The mortality and morbidity of emergency total aortic arch replacement (TAAR) for acute type A aortic dissection (ATAAD… | American heart journal 2026-08-16 13:02:33 | Source |
| Comparative effectiveness of ofatumumab and ocrelizumab in relapsing… Ocrelizumab SC · PMID 42601218 | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Ofatumumab and ocrelizumab are widely used high-efficacy anti-CD20 therapies for relapsing-remitting multiple sclerosis… | Journal of neurology, neurosurgery, and psychiatry 2026-08-16 13:02:32 | Source |
| Real-world siponimod use in secondary progressive multiple sclerosis:… Ocrelizumab SC · PMID 42602134 | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Siponimod is approved in Europe for active secondary progressive multiple sclerosis (SPMS), but real-world data on its… | Therapeutic advances in neurological disorders 2026-08-16 13:02:32 | Source |
| Transitioning from intravenous to subcutaneous ocrelizumab in a high-… Ocrelizumab IV · PMID 42259159 | Sclérose en plaques | Thérapie génique | Publication | PubMed | Voir la publication source Subcutaneous (SC) ocrelizumab offers a streamlined alternative to intravenous (IV) infusion in the management of multip… | Multiple sclerosis and related disorders 2026-08-16 13:02:31 | Source |
| A Cognitive Occupation-Based programme for people with MS: acceptabil… Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study… | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source COB-MS is an eight-session, Cognitive Occupation-Based programme for people with both MS and cognitive difficulty - des… | Disability and rehabilitation 2026-08-16 13:02:29 | Source |
| Artificial intelligence for pulmonary embolism detection: Is it compa… AI software · PMID 42518755 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source To assess the diagnostic performance of a commercial artificial intelligence (AI) software in detecting pulmonary embol… | European journal of radiology open 2026-08-16 13:02:27 | Source |
| Clinical and artificial intelligence assessed echocardiographic predi… AI software · PMID 42331183 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Early risk stratification in patients after acute myocardial infarction (AMI) is critical for guiding therapy and resou… | International journal of cardiology 2026-08-16 13:02:27 | Source |
| Clinical integration of an inferior vena cava filter alert system usi… AI software · PMID 42470933 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Timely follow-up and removal of inferior vena cava (IVC) filters is important for preventing filter-related complicatio… | Clinical imaging 2026-08-16 13:02:27 | Source |
| Cognition beyond relapses: cognitive progression independent of relap… RRMS — Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multip… | Sclérose en plaques | Ralentissement de la progression | Publication | PubMed | Voir la publication source Progression independent of relapse activity (PIRA) is frequent in relapsing-remitting MS patients (RRMS). While often s… | Multiple sclerosis and related disorders 2026-08-16 13:02:25 | Source |
| Absence of PD-1 expression on T and T cell subsets correlates with se… Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS) · PMID 424190… | Sclérose en plaques | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Follicular CD4 T (T) cells have been implicated in the pathogenesis of multiple sclerosis (MS). However, studies evalua… | Journal of neuroimmunology 2026-08-16 13:02:22 | Source |
| Translating neurofilament light chain testing into clinical practice:… Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS) · PMID 418313… | Maladie d’Alzheimer · Sclérose en plaques · Sclérose latérale amyotro… | Neuroprotection · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Neurofilament light chain (NfL) has been identified as a sensitive and broadly validated biomarker of neuroaxonal injur… | Clinical chemistry and laboratory medicine 2026-08-16 13:02:22 | Source |
| Value of Annual MRI Monitoring in Patients With Multiple Sclerosis Tr… Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS) · PMID 425259… | Sclérose en plaques | Traitement symptomatique | Publication | PubMed | Voir la publication source Current guidelines recommend annual MRI scans during treatment with disease-modifying therapies, including ocrelizumab,… | Neurology 2026-08-16 13:02:22 | Source |
| An Evaluation of the Long-term Impact of Gadolinium-based Contrast Ag… Gadoteridol · PMID 41378765 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source Previous studies in rodents have investigated the potential effects of gadolinium-based contrast agents (GBCAs) on the… | Investigative radiology 2026-08-16 13:02:21 | Source |
| Dynamic Susceptibility Contrast MRI Using Gadopiclenol for Evaluation… Gadoteridol · PMID 41672714 | Sclérose en plaques | À vérifier | Publication | PubMed | Voir la publication source DSC MRI is widely used to assess relative cerebral blood volume (rCBV) in brain tumors using gadolinium-based contrast… | AJNR. American journal of neuroradiology 2026-08-16 13:02:21 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||