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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Carbon-coated CoNiFeCuCr high-entropy alloy nanoparticles for robust… biological samples · PMID 42700498 | Lupus · Myopathies · Myopathies | À vérifier | Publication | PubMed | Voir la publication source Simultaneous electrochemical detection of dopamine (DA) and uric acid (UA) in complex biological media remains challeng… | Talanta 2026-10-11 04:37:02 | Source |
| DNA- and aptamer-based biosensors for Alzheimer's disease biomarkers… biological samples · PMID 42715723 | Maladie d’Alzheimer | Thérapie génique | Publication | PubMed | Voir la publication source Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which early diagnosis remains a major challeng… | Talanta 2026-10-11 04:37:02 | Source |
| Immunoaffinity functionalisation of coated blades for fast, specific… biological samples · PMID 42753453 | Lupus · Myopathies · Myopathies | À vérifier | Publication | PubMed | Voir la publication source Immunoaffinity-coated blades were prepared by covalently binding antibodies via carbodiimide coupling to carboxyl-modif… | Talanta 2026-10-11 04:37:02 | Source |
| Agree to disagree: Increasing the impact of recommendations formulate… ODT Reference formulation · PMID 42235610 | Migraine | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Journal of hepatology 2026-10-11 04:36:45 | Source |
| Bioequivalence of Aripiprazole Oral Soluble Films and Orally Disinteg… ODT Reference formulation · PMID 39937655 | Migraine | Ralentissement de la progression · Thérapie génique | Publication | PubMed | Voir la publication source Schizophrenia is a serious mental disorder with high disability rates, and antipsychotics, especially second-generation… | Clinical and translational science 2026-10-11 04:36:45 | Source |
| Pharmacokinetic and Bioequivalence of Mirtazapine Orally Disintegrati… ODT Reference formulation · PMID 42850927 | Migraine | À vérifier | Publication | PubMed | Voir la publication source The study aimed to assess the bioequivalence of a new generic orally disintegrating tablet (ODT) formulation containing… | Clinical pharmacology in drug development 2026-10-11 04:36:44 | Source |
| Females exhibit greater cardiac volume reductions with expiratory mus… Expiratory load compensation · PMID 41731905 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Intrathoracic pressure (ITP) modulates venous return, ventricular filling and ejection throughout the respiratory cycle… | The Journal of physiology 2026-10-11 04:36:34 | Source |
| First-Month Adherence to Home Non-Invasive Ventilation in Stable Hype… Expiratory load compensation · PMID 42670381 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Long-term home non-invasive mechanical ventilation (NIV) is widely used in patients with hypercapnic chronic obstructiv… | International journal of chronic obstructive pulmonary… 2026-10-11 04:36:34 | Source |
| Respiratory physiological reactions during expiratory muscle training… Expiratory load compensation · PMID 39722369 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source This study aimed to investigate the physiological responses of patients with severe Chronic Obstructive Pulmonary Disea… | Physiology & behavior 2026-10-11 04:36:34 | Source |
| AAVcc47- Gene Therapy Ameliorates Respiratory Pathology in Mouse Mode… Hypercapnic challenge · PMID 42852007 | Épilepsie | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Duchenne muscular dystrophy (DMD) is a progressive X-linked neuromuscular disorder caused by deficiency of dystrophin -… | The Yale journal of biology and medicine 2026-10-11 04:36:33 | Source |
| Effect of chronic high-altitude hypoxia on retinal vascular phenotype… Hypercapnic challenge · PMID 42603100 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source High-altitude chronic hypoxia can induce excessive erythrocytosis (EE, defined as a haemoglobin concentration of ≥21 g/… | Experimental physiology 2026-10-11 04:36:33 | Source |
| Sex differences in cerebrovascular function across an aerobic exercis… Hypercapnic challenge · PMID 41999060 | Épilepsie | À vérifier | Publication | PubMed | Voir la publication source Sex differences in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) with aging, and across an aerobic exe… | Physiological reports 2026-10-11 04:36:33 | Source |
| Development of AL101 (GSK4527226), a progranulin-elevating monoclonal… GSK4527226 · PMID 40713730 | Maladie d’Alzheimer | Neuroprotection | Publication | PubMed | Voir la publication source Alzheimer's disease (AD) is characterized by amyloid plaques, tau tangles, and neuronal loss. Progranulin (PGRN) is a s… | Alzheimer's research & therapy 2026-10-11 04:36:30 | Source |
| Brain state-contingent stimulation to probe task-dependent functional… TMS-EEG · PMID 42759098 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Transcranial magnetic stimulation (TMS) is a fundamental tool for causal inference, but identical stimulation produces… | Clinical neurophysiology : official journal of the Int… 2026-10-11 04:36:29 | Source |
| Dorsolateral prefrontal cortex to subgenual cingulate anticorrelation… TMS-EEG · PMID 42632228 | Maladie d’Alzheimer | Traitement symptomatique | Publication | PubMed | Voir la publication source Transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex (DLPFC) may achieve its antidepressant ef… | Clinical neurophysiology : official journal of the Int… 2026-10-11 04:36:29 | Source |
| Timing-dependent inhibitory effects of peripheral somatosensory input… TMS-EEG · PMID 42787703 | Maladie d’Alzheimer | À vérifier | Publication | PubMed | Voir la publication source Short-latency afferent inhibition (SAI) is a transient suppression of corticomotor excitability elicited by peripheral… | Neuroimage. Reports 2026-10-11 04:36:29 | Source |
| Leukotriene receptor antagonists inhibit SLC19A1 and SLC46A1-mediated… Montelukast · PMID 42716456 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Folic acid and antifolates rely on SLC19A1 and SLC46A1 for membrane transport, which is critical for their biological f… | Chemico-biological interactions 2026-10-11 04:36:25 | Source |
| Not always a good night's sleep: A global pharmacovigilance risk prof… Montelukast · PMID 42551056 | Maladie de Parkinson | Immunomodulation | Publication | PubMed | Voir la publication source Sleep disorders and disturbances affect more than one-third of the global population. Although certain drugs have been… | Sleep medicine 2026-10-11 04:36:25 | Source |
| The dual role of leukotrienes in the tumor microenvironment: balancin… Montelukast · PMID 42335104 | Cancer | Ralentissement de la progression · Immunomodulation | Publication | PubMed | Voir la publication source Leukotrienes are bioactive lipid mediators produced via the 5-lipoxygenase (5-LO) pathway and are essential for inflamm… | Cancer biology & therapy 2026-10-11 04:36:25 | Source |
| Correction: . Levodopa inhalation powder · PMID 42749463 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Drug and therapeutics bulletin 2026-10-11 04:36:24 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||