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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Ablation Treatment with FARAPULSE™ Pulsed Field Ablation (PFA) System… NCT07925359 · NAVigate-ULTRA — The Evaluation of User Experience With FARAVIEW™ Technology of… | Maladie coronarienne | À vérifier | Non applicable | NOT_YET_RECRUITING | The objective of this study is to obtain experience with new and modified… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| SESAME Procedure NCT07806149 · NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective… | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This is an early study of a catheter-based minimally invasive procedure ca… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Topical cyanoacrylate tissue adhesive NCT07926191 · Tissue Adhesive Versus Figure-of-Eight Suture for Femoral Venous Closure After E… | Maladie coronarienne | Thérapie génique | À vérifier | NOT_YET_RECRUITING | In July 2026 the electrophysiology laboratory of a Czech tertiary cardiolo… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Truvaga Plus NCT07926945 · U54: nVNS RCT — Effects of nVNS on Stress Reactivity in IBS | Maladie coronarienne | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interact… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:06 | Détail |
| Capstan Compass Robotic System for Transcatheter Mitral Valve Replace… NCT07917208 · Early Feasibility Study of the Capstan Medical TMVR System | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This early feasibility study is evaluating the safety and performance of t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Discontinuation of aspirin (ATC-code B01AC06 and N02BA01) NCT07854795 · RELEASE-Norway — Reconsidering Long-Term Apirin in the Elderly in Secondary Prev… | Maladie coronarienne | À vérifier | Phase 4 | NOT_YET_RECRUITING | Lifelong aspirin has been a cornerstone of secondary prevention after coro… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Extracorporeal Shock Wave Therapy NCT07068399 · CSWT — Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronar… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized single-blind controlled trial aims to compare the effectiv… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Modified ultrafiltration NCT00246779 · A Study of the Effect of Blinding in a Trial of Blood Filtration During Heart Su… | Maladie coronarienne | À vérifier | Non applicable | COMPLETED | Cardiac surgery is a major consumer of blood products worldwide. The natur… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Naproxen NCT07549490 · Human Experimental Models of Pain (HEMP) | Maladie coronarienne | Immunomodulation · Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This pilot study will test an innovative way to establish how pain medicin… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Prescription of Aspirin NCT07524335 · ASCAD-P — Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Con… | Maladie coronarienne | À vérifier | Phase 3 | RECRUITING | In patients with subclinical coronary artery disease, the ASCAD-P study ai… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Pulmonary Vein Isolation NCT06402617 · RETRO-AF — Ablation of Focal Activation in Atrial Fibrillation | Maladie coronarienne | Ralentissement de la progression | Non applicable | RECRUITING | Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardi… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Serratus Posterior Superior Intercostal Plane Block With Bupivacaine NCT07588230 · Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardia… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | This randomized, double-blind, placebo-controlled study aims to evaluate t… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| TAVI NCT07926022 · TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patient… | Maladie coronarienne | À vérifier | À vérifier | RECRUITING | \# WHAT IS THIS STUDY ABOUT? This study compares two different treatment a… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| This study involved an auxillary CE-marked medical device (implantabl… NCT07545512 · ODISSEY — ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Car… | Maladie coronarienne | Traitement symptomatique | Non applicable | RECRUITING | Although advances in treatment and patient management have considerably im… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:05 | Détail |
| Evolocumab NCT05284747 · EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Maladie coronarienne | À vérifier | Phase 4 | ACTIVE_NOT_RECRUITING | The primary objective of this study is to evaluate the effectiveness of ea… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Microaxial flow pump (left ventricular assist device) NCT07762560 · DOUBLE-SHOCK — Routine Microaxial Heart Pump Support and Protocolized Pulmonary… | Maladie coronarienne | Thérapie génique | Non applicable | RECRUITING | The goal of this clinical trial is to learn which treatment strategies imp… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| No aspirin (Prasugurel monotherapy) NCT05709626 · PREMIUM — PRasugrEl Monotherapy Following prImary percUtaneous Coronary Interven… | Maladie coronarienne | À vérifier | Phase 4 | COMPLETED | The aim of this study is to evaluate the safety of prasugrel monotherapy w… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| Percutaneous Mechanical Circulatory Support NCT06445608 · PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm | Maladie coronarienne | À vérifier | Non applicable | RECRUITING | This purpose of this trial is to demonstrate 30 day safety and effectivene… À vérifier | ClinicalTrials.gov 2026-11-09 21:03:04 | Détail |
| 26G Needle NCT07926113 · MASS-NEEDLE — Comparison of 26G and 30G Needles for Masseter Trigger Point Injec… | Myopathies | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | This randomized split-face study aims to compare the effects of 26G and 30… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
| ABSK021 NCT04192344 · A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-021 in… | Myopathies | À vérifier | Phase 1 | RECRUITING | This is an open-label phase 1 study to determine the safety and tolebility… À vérifier | ClinicalTrials.gov 2026-11-09 21:02:59 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| pH-responsive injectable hydrogel dressing integrating antibacteria,… Minocycline · PMID 42404727 | Maladie de Parkinson · Sclérose latérale amyotrophique · Maladie de P… | Remyélinisation indirecte / réparation · Neuroprotection · Immunomodulation | Publication | PubMed | Voir la publication source Infected wounds have presented a significant clinical challenge due to persistent inflammatory responses, elevated oxid… | International journal of pharmaceutics: X 2026-08-16 13:07:04 | Source |
| Delaying task failure in high-intensity exercise: a Pi-afferent-effor… Creatine · PMID 42530633 | Maladie de Parkinson · Sclérose latérale amyotrophique · Maladie de P… | Traitement symptomatique | Publication | PubMed | Voir la publication source Task failure during high-intensity exercise may reflect the convergence of intramuscular, neural, perceptual, and behav… | Journal of the International Society of Sports Nutriti… 2026-08-16 13:07:03 | Source |
| Real-world creatine supplementation: a large-scale cross-sectional st… Creatine · PMID 42479961 | Maladie de Parkinson · Sclérose latérale amyotrophique · Maladie de P… | À vérifier | Publication | PubMed | Voir la publication source Creatine is among the most extensively studied dietary supplements in sports nutrition, yet real-world supplementation… | Journal of the International Society of Sports Nutriti… 2026-08-16 13:07:03 | Source |
| Shuxin oral liquid attenuates isoproterenol-induced myocardial fibros… Creatine · PMID 42476205 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Shuxin oral liquid (SX) is a traditional Chinese medicine formulation widely used for coronary heart disease (CHD) char… | Journal of ethnopharmacology 2026-08-16 13:07:03 | Source |
| Early neutrophil infiltration promotes TRIMELVax-induced antitumor im… G-CSF · PMID 42345602 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Enhancing innate-adaptive immune crosstalk is key for improving cancer vaccine efficacy. TRIMELVax is a heat shock-cond… | Oncoimmunology 2026-08-16 13:07:02 | Source |
| Ex vivo-generated conventional dendritic cells type 1 and type 2 from… G-CSF · PMID 42381384 | Cancer | Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source While existing cancer therapies manage to reduce tumor burden, they often fail to produce durable or curative outcomes.… | Oncoimmunology 2026-08-16 13:07:02 | Source |
| Enhancing cognitive processing therapy via stellate ganglion blocks:… Stellate ganglion block · PMID 42600065 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Although trauma-focused psychotherapies, such as cognitive processing therapy (CPT), are effective treatments for postt… | Journal of traumatic stress 2026-08-16 13:07:00 | Source |
| Sympathetic nerve blockade for ventricular arrhythmias: stellate gang… Stellate ganglion block · PMID 42479813 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source To review and summarize the current clinical evidence supporting sympathetic neural blockade for recurrent and refracto… | Current opinion in anaesthesiology 2026-08-16 13:07:00 | Source |
| [Anesthesia and sleep: from perioperative management to chronic refra… Stellate ganglion block · PMID 42595502 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Currently, anesthesia-based sleep therapy is experiencing a role expansion from short-term intervention for perioperati… | Zhonghua yi xue za zhi 2026-08-16 13:07:00 | Source |
| Open-label titration of apomorphine sublingual film in patients with… APL-130277 · PMID 32927285 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source The efficacy and safety of apomorphine sublingual film (APL-130277; APL) for the on-demand treatment of "OFF" episodes… | Parkinsonism & related disorders 2026-08-16 13:06:59 | Source |
| Parkinsonian syndromes in institutionalized older adults in the Frenc… In-Home Care for Patients With Parkinson's Disease · PMID 42330831 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Parkinsonian syndromes are increasingly recognized in aging populations, but data from the Caribbean remain limited. In… | Parkinsonism & related disorders 2026-08-16 13:06:59 | Source |
| Observational Retrospective Cohort of Patient Support Program Data on… Levodopa (L-DOPA) + Standard care · PMID 42322391 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Foslevodopa/foscarbidopa (LDp/CDp) is a continuous 24-h subcutaneous infusion therapy for advanced Parkinson's disease… | Neurology and therapy 2026-08-16 13:06:56 | Source |
| Advanced Parkinson's disease treatment patterns in Italy: results fro… Opicapone · PMID 41782314 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Substitution therapy with oral levodopa is the primary treatment of Parkinson's disease (PD). However, long-term levodo… | Annals of medicine 2026-08-16 13:06:55 | Source |
| Recent Developments in the Drug Treatment of Parkinson's Disease. Opicapone · PMID 42162439 | Maladie de Parkinson | Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Parkinson's disease (PD) is a common neurodegenerative disorder caused by a spread of misfolded α-synuclein and ascendi… | Drugs 2026-08-16 13:06:55 | Source |
| An alternative scalp incision for deep brain stimulation surgery: A l… Deep brain stimulation surgery · PMID 42190495 | Maladie de Parkinson | Thérapie génique | Publication | PubMed | Voir la publication source This study aimed to evaluate an alternative scalp incision technique designed to enhance flap vascularity and to positi… | Clinical neurology and neurosurgery 2026-08-16 13:06:54 | Source |
| Cortical-Subthalamic Interplay During Eyes-Open and Eyes-Closed Resti… Deep brain stimulation surgery · PMID 42099057 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source Resting-state eye conditions modulate cortical oscillations, but their impact on subthalamic nucleus (STN) and cortico-… | International journal of neural systems 2026-08-16 13:06:54 | Source |
| Implantation of autologous peripheral nerve tissue to the nucleus bas… Deep brain stimulation surgery · PMID 42600181 | Maladie de Parkinson | Neuroprotection · Ralentissement de la progression · Traitement symptomatique | Publication | PubMed | Voir la publication source Parkinson's disease (PD) is characterized by both motor and nonmotor symptoms, including cognitive impairment. Neuronal… | Journal of neurosurgery 2026-08-16 13:06:54 | Source |
| Radiation Dose during Transarterial Radioembolization: A Dosimetric C… conventional treatment plan · PMID 33358328 | Maladie de Parkinson | À vérifier | Publication | PubMed | Voir la publication source To evaluate the radiation dose differences for intraprocedural computed tomography (CT) imaging between cone-beam CT an… | Journal of vascular and interventional radiology : JVIR 2026-08-16 13:06:53 | Source |
| ABHD17C regulates the efficacy of lenvatinib in suppressing hepatocel… Lenvatinib · PMID 42358063 | Cancer · Maladie de Parkinson · Sclérose en plaques · Cancer | Ralentissement de la progression · Immunomodulation · Thérapie génique | Publication | PubMed | Voir la publication source Lenvatinib is a first-line therapy for hepatocellular carcinoma (HCC), but its clinical efficacy is limited by drug res… | Cancer biology & therapy 2026-08-16 13:06:49 | Source |
| Associations of ADH1B and ALDH2 genotypes and alcohol flushing with d… The Effect of Alcohol on Common Tremor Syndromes · PMID 38465575 | Maladie de Parkinson | Traitement symptomatique | Publication | PubMed | Voir la publication source Given the high prevalence of fast-metabolizing alcohol dehydrogenase-1B*2 (ADH1B*2 ) and inactive aldehyde dehydrogenas… | Pharmacogenetics and genomics 2026-08-16 13:06:49 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||