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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Monoclonal antibody anti-CGRP NCT06459648 · PREDI-CGRP — Study for Prevent Chronification Migraine Through Prediction of Res… | Migraine | À vérifier | À vérifier | ACTIVE_NOT_RECRUITING | Being able to predict each patients response to a specific treatment can m… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:36 | Détail |
| Rimegepant NCT07609914 · A Study to Learn About the Safety of Taking an Additional Dose of the Medicine R… | Migraine | À vérifier | Phase 4 | RECRUITING | The purpose of this study is to evaluate safety and tolerability of BHV-30… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:36 | Détail |
| Rimegepant NCT07729462 · A Study to Learn About the Study Medicine Called Rimegepant in Adults When Used… | Migraine | À vérifier | Phase 3 | RECRUITING | The purpose of this study is to evaluate safety and tolerability of BHV-30… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:36 | Détail |
| Rimegepant NCT06473597 · A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine… | Migraine | À vérifier | Phase 4 | RECRUITING | The purpose of this study is to evaluate safety and tolerability of BHV-30… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:36 | Détail |
| Rimegepant sulfate NCT07497854 · Rimegepant PMS — A Study to Learn About the Study Medicine NURTEC® ODT 75 mg Aft… | Migraine | À vérifier | À vérifier | NOT_YET_RECRUITING | The purpose of this study is to evaluate safety and effectiveness of NURTE… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:36 | Détail |
| Active Cathodal tDCS NCT05825274 · TDCs to Treat Drug-resistant Epilepsy | Épilepsie | À vérifier | Non applicable | COMPLETED | Epilepsy is the fourth overall neurologic disorder, regardless of age and… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:32 | Détail |
| Diazepam Nasal Spray [Valtoco] NCT05076838 · Pharmacokinetics Study of VALTOCO® in Pediatric Subjects With Epilepsy | Épilepsie | À vérifier | Phase 1/2 | COMPLETED | This is a Phase 1/2a, open-label, single-dose, PK study of VALTOCO with op… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:32 | Détail |
| SEEG monitoring NCT07599150 · ICARE — Intracranial CArtography of Cortical Contribution to Respiratory Load Co… | Épilepsie | Thérapie génique | Non applicable | RECRUITING | 30% of patients with epilepsy suffer from drug-resistant seizures and have… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:32 | Détail |
| Sham TMS3 stimulation NCT03233399 · Modulating Movement Intention Via Cortical Stimulation | Épilepsie | Traitement symptomatique · Thérapie génique | Non applicable | RECRUITING | The purpose of this protocol is to learn about movement intention and voli… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:32 | Détail |
| Test drug CB03-154 5mg group NCT06612775 · A Study to Evaluate the Safety, Tolerability, and Efficacy of CB03-154 in Adult… | Épilepsie | À vérifier | Phase 2 | RECRUITING | CB03-154 is an investigational drug developed by Shanghai Zhimeng Biopharm… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:32 | Détail |
| Textile-based wearable electrocardiography NCT07835594 · EpHR-DP — Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Se… | Épilepsie | Thérapie génique | À vérifier | NOT_YET_RECRUITING | The goal of this observational study is to understand heart rhythm changes… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:32 | Détail |
| UNEEG SubQ device, seizure forecasts, nasal diazepam NCT07012148 · FORESITE — Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and We… | Épilepsie | À vérifier | Phase 1 | RECRUITING | Mayo Clinic is conducting a research study to test a new approach to manag… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:32 | Détail |
| BMS-986446 NCT07780383 · A Study to Evaluate the Drug Levels, Absolute Bioavailability, Safety, Tolerabil… | Maladie d’Alzheimer | À vérifier | Phase 1 | RECRUITING | The purpose of this study is to evaluate the drug levels, absolute bioavai… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:28 | Détail |
| IL-2 (Aldesleukin) NCT07651319 · Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease | Maladie d’Alzheimer | Ralentissement de la progression · Immunomodulation | Phase 1/2 | RECRUITING | Alzheimer's disease (AD) is the most common cause of dementia. Despite maj… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:28 | Détail |
| ONO-2020 NCT06803823 · A Study of ONO-2020 in Patients With Agitation Associated With Alzheimer's Disea… | Maladie d’Alzheimer | À vérifier | Phase 2 | RECRUITING | This is a Phase 2, double-blind, parallel-group, placebo-controlled study… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:28 | Détail |
| RB-ADSC NCT05667649 · Autologous Activated Adipose-derived Stem Cells (RB-ADSC) Injected Directly Into… | Maladie d’Alzheimer | Thérapie cellulaire · Thérapie génique | Phase 1 | COMPLETED | The goal of this Phase 2 clinical trial is to learn if repeated dosing of… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:28 | Détail |
| TMS-EEG NCT07841808 · Precuneus Mapping With Sinaptistim® (an Investigational TMS-EEG System) in Mild… | Maladie d’Alzheimer | À vérifier | À vérifier | NOT_YET_RECRUITING | Transcranial magnetic stimulation (TMS), electroencephalography (EEG), and… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:28 | Détail |
| Transcranial Alternating Current Stimulation NCT07839650 · AD_tACSrehab — Transcranial Alternating Current Stimulation (tACS) Combined With… | Maladie d’Alzheimer | Immunomodulation · Thérapie génique | Non applicable | RECRUITING | The aim of the study is to evaluate the clinical and biological efficacy,… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:28 | Détail |
| Blood samples NCT05888961 · MAPEG 2 — Single-center Prospective Longitudinal Study of Taste in Patients With… | Maladie d’Alzheimer | À vérifier | Non applicable | RECRUITING | Semantic AD À vérifier | ClinicalTrials.gov 2026-09-27 04:36:27 | Détail |
| Trontinemab NCT07170150 · TRONTIER 2 — A Clinical Trial of Trontinemab in Participants With Early Symptoma… | Maladie d’Alzheimer | Traitement symptomatique | Phase 3 | ACTIVE_NOT_RECRUITING | The purpose of this study is to assess the efficacy and safety of trontine… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:27 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||