Fiche traitement
Blood samples
Centre Hospitalier Universitaire Dijon • Alzheimer
Suivi actif
Non applicable
Résumé
Blood samples est développé par Centre Hospitalier Universitaire Dijon. Le traitement est actuellement en Non applicable. Il est associé à Alzheimer. Son objectif thérapeutique principal est À vérifier. Le statut actuel est : suivi actif.
À vérifier
À vérifier
Non applicable
Centre Hospitalier Universitaire Dijon
France
The aim of the MAPEG 2 study is to explore gustatory function and to follow its evolution in the 4 following groups of participants:
* Healthy subjects
* Participants with isolated cognitive complaint
* Participants with minor neurocognitive disorder
* Participants with mild and moderate Alzheimer-type major neurocognitive disorders
For this purpose, we want to compare the results of the following tests:
* Subjective taste tests (tasting solutions, answering food preference questionnaires),
* Gustatory evoked potential (GEP) parameters, recorded by electrodes placed on the scalp,
* And nutritional parameters (hormones of food intake by blood test, measurement of the global body composition).
Identifying and following the evolution of early taste disorders in case of cognitive disorders could improve the diagnosis of Alzheimer\'s disease in two ways:
* To allow an early diagnosis of Alzheimer\'s disease, and thus improve its management,
* To define groups of subjects at risk of developing Alzheimer\'s disease in later years.
2026-09-22
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Non applicable
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
À vérifier
Confiance automatique : 0%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT05888961, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Contrôle de cohérence : 85/100
L’objectif est absent ou classé « Autre » et doit être recalculé à partir du protocole.
Transparence et qualité de la fiche
données vérifiablesClassificationÀ vérifier
Confiance de la fiche85 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-09-22
Anomalies détectées1
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeRecrutement en cours
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréeNon applicable
Études associées1
Publications associées42
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
46 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2023-06-12 | Début de l’étudeNCT05888961 | Registre d’essai clinique |
| 2026-07-08 | PublicationSteroid-Sparing Effect of Efgartigimod in Generalized Myasthenia Gravis: Study Protocol for a Single-Arm, Open-Label Clinical Trial. | Neurology and therapy |
| 2026-07-08 | PublicationDiagnostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in Differentiating Primary From Serious Secondary Headache. | European journal of neurology |
| 2026-07-08 | PublicationFoslevodopa/Foscarbidopa: A New Subcutaneous Treatment for Parkinson's Disease. | Annals of neurology |
| 2026-07-10 | PublicationObesity Alters the Estrogen-Induced Luteinizing Hormone Surge in Ovariectomized Ewes. | Biology of reproduction |
| 2026-07-12 | PublicationCD8+ T Cells in Acute Lymphoblastic Leukemia Show a Progenitor-exhausted Phenotype. | Iranian journal of allergy, asthma, and immunology |
| 2026-07-12 | PublicationThe ITALIC-RCC: A Randomized Trial on Clinical and Humoral Impact of Primary Tumor Ablation by Surgery or Radiotherapy in Metastatic Renal Cell Carcinoma Treated with Checkpoint Inhibitors. | European urology open science |
| 2026-07-14 | PublicationEvaluation of insulin, leptin, ghrelin, and adiponectin levels in type 2 diabetic patients receiving combined metformin-sulfonylurea therapy. | Biomeditsinskaia khimiia |
| 2026-07-22 | PublicationSequential Onset and Prognostic Impact of Japanese Spotted Fever in a Family Cluster: A Case Report and Brief Literature Review. | Cureus |
| 2026-07-22 | PublicationEffects of TNF-α, IL-1β and IL-2 on regulatory T cells in children with idiopathic nephrotic syndrome. | Frontiers in pediatrics |
| 2026-07-22 | PublicationDifferential Transthyretin Stabilization in Patients With Wild Type and Variant Transthyretin Amyloidosis. | JACC. CardioOncology |
| 2026-08-08 | PublicationPharmacokinetic Drug Interactions Between Amlodipine, Valsartan, and Rosuvastatin in Healthy Volunteers. | Advances in therapy |
| 2026-08-08 | PublicationA Phase I, Randomized, Single‑Blind, Placebo‑Controlled, Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of Subcutaneous and Oral TRV250, a G Protein-Selective Delta Receptor Agonist, in Healthy Subjects. | CNS drugs |
| 2026-08-08 | PublicationSerum anti-Müllerian hormone response to pyrroloquinoline quinone supplementation in healthy women: no overall change and exploratory subgroup findings. | Frontiers in endocrinology |
| 2026-08-13 | PublicationEffects of creatine supplementation with and without exercise and diet intervention on body composition, cognitive function, and markers of health in middle-aged and older adults. | Journal of the International Society of Sports Nutrition |
| 2026-08-13 | PublicationPharmacodynamics of the S1P receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE. | Annals of the rheumatic diseases |
| 2026-08-13 | PublicationHormone levels of female patients with SLE after anti-CD19 CAR T-cell treatment do not indicate a signal of impaired ovarian reserve. | Rheumatology (Oxford, England) |
| 2026-08-13 | PublicationRandomized controlled trial evaluating synbiotic supplementation as an adjuvant therapy in the treatment of Parkinson's disease. | Inflammopharmacology |
| 2026-08-13 | PublicationCoordinated oxidative shift during relapse and recovery in multiple sclerosis: A paired analysis of multiple biomarkers. | Journal of neuroimmunology |
| 2026-08-13 | PublicationPharmacokinetic comparison between fixed-dose combination and loose combination of enavogliflozin 0.3 mg and metformin HCl 1000 mg in healthy subjects under fasting and fed conditions. | Naunyn-Schmiedeberg's archives of pharmacology |
| 2026-08-13 | PublicationRelative increase of memory B-cell subsets under s.c. B-cell-depleting therapies in multiple sclerosis. | Frontiers in immunology |
| 2026-08-16 | PublicationEffects of wildfire smoke exposure on health parameters and inflammatory responses of beef-on-dairy calves. | Journal of animal science |
| 2026-08-16 | PublicationA phase 1, multicenter, open-label study to evaluate the pharmacokinetics, safety, and tolerability of a single dose of rimegepant in children (aged ≥6 to <12 years) with a history of migraine. | Headache |
| 2026-08-16 | PublicationPaeoniae Radix Alba-Chuanxiong Rhizoma herbal pair alleviates trigeminal nucleus caudalis neuroinflammation in chronic migraine associated with P2Y12R/PPARγ-related NF-κB signaling. | Journal of ethnopharmacology |
| 2026-08-16 | PublicationEvaluation of Flavonoid-rich Fraction of Aerial Part Extract in Atherogenic Diet-induced Atherosclerosis. | Combinatorial chemistry & high throughput screening |
| 2026-08-16 | PublicationA phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a regimen of stiripentol, clobazam, and valproate in healthy subjects . | International journal of clinical pharmacology and therapeutics |
| 2026-08-16 | PublicationPeripheral Alzheimer's Disease Biomarkers Are Related to Change in Subjective Memory in Older Women with Cardiovascular Risk Factors in a Trial of Yoga vs. Memory Training: Lien établi entre les biomarqueurs périphériques de la maladie d'Alzheimer et l'amélioration de la mémoire subjective chez les femmes âgées présentant des facteurs de risque cardiovasculaire dans le cadre d'un essai comparant le yoga à l'entraînement de la mémoire. | Canadian journal of psychiatry. Revue canadienne de psychiatrie |
| 2026-08-16 | PublicationPharmacokinetic Drug Interaction Studies of Limnetrelvir with Midazolam and Itraconazole in Healthy Participants. | Clinical drug investigation |
| 2026-08-16 | PublicationAnti-SARS-CoV-2 response in alveolar blood sample and bronchoalveolar lavage fluid of individuals vaccinated with inactivated COVID-19 vaccines. | Human vaccines & immunotherapeutics |
| 2026-08-16 | PublicationAssociation between PFAS and renal function indicators in cord blood of newborns: modifying effects of newborn sex and maternal factors. | Annals of medicine |
| 2026-08-16 | PublicationChanges in hormones and experimental pain sensitivity in healthy girls: an exploratory longitudinal pilot study. | Pain reports |
| 2026-08-16 | PublicationThe impact of (poly)phenol-rich sugarcane extract intervention on markers of gastrointestinal integrity and systemic inflammation in response to exertional-heat stress. | Journal of the International Society of Sports Nutrition |
| 2026-08-16 | PublicationRepeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back-to-Back Neuroimaging and Blood Analysis. | Magnetic resonance in medicine |
| 2026-08-16 | PublicationThe dynamic evolution of circulating tumor cells during glecirasib treatment predicts survival and resistance in gastrointestinal tumors with KRAS mutation. | Human cell |
| 2026-08-16 | PublicationRationale and design of Dongzong CArdIovascuLar Bio-imaging RegistrY (DAILY) study: Bridging multiomics, imaging and cardiovascular disease. | American journal of preventive cardiology |
| 2026-08-16 | PublicationPharmacokinetic comparison between a fixed-dose combination of fimasartan/amlodipine/hydrochlorothiazide 60/10/25 mg and a corresponding loose combination of fimasartan/amlodipine 60/25 mg and hydrochlorothiazide 25 mg in healthy subjects. | Translational and clinical pharmacology |
| 2026-08-16 | PublicationThe correlation between serum endothelin-1 levels and aortic stiffness in patients with non-dialysis chronic kidney disease. | Renal failure |
| 2026-08-16 | PublicationHeat-activated intravenous liposomal doxorubicin combined with mitomycin C hyperthermic intravesical chemotherapy (HIVEC) for treatment of bladder cancer. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group |
| 2026-08-16 | PublicationTranscranial direct current stimulation enhances cognitive performance and modulates QEEG beta- and theta-band power in patients undergoing whole-brain radiotherapy. | IBRO neuroscience reports |
| 2026-08-16 | PublicationDoes desloratadine alter the serum levels of montelukast when administered in a fixed-dose combination? | The Laryngoscope |
| 2026-08-16 | PublicationELISA-based validation of differentially expressed Fibrinogen, S100A9, SERPINA3 and SERPINA6 proteins in Polycystic Ovary Syndrome (PCOS). | Steroids |
| 2026-09-01 | PublicationHyperthermia-targeted rectal delivery of thermosensitive liposomal doxorubicin via intra-arterial and intravenous administration. | Frontiers in pharmacology |
| 2026-09-22 | Dernière mise à jour des donnéesBlood samples | Biomedical Watch |
| 2026-09-27 | Création de l’enregistrementNCT05888961 | Registre d’essai clinique |
| 2026-10-11 | PublicationBioequivalence Study of Two Empagliflozin Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions. | Clinical pharmacology in drug development |
| 2027-12-01 | Fin de l’étude prévue / enregistréeNCT05888961 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
1 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT05888961 | MAPEG 2 — Single-center Prospective Longitudinal Study of Taste in Patients With Cognitive Disorders at Different Stages of Severity (Isolated Cognitive Complaint, Minor or Major Neurocognitive Alzheimer-type Disorders) by Analysis of Gustatory Evoked Potentials | Non applicable | RECRUITING | France | Centre Hospitalier Universitaire Dijon |
Publications liées
42 publication(s)Publications liées
42 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Bioequivalence Study of Two Empagliflozin Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions. Voir source | 40277386 | 10.1002/cpdd.1530 | Clinical pharmacology in drug development | |
| Hyperthermia-targeted rectal delivery of thermosensitive liposomal doxorubicin via intra-arterial and intravenous administration. Voir source | 41788800 | 10.3389/fphar.2026.1760944 | Frontiers in pharmacology | |
| Effects of wildfire smoke exposure on health parameters and inflammatory responses of beef-on-dairy calves. Voir source | 41678211 | 10.1093/jas/skag040 | Journal of animal science | |
| A phase 1, multicenter, open-label study to evaluate the pharmacokinetics, safety, and tolerability of a single dose of rimegepant in children (aged ≥6 to <12 years) with a history of migraine. Voir source | 41133671 | 10.1111/head.15074 | Headache | |
| Paeoniae Radix Alba-Chuanxiong Rhizoma herbal pair alleviates trigeminal nucleus caudalis neuroinflammation in chronic migraine associated with P2Y12R/PPARγ-related NF-κB signaling. Voir source | 42431281 | 10.1016/j.jep.2026.122177 | Journal of ethnopharmacology | |
| Evaluation of Flavonoid-rich Fraction of Aerial Part Extract in Atherogenic Diet-induced Atherosclerosis. Voir source | 37807415 | 10.2174/0113862073267025230925062407 | Combinatorial chemistry & high throughput screening | |
| A phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a regimen of stiripentol, clobazam, and valproate in healthy subjects . Voir source | 30336805 | 10.5414/CP203276 | International journal of clinical pharmacology and therapeutics | |
| Peripheral Alzheimer's Disease Biomarkers Are Related to Change in Subjective Memory in Older Women with Cardiovascular Risk Factors in a Trial of Yoga vs. Memory Training: Lien établi entre les biomarqueurs périphériques de la maladie d'Alzheimer et l'amélioration de la mémoire subjective chez les femmes âgées présentant des facteurs de risque cardiovasculaire dans le cadre d'un essai comparant le yoga à l'entraînement de la mémoire. Voir source | 40448323 | 10.1177/07067437251343291 | Canadian journal of psychiatry. Revue canadienne de psychiatrie | |
| Pharmacokinetic Drug Interaction Studies of Limnetrelvir with Midazolam and Itraconazole in Healthy Participants. Voir source | 42133202 | 10.1007/s40261-026-01551-1 | Clinical drug investigation | |
| Anti-SARS-CoV-2 response in alveolar blood sample and bronchoalveolar lavage fluid of individuals vaccinated with inactivated COVID-19 vaccines. Voir source | 42081587 | 10.1080/21645515.2026.2666696 | Human vaccines & immunotherapeutics | |
| Association between PFAS and renal function indicators in cord blood of newborns: modifying effects of newborn sex and maternal factors. Voir source | 42222903 | 10.1080/07853890.2026.2678686 | Annals of medicine | |
| Changes in hormones and experimental pain sensitivity in healthy girls: an exploratory longitudinal pilot study. Voir source | 42549441 | 10.1097/PR9.0000000000001476 | Pain reports | |
| The impact of (poly)phenol-rich sugarcane extract intervention on markers of gastrointestinal integrity and systemic inflammation in response to exertional-heat stress. Voir source | 42316869 | 10.1080/15502783.2026.2684574 | Journal of the International Society of Sports Nutrition | |
| Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back-to-Back Neuroimaging and Blood Analysis. Voir source | 42026769 | 10.1002/mrm.70402 | Magnetic resonance in medicine | |
| The dynamic evolution of circulating tumor cells during glecirasib treatment predicts survival and resistance in gastrointestinal tumors with KRAS mutation. Voir source | 42384131 | 10.1007/s13577-026-01405-0 | Human cell | |
| Rationale and design of Dongzong CArdIovascuLar Bio-imaging RegistrY (DAILY) study: Bridging multiomics, imaging and cardiovascular disease. Voir source | 42403449 | 10.1016/j.ajpc.2026.101612 | American journal of preventive cardiology | |
| Pharmacokinetic comparison between a fixed-dose combination of fimasartan/amlodipine/hydrochlorothiazide 60/10/25 mg and a corresponding loose combination of fimasartan/amlodipine 60/25 mg and hydrochlorothiazide 25 mg in healthy subjects. Voir source | 33855001 | 10.12793/tcp.2021.29.e5 | Translational and clinical pharmacology | |
| The correlation between serum endothelin-1 levels and aortic stiffness in patients with non-dialysis chronic kidney disease. Voir source | 41820016 | 10.1080/0886022X.2026.2641961 | Renal failure | |
| Heat-activated intravenous liposomal doxorubicin combined with mitomycin C hyperthermic intravesical chemotherapy (HIVEC) for treatment of bladder cancer. Voir source | 41631502 | 10.1080/02656736.2026.2615462 | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group | |
| Transcranial direct current stimulation enhances cognitive performance and modulates QEEG beta- and theta-band power in patients undergoing whole-brain radiotherapy. Voir source | 42598132 | 10.1016/j.ibneur.2026.07.021 | IBRO neuroscience reports | |
| Does desloratadine alter the serum levels of montelukast when administered in a fixed-dose combination? Voir source | 23918211 | 10.1002/lary.24134 | The Laryngoscope | |
| ELISA-based validation of differentially expressed Fibrinogen, S100A9, SERPINA3 and SERPINA6 proteins in Polycystic Ovary Syndrome (PCOS). Voir source | 42034305 | 10.1016/j.steroids.2026.109791 | Steroids | |
| Effects of creatine supplementation with and without exercise and diet intervention on body composition, cognitive function, and markers of health in middle-aged and older adults. Voir source | 42578920 | 10.1080/15502783.2026.2716273 | Journal of the International Society of Sports Nutrition | |
| Pharmacodynamics of the S1P receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE. Voir source | 39919901 | 10.1136/ard-2024-226547 | Annals of the rheumatic diseases | |
| Hormone levels of female patients with SLE after anti-CD19 CAR T-cell treatment do not indicate a signal of impaired ovarian reserve. Voir source | 42584071 | 10.1093/rheumatology/keag413 | Rheumatology (Oxford, England) | |
| Randomized controlled trial evaluating synbiotic supplementation as an adjuvant therapy in the treatment of Parkinson's disease. Voir source | 40434674 | 10.1007/s10787-025-01752-8 | Inflammopharmacology | |
| Coordinated oxidative shift during relapse and recovery in multiple sclerosis: A paired analysis of multiple biomarkers. Voir source | 42470870 | 10.1016/j.jneuroim.2026.579030 | Journal of neuroimmunology | |
| Pharmacokinetic comparison between fixed-dose combination and loose combination of enavogliflozin 0.3 mg and metformin HCl 1000 mg in healthy subjects under fasting and fed conditions. Voir source | 41579170 | 10.1007/s00210-026-04986-7 | Naunyn-Schmiedeberg's archives of pharmacology | |
| Relative increase of memory B-cell subsets under s.c. B-cell-depleting therapies in multiple sclerosis. Voir source | 42375380 | 10.3389/fimmu.2026.1812392 | Frontiers in immunology | |
| Pharmacokinetic Drug Interactions Between Amlodipine, Valsartan, and Rosuvastatin in Healthy Volunteers. Voir source | 31119689 | 10.1007/s12325-019-00976-9 | Advances in therapy | |
| A Phase I, Randomized, Single‑Blind, Placebo‑Controlled, Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of Subcutaneous and Oral TRV250, a G Protein-Selective Delta Receptor Agonist, in Healthy Subjects. Voir source | 32676977 | 10.1007/s40263-020-00738-0 | CNS drugs | |
| Serum anti-Müllerian hormone response to pyrroloquinoline quinone supplementation in healthy women: no overall change and exploratory subgroup findings. Voir source | 42500134 | 10.3389/fendo.2026.1831604 | Frontiers in endocrinology | |
| Sequential Onset and Prognostic Impact of Japanese Spotted Fever in a Family Cluster: A Case Report and Brief Literature Review. Voir source | 42483121 | 10.7759/cureus.111249 | Cureus | |
| Effects of TNF-α, IL-1β and IL-2 on regulatory T cells in children with idiopathic nephrotic syndrome. Voir source | 42483409 | 10.3389/fped.2026.1881956 | Frontiers in pediatrics | |
| Differential Transthyretin Stabilization in Patients With Wild Type and Variant Transthyretin Amyloidosis. Voir source | 42307157 | 10.1016/j.jaccao.2026.04.006 | JACC. CardioOncology | |
| Evaluation of insulin, leptin, ghrelin, and adiponectin levels in type 2 diabetic patients receiving combined metformin-sulfonylurea therapy. Voir source | 42446258 | 10.18097/PBMCE0047 | Biomeditsinskaia khimiia | |
| CD8+ T Cells in Acute Lymphoblastic Leukemia Show a Progenitor-exhausted Phenotype. Voir source | 42437313 | Iranian journal of allergy, asthma, and immunology | ||
| The ITALIC-RCC: A Randomized Trial on Clinical and Humoral Impact of Primary Tumor Ablation by Surgery or Radiotherapy in Metastatic Renal Cell Carcinoma Treated with Checkpoint Inhibitors. Voir source | 42433301 | 10.1016/j.euros.2026.06.004 | European urology open science | |
| Obesity Alters the Estrogen-Induced Luteinizing Hormone Surge in Ovariectomized Ewes. Voir source | 42421243 | 10.1093/biolre/ioag135 | Biology of reproduction | |
| Steroid-Sparing Effect of Efgartigimod in Generalized Myasthenia Gravis: Study Protocol for a Single-Arm, Open-Label Clinical Trial. Voir source | 42371330 | 10.1007/s40120-026-00980-6 | Neurology and therapy | |
| Diagnostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in Differentiating Primary From Serious Secondary Headache. Voir source | 42405663 | 10.1111/ene.70691 | European journal of neurology | |
| Foslevodopa/Foscarbidopa: A New Subcutaneous Treatment for Parkinson's Disease. Voir source | 33772855 | 10.1002/ana.26073 | Annals of neurology |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-09-22
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.