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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| CD19/CD20 Dual-CAR-T cells NCT04697290 · CD19/CD20 Dual-CAR-T in B-cell Non-Hodgkin's Lymphoma Patients. | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | SUSPENDED | This is a single center, single arm, open-label, phase I study to evaluate… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:36 | Détail |
| Cyclophosphamide NCT02629809 · Ibrutinib, Fludarabine Phosphate, Cyclophosphamide, and Obinutuzumab in Treating… | Sclérose en plaques | À vérifier | Phase 2 | ACTIVE_NOT_RECRUITING | This randomized phase II trial studies how well paclitaxel with or without… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:36 | Détail |
| Drug Product is administered by IV infusion following myeloablative c… NCT06399107 · Investigation Into the Use of BAH243 Lentiviral Vector for Gene Therapy in Treat… | Sclérose en plaques | Thérapie cellulaire · Thérapie génique | Phase 1/2 | RECRUITING | This study is an open-label, non-randomized, single-dose Phase 1/2 trial i… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:36 | Détail |
| Relma-cel NCT05765006 · CD19-CART(Relma-cel) for Moderate to Severe Active Systemic Lupus Erythematosus | Sclérose en plaques | À vérifier | Phase 1 | UNKNOWN | This is a phase I, open-label, single-arm, multicenter study to asess the… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:36 | Détail |
| Alemtuzumab NCT01361711 · Alemtuzumab-Ofatumumab in Previously Untreated Symptomatic Chronic Lymphocytic L… | Sclérose en plaques | Remyélinisation · Immunomodulation · Traitement symptomatique | Phase 2 | ACTIVE_NOT_RECRUITING | The MRI study is designed to identify possible mechanisms by which alemtuz… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:35 | Détail |
| DRL_RI NCT02296775 · Comparative Pharmacokinetic, Pharmacodynamic, Safety and Efficacy Study of Three… | Sclérose en plaques | Immunomodulation | Phase 1/2 | COMPLETED | This study will compare the plasma pharmacokinetic profile and the change… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:35 | Détail |
| Epcoritamab NCT05660967 · EPCORE DLBCL-3 — Subcutaneous Epcoritamab With or Without Lenalidomide as First… | Sclérose en plaques | À vérifier | Phase 2 | TERMINATED | The most common types of mature B-cell lymphomas (MBLs) in children are Bu… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:35 | Détail |
| Methotrexate NCT00905034 · Methotrexate, Vincristine, Pegylated L-Asparaginase and Dexamethasone (MOAD) in… | Sclérose en plaques | Ralentissement de la progression | Phase 2 | COMPLETED | This is a prospective, open-label, multicenter, randomized controlled stud… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:35 | Détail |
| Rituximab 375 mg/m2 NCT00225212 · Rituximab After Autologous Stem Cell Transplant for Relapsed B-cell Non-Hodgkin'… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire · Thérapie génique | Phase 2 | COMPLETED | Conventional therapy is effective for diffuse aggressive lymphomas and low… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:35 | Détail |
| YM155 NCT01007292 · A Study of YM155 Plus Rituximab in Subjects With Non-Hodgkin's Lymphoma Who Have… | Sclérose en plaques | À vérifier | Phase 2 | COMPLETED | The purpose of this study is to evaluate response rate, survival, safety a… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:35 | Détail |
| Fluticasone 250 mg/salmeterol 50 mg NCT01696214 · SAPS — A Pilot Study to Determine the Feasibility and Utility of Implementing of… | Sclérose en plaques | À vérifier | Phase 4 | COMPLETED | The primary aim of the pilot (SAPS) protocol is to determine the feasibili… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:30 | Détail |
| Group (E): receive aminophylline early intraoperatively, NCT07011134 · ELEAR-PAP — Timing of Aminophylline and Recovery in Pediatric Ambulatory Surgery | Sclérose en plaques | À vérifier | Phase 3 | COMPLETED | Beyond its established use as a bronchodilator and therapy for apnea of pr… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:30 | Détail |
| N-acetylcysteine NCT02088502 · Theophylline, N-acetylcysteine, and Theophylline Plus N-acetylcysteine in Preven… | Sclérose en plaques | Neuroprotection | Phase 2/3 | UNKNOWN | The overall objective of this developmental/exploratory study is to use no… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:30 | Détail |
| Theophylline NCT01601132 · Drug Interaction Study of Colchicine and Theophylline | Sclérose en plaques | À vérifier | Phase 4 | COMPLETED | To evaluate the effect of multiple doses of BIIL 284 BS on the pharmacokin… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:30 | Détail |
| Acetyl-l-carnitine NCT06126315 · ALCALS — Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in A… | Sclérose latérale amyotrophique | Ralentissement de la progression · Traitement symptomatique | Phase 2/3 | RECRUITING | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:15 | Détail |
| Darifenacin 7.5 MG Extended Release Oral Tablet NCT06249867 · A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in P… | Sclérose latérale amyotrophique | À vérifier | Phase 2 | RECRUITING | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:15 | Détail |
| LAM-002A NCT05163886 · Study of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-As… | Sclérose latérale amyotrophique | À vérifier | Phase 2 | COMPLETED | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:15 | Détail |
| PhiCube NCT07865260 · PhiCube-Adults — PhiCube for Bilateral Upper Limb Neuromotor and Cognitive Rehab… | Sclérose latérale amyotrophique | À vérifier | Non applicable | NOT_YET_RECRUITING | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:15 | Détail |
| Ulefnersen NCT07862959 · Early Access Program for Ulefnersen in Children, Adolescents and Adults With FUS… | Sclérose latérale amyotrophique | À vérifier | À vérifier | AVAILABLE | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:15 | Détail |
| Inebilizumab NCT06987539 · THYME — A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and T… | Myasthénie | À vérifier | Phase 2 | RECRUITING | The main objective is to assess the safety and tolerability of inebilizuma… À vérifier | ClinicalTrials.gov 2026-10-11 04:37:11 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||