Vue transversale globale
Toutes les maladies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
Filtrer toute la vue
Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
· 41 visibles sur cette page
dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| ACTION-MS website - an 8-week cognitive behavioural therapy intervent… NCT07875309 · An Online Tailored Cognitive Therapy-Based Intervention for Depression in Multip… | Sclérose en plaques | À vérifier | Non applicable | NOT_YET_RECRUITING | Individuals with MS experience significantly high levels of depression whi… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:04 | Détail |
| Autologous haemopoietic stem cell transplantation NCT06228781 · Autologous Hematopoietic Stem Cell Transplantation for Refractory Multiple Scler… | Sclérose en plaques | Immunomodulation · Traitement symptomatique · Thérapie cellulaire | Non applicable | NOT_YET_RECRUITING | Autologous hematopoietic stem cell transplantation (aHSCT) is the only tre… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:04 | Détail |
| C-CAR168 NCT07825389 · C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy,… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire · Thérapie génique | Phase 1/2 | NOT_YET_RECRUITING | This Phase 2, multicenter, open-label study will evaluate the safety and e… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:04 | Détail |
| Diroximel Fumarate NCT05688436 · A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Part… | Sclérose en plaques | Thérapie génique | À vérifier | ACTIVE_NOT_RECRUITING | The primary objectives of the study are to estimate the risk of major cong… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:04 | Détail |
| Frexalimab NCT07325292 · Frexcite — Non-inferiority Study of Frexalimab Subcutaneous Administration Compa… | Sclérose en plaques | À vérifier | Phase 3 | RECRUITING | This is a randomized, open-label, parallel, Phase 3 study with 2-arms for… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:04 | Détail |
| Obecabtagene autoleucel (obe-cel) NCT07139743 · BOBCAT — Obe-cel in Refractory Progressive Forms of Multiple Sclerosis | Sclérose en plaques | Immunomodulation | Phase 1 | RECRUITING | This is a Phase 1 study of obecabtagene autoleucel (obe-cel), autologous T… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:04 | Détail |
| Ocrelizumab Co-formulated With rHuPH20 NCT07503340 · Operetta III — A Study to Evaluate Pharmacokinetics, Safety, Tolerability, Immun… | Sclérose en plaques | À vérifier | Phase 2 | NOT_YET_RECRUITING | The main purpose of this study is to evaluate the safety and tolerability… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:04 | Détail |
| P-CD19CD20-ALLO1 Cells NCT07008378 · A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, and Pharmacodyn… | Sclérose en plaques | Immunomodulation | Phase 1 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the safety and tolerability of P-… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:04 | Détail |
| Turning ON the neuromodulator NCT05380856 · Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysf… | Sclérose en plaques | Traitement symptomatique | Non applicable | RECRUITING | A multi-center double-blinded placebo-controlled randomized clinical trial… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:04 | Détail |
| [F-18]PBR06 NCT04144257 · Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pa… | Sclérose en plaques | Immunomodulation · Traitement symptomatique | Phase 1/2 | COMPLETED | The specific aims of the study are: Primary: To determine the presence and… À vérifier | ClinicalTrials.gov 2026-10-18 04:36:04 | Détail |
| Active Repetitive Transcranial Magnetic Stimulation Étude non communiquée | Accident vasculaire cérébral | Traitement symptomatique · Thérapie cellulaire | Non applicable | Prévu | This randomized, double-blind, controlled clinical trial evaluates the eff… À vérifier | ClinicalTrials.gov 2026-10-18 | Détail |
| Sham Repetitive Transcranial Magnetic Stimulation Étude non communiquée | Accident vasculaire cérébral | Traitement symptomatique · Thérapie cellulaire | Non applicable | Prévu | This randomized, double-blind, controlled clinical trial evaluates the eff… À vérifier | ClinicalTrials.gov 2026-10-18 | Détail |
| Dantrolene Étude non communiquée | Sclérose en plaques | Immunomodulation | Phase 1/2 | Actif | Background: In people with multiple sclerosis (MS), brain and cerebrospina… À vérifier | ClinicalTrials.gov 2026-10-17 | Détail |
| Mechanical thrombectomy alone Étude non communiquée | Accident vasculaire cérébral | Neuroprotection | Phase 2 | Terminé | Ischemic post-conditioning is a neuroprotective strategy that has been pro… À vérifier | ClinicalTrials.gov 2026-10-17 | Détail |
| Pioglitazone Étude non communiquée | Sclérose en plaques | Immunomodulation | Phase 1/2 | Actif | Background: In people with multiple sclerosis (MS), brain and cerebrospina… À vérifier | ClinicalTrials.gov 2026-10-17 | Détail |
| Pirfenidone Étude non communiquée | Sclérose en plaques | Immunomodulation | Phase 1/2 | Actif | Background: In people with multiple sclerosis (MS), brain and cerebrospina… À vérifier | ClinicalTrials.gov 2026-10-17 | Détail |
| Amlodipine tablet Étude non communiquée | Maladie rénale chronique | Thérapie génique | Phase 3 | Prévu | The goal of this clinical trial is to learn if Ramipril works better than… À vérifier | ClinicalTrials.gov 2026-10-16 | Détail |
| MEG Étude non communiquée | Épilepsie | À vérifier | À vérifier | Actif | Objectives: The overall study objective is to compare the sensitivities an… À vérifier | ClinicalTrials.gov 2026-10-16 | Détail |
| Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System Étude non communiquée | Maladie coronarienne | À vérifier | Non applicable | Terminé | It is a randomized controlled trial to evaluate the safety and efficacy of… À vérifier | ClinicalTrials.gov 2026-10-16 | Détail |
| Sham Laser Acupuncture Étude non communiquée | Migraine | Traitement symptomatique | Non applicable | Prévu | The PRISM-CM study will test whether 810-nanometer laser acupuncture reduc… À vérifier | ClinicalTrials.gov 2026-10-16 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||