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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| SHR 3201 Injection NCT07889349 · A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of SHR 3201 In… | Maladie d’Alzheimer | À vérifier | Phase 1 | NOT_YET_RECRUITING | This study is a randomized, double-blind, dose-escalation, placebo-control… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:22 | Détail |
| Theta-burst stimulation (TBS) NCT04042532 · Theta-burst Stimulation on Cognitive Function in the Patients With Young-onset A… | Maladie d’Alzheimer | Thérapie génique | Non applicable | COMPLETED | Young-onset dementia (YOD) is a devastating condition, and it produces sub… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:22 | Détail |
| VY7523 NCT06874621 · VY7523-102: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dos… | Maladie d’Alzheimer | À vérifier | Phase 1/2 | ACTIVE_NOT_RECRUITING | This study is to be conducted in participants with early Alzheimer's Disea… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:22 | Détail |
| Xanamem NCT06125951 · XanaMIA — Effect of 10 mg Xanamem on Dementia Due to Alzheimer's Disease | Maladie d’Alzheimer | Traitement symptomatique | Phase 2/3 | ACTIVE_NOT_RECRUITING | Xanamem® is being developed as a potential treatment for symptomatic, earl… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:22 | Détail |
| [18F]PI-2620 NCT05641688 · [18F]PI-2620 Phase 3 Histopathological Study | Maladie d’Alzheimer | À vérifier | Phase 3 | RECRUITING | The study aims to evaluate the burden of tau pathology in people with Spor… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:22 | Détail |
| bilateral high frequency deep brain stimulation of the subthalamic ne… NCT06561919 · STIMPulseControl Ancillary Speech Study | Maladie de Parkinson | À vérifier | Non applicable | RECRUITING | Speech assessment is a substudy to the STIMPulseControl study (hereinafter… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| bilateral high frequency deep brainstimulation of the subthalamic nuc… NCT06498349 · Bilateral Subthalamic Stimulation in PD Patients With Impulse Control Disorders… | Maladie de Parkinson | À vérifier | Non applicable | RECRUITING | The focus of the study is on patients Parkinson's disease showing as well… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| Coenzyme Q10 Nanodispersion (Nanoquinone) NCT00180037 · Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease | Maladie de Parkinson | Traitement symptomatique | Phase 3 | COMPLETED | This study was designed to evaluate the symptomatic effects of Coenzyme Q1… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| Deep Brain Stimulation NCT04922411 · Cortical Network Modulation by Subthalamic Nucleus DBS | Maladie de Parkinson | À vérifier | Non applicable | COMPLETED | Background: \- Deep brain stimulation (DBS) is an approved surgery for cer… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| Droxidopa NCT02897063 · Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure | Maladie de Parkinson | Thérapie génique | Phase 1 | TERMINATED | The purpose of this study is to learn more about the effects of midodrine… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| DSP-1083 implantation NCT06753331 · A Multicenter Study to Evaluate Safety, Tolerability, and Clinical Responses of… | Maladie de Parkinson | À vérifier | Phase 1/2 | RECRUITING | The Goal of this study is to evaluate the safety, tolerability, and clinic… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| Edge-AI Eye-Tracking Assessment NCT07886450 · Oculomotor-Pupillary AI Biomarkers in Parkinson's | Maladie de Parkinson | Ralentissement de la progression · Traitement symptomatique | À vérifier | NOT_YET_RECRUITING | The goal of this prospective observational study is to investigate whether… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| EEG NCT05808504 · STIMPARK — Investigation of the Benefits of Electrical Non-invasive Stimulation… | Maladie de Parkinson | Immunomodulation · Traitement symptomatique | Non applicable | ACTIVE_NOT_RECRUITING | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involvi… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| MK-1484 NCT05382325 · A Study of MK-1484 as Monotherapy and in Combination With Pembrolizumab (MK-3475… | Maladie de Parkinson | À vérifier | Phase 1 | TERMINATED | The purpose of this study is to assess the safety and tolerability and to… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| MTX325 NCT07630545 · A Phase I Study in Healthy Volunteers and Parkinson's Disease (PD) Patients. | Maladie de Parkinson | Thérapie génique | Phase 1 | RECRUITING | The goal of this trial is to learn if MTX325 can be developed as a potenti… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| Neptune NCT06284629 · PD-DigiCare — Enhancing Referral Decision-making for Advanced Treatment in Parki… | Maladie de Parkinson | À vérifier | Non applicable | ACTIVE_NOT_RECRUITING | The overall aim of the trial is to compare the efficacy of using wearables… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| PASC transplantation (25 million PASCs/patient) NCT06141317 · Randomized Clinical Trial in Parkinson's Disease Patients Using Pluripotent Adip… | Maladie de Parkinson | Thérapie cellulaire | Phase 1/2 | COMPLETED | The purpose of this study is to assess the safety and efficacy of allogeni… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| VRRS Tablet (Khymeia s.r.l., Noventa Padovana, Italy) NCT05773885 · TEMPO — Telerehabilitation in People With Parkinson's Disease | Maladie de Parkinson | Traitement symptomatique | Non applicable | COMPLETED | Although TeleRehabilitation (TR) is widely accepted as an appropriate mode… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:18 | Détail |
| Pembrolizumab NCT03711032 · Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calm… | Maladie de Parkinson | Traitement symptomatique | Phase 3 | ACTIVE_NOT_RECRUITING | The purpose of this study was to evaluate the efficacy and safety of pembr… Dispositif/procédure : résultats à interpréter par essai et indication. | ClinicalTrials.gov 2026-10-25 04:36:17 | Détail |
| Prasinezumab NCT07055087 · PreCoDe — Prevent Cognitive Decline in GBA-associated Parkinson's Disease | Maladie de Parkinson | Traitement symptomatique | Phase 2 | RECRUITING | The purpose of this study is to evaluate the efficacy, safety, and pharmac… À vérifier | ClinicalTrials.gov 2026-10-25 04:36:17 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||