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Mayo Clinic
Traitements, essais et publications liés.
Traitements74programmes
Essais36liés
Publications39liées
SourceDBlocale
Traitements
74| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| 18F-AV-1451This is an imaging study of patients with mild Alzheimer's disease receiving amyloid-targeting therapy and under the care of neurologists at Mayo Clinic in Rochester, MN. | Alzheimer | Phase 2 | À vérifier | United States | À vérifier |
| A Study of Wearable Devices to Predict MigrainesThe purpose of this research is to determine if data from smart devices, including heart rate and movement during sleep and wake times, will be able to track headaches and predict recurrence and exacerbations (make worse). This use of this information may in the future allow patients earlier and more effective treatments if these devices can help predict when the headaches may occur. | Migraine | Non applicable | À vérifier | United States | À vérifier |
| AMSCsThis study is a non-randomized, open label, phase 1 clinical trial to evaluate the fesibility and safety of intrathalamic delivery of MSCs during standard of care DBS surgery for epilepsy. Subjects will be screened at our outpatient clinic and interested qualified subjects will be consented and offered participation in this trial. Once consent has been obtained, patients will undergo a standard preoperative evaluation which includes baseline laboratory values and a high-definition MRI. Patients will then undergo a stereotactic procedure for bilateral thalamic implantation of DBS leads through the ClearPoint® system. After the thalamic target for DBS is identified, cells will be infused directly into the anterior nucleus of the thalamus previous to lead implantation. Patients will be followed in the outpatient setting for up to a year after therapy application. Surgical, clinical, and radiographic data will be obtained during these visits | Épilepsie | Phase 1 | À vérifier | United States | À vérifier |
| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD for 2019 and beyond. | Sclérose latérale amyotrophique | À vérifier | À vérifier | United States, Canada | À vérifier |
| BiopsyBackground: EP0057 (formerly CRLX101) consists of a sugar molecule cyclodextrin linked to a chemotherapy drug called camptothecin. The combined molecule or "nanoparticle drug conjugate" travels through the blood. Once inside cancer cells, the chemotherapy drug is released from the molecule. Olaparib is a drug that may stop cancer cells from repairing the deoxyribonucleic acid (DNA) damage caused by chemotherapy. Researchers want to see how safe it is to give EP0057 and olaparib together and to see how well the combination treats a specific type of lung cancer called small cell lung cancer (SCLC). Objectives: To test the safety and maximum dose of EP0057 and olaparib together. To test how well they treat small cell lung cancer. Eligibility: Adults 18 and older with small cell lung cancer. Design: Participants will be screened with standard cancer care tests. Participants will get the 2 study drugs in 28-day cycles. EP0057 will be given every 2 weeks, through a small plastic tube in an arm vein. Olaparib will be taken by mouth twice a day most days. Participants will keep a pill diary. For Cycle 1, participants will have 3 visits. All other cycles will have 2 visits. At study visits, participants may have: * Blood and hair samples taken * History and Physical exam * Questions about health and side effects * Pregnancy test * Optional tumor biopsy where a piece of tumor is removed by needle after numbing the skin. * Computed tomography (CT) scan * Injection of EP0057 (twice per cycle) * Olaparib prescription Participants will have a follow-up visit 4 weeks after finish taking the drugs. They will have a physical exam and blood tests. They may have a tumor biopsy. The study team will call the patient every 3 months for follow up after completing the study treatment. | Cancer, SEP | Non applicable | À vérifier | United States | À vérifier |
| Bone ScanThis phase III trial compares standard of care hormone therapy plus ribociclib to chemotherapy followed by hormone therapy plus ribociclib for the treatment of patients with high anatomic stage breast cancer with low risk of the cancer returning (low risk recurrence). Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hormone therapy, with letrozole, anastrozole or exemestane, lowers the amount of estrogen made by the body. This may help stop the growth of tumor cells that need estrogen to grow. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Hormone therapy plus ribociclib may work as well as chemotherapy followed by hormone therapy plus ribociclib for the treatment of high anatomic stage breast cancer with low recurrence risk. | Cancer | Non applicable | À vérifier | United States | À vérifier |
| Brain Interchange SystemOverall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting. | Épilepsie | Non applicable | À vérifier | United States | À vérifier |
| Bupivacaine HCl 0.5% Injectable SolutionThe purpose of this study is to see how well blocking two to ten of the scalp nerves (that give feeling to the scalp and are painful during migraine headaches) with bupivacaine anesthetic (numbing medication) and low dose methylprednisolone (cortisone-like medicine or steroid) work for treating and preventing migraines. Our hypothesis is that the pain of most episodic migraine headaches can be eliminated and prevented for months by blocking the nerves that give pain sensation during a migraine. | Migraine | Phase 2 | Traitement symptomatique | United States | À vérifier |
| C-11 ER-176This is an imaging study of patients with mild Alzheimer's disease receiving amyloid-targeting therapy and under the care of neurologists at Mayo Clinic in Rochester, MN. | Alzheimer | Phase 2 | À vérifier | United States | À vérifier |
| C-11 ER176 RadiotracerThis purpose of this study is research the usefulness of MRI with PET/CT imaging for measuring brain inflammation and its relation to Multiple Sclerosis (MS). | SEP | Phase 2 | Immunomodulation | United States | À vérifier |
| C11 Pittsburgh Compound BThis purpose of this study is research the usefulness of MRI with PET/CT imaging for measuring brain inflammation and its relation to Multiple Sclerosis (MS). | SEP | Phase 2 | Immunomodulation | United States | À vérifier |
| Cardiac Event MonitorThis trial studies cardiac changes after radiation or chemo-radiation for the treatment of lung or esophageal cancer that has not spread to other places in the body (non-metastatic) or has not come back (non-recurrent). Continuous cardiac monitoring with an implanted device may help to identify cardiac changes that would remain unnoticed, and facilitate the treatment of these early cardiac changes as part of standard care. | Cancer | À vérifier | À vérifier | United States | À vérifier |
| CystoscopyThis clinical trial tests whether the magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) procedure is safe and effective in treating patients with low to intermediate grade prostate cancer. MRI-guided TULSA ablation is a minimally invasive procedure that uses an ultrasound device guided by MRI imaging to deliver high-energy sound waves, producing very high temperature to ablate (destroy) tumor cells in a targeted manner. The MRI-guided TULSA procedure may help patients avoid surgery and help improve prostate cancer patients' quality of life. | Cancer | Non applicable | À vérifier | United States | À vérifier |
| DaratumumabMultiple myeloma (MM) is a plasma cell disease characterized by the growth of clonal plasma cells in the bone marrow. The purpose of this study is to assess the safety and toxicity of etentamig (ABBV-383) when co-administered with pomalidomide-dexamethasone (Pd), lenalidomide-dexamethasone (Rd), or daratumumab-dexamethasone (Dd), in adult participants with relapsed/refractory (R/R) multiple myeloma (MM). Adverse events and change in disease activity will be assessed. Etentamig is an investigational drug being developed for the treatment of R/R MM. Study doctors put the participants in groups called treatment arms. Etentamig co-administered with Pd, Rd, or Dd, will be explored. Each treatment arm receives a different treatment combination depending on stage of the study and eligibility. This study will include a dose escalation phase to determine the best dose of etentamig, followed by a dose expansion phase to confirm the dose. Approximately 320 adult participants with R/R MM will be enrolled in the study in approximately 48 sites worldwide. Participants will receive intravenous (IV) etentamig co-administered with oral/IV Pd, oral/IV Rd, or oral/IV/subcutaneous (SC) Dd in 28-day cycles. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects. | Cancer, Lupus | Phase 2 | À vérifier | United States | À vérifier |
| Digital Rectal ExaminationThis clinical trial tests whether the magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) procedure is safe and effective in treating patients with low to intermediate grade prostate cancer. MRI-guided TULSA ablation is a minimally invasive procedure that uses an ultrasound device guided by MRI imaging to deliver high-energy sound waves, producing very high temperature to ablate (destroy) tumor cells in a targeted manner. The MRI-guided TULSA procedure may help patients avoid surgery and help improve prostate cancer patients' quality of life. | Cancer | Non applicable | À vérifier | United States | À vérifier |
| Feasibility of Patient-Centered Home Care (PCHC) to Reduce Disparities in High-Risk Black Men (BM) With Prostate Cancer (CaP)This study evaluates the possibility of patient-centered home care as a new model of cancer care to reduce disparities and improve health related quality of life and patient-reported outcomes in Black patients with prostate cancer. | Cancer | À vérifier | À vérifier | United States | À vérifier |
| fMRI of Active DBS Stimulation in EpilepsyResearchers are trying to incorporate a process known as Functional MRI (fMRI) scanning to reveal a pattern in brain activity during Deep Brain Stimulation (DBS), which will correlate to possible seizure freedom. | Épilepsie | NA | À vérifier | United States | À vérifier |
| Landmark-Based Greater Occipital Nerve BlockThis study will compare the analgesic benefit of a traditional landmark-guided GON block with the ultrasound-guided approach over a four week period in patients with occipital neuralgia or cervicogenic headache. | Migraine | Non applicable | À vérifier | United States | À vérifier |
| LosartanThe purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta. | Hypertension | Phase 3 | À vérifier | United States | À vérifier |
| Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical TrialThe purpose of this research is to study the effects of 12 weeks of melatonin supplementation compared to placebo in women who are in the menopause transition (perimenopause) and have high blood pressure. | Hypertension | Non applicable | À vérifier | United States | À vérifier |
| Methylprednisolone 40 MG InjectionThe purpose of this study is to see how well blocking two to ten of the scalp nerves (that give feeling to the scalp and are painful during migraine headaches) with bupivacaine anesthetic (numbing medication) and low dose methylprednisolone (cortisone-like medicine or steroid) work for treating and preventing migraines. Our hypothesis is that the pain of most episodic migraine headaches can be eliminated and prevented for months by blocking the nerves that give pain sensation during a migraine. | Migraine | Phase 2 | Traitement symptomatique | United States | À vérifier |
| MN-166Description non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé. | Sclérose latérale amyotrophique | À vérifier | Ralentissement de la progression | United States | À vérifier |
| MRI-Guided Transurethral Ultrasound AblationThis clinical trial tests whether the magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) procedure is safe and effective in treating patients with low to intermediate grade prostate cancer. MRI-guided TULSA ablation is a minimally invasive procedure that uses an ultrasound device guided by MRI imaging to deliver high-energy sound waves, producing very high temperature to ablate (destroy) tumor cells in a targeted manner. The MRI-guided TULSA procedure may help patients avoid surgery and help improve prostate cancer patients' quality of life. | Cancer | Non applicable | À vérifier | United States | À vérifier |
| Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN)The purpose of this research is to determine if the electrophysiologic data collected from standard-of-care microelectrode recordings during human deep brain stimulation (DBS) surgery will be the same using the MAVEN device compared with the standard Alpha Omega device with either a tungsten standard-of-care microelectrode (for microelectrode recordings), or a carbon-fiber microelectrode (for neurotransmitter recordings). The number of microelectrodes used for both the tungsten and the carbon-fiber version will be the same as the standard-of-care. | Parkinson | À vérifier | À vérifier | United States | À vérifier |
| Music TherapyAlzheimer disease is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly but also behavioral and psychological symptoms. Among these symptoms, agitation is one of the most dangerous because it put the patient and their caregivers in danger. Sleep disorders can be the cause of many psychiatric symptoms leading directly or indirectly to agitation. Music therapy is the non-drug therapy which has been shown to be the most effective in managing agitation and sleep disorders. With the MAGE protocol, the investigators propose to take care of behavioral disorders in severe Alzheimer patients living in nursing home through sequences of music therapy (stimulation, relaxation) automatically initiated by an actigraph that will detect sleep disorders. These subjects will be exposed for 2 weeks over a month. Behavioral and sleep disorders will be evaluated objectively by actigraphy but also by standardized scales, as the others neuropsychiatric symptoms found classically in this disease. Thanks to this project, the investigators hope to improve the quality of life of these patients by preventing them from putting themselves in danger, by reducing their neuropsychiatric symptoms and their use of medication, which has often deleterious side effect and also by reducing the workload of caregivers. | Alzheimer, Cancer | Non applicable | Traitement symptomatique | United States | À vérifier |
| NC-SUDEP — Neural Circulatory Control and SUDEP Risk.The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP). SUDEP-7 is a risk scoring tool which may correlate with these changes to the heart and blood vessels. This research study measures those differences which may help identify new markers to help predict those patients at greatest risk in the future. | Épilepsie | À vérifier | À vérifier | United States | À vérifier |
| Nerivio ®The purpose of this study is to assess the effectiveness of using remote electrical neuromodulation, using the Nerivio ® device, to relieve pain associated with receiving onabotulinumtoxinA (Botox) injections for chronic migraine prevention. | Migraine | NA | Traitement symptomatique | United States | À vérifier |
| Preventative Medication (PM)Mayo Clinic is conducting a research study to test a new approach to managing seizures in people with epilepsy whose seizures have not been fully controlled with regular medications. The study uses a small sensor placed just under the skin (not inside the brain) that continuously records electrical brain activity. This information is used to train a personalized computer algorithm that learns your individual seizure patterns and forecasts when a seizure is more likely to occur. If you are eligible and choose to participate, you would receive advance warning of elevated seizure risk, allowing you to take a fast-acting medication before a seizure happens. This medication would be in addition to the regular medicines prescribed by your doctor. The goal of the study is to understand whether this kind of forecasting system is safe, comfortable to live with, and capable of helping people gain more control over their seizures with a minimum amount of additional medication. Participation involves a minor surgical procedure to implant a small electrode under the skin above your ear that records your brain's electrical signals continuously over time. You would also wear a smart watch during the study. For the first six months, the system collects data to personalize your seizure forecast model and would not give you an alert. In the second six months, we would calculate your daily seizure risk and you would receive alerts on days when your risk is elevated. On these higher seizure risk days you would take a prescribed fast-acting nasal spray medication. The study is open to adults who continue to have 2 or more seizures per month in spite of having tried at least two antiseizure medications in the past, and whose seizures have shown involvement of the temporal lobe. All study-related procedures, devices, and study medication are provided at no cost to participants. Participants receive financial compensation for their time, and travel expenses to and from Mayo Clinic Rochester are reimbursed for anyone traveling more than 100 miles. If you are interested in learning more, please contact our research coordinator by email at Laivell.Jeffrey@mayo.edu. | Épilepsie | Phase 1 | À vérifier | United States | À vérifier |
| PROMOTE — Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition TherapyThis research trial studies gene expression in patients with prostate cancer that has spread to other places in the body receiving cytochrome P450 17 alpha hydroxylase/17,20 lyase (CYP-17) inhibition therapy. Studying samples of tissue, blood, and urine in the laboratory from patients receiving CYP-17 inhibition therapy may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer. It may also help doctors understand how well patients respond to treatment. | Cancer | À vérifier | À vérifier | United States | À vérifier |
| Propranolol 160 mgThis goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits. | Migraine | Phase 4 | À vérifier | United States | À vérifier |
| PSMA PET ScanThis clinical trial tests whether the magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) procedure is safe and effective in treating patients with low to intermediate grade prostate cancer. MRI-guided TULSA ablation is a minimally invasive procedure that uses an ultrasound device guided by MRI imaging to deliver high-energy sound waves, producing very high temperature to ablate (destroy) tumor cells in a targeted manner. The MRI-guided TULSA procedure may help patients avoid surgery and help improve prostate cancer patients' quality of life. | Cancer | Non applicable | À vérifier | United States | À vérifier |
| qMT-MRI to detect fibrosis.The purpose of this study is to evaluate whether or not an MRI technique (quantitative magnetization transfer or qMT) in narrowing human kidneys is feasible, reproducible, and predicts recovery. | Hypertension | Non applicable | À vérifier | United States | À vérifier |
| RLB — Determining the Utility of a Behavioral Intervention in Chronic MigraineThis proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of a lifestyle behavior protocol in managing chronic migraine. Additionally, the proposal will investigate biomolecules that are uniquely involved in chronic migraine patients who respond to the protocol. Successful completion of this proposal will inform the design of a future full-scale behavioral clinical trial to control chronic migraine. | Migraine | Non applicable | À vérifier | United States | À vérifier |
| Sleep Restriction and Parental History of HypertensionThe purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure. | Hypertension | Non applicable | À vérifier | United States | À vérifier |
| SMARTMig — Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral TrialThis study will unpack the behavioral intervention for migraine and determine the optimum combinations. In addition, the study will test preference and self-selection effects during the trial. | Migraine | Non applicable | À vérifier | United States | À vérifier |
| Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron DisordersDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé. | Sclérose latérale amyotrophique | À vérifier | À vérifier | United States | À vérifier |
| Study of Disrupted Sleep in Somali AmericansThe aims of this study are to determine the types and severity of previously undiagnosed sleep deficiencies in otherwise healthy Somali Americans, apply a research framework to define psychosocial, behavioral, environmental, and biological mechanisms mediating sleep deficiencies in Somali Americans, and examine the relationship between sleep deficiencies and increased blood pressure in Somali Americans. | Hypertension | À vérifier | À vérifier | United States | À vérifier |
| Topiramate 100 mgThis goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits. | Migraine | Phase 4 | À vérifier | United States | À vérifier |
| Ultrasound Guided Greater Occipital Nerve Block at C2This study will compare the analgesic benefit of a traditional landmark-guided GON block with the ultrasound-guided approach over a four week period in patients with occipital neuralgia or cervicogenic headache. | Migraine | Non applicable | À vérifier | United States | À vérifier |
| UNEEG SubQ device, seizure forecasts, nasal diazepamMayo Clinic is conducting a research study to test a new approach to managing seizures in people with epilepsy whose seizures have not been fully controlled with regular medications. The study uses a small sensor placed just under the skin (not inside the brain) that continuously records electrical brain activity. This information is used to train a personalized computer algorithm that learns your individual seizure patterns and forecasts when a seizure is more likely to occur. If you are eligible and choose to participate, you would receive advance warning of elevated seizure risk, allowing you to take a fast-acting medication before a seizure happens. This medication would be in addition to the regular medicines prescribed by your doctor. The goal of the study is to understand whether this kind of forecasting system is safe, comfortable to live with, and capable of helping people gain more control over their seizures with a minimum amount of additional medication. Participation involves a minor surgical procedure to implant a small electrode under the skin above your ear that records your brain's electrical signals continuously over time. You would also wear a smart watch during the study. For the first six months, the system collects data to personalize your seizure forecast model and would not give you an alert. In the second six months, we would calculate your daily seizure risk and you would receive alerts on days when your risk is elevated. On these higher seizure risk days you would take a prescribed fast-acting nasal spray medication. The study is open to adults who continue to have 2 or more seizures per month in spite of having tried at least two antiseizure medications in the past, and whose seizures have shown involvement of the temporal lobe. All study-related procedures, devices, and study medication are provided at no cost to participants. Participants receive financial compensation for their time, and travel expenses to and from Mayo Clinic Rochester are reimbursed for anyone traveling more than 100 miles. If you are interested in learning more, please contact our research coordinator by email at Laivell.Jeffrey@mayo.edu. | Épilepsie | Phase 1 | À vérifier | United States | À vérifier |
| Vagal nerve stimulantThe specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to a caloric meal In patients who have previously undergone activation of left cervical VNS for the treatment of medication-resistant depression. Our hypothesis is that cervical VNS increases gastric accommodation and accelerates gastric emptying compared to a bank of healthy control data. | Épilepsie | Non applicable | À vérifier | United States | À vérifier |
| fMRI of Active DBS Stimulation in EpilepsyResearchers are trying to incorporate a process known as Functional MRI (fMRI) scanning to reveal a pattern in brain activity during Deep Brain Stimulation (DBS), which will correlate to possible seizure freedom. | Épilepsie | NA | À vérifier | United States | À vérifier |
| Music TherapyAlzheimer disease is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly but also behavioral and psychological symptoms. Among these symptoms, agitation is one of the most dangerous because it put the patient and their caregivers in danger. Sleep disorders can be the cause of many psychiatric symptoms leading directly or indirectly to agitation. Music therapy is the non-drug therapy which has been shown to be the most effective in managing agitation and sleep disorders. With the MAGE protocol, the investigators propose to take care of behavioral disorders in severe Alzheimer patients living in nursing home through sequences of music therapy (stimulation, relaxation) automatically initiated by an actigraph that will detect sleep disorders. These subjects will be exposed for 2 weeks over a month. Behavioral and sleep disorders will be evaluated objectively by actigraphy but also by standardized scales, as the others neuropsychiatric symptoms found classically in this disease. Thanks to this project, the investigators hope to improve the quality of life of these patients by preventing them from putting themselves in danger, by reducing their neuropsychiatric symptoms and their use of medication, which has often deleterious side effect and also by reducing the workload of caregivers. | Alzheimer | NA | Traitement symptomatique | À vérifier | |
| Nerivio ®The purpose of this study is to assess the effectiveness of using remote electrical neuromodulation, using the Nerivio ® device, to relieve pain associated with receiving onabotulinumtoxinA (Botox) injections for chronic migraine prevention. | Migraine | NA | Traitement symptomatique | United States | À vérifier |
| Brain Interchange SystemOverall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting. | Épilepsie | Non applicable | À vérifier | United States | À vérifier |
| A Study of Wearable Devices to Predict MigrainesThe purpose of this research is to determine if data from smart devices, including heart rate and movement during sleep and wake times, will be able to track headaches and predict recurrence and exacerbations (make worse). This use of this information may in the future allow patients earlier and more effective treatments if these devices can help predict when the headaches may occur. | Migraine | Non applicable | À vérifier | United States | À vérifier |
| SMARTMig — Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral TrialThis study will unpack the behavioral intervention for migraine and determine the optimum combinations. In addition, the study will test preference and self-selection effects during the trial. | Migraine | Non applicable | À vérifier | United States | À vérifier |
| RLB — Determining the Utility of a Behavioral Intervention in Chronic MigraineThis proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of a lifestyle behavior protocol in managing chronic migraine. Additionally, the proposal will investigate biomolecules that are uniquely involved in chronic migraine patients who respond to the protocol. Successful completion of this proposal will inform the design of a future full-scale behavioral clinical trial to control chronic migraine. | Migraine | Non applicable | À vérifier | United States | À vérifier |
| Bupivacaine HCl 0.5% Injectable SolutionThe purpose of this study is to see how well blocking two to ten of the scalp nerves (that give feeling to the scalp and are painful during migraine headaches) with bupivacaine anesthetic (numbing medication) and low dose methylprednisolone (cortisone-like medicine or steroid) work for treating and preventing migraines. Our hypothesis is that the pain of most episodic migraine headaches can be eliminated and prevented for months by blocking the nerves that give pain sensation during a migraine. | Migraine | Phase 2 | Traitement symptomatique | United States | À vérifier |
| Sleep Restriction and Parental History of HypertensionThe purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure. | Hypertension | Non applicable | À vérifier | United States | À vérifier |
| Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical TrialThe purpose of this research is to study the effects of 12 weeks of melatonin supplementation compared to placebo in women who are in the menopause transition (perimenopause) and have high blood pressure. | Hypertension | Non applicable | À vérifier | United States | À vérifier |
| LosartanThe purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta. | Hypertension | Phase 3 | À vérifier | United States | À vérifier |
| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD for 2019 and beyond. | Sclérose latérale amyotrophique | À vérifier | À vérifier | United States, Canada | À vérifier |
| Bone ScanThis phase III trial compares standard of care hormone therapy plus ribociclib to chemotherapy followed by hormone therapy plus ribociclib for the treatment of patients with high anatomic stage breast cancer with low risk of the cancer returning (low risk recurrence). Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hormone therapy, with letrozole, anastrozole or exemestane, lowers the amount of estrogen made by the body. This may help stop the growth of tumor cells that need estrogen to grow. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Hormone therapy plus ribociclib may work as well as chemotherapy followed by hormone therapy plus ribociclib for the treatment of high anatomic stage breast cancer with low recurrence risk. | Cancer | Phase 2/3 | À vérifier | United States, Australia, Canada, New Zealand | À vérifier |
| Brain Interchange SystemOverall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting. | Épilepsie | Non applicable | À vérifier | United States | À vérifier |
| Ultrasound Guided Greater Occipital Nerve Block at C2This study will compare the analgesic benefit of a traditional landmark-guided GON block with the ultrasound-guided approach over a four week period in patients with occipital neuralgia or cervicogenic headache. | Migraine | Non applicable | À vérifier | United States | À vérifier |
| PROMOTE — Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition TherapyThis research trial studies gene expression in patients with prostate cancer that has spread to other places in the body receiving cytochrome P450 17 alpha hydroxylase/17,20 lyase (CYP-17) inhibition therapy. Studying samples of tissue, blood, and urine in the laboratory from patients receiving CYP-17 inhibition therapy may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer. It may also help doctors understand how well patients respond to treatment. | Cancer | À vérifier | À vérifier | United States | À vérifier |
| Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron DisordersDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé. | Sclérose latérale amyotrophique | À vérifier | À vérifier | United States | À vérifier |
| MN-166Description non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé. | Sclérose latérale amyotrophique | À vérifier | Ralentissement de la progression | United States | À vérifier |
| Feasibility of Patient-Centered Home Care (PCHC) to Reduce Disparities in High-Risk Black Men (BM) With Prostate Cancer (CaP)This study evaluates the possibility of patient-centered home care as a new model of cancer care to reduce disparities and improve health related quality of life and patient-reported outcomes in Black patients with prostate cancer. | Cancer | À vérifier | À vérifier | United States | À vérifier |
| NC-SUDEP — Neural Circulatory Control and SUDEP Risk.The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP). SUDEP-7 is a risk scoring tool which may correlate with these changes to the heart and blood vessels. This research study measures those differences which may help identify new markers to help predict those patients at greatest risk in the future. | Épilepsie | À vérifier | À vérifier | United States | À vérifier |
| AMSCsThis study is a non-randomized, open label, phase 1 clinical trial to evaluate the fesibility and safety of intrathalamic delivery of MSCs during standard of care DBS surgery for epilepsy. Subjects will be screened at our outpatient clinic and interested qualified subjects will be consented and offered participation in this trial. Once consent has been obtained, patients will undergo a standard preoperative evaluation which includes baseline laboratory values and a high-definition MRI. Patients will then undergo a stereotactic procedure for bilateral thalamic implantation of DBS leads through the ClearPoint® system. After the thalamic target for DBS is identified, cells will be infused directly into the anterior nucleus of the thalamus previous to lead implantation. Patients will be followed in the outpatient setting for up to a year after therapy application. Surgical, clinical, and radiographic data will be obtained during these visits | Épilepsie | Phase 1 | Thérapie cellulaire | United States | À vérifier |
| Music TherapyAlzheimer disease is the most common neurodegenerative brain disease that causes cognitive impairment in the elderly but also behavioral and psychological symptoms. Among these symptoms, agitation is one of the most dangerous because it put the patient and their caregivers in danger. Sleep disorders can be the cause of many psychiatric symptoms leading directly or indirectly to agitation. Music therapy is the non-drug therapy which has been shown to be the most effective in managing agitation and sleep disorders. With the MAGE protocol, the investigators propose to take care of behavioral disorders in severe Alzheimer patients living in nursing home through sequences of music therapy (stimulation, relaxation) automatically initiated by an actigraph that will detect sleep disorders. These subjects will be exposed for 2 weeks over a month. Behavioral and sleep disorders will be evaluated objectively by actigraphy but also by standardized scales, as the others neuropsychiatric symptoms found classically in this disease. Thanks to this project, the investigators hope to improve the quality of life of these patients by preventing them from putting themselves in danger, by reducing their neuropsychiatric symptoms and their use of medication, which has often deleterious side effect and also by reducing the workload of caregivers. | Cancer | Non applicable | Traitement symptomatique | United States | À vérifier |
| Study of Disrupted Sleep in Somali AmericansThe aims of this study are to determine the types and severity of previously undiagnosed sleep deficiencies in otherwise healthy Somali Americans, apply a research framework to define psychosocial, behavioral, environmental, and biological mechanisms mediating sleep deficiencies in Somali Americans, and examine the relationship between sleep deficiencies and increased blood pressure in Somali Americans. | Hypertension | À vérifier | À vérifier | United States | À vérifier |
| C-11 ER176 RadiotracerThis purpose of this study is research the usefulness of MRI with PET/CT imaging for measuring brain inflammation and its relation to Multiple Sclerosis (MS). | SEP | Phase 2 | Immunomodulation | United States | À vérifier |
| UNEEG SubQ device, seizure forecasts, nasal diazepamMayo Clinic is conducting a research study to test a new approach to managing seizures in people with epilepsy whose seizures have not been fully controlled with regular medications. The study uses a small sensor placed just under the skin (not inside the brain) that continuously records electrical brain activity. This information is used to train a personalized computer algorithm that learns your individual seizure patterns and forecasts when a seizure is more likely to occur. If you are eligible and choose to participate, you would receive advance warning of elevated seizure risk, allowing you to take a fast-acting medication before a seizure happens. This medication would be in addition to the regular medicines prescribed by your doctor. The goal of the study is to understand whether this kind of forecasting system is safe, comfortable to live with, and capable of helping people gain more control over their seizures with a minimum amount of additional medication. Participation involves a minor surgical procedure to implant a small electrode under the skin above your ear that records your brain's electrical signals continuously over time. You would also wear a smart watch during the study. For the first six months, the system collects data to personalize your seizure forecast model and would not give you an alert. In the second six months, we would calculate your daily seizure risk and you would receive alerts on days when your risk is elevated. On these higher seizure risk days you would take a prescribed fast-acting nasal spray medication. The study is open to adults who continue to have 2 or more seizures per month in spite of having tried at least two antiseizure medications in the past, and whose seizures have shown involvement of the temporal lobe. All study-related procedures, devices, and study medication are provided at no cost to participants. Participants receive financial compensation for their time, and travel expenses to and from Mayo Clinic Rochester are reimbursed for anyone traveling more than 100 miles. If you are interested in learning more, please contact our research coordinator by email at Laivell.Jeffrey@mayo.edu. | Épilepsie | Phase 1 | À vérifier | United States | À vérifier |
| BiopsyBackground: EP0057 (formerly CRLX101) consists of a sugar molecule cyclodextrin linked to a chemotherapy drug called camptothecin. The combined molecule or "nanoparticle drug conjugate" travels through the blood. Once inside cancer cells, the chemotherapy drug is released from the molecule. Olaparib is a drug that may stop cancer cells from repairing the deoxyribonucleic acid (DNA) damage caused by chemotherapy. Researchers want to see how safe it is to give EP0057 and olaparib together and to see how well the combination treats a specific type of lung cancer called small cell lung cancer (SCLC). Objectives: To test the safety and maximum dose of EP0057 and olaparib together. To test how well they treat small cell lung cancer. Eligibility: Adults 18 and older with small cell lung cancer. Design: Participants will be screened with standard cancer care tests. Participants will get the 2 study drugs in 28-day cycles. EP0057 will be given every 2 weeks, through a small plastic tube in an arm vein. Olaparib will be taken by mouth twice a day most days. Participants will keep a pill diary. For Cycle 1, participants will have 3 visits. All other cycles will have 2 visits. At study visits, participants may have: * Blood and hair samples taken * History and Physical exam * Questions about health and side effects * Pregnancy test * Optional tumor biopsy where a piece of tumor is removed by needle after numbing the skin. * Computed tomography (CT) scan * Injection of EP0057 (twice per cycle) * Olaparib prescription Participants will have a follow-up visit 4 weeks after finish taking the drugs. They will have a physical exam and blood tests. They may have a tumor biopsy. The study team will call the patient every 3 months for follow up after completing the study treatment. | Cancer | Non applicable | Traitement symptomatique | À vérifier | |
| Vagal nerve stimulantThe specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to a caloric meal In patients who have previously undergone activation of left cervical VNS for the treatment of medication-resistant depression. Our hypothesis is that cervical VNS increases gastric accommodation and accelerates gastric emptying compared to a bank of healthy control data. | Épilepsie | Non applicable | À vérifier | United States | À vérifier |
| Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN)The purpose of this research is to determine if the electrophysiologic data collected from standard-of-care microelectrode recordings during human deep brain stimulation (DBS) surgery will be the same using the MAVEN device compared with the standard Alpha Omega device with either a tungsten standard-of-care microelectrode (for microelectrode recordings), or a carbon-fiber microelectrode (for neurotransmitter recordings). The number of microelectrodes used for both the tungsten and the carbon-fiber version will be the same as the standard-of-care. | Parkinson | À vérifier | À vérifier | United States | À vérifier |
| DaratumumabMultiple myeloma (MM) is a plasma cell disease characterized by the growth of clonal plasma cells in the bone marrow. The purpose of this study is to assess the safety and toxicity of etentamig (ABBV-383) when co-administered with pomalidomide-dexamethasone (Pd), lenalidomide-dexamethasone (Rd), or daratumumab-dexamethasone (Dd), in adult participants with relapsed/refractory (R/R) multiple myeloma (MM). Adverse events and change in disease activity will be assessed. Etentamig is an investigational drug being developed for the treatment of R/R MM. Study doctors put the participants in groups called treatment arms. Etentamig co-administered with Pd, Rd, or Dd, will be explored. Each treatment arm receives a different treatment combination depending on stage of the study and eligibility. This study will include a dose escalation phase to determine the best dose of etentamig, followed by a dose expansion phase to confirm the dose. Approximately 320 adult participants with R/R MM will be enrolled in the study in approximately 48 sites worldwide. Participants will receive intravenous (IV) etentamig co-administered with oral/IV Pd, oral/IV Rd, or oral/IV/subcutaneous (SC) Dd in 28-day cycles. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects. | Lupus | Phase 2 | À vérifier | United States | À vérifier |
| qMT-MRI to detect fibrosis.The purpose of this study is to evaluate whether or not an MRI technique (quantitative magnetization transfer or qMT) in narrowing human kidneys is feasible, reproducible, and predicts recovery. | Hypertension | Non applicable | À vérifier | United States | À vérifier |
| 18F-AV-1451This is an imaging study of patients with mild Alzheimer's disease receiving amyloid-targeting therapy and under the care of neurologists at Mayo Clinic in Rochester, MN. | Alzheimer | Phase 2 | À vérifier | United States | À vérifier |
| BiopsyBackground: EP0057 (formerly CRLX101) consists of a sugar molecule cyclodextrin linked to a chemotherapy drug called camptothecin. The combined molecule or "nanoparticle drug conjugate" travels through the blood. Once inside cancer cells, the chemotherapy drug is released from the molecule. Olaparib is a drug that may stop cancer cells from repairing the deoxyribonucleic acid (DNA) damage caused by chemotherapy. Researchers want to see how safe it is to give EP0057 and olaparib together and to see how well the combination treats a specific type of lung cancer called small cell lung cancer (SCLC). Objectives: To test the safety and maximum dose of EP0057 and olaparib together. To test how well they treat small cell lung cancer. Eligibility: Adults 18 and older with small cell lung cancer. Design: Participants will be screened with standard cancer care tests. Participants will get the 2 study drugs in 28-day cycles. EP0057 will be given every 2 weeks, through a small plastic tube in an arm vein. Olaparib will be taken by mouth twice a day most days. Participants will keep a pill diary. For Cycle 1, participants will have 3 visits. All other cycles will have 2 visits. At study visits, participants may have: * Blood and hair samples taken * History and Physical exam * Questions about health and side effects * Pregnancy test * Optional tumor biopsy where a piece of tumor is removed by needle after numbing the skin. * Computed tomography (CT) scan * Injection of EP0057 (twice per cycle) * Olaparib prescription Participants will have a follow-up visit 4 weeks after finish taking the drugs. They will have a physical exam and blood tests. They may have a tumor biopsy. The study team will call the patient every 3 months for follow up after completing the study treatment. | Cancer | Phase 2 | À vérifier | United States | À vérifier |
| MRI-Guided Transurethral Ultrasound AblationThis clinical trial tests whether the magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) procedure is safe and effective in treating patients with low to intermediate grade prostate cancer. MRI-guided TULSA ablation is a minimally invasive procedure that uses an ultrasound device guided by MRI imaging to deliver high-energy sound waves, producing very high temperature to ablate (destroy) tumor cells in a targeted manner. The MRI-guided TULSA procedure may help patients avoid surgery and help improve prostate cancer patients' quality of life. | Cancer | Non applicable | À vérifier | United States | À vérifier |
Essais cliniques
36| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| MRI-Guided Transurethral Ultrasound Ablation | Cancer | Non applicable | NCT05438563 | MRI-guided Transurethral Urethral Ultrasound Ablation for the Treatment of Low to Intermediate Grade Prostate Cancer | RECRUITING |
| Biopsy | Cancer | Phase 2 | NCT06499870 | Relugolix and Enzalutamide in Combination With Radiation Therapy for the Treatment of Very High Risk Prostate Cancer, OPTIMAL Trial | RECRUITING |
| 18F-AV-1451 | Alzheimer | Phase 2 | NCT06723015 | Tau PET Outcomes With Anti-amyloid Immunotherapies | ENROLLING_BY_INVITATION |
| qMT-MRI to detect fibrosis. | Hypertension | Non applicable | NCT04508049 | A Study to Evaluate Renal Fibrosis Using MRI Techniques | ACTIVE_NOT_RECRUITING |
| Daratumumab | Lupus | Phase 2 | NCT04868838 | Daratumumab to Treat Active Lupus Nephritis | ACTIVE_NOT_RECRUITING |
| Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN) | Parkinson | À vérifier | NCT07868614 | Intraoperative Microelectrode Recordings Using MAVEN Compared to Standard Recording Apparatuses | RECRUITING |
| Vagal nerve stimulant | Épilepsie | Non applicable | NCT06038929 | Effect of Vagal Nerve Stimulation on Gastric Motor Functions | RECRUITING |
| Biopsy | Cancer | Non applicable | NCT03238664 | Robot-Assisted Laparoscopic High-Intensity Focused Ultrasound and Radical Cystectomy for Thermal Ablation of Muscle Invasive Cells in Patients With Bladder Tumors | WITHDRAWN |
| UNEEG SubQ device, seizure forecasts, nasal diazepam | Épilepsie | Phase 1 | NCT07012148 | FORESITE — Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables | RECRUITING |
| Zavegepant | Migraine | Phase 4 | NCT06401642 | Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive Medications | RECRUITING |
| C-11 ER176 Radiotracer | SEP | Phase 2 | NCT05805839 | A Study of Imaging in Demyelinating Diseases | ENROLLING_BY_INVITATION |
| Study of Disrupted Sleep in Somali Americans | Hypertension | À vérifier | NCT05411029 | Study of Disrupted Sleep in Somali Americans | RECRUITING |
| Music Therapy | Cancer | Non applicable | NCT07729384 | Strengthening Teen Brain Resilience Using Music Intervention to Improve Radiation Induced Cognitive Decline for Adolescents Undergoing Radiation Therapy for Cancer Treatment | NOT_YET_RECRUITING |
| AMSCs | Épilepsie | Phase 1 | NCT06280092 | Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery | TERMINATED |
| NC-SUDEP — Neural Circulatory Control and SUDEP Risk. | Épilepsie | À vérifier | NCT02813980 | NC-SUDEP — Neural Circulatory Control and SUDEP Risk. | ACTIVE_NOT_RECRUITING |
| Biospecimen Collection | Cancer | À vérifier | NCT04183218 | Characterizing Chemo-Radiotherapy Treatment-Related Cardiac Changes | COMPLETED |
| Feasibility of Patient-Centered Home Care (PCHC) to Reduce Disparities in High-Risk Black Men (BM) With Prostate Cancer (CaP) | Cancer | À vérifier | NCT06470750 | Feasibility of Patient-Centered Home Care (PCHC) to Reduce Disparities in High-Risk Black Men (BM) With Prostate Cancer (CaP) | COMPLETED |
| MN-166 | Sclérose latérale amyotrophique | À vérifier | NCT06743776 | SEANOBI-ALS — Scalable Expanded Access With Analysis of Neurofilament and Other Biomarkers for Ibudilast in ALS | NO_LONGER_AVAILABLE |
| Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders | Sclérose latérale amyotrophique | À vérifier | NCT05474235 | Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders | RECRUITING |
| PROMOTE — Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition Therapy | Cancer | À vérifier | NCT01953640 | PROMOTE — Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition Therapy | COMPLETED |
| Ultrasound Guided Greater Occipital Nerve Block at C2 | Migraine | Non applicable | NCT03478735 | Ultrasound Greater Occipital Nerve Block at C2 Level Compared to Landmark-based Greater Occipital Nerve Block | COMPLETED |
| Brain Interchange System | Épilepsie | Non applicable | NCT05439655 | Acute Recording of Stereotyped High-Frequency Oscillations | ACTIVE_NOT_RECRUITING |
| Bone Scan | Cancer | Phase 2/3 | NCT05691478 | A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma | SUSPENDED |
| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) | Sclérose latérale amyotrophique | À vérifier | NCT04363684 | ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) | RECRUITING |
| Losartan | Hypertension | Phase 3 | NCT06150560 | A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial) | RECRUITING |
| Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial | Hypertension | Non applicable | NCT06826755 | Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial | RECRUITING |
| Sleep Restriction and Parental History of Hypertension | Hypertension | Non applicable | NCT06482814 | Sleep Restriction and Parental History of Hypertension | RECRUITING |
| Bupivacaine HCl 0.5% Injectable Solution | Migraine | Phase 2 | NCT05734625 | Efficacy of Nerve Blocks for Episodic Migraine | RECRUITING |
| RLB — Determining the Utility of a Behavioral Intervention in Chronic Migraine | Migraine | Non applicable | NCT05415020 | RLB — Determining the Utility of a Behavioral Intervention in Chronic Migraine | RECRUITING |
| SMARTMig — Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial | Migraine | Non applicable | NCT06170281 | SMARTMig — Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial | NOT_YET_RECRUITING |
| A Study of Wearable Devices to Predict Migraines | Migraine | Non applicable | NCT05755945 | A Study of Wearable Devices to Predict Migraines | ACTIVE_NOT_RECRUITING |
| Brain Interchange System | Épilepsie | Non applicable | NCT06898138 | Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations | NOT_YET_RECRUITING |
| Nerivio ® | Migraine | NA | NCT05730556 | A Study of Remote Electrical Neuromodulation for Acute Procedural Pain | TERMINATED |
| Music Therapy | Alzheimer | NA | NCT04327778 | MAGE — Automate Music Therapy for the Management of Behavioral Disorders in Nursing Homes | WITHDRAWN |
| Atogepant 60 mg | Migraine | Phase 4 | NCT06972056 | Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study | RECRUITING |
| fMRI of Active DBS Stimulation in Epilepsy | Épilepsie | NA | NCT03870308 | fMRI of Active DBS Stimulation in Epilepsy | COMPLETED |
Publications
39| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Vagal nerve stimulant | The importance of sensory nerve endings as sites of drug action. | Naunyn-Schmiedeberg's archives of pharmacology | ||
| Vagal nerve stimulant | Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract. | Archives of toxicology | ||
| Vagal nerve stimulant | Cough sensors. I. Physiological and pharmacological properties of the afferent nerves regulating cough. | Handbook of experimental pharmacology | ||
| Multifunctional Apparatus for Voltammetry, Electrophysiology, and Neuromodulation (MAVEN) | A multimodal platform for real-time neurochemical and electrophysiologic monitoring for intraoperative neurosurgical applications. | Biosensors & bioelectronics | ||
| MN-166 | Effect of MN-166 (ibudilast) on acute respiratory failure prevention in hospitalized participants with COVID-19: a randomized, double-blind, placebo-controlled phase 2 study. | BMC pulmonary medicine | ||
| Methylprednisolone 40 MG Injection | Use and safety of corticosteroid injections in joints and musculoskeletal soft tissue: guidelines from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, the American Society of Interventional Pain Physicians, and the International Pain and Spine Intervention Society. | Regional anesthesia and pain medicine | ||
| Methylprednisolone 40 MG Injection | Long-term durability of a time-limited methotrexate intervention in patients with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative arthralgia at increased risk for rheumatoid arthritis (TREAT EARLIER): 5-year data from a double-blind, randomised, placebo-controlled trial. | The Lancet. Rheumatology | ||
| Methylprednisolone 40 MG Injection | An Emerging Autoimmune Neuroinflammatory Disease: Myelin Oligodendrocyte Glycoprotein Antibody Disease. | Annals of African medicine | ||
| Bupivacaine HCl 0.5% Injectable Solution | The true benefit of the regional block in orthognathic surgery lies in the preemptive effect. | Oral and maxillofacial surgery | ||
| Bupivacaine HCl 0.5% Injectable Solution | An evaluation of peripheral nerve damage that may develop following intraneural bupivacaine, dexmedetomidine, and lidocaine injections: multifaceted analysis in an experimental model. | BMC anesthesiology | ||
| Bupivacaine HCl 0.5% Injectable Solution | Does Liposomal Bupivacaine Provide Superior Postoperative Analgesia Compared With Ropivacaine With Dexamethasone in Suprainguinal Fascia Iliaca Compartment Block for THA? A Randomized Controlled Trial. | Clinical orthopaedics and related research | ||
| A Study of Wearable Devices to Predict Migraines | Digital phenotyping for migraine: A game-changer for research and management. | Cephalalgia : an international journal of headache | ||
| A Study of Wearable Devices to Predict Migraines | Heart rate variability as a predictor of migraine: Sleep-time data analysis of pre-migraine nights. | Technology and health care : official journal of the European Society for Engineering and Medicine | ||
| A Study of Wearable Devices to Predict Migraines | Bridging Objective and Subjective Data: A Comprehensive Architecture for Wearable Health Research. | Studies in health technology and informatics | ||
| Nerivio ® | Practice-Based Consensus Amongst Indian Neurologists: Adopting Remote Electrical Neuromodulation for Effective Management of Migraine. | Advances in therapy | ||
| Topiramate 100 mg | Pharmacological interventions for antipsychotic-induced weight gain in schizophrenia: A network meta-analysis. | General hospital psychiatry | ||
| Propranolol 160 mg | Propranolol Versus Metoprolol for Treatment of Electrical Storm in Patients With Implantable Cardioverter-Defibrillator. | Journal of the American College of Cardiology | ||
| Brain Interchange System | A RAPID PROTOTYPING ENVIRONMENT FOR CLOSED-LOOP NEUROMODULATION USING THE BRAIN INTERCHANGE SYSTEM. | Proceedings of the ... Design of Medical Devices Conference. Design of Medical Devices Conference | ||
| fMRI of Active DBS Stimulation in Epilepsy | Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial. | Cell reports. Medicine | ||
| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) | Cortical microstructure in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants: Looking beyond atrophy. | The journal of prevention of Alzheimer's disease | ||
| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) | Cortical free-water imaging in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants. | Research square | ||
| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) | Glymphatic dysfunction, plasma neurofilament light, and cortical free water mediate cognitive decline in familial frontotemporal lobar degeneration. | The journal of prevention of Alzheimer's disease | ||
| Biopsy | Crystal Violet Staining for Colitis-associated Neoplasia-guided Delineation of Ulcerative Colitis-associated Neoplasia for Endoscopic Submucosal Dissection: A Four-case Report. | DEN open | ||
| Bone Scan | Localisation and outcome of presumed thoracolumbar vertebral stress fracture in 35 UK Thoroughbred racehorses using nuclear scintigraphy. | Equine veterinary journal | ||
| Bone Scan | Alternative trials of recipient site vessel in maxillomandibular reconstruction with multisegment fibular flaps including only one pedicle anastomosis. | Injury | ||
| Bone Scan | Redefining bone metastasis imaging in breast cancer: whole body low-dose computed tomography compared with skeletal scintigraphy in a real-world cohort. | Nuclear medicine communications | ||
| Losartan | Precise diagnosis of hepatocellular carcinoma and acute kidney injury through near-infrared imaging utilizing a fluorescence probe for monitoring α-l-fucosidase. | Analytica chimica acta | ||
| Losartan | Determination of five antihypertensives in dried capillary plasma spots by LC-MS/MS: A novel method for monitoring pharmacotherapy adherence. | Journal of pharmaceutical and biomedical analysis | ||
| Losartan | Mechanisms of obesogenic adipocyte signaling in mouse 3T3-L1 cells in response to plasma from C57BL/6 mice exposed to traffic-generated emissions and high-fat diet. | Toxicology reports | ||
| Nerivio ® | A Real-World Evidence Study on US Patients Demonstrating Safety of High-Frequency Use of the Remote Electrical Neuromodulation (REN) Wearable Device for Migraine Treatment. | Pain and therapy | ||
| Nerivio ® | U.S. Veterans Using Remote Electrical Neuromodulation for Migraine: A Prospective Real-World Evidence Study of Treatment Patterns, Medication Use, Effectiveness, and Safety (2020-2025). | Military medicine | ||
| Topiramate 100 mg | Use of obesity medications in a young pediatric patient with optic nerve hypoplasia and severe early-onset obesity: A case report. | Obesity pillars | ||
| Topiramate 100 mg | Phentermine/Topiramate in Obese, Diabetic Uric Acid Stone Formers: An Open-Label Randomized Feasibility Trial. | The Journal of urology | ||
| Propranolol 160 mg | TOP-PRO study: A randomized double-blind controlled trial of topiramate versus propranolol for prevention of chronic migraine. | Cephalalgia : an international journal of headache | ||
| Propranolol 160 mg | Blood pressure lowering for prevention of episodic migraine: results of a pilot randomized, placebo-controlled trial of combination blood pressure lowering medication with propranolol. | Frontiers in neurology | ||
| Music Therapy | Exploring expectations of music interventions in pulmonary rehabilitation: a cross-sectional survey protocol. | BMJ open respiratory research | ||
| Music Therapy | Agitation in dementia: Evidence-based consensus recommendations. | Journal of the Chinese Medical Association : JCMA | ||
| fMRI of Active DBS Stimulation in Epilepsy | Implanted Devices for Management of Drug-Resistant Epilepsy: Background and MR Imaging Considerations. | Neuroimaging clinics of North America | ||
| fMRI of Active DBS Stimulation in Epilepsy | Pulvinar subdivisions and connectivity patterns across primate species: a comparative perspective. | Frontiers in neuroanatomy |