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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Trontinemab NCT07169578 · TRONTIER 1 — A Study of Trontinemab in Participants With Early Symptomatic Alzhe… | Maladie d’Alzheimer | Traitement symptomatique | Phase 3 | ACTIVE_NOT_RECRUITING | The purpose of this study is to assess the efficacy and safety of trontine… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:27 | Détail |
| Green Tea Polyphenols (EGCG/ECG) NCT00461942 · Efficacy and Safety of Green Tea Polyphenol in De Novo Parkinson's Disease Patie… | Maladie de Parkinson | À vérifier | Phase 2 | COMPLETED | The purpose of this study is to determine whether Green Tea Polyphenol, an… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:24 | Détail |
| Physiotherapy NCT07838636 · EPA-DBS — Effect of Physical Activity on the Course of Parkinson's Disease in Pa… | Maladie de Parkinson | Traitement symptomatique | Non applicable | RECRUITING | Parkinson's disease is a common, progressive neurodegenerative disorder. T… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:24 | Détail |
| Deep Brain Stimulation NCT06891781 · ADVENT — Investigating Adaptive Deep Brain Stimulation in Parkinson's Disease Ma… | Maladie de Parkinson | À vérifier | Non applicable | RECRUITING | Background: \- Deep brain stimulation (DBS) is an approved surgery for cer… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:23 | Détail |
| OraFID dosing device, Levodopa/Carbidopa minitablets delivered via Or… NCT07839793 · FLORA — A 12-Week Study of Flexilev With the OraFID Device and App in Parkinson'… | Maladie de Parkinson | À vérifier | Phase 4 | RECRUITING | Flexilev is a Parkinson's disease medicine made of small, dissolvable tabl… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:23 | Détail |
| Pembrolizumab NCT04626479 · Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participan… | Maladie de Parkinson | À vérifier | Phase 1/2 | COMPLETED | The purpose of this study was to evaluate the efficacy and safety of pembr… Dispositif/procédure : résultats à interpréter par essai et indication. | ClinicalTrials.gov 2026-09-27 04:36:23 | Détail |
| Pembrolizumab NCT04626518 · Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participan… | Maladie de Parkinson | À vérifier | Phase 1/2 | COMPLETED | The purpose of this study was to evaluate the efficacy and safety of pembr… Dispositif/procédure : résultats à interpréter par essai et indication. | ClinicalTrials.gov 2026-09-27 04:36:23 | Détail |
| Repetitive Transcranial Magnetic Stimulation (rTMS) NCT07569133 · Efficacy of Repetitive Transcranial Magnetic Stimulation for Improving Depressiv… | Maladie de Parkinson | Traitement symptomatique | Non applicable | ENROLLING_BY_INVITATION | The purpose of this study is to evaluate the efficacy of repetitive transc… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:23 | Détail |
| transcutaneous vagus nerve stimulation NCT07839481 · tcVNS-PD — Effects of Transcutaneous Cervical Vagus Nerve Stimulation on Non-mot… | Maladie de Parkinson | Traitement symptomatique | Non applicable | NOT_YET_RECRUITING | Attaining goals or rewards commonly entails response costs. In light of co… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:23 | Détail |
| TRB-001 NCT07840027 · Assessment of the Safety, Immunogenicity, and Pharmacodynamics of TRB-001 in Pat… | Maladie de Parkinson | À vérifier | Phase 1 | RECRUITING | An unblinded, single arm, pilot observational study to test the safety, to… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:23 | Détail |
| Zanidatamab NCT05152147 · HERIZON-GEA-01 — A Study of Zanidatamab in Combination With Chemotherapy Plus or… | Maladie de Parkinson | À vérifier | Phase 3 | ACTIVE_NOT_RECRUITING | The purpose of this study is to evaluate the efficacy and safety of Zanida… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:23 | Détail |
| Sanacoach Parkinson (SCP) NCT05164783 · EPD — Multicenter Implementation of E-monitoring in Parkinson's Disease | Maladie de Parkinson | Immunomodulation · Traitement symptomatique · Thérapie génique | Non applicable | COMPLETED | Introduction and rationale: Parkinson´s disease (PD) is a slowly progressi… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:22 | Détail |
| LBT-3627 NCT06466525 · A Two-Part Single and Multiple Ascending Dose Trial of the Safety, Tolerability,… | Maladie de Parkinson | À vérifier | Phase 1 | RECRUITING | Phase I a/b SAD/MAD study to evaluate safety and tolerability of LBT-3627… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:21 | Détail |
| B001 NCT03332121 · B001 in Patients With CD20 Positive B-cell Non Hodgkin's Lymphoma | Sclérose en plaques | Immunomodulation | Phase 1 | COMPLETED | It's the first-in-human study of Recombinant Humanized Anti-CD20 Monoclona… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:15 | Détail |
| Rituximab NCT00244855 · Rituximab and Dexamethasone in Treating Patients With Low-Grade Non-Hodgkin Lymp… | Sclérose en plaques | À vérifier | Phase 2 | COMPLETED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:15 | Détail |
| Rituximab NCT00244985 · Rituximab and Liposomal Doxorubicin in Treating Patients With Relapsed or Refrac… | Sclérose en plaques | À vérifier | Phase 1/2 | COMPLETED | The primary objective of this phase III trial is to investigate if Rituxim… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:15 | Détail |
| Rituximab IV NCT04660799 · A Study on Pharmacokinetics (PK), Efficacy and Safety of Subcutaneous (SC) Versu… | Sclérose en plaques | Immunomodulation | Phase 2 | COMPLETED | This is a multicenter China-only study to investigate the PK, efficacy and… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:15 | Détail |
| Biopsy Procedure NCT02143414 · Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatum… | Sclérose en plaques | À vérifier | Phase 2 | ACTIVE_NOT_RECRUITING | This phase I/II trial studies the side effects and best dose of pidnarulex… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:14 | Détail |
| IL-2 pre-treated CD19 cells NCT02992834 · Anti-CD19:TCRζ Chimeric Antigen Receptor-T Cells in the Treatment for CD19+ B Ce… | Sclérose en plaques | Immunomodulation | Phase 4 | UNKNOWN | This study aims to evaluate the safety, efficacy and duration of response… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:14 | Détail |
| QH103 Cell Injection NCT07367685 · Clinical Study of Universal CD19 CAR-γδT Cell Injection in the Treatment of Adul… | Sclérose en plaques | Immunomodulation | Phase 1 | NOT_YET_RECRUITING | This study is an open-label, single-arm clinical trial designed to evaluat… À vérifier | ClinicalTrials.gov 2026-09-27 04:36:14 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||