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Périmètre
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Chaque choix s’applique immédiatement aux quatre sections. Le filtre « type de SEP » n’apparaît que lorsque la sclérose en plaques est sélectionnée.
10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| anti-CD19 CAR T cell therapy NCT06828042 · Safety and Efficacy of Universal CD19-targeting CAR-γδT Cells in Refractory Auto… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1/2 | RECRUITING | Autoimmune diseases refer to a common category of diseases caused by the i… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:29 | Détail |
| CD19 CARvac T cells NCT04156243 · CD19 CARvac T Cells for Patients With Relapsed / Refractory B Cell Malignancies | Sclérose en plaques | Immunomodulation | Phase 1 | UNKNOWN | This is a phase I, interventional, single arm, open label, treatment study… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:29 | Détail |
| CD19-BAFF Targeted CAR T-cells NCT06279923 · CD19-BAFF CAR-T Cells Therapy for Patients With Autoimmune Diseases | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | RECRUITING | Clinical Trial for the safety and efficacy of CD19-BAFF CAR-T cells therap… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:29 | Détail |
| Human CD19 targeted T Cells Injection NCT03720457 · Human CD19 Targeted T Cells Injection(CD19 CAR-T) Therapy for Relapsed and Refra… | Sclérose en plaques | Immunomodulation · Thérapie cellulaire | Phase 1 | UNKNOWN | To evaluate the safety and tolerance of human CD19 targeted T Cells inject… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:29 | Détail |
| Alemtuzumab NCT00818961 · Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Cancer | Sclérose en plaques | Remyélinisation · Immunomodulation · Thérapie cellulaire | Phase 2 | TERMINATED | The MRI study is designed to identify possible mechanisms by which alemtuz… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:28 | Détail |
| Anti-CD19 iCAR NK Cells NCT03824951 · Study of Anti-CD19 iCAR NK Cells in Relapsed and Refractory B Cell Lymphoma | Sclérose en plaques | Immunomodulation | Phase 1 | UNKNOWN | This is a single-centre, single-arm and open-label study to investigate th… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:28 | Détail |
| Asparaginase NCT02538926 · Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin Hy… | Sclérose en plaques | À vérifier | Phase 2 | WITHDRAWN | This phase II trial studies how well etoposide, prednisone, vincristine su… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:28 | Détail |
| Autologous humanized anti-CD19 and anti-CD20 dual specific CAR-T Cells NCT04486872 · An Exploratory Clinical Trial of Autologous Humanized Anti-cluster of Differenti… | Sclérose en plaques | Immunomodulation | Phase 1 | UNKNOWN | This is a single-arm, open-label, dose escalation, phase I study, aiming t… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:28 | Détail |
| Filgrastim NCT00003595 · Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating… | Sclérose en plaques | À vérifier | Phase 3 | COMPLETED | This phase Ib/II trial studies the best dose and side effects of venetocla… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:28 | Détail |
| Radiotracer [11C]-CS1P1 NCT06591429 · Smoldering Inflammation in MS | Sclérose en plaques | Immunomodulation · Thérapie génique | À vérifier | RECRUITING | The goal of this observational study is to learn about inflammation in tho… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:28 | Détail |
| SIBP-02 NCT04361279 · A Study Comparing SIBP-02 and Rituximab Combination With CHOP in Previously Untr… | Sclérose en plaques | Immunomodulation | Phase 3 | COMPLETED | This is a randomised, double-blind, positive drug parallel controlled equi… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:28 | Détail |
| TQB2825 Injection (Subcutaneous Injection) NCT07110194 · Phase I Clinical Trial of TQB2825 Subcutaneous Injection in CD20-positive Hemato… | Sclérose en plaques | Immunomodulation | Phase 1 | NOT_YET_RECRUITING | The aim of this study is to evaluate the pharmacokinetic characteristics,… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:28 | Détail |
| Venetoclax NCT03379051 · Phase I/II Study of Venetoclax or Lenalidomide in Combination With Ublituximab a… | Sclérose en plaques | Thérapie cellulaire · Thérapie génique | Phase 1/2 | TERMINATED | This study evaluates the effectiveness and safety of a new conditioning re… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:28 | Détail |
| Theophylline NCT01066728 · CO2 Inhalation as a New Treatment Modality for Apnea of Prematurity | Sclérose en plaques | À vérifier | Phase 2/3 | COMPLETED | To evaluate the effect of multiple doses of BIIL 284 BS on the pharmacokin… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:23 | Détail |
| ambrisentan and theophylline NCT01902758 · Drug Combination on Exercise Performance at High Altitude | Sclérose en plaques | Traitement symptomatique | Phase 2/3 | COMPLETED | This study is being conducted to determine the effectiveness of using two… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:22 | Détail |
| Symbicort, used twice daily (b.i.d) and as needed (prn) NCT00252863 · DESOLO - SiT Peri-Launch: A Comparison of Symbicort Single Inhaler Therapy and C… | Sclérose en plaques | À vérifier | Phase 3 | COMPLETED | The purpose of this study is to determine whether Symbicort dosed accordin… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:22 | Détail |
| Theophylline NCT03115294 · CardiomeDIC — Digital Image Correlation in Right Ventricular Evaluation | Sclérose en plaques | À vérifier | Non applicable | COMPLETED | To evaluate the effect of multiple doses of BIIL 284 BS on the pharmacokin… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:22 | Détail |
| Acamprosate calcium NCT07204977 · Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Scler… | Sclérose latérale amyotrophique | Traitement symptomatique | Phase 1 | RECRUITING | Description non affichée : incohérence de maladie détectée. Consultez l’es… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:09 | Détail |
| AP-101 NCT05039099 · A Study to Evaluate, Safety, Tolerability, and PK of AP-101 in Participants With… | Sclérose latérale amyotrophique | À vérifier | Phase 2 | COMPLETED | The purpose of this study is to evaluate the safety, tolerability, PK, and… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:09 | Détail |
| Mind Extender (MindEx) NCT05936619 · MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System | Sclérose latérale amyotrophique | Traitement symptomatique | Non applicable | RECRUITING | This research study is being done to develop a novel brain-computer interf… À vérifier | ClinicalTrials.gov 2026-10-04 04:37:09 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||