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Périmètre
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10635 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 5743
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Metoprolol Succinate NCT07490067 · Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Me… | Insuffisance cardiaque | À vérifier | Phase 4 | RECRUITING | The purpose of this trial is to better understand how the beta-blocker met… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:31 | Détail |
| Nudging NCT06844006 · ADMINISTER II — Investigating the Impact of Nudging Cardiologists to Prescribe C… | Insuffisance cardiaque | À vérifier | Non applicable | ACTIVE_NOT_RECRUITING | This study investigates the impact of a nudge-based intervention on improv… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:31 | Détail |
| Percutaneous transluminal angioplasty (PTA) NCT07531966 · DAN-PTRAIII — Vascular Complications After Kidney Transplantation | Insuffisance cardiaque | À vérifier | À vérifier | RECRUITING | * To determine the incidence of arterial inflow problems and venous outflo… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:31 | Détail |
| POWERbreathe KH2 NCT07862738 · Inspiratory Muscle Training in Hospitalized Patients With Heart Failure Awaiting… | Insuffisance cardiaque | À vérifier | Non applicable | NOT_YET_RECRUITING | The primary objective of this study is to evaluate the feasibility and saf… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:31 | Détail |
| SherpaPak Cardiac Transport System NCT04141605 · GUARDIAN — Global Utilization And Registry Database for Improved heArt preservat… | Insuffisance cardiaque | À vérifier | À vérifier | ENROLLING_BY_INVITATION | The primary objective of this study is to collect real-world clinical perf… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:31 | Détail |
| TNX-103 NCT07288398 · LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2 | Insuffisance cardiaque | À vérifier | Phase 3 | ACTIVE_NOT_RECRUITING | The purpose of this study is to assess the efficacy and safety of the stud… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:31 | Détail |
| Vericiguat NCT07877831 · Vericiguat Use and Incident Atrial Fibrillation in Chronic Heart Failure | Insuffisance cardiaque | À vérifier | À vérifier | ACTIVE_NOT_RECRUITING | This ambispective observational cohort study aims to evaluate the associat… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:31 | Détail |
| Watch HOP NCT06335264 · WEAR-HF — A Multimodal Wearable Platform for Heart Failure Disease Stratification | Insuffisance cardiaque | À vérifier | À vérifier | COMPLETED | The purpose of this study is to find out if there are any patterns in the… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:31 | Détail |
| WiSE System NCT02922036 · SOLVE-CRT — Cardiac Resynchronization Therapy in Previously Untreatable and High… | Insuffisance cardiaque | À vérifier | Non applicable | ACTIVE_NOT_RECRUITING | This study is a prospective, multi-center, pivotal trial to study the safe… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:31 | Détail |
| Acetazolamide NCT05802849 · ORION-A — Acetazolamide Per os for Decompensation of Heart Failure | Insuffisance cardiaque | À vérifier | Phase 4 | COMPLETED | The main causes of chronic heart failure (CHF) are arterial hypertension a… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:30 | Détail |
| Beta-blockers NCT07298993 · Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection… | Insuffisance cardiaque | Traitement symptomatique · Thérapie génique | Phase 4 | ENROLLING_BY_INVITATION | The goal of this study is to learn whether stopping beta-blockers can help… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:30 | Détail |
| Elective redo transcatheter aortic valve implantation (redo-TAVI) NCT05601453 · The ReTAVI Prospective Observational Registry | Insuffisance cardiaque | À vérifier | À vérifier | RECRUITING | Patients with severe aortic stenosis (sAS) treated with transcatheter aort… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:30 | Détail |
| Finerenone NCT07575672 · FINE-VALUE — Finerenone in Patients Undergoing Transcatheter Aortic Valve Implan… | Insuffisance cardiaque | Traitement symptomatique | Phase 3 | RECRUITING | This study is a multicenter, double-blind, randomized, placebo-controlled… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:30 | Détail |
| High Intensity His Bundle pacing NCT05491655 · HIPPOS — High Intensity His Bundle Pacing in Heart Failure Patients With Narrow… | Insuffisance cardiaque | À vérifier | Non applicable | COMPLETED | Cardiac Resynchronization Therapy (CRT) decreases heart failure hospitaliz… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:30 | Détail |
| IVC Sensor NCT07574593 · NORM-HF Pivotal Study | Insuffisance cardiaque | Thérapie génique | Non applicable | RECRUITING | This is an international, multi-center, prospective, randomized, open-labe… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:30 | Détail |
| Resmetirom NCT07830758 · Resmetirom in Patients With MASH and HFpEF | Insuffisance cardiaque | À vérifier | Phase 1 | RECRUITING | This Phase 1b multicenter randomized double-blind placebo-controlled study… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:30 | Détail |
| Satelia® Cardio Remote Patient Monitoring System NCT07439081 · OPTIMUM Study of Remote Patient Monitoring in Ambulatory Heart Failure Care | Insuffisance cardiaque | Traitement symptomatique | Non applicable | COMPLETED | Heart failure is a leading cause of hospitalization and readmission, parti… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:30 | Détail |
| The Wise System NCT07098858 · The WiSE®-UP Study (The WiSE System Utilization & Performance Study) | Insuffisance cardiaque | À vérifier | À vérifier | RECRUITING | Observe to understand product performance, including patient safety, clini… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:30 | Détail |
| Antipac NCT06850831 · Early Intracoronary N-Acetylcysteine During Primary PCI in STEMI: A Pilot Random… | Maladie coronarienne | Neuroprotection · Immunomodulation | Phase 2 | COMPLETED | Myocardial ischemia-reperfusion injury still poses a major therapeutic cha… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:27 | Détail |
| Continuation of daily low-dose Aspirin NCT07795398 · DAN-RELEASE - Reconsidering Long-Term Aspirin in the Elderly Patients With Stabl… | Maladie coronarienne | À vérifier | Phase 4 | RECRUITING | DAN-RELEASE is a national, randomized, registry-based trial including 7,00… À vérifier | ClinicalTrials.gov 2026-10-18 04:37:27 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4871
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Effects of continuous vs. intermittent transcutaneous electrical stim… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 41866984 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of… | Cranio : the journal of craniomandibular practice 2026-11-08 04:38:07 | Source |
| Optimizing Percutaneous Tibial Nerve Stimulation Intensity for Overac… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42554545 | Maladie rénale chronique | Traitement symptomatique | Publication | PubMed | Voir la publication source Overactive bladder (OAB) is a significant global health issue. The standard percutaneous tibial nerve stimulation (PTNS… | Neuromodulation : journal of the International Neuromo… 2026-11-08 04:38:07 | Source |
| Transcutaneous auricular vagus nerve stimulation improves dysautonomi… Transcutaneous electrical nerve stimulation unit (TENS) · PMID 42802247 | Maladie rénale chronique | Immunomodulation · Traitement symptomatique | Publication | PubMed | Voir la publication source Autonomic nervous system dysfunction is highly prevalent in hypermobile Ehlers-Danlos syndrome (hEDS) and contributes s… | Neurological sciences : official journal of the Italia… 2026-11-08 04:38:07 | Source |
| Factors associated with high-flow therapy failure in COVID-19-related… Non-Invasive Positive Pressure Ventilation · PMID 42888091 | Maladie rénale chronique | Traitement symptomatique · Thérapie génique | Publication | PubMed | Voir la publication source The optimal selection of non-invasive respiratory support for patients with COVID-19-related acute hypoxemic respirator… | Enfermedades infecciosas y microbiologia clinica (Engl… 2026-11-08 04:38:06 | Source |
| High-Flow Nasal Cannula in Adult Acute Care: Physiological Mechanisms… Non-Invasive Positive Pressure Ventilation · PMID 42942512 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source High-flow nasal cannula (HFNC) oxygen therapy is widely used in emergency, intensive care, perioperative, and procedura… | Medicina (Kaunas, Lithuania) 2026-11-08 04:38:06 | Source |
| Impact of respiratory support on time to achieve full oral feeding in… Non-Invasive Positive Pressure Ventilation · PMID 42871336 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Very low birth weight infants often require respiratory support, which may delay full oral feeding. The independent rol… | Frontiers in pediatrics 2026-11-08 04:38:06 | Source |
| A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever… Thromboaspiration catheter · PMID 31243066 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Although aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series ar… | Journal of neurointerventional surgery 2026-11-08 04:38:02 | Source |
| Percutaneous Pulmonary Thrombectomy Beyond Acute Pulmonary Embolism:… Thromboaspiration catheter · PMID 38385241 | Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Subacute massive pulmonary embolism is an uncommon manifestation of severe pulmonary embolism associated with poor prog… | Journal of endovascular therapy : an official journal… 2026-11-08 04:38:02 | Source |
| Simplified classification of cavernous internal carotid artery tortuo… Thromboaspiration catheter · PMID 35475775 | Hypertension artérielle · Accident vasculaire cérébral | Thérapie génique | Publication | PubMed | Voir la publication source Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while to… | Neurological research 2026-11-08 04:38:02 | Source |
| Multifocal continuous theta burst stimulation in idiopathic generaliz… Continuous Theta Burst Stimulation (cTBS) · PMID 42731195 | Accident vasculaire cérébral | Traitement symptomatique | Publication | PubMed | Voir la publication source Idiopathic generalized epilepsy (IGE) is a disorder of the cortico-subcortical networks. Continuous theta burst stimula… | Clinical neurophysiology : official journal of the Int… 2026-11-08 04:38:00 | Source |
| Optimizing brain functional-structural architecture with cTBS to redu… Continuous Theta Burst Stimulation (cTBS) · PMID 42457860 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Alcohol use disorder (AUD) is characterized by high relapse rates, necessitating novel interventions. Continuous theta-… | Molecular psychiatry 2026-11-08 04:38:00 | Source |
| Digital Outreach to Improve Statin Refills in Patients With Low Stati… Cordio System · PMID 42667613 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems rout… | JAMA 2026-11-08 04:37:54 | Source |
| Endovascular ablation of the right greater splanchnic nerve for the m… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42257781 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often… | The Egyptian heart journal : (EHJ) : official bulletin… 2026-11-08 04:37:54 | Source |
| Incidence, medical therapy, and outcomes in heart failure with improv… Cordio System · PMID 42702264 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source To assess the incidence of heart failure with improved ejection fraction (HFimpEF) across guideline definitions (ACC/AH… | American heart journal 2026-11-08 04:37:54 | Source |
| Relationship Between the Azygos Vein and the Greater Splanchnic Nerve… Right Greater Splanchnic Nerve (GSN) ablation · PMID 42249803 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Although ablation of the greater splanchnic nerve is now being used to treat some patients with heart failure, the anat… | Clinical anatomy (New York, N.Y.) 2026-11-08 04:37:54 | Source |
| Validation of the PREVENT-HF Risk Prediction Equation in US Veterans. Cordio System · PMID 42969140 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Résumé non disponible dans la base locale. | Circulation 2026-11-08 04:37:54 | Source |
| Changes in right ventricular-pulmonary artery coupling after transcat… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42822601 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Right ventricular-pulmonary artery (RV-PA) coupling is an established marker of prognosis in mitral regurgitation (MR),… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Intraprocedural evaluation of residual mitral and tricuspid regurgita… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42982241 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Transcatheter edge-to-edge repair (TEER) has emerged as an established therapeutic option for selected patients with se… | International journal of cardiology 2026-11-08 04:37:47 | Source |
| Tricuspid transcatheter edge-to-edge repair versus transcatheter tric… Tricuspid Transcatheter Edge-to-Edge Repair (TEER) · PMID 42989943 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source Recent clinical studies of tricuspid transcatheter edge-to-edge repair (T-TEER) and transcatheter tricuspid valve repla… | Current opinion in cardiology 2026-11-08 04:37:47 | Source |
| Automated Production of Gene-Edited CAR-T Cells for People Living wit… RAPA-501 Autologous T stem cells · PMID 42847201 | Cancer | Thérapie cellulaire · Thérapie génique | Publication | PubMed | Voir la publication source Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a… | Human gene therapy 2026-11-08 04:37:39 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||