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Toutes les maladies
Un même point d’entrée pour les études cliniques, les découvertes scientifiques, les publications et les pistes exploratoires présentes dans Biomedical Watch.
Périmètre
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9643 résultats correspondants
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dans le périmètre Toutes les maladies
Niveau clinique
Études et traitements 4897
Interventions, programmes et essais cliniques rattachés au périmètre sélectionné.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Part B: TRV250 Dose 2 Étude non communiquée | Migraine | À vérifier | Phase 1 | Échec | A trial to assess the efficacy, safety, tolerability and effect of a drug… À vérifier | ClinicalTrials.gov 2021-09-20 | Détail |
| Part B: TRV250 Dose 3 Étude non communiquée | Migraine | À vérifier | Phase 1 | Échec | A trial to assess the efficacy, safety, tolerability and effect of a drug… À vérifier | ClinicalTrials.gov 2021-09-20 | Détail |
| conventional treatment plan Étude non communiquée | Maladie de Parkinson | À vérifier | NA | Terminé | To compare the effects of exer-gaming with conventional physiotherapy on b… À vérifier | ClinicalTrials.gov 2021-09-13 | Détail |
| Copaxone-Teva Étude non communiquée | Sclérose en plaques | Neuroprotection | Phase 3 | Terminé | The objective of the clinical study of the medicinal product for medical u… À vérifier | ClinicalTrials.gov 2021-09-08 | Détail |
| injectable MS DMT Étude non communiquée | Sclérose en plaques | À vérifier | Phase 4 | Terminé | The primary objective of the study is to determine if dimethyl fumarate (D… À vérifier | ClinicalTrials.gov 2021-09-03 | Détail |
| Landmark-Based Greater Occipital Nerve Block Étude non communiquée | Migraine | À vérifier | Non applicable | Terminé | This study will compare the analgesic benefit of a traditional landmark-gu… À vérifier | ClinicalTrials.gov 2021-06-14 | Détail |
| Sumatriptan Succinate Oral Tablet Étude non communiquée | Sclérose en plaques | À vérifier | Phase 4 | Terminé | Objectives: To compare the safety and efficacy of oral theophylline versus… À vérifier | ClinicalTrials.gov 2021-05-31 | Détail |
| Lumishade® Sham Lens Étude non communiquée | Migraine | Traitement symptomatique | Non applicable | UNKNOWN | This proof of concept clinical study will investigate the efficacy of acti… À vérifier | ClinicalTrials.gov 2021-05-21 | Détail |
| Sham gammaCore/electroCore Étude non communiquée | Sclérose en plaques | Immunomodulation | Phase 3 | Terminé | The tasks of the project are to map the potency and kinetics of the neurol… À vérifier | ClinicalTrials.gov 2021-05-20 | Détail |
| Nerivio Migra-1 Sham device Étude non communiquée | Migraine | Traitement symptomatique | Non applicable | Terminé | Migraine is a common neurologic with attacks of headache and associated sy… À vérifier | ClinicalTrials.gov 2021-05-17 | Détail |
| Acetaminophen Alone Étude non communiquée | Migraine | À vérifier | Phase 2 | Terminé | The study consists of a screening visit, out-patient treatment of a modera… À vérifier | ClinicalTrials.gov 2021-04-11 | Détail |
| Naltrexone Alone (regular dose) Étude non communiquée | Migraine | À vérifier | Phase 2 | Terminé | The study consists of a screening visit, out-patient treatment of a modera… À vérifier | ClinicalTrials.gov 2021-04-11 | Détail |
| Naltrexone and Acetaminophen-High Dose Étude non communiquée | Migraine | À vérifier | Phase 2 | Terminé | The study consists of a screening visit, out-patient treatment of a modera… À vérifier | ClinicalTrials.gov 2021-04-11 | Détail |
| Inactive device Étude non communiquée | Sclérose en plaques | Traitement symptomatique | Non applicable | Terminé | The researchers propose studying Gulf veterans with Gulf War Illness (GWI)… À vérifier | ClinicalTrials.gov 2021-04-09 | Détail |
| ET1402L1-ARTEMIS™ T cells -intra-hepatic artery Étude non communiquée | Cancer | Immunomodulation | Phase 1 | Terminé | Clinical study to evaluate safety (primary objectives) and efficacy (secon… À vérifier | ClinicalTrials.gov 2021-03-26 | Détail |
| ET1402L1-ARTEMIS™ T cells -Intratumoral Injections Étude non communiquée | Cancer | Immunomodulation | Phase 1 | Terminé | Clinical study to evaluate safety (primary objectives) and efficacy (secon… À vérifier | ClinicalTrials.gov 2021-03-26 | Détail |
| CHOP regimen Étude non communiquée | Sclérose en plaques | À vérifier | Phase 3 | Terminé | Randomized phase III trial to compare the effectiveness of combination che… À vérifier | ClinicalTrials.gov 2021-02-11 | Détail |
| Doxorubicin Hydrochloride Étude non communiquée | Cancer · Sclérose en plaques | À vérifier | Phase 3 | Terminé | This randomized phase II trial studies how well paclitaxel with or without… À vérifier | ClinicalTrials.gov 2021-02-11 | Détail |
| vincristine sulfate Étude non communiquée | Sclérose en plaques | À vérifier | Phase 3 | Terminé | RATIONALE: Drugs used in chemotherapy use different ways to stop cancer ce… À vérifier | ClinicalTrials.gov 2021-02-11 | Détail |
| Eletriptan 80 mg Étude non communiquée | Migraine | À vérifier | Phase 3 | Terminé | The objective of this study was to compare the efficacy, toleration and sa… À vérifier | ClinicalTrials.gov 2021-01-26 | Détail |
Découverte scientifique
Recherches et trouvailles 21
Projets précliniques, publications émergentes et programmes de recherche suivis dans le pipeline.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| 4-octyl itaconate et dérivés Dérivés de l’itaconate — neuroinflammation | Sclérose latérale amyotrophique | Neuroprotection · Immunomodulation | Découverte fondamentale | Exploratoire | Modulation immunométabolique de la microglie · NRF2 / inflammation microgl… Piste mécanistique visant à reprogrammer la réponse inflammatoire de la microglie. Le lien avec la SLA reste exploratoi… | Revue scientifique 2024-07-01 | Détail |
Bibliographie
Publications 4725
Références bibliographiques de la base locale et accès à leur source originale.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Biochemical characterization and catalytic features of a GH5 endo-β-1… isolated Ultrafiltration (iso-UF) · PMID 42561523 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Endo-β-1,4-mannanases (EC 3.2.1.78) hydrolyze β-1,4-mannan backbones, enabling the conversion of mannan-rich biomass in… | Enzyme and microbial technology 2026-10-18 04:37:54 | Source |
| Camel milk-derived extracellular vesicles using a two-step PEG precip… isolated Ultrafiltration (iso-UF) · PMID 42648587 | Maladie rénale chronique | Thérapie génique | Publication | PubMed | Voir la publication source Isolation of extracellular vesicles (EVs) from milk is technically challenging due to the presence of high concentratio… | Analytical biochemistry 2026-10-18 04:37:54 | Source |
| Effects of dapagliflozin on proteinuria, glycemic control, and treatm… Dapagliflozin 10 mg/day (oral) · PMID 42675203 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Diabetes mellitus and persistent proteinuria are major determinants of cardiovascular morbidity, graft dysfunction, and… | Acta diabetologica 2026-10-18 04:37:54 | Source |
| Orforglipron compared with dapagliflozin in adults with type 2 diabet… Dapagliflozin 10 mg/day (oral) · PMID 42259339 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Type 2 diabetes is a complex metabolic disorder often requiring combination therapy for optimal glycaemic control. This… | Lancet (London, England) 2026-10-18 04:37:54 | Source |
| Partial restoration of counterregulatory circulating glucagon by dapa… Dapagliflozin 10 mg/day (oral) · PMID 42155411 | Maladie rénale chronique | À vérifier | Publication | PubMed | Voir la publication source Hypoglycaemia, a common complication of insulin-treated diabetes, especially type 1 diabetes (T1D), is caused by impair… | EBioMedicine 2026-10-18 04:37:54 | Source |
| Baseline Sleep Efficiency and Arousal Index Do Not Predict Who Will B… Trazodone + positive airway pressure (PAP) therapy · PMID 28530153 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Positive airway pressure (PAP) is the preferred treatment for obstructive sleep apnea (OSA), but adherence is low. Educ… | Clinical EEG and neuroscience 2026-10-18 04:37:34 | Source |
| Successful treatment of auto-trilevel positive airway pressure plus t… Trazodone + positive airway pressure (PAP) therapy · PMID 37632420 | Insuffisance cardiaque | Traitement symptomatique | Publication | PubMed | Voir la publication source Obstructive sleep apnea (OSA) is a highly prevalent type of sleep-disordered breathing, which is often comorbid with af… | The Journal of international medical research 2026-10-18 04:37:34 | Source |
| A 10-year nationwide analysis of nocturnal device prescriptions for s… Oxygen + positive airway pressure (PAP) therapy · PMID 42714748 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Sleep apnea has become an increasingly important condition to address, given its growing prevalence in the general popu… | Sleep & breathing = Schlaf & Atmung 2026-10-18 04:37:33 | Source |
| Feasibility, acceptability, and usability of a novel self-monitoring… Oxygen + positive airway pressure (PAP) therapy · PMID 42549209 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Obstructive sleep apnea (OSA) is characterized by repeated airway obstruction and associated oxygen desaturation during… | Human factors in healthcare 2026-10-18 04:37:33 | Source |
| Subjective sleep quality reflects sleep continuity rather than respir… Oxygen + positive airway pressure (PAP) therapy · PMID 42526098 | Insuffisance cardiaque | À vérifier | Publication | PubMed | Voir la publication source Positive airway pressure (PAP) therapy normalizes respiratory events in obstructive sleep apnea (OSA), yet many patient… | Sleep medicine 2026-10-18 04:37:33 | Source |
| Biodistribution and Immunogenicity of Allogeneic Mesenchymal Stem Cel… Antipac · PMID 29163532 | Maladie coronarienne | Immunomodulation · Thérapie cellulaire | Publication | PubMed | Voir la publication source Xenogeneic chondrocytes and allogeneic mesenchymal stem cells (MSC) are considered a potential source of cells for arti… | Frontiers in immunology 2026-10-18 04:37:28 | Source |
| CCL17 combined with CCL19 as a nasal adjuvant enhances the immunogeni… Antipac · PMID 27546005 | Maladie coronarienne | À vérifier | Publication | PubMed | Voir la publication source CCL19 and its receptor CCR7 are essential molecules for facilitating the trafficking of mature dendritic cells (DCs) an… | Acta pharmacologica Sinica 2026-10-18 04:37:28 | Source |
| Pulsatilla Decoction and its bioactive component β-peltatin induce G2… Antipac · PMID 37246229 | Cancer | Immunomodulation | Publication | PubMed | Voir la publication source Pancreatic cancer (PAC), a malignancy that is fatal and commonly diagnosed at a late stage. Despite considerable advanc… | Chinese medicine 2026-10-18 04:37:28 | Source |
| Medical and Non-Surgical Strategies for Mild Traumatic Brain Injury. MLC901 · PMID 42111458 | Maladie coronarienne | Neuroprotection | Publication | PubMed | Voir la publication source Historically, mild traumatic brain injury (mTBI) was often overlooked. However, growing clinical consensus emphasizes t… | Korean journal of neurotrauma 2026-10-18 04:37:27 | Source |
| Research-Evidence-Practice Gaps in Post-stroke Neuro-recovery Pharmac… MLC901 · PMID 42525569 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Our recently-published systematic-search-and-review identified eight registered treatments with level A or B-R evidence… | Cerebrovascular diseases extra 2026-10-18 04:37:27 | Source |
| Review and Meta-Analyses of the Effects of MLC601/MLC901 (NeuroAiD) o… MLC901 · PMID 42646363 | Accident vasculaire cérébral | À vérifier | Publication | PubMed | Voir la publication source Post-stroke recovery varies widely, and pharmacological options to enhance rehabilitation outcomes remain limited. MLC6… | Neurology international 2026-10-18 04:37:27 | Source |
| Physical demands of hernia repair segments and the effect of exoskele… neck exoskeleton controller · PMID 42481837 | Sclérose latérale amyotrophique | À vérifier | Publication | PubMed | Voir la publication source Previous work has examined the ergonomics of surgical procedures and the effect exoskeletons may have to support surgeo… | Surgical endoscopy 2026-10-18 04:37:18 | Source |
| Preliminary Investigation of Myoelectric Control of an Assistive Neck… neck exoskeleton controller · PMID 42430317 | Sclérose latérale amyotrophique | Thérapie génique | Publication | PubMed | Voir la publication source Neck weakness limits head control and quality of life for individuals with Amyotrophic Lateral Sclerosis (ALS). The Uta… | IEEE transactions on neural systems and rehabilitation… 2026-10-18 04:37:18 | Source |
| Use of an Intraoperative Head, Neck, and Back Support Exoskeleton on… neck exoskeleton controller · PMID 40201977 | Sclérose latérale amyotrophique | Traitement symptomatique | Publication | PubMed | Voir la publication source To evaluate the effectiveness of an intraoperative exoskeleton that supports surgeons' heads, necks, and backs to reduc… | Annals of surgery 2026-10-18 04:37:18 | Source |
| Ameliorative effects of half-dose saffron and chamomile combination o… Test drug CB03-154 15mg group · PMID 36302045 | Sclérose latérale amyotrophique | Neuroprotection · Traitement symptomatique | Publication | PubMed | Voir la publication source Diabetes mellitus is a chronic metabolic disorder with an increasing prevalence worldwide. Reduction in blood insulin l… | PloS one 2026-10-18 04:37:16 | Source |
Exploration — prudence
Pistes exploratoires 0
Rapprochements mécanistiques et hypothèses de recherche : ils ne constituent pas une preuve d’efficacité ni une recommandation thérapeutique.
Hypothèses non validéesÀ confirmer par des travaux précliniques, cliniques et une revue scientifique indépendante.
| Molécule / élément | Maladie / population | Objectif | Phase / stade | Statut / preuve | Mécanisme / résumé | Source | Détail |
|---|---|---|---|---|---|---|---|
| Aucune piste exploratoire ne correspond aux filtres. | |||||||