Fiche société
University of Rochester
Traitements, essais et publications liés.
Traitements17programmes
Essais8liés
Publications13liées
SourceDBlocale
Traitements
17| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| AmlodipineThe purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta. | Hypertension, Myopathies | Phase 1 | À vérifier | United States | À vérifier |
| CoQ10The goal of this study is to assess the impact of CoQ10 and GPI 1485 on the progression of Parkinson's disease, in order to determine whether it is reasonable to proceed with further study of either of these agents. | Parkinson | Phase 2 | Ralentissement de la progression | United States | À vérifier |
| CreatineDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé. | Parkinson, Sclérose latérale amyotrophique | Phase 2 | À vérifier | United States | À vérifier |
| Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their CaregiversThe purpose of this study is to evaluate the efficacy of Dyadic Life Review (DLR) therapy for reducing caregiver distress, measured by caregiver burden to capture the multifaceted experience of distress, among older adults with advanced cancer and cognitive impairment and their caregivers. | Alzheimer | Non applicable | À vérifier | United States | À vérifier |
| GPI 1485The goal of this study is to assess the impact of CoQ10 and GPI 1485 on the progression of Parkinson's disease, in order to determine whether it is reasonable to proceed with further study of either of these agents. | Parkinson | Phase 2 | Ralentissement de la progression | United States | À vérifier |
| MinocyclineDescription non affichée : incohérence de maladie détectée. Consultez l’essai clinique officiel associé. | Parkinson, Sclérose latérale amyotrophique | Phase 2 | À vérifier | United States | À vérifier |
| REACH-DM KIDS — Remote Assessments and Genetic Determinants of Congenital and Childhood Myotonic DystrophyMyotonic dystrophy type 1 (DM1) can affect people in many different ways, even in the same family. The symptoms that children experience can be different and more severe than adults. Prior studies in children have been limited because only a small number of children could participate. In this study, we hope to learn more about these differences and what causes them. This is an observational study conducted in participants' homes and does not require travel. Instead, we will use video calls to talk with children and their parents/guardians about DM1 symptoms and how it affects the child's muscles, heart, and brain. We'll send families an iPad and the other tools they need for the study. During the video call, kids will do some simple activities to see how their body moves and functions. Parents/guardians might need to help their child with some of these activities. After the video visit, we'll get a small blood sample from the child. This can be done at a local lab or even at home. We'll then look at the child's genes in the blood sample to understand how they might be linked to their symptoms. Parents/guardians can chose to have their child's genetic test result returned to them. | Myopathies | À vérifier | Traitement symptomatique | United States | À vérifier |
| The Baby Duchenne Study: Characterizing Developmental and Clinical Outcomes in the First Three Years in Children With Duchenne Muscular DystrophyThe aim of the BABY DUCHENNE study is to evaluate the natural history and characterize the early clinical outcomes in very young children (0-3 years) with Duchenne muscular dystrophy (DMD) identified by newborn screening programs. | Myopathies | À vérifier | À vérifier | United States | À vérifier |
| Vision Training and Learning TaskThis project aims to develop a novel visual training paradigm for use in visually-intact participants and those sufferings from stroke-induced visual impairments. Our task design is built upon theories of statistical learning to reduce the overall training burden while still producing profound improvements to visual abilities. Efficacy will be first established in visually-intact controls before testing in stroke survivors to assess the feasibility of this form of learning in the damaged visual system. | Accident vasculaire cérébral | Non applicable | À vérifier | United States | À vérifier |
| MinocyclineThe objective of this study is to compare two combinations of drugs, minocycline and creatine or celecoxib and creatine, in a phase II trial designed to determine which combination is more effective for ALS. | Parkinson | Phase 2 | Neuroprotection | United States | À vérifier |
| REACH-DM KIDS — Remote Assessments and Genetic Determinants of Congenital and Childhood Myotonic DystrophyMyotonic dystrophy type 1 (DM1) can affect people in many different ways, even in the same family. The symptoms that children experience can be different and more severe than adults. Prior studies in children have been limited because only a small number of children could participate. In this study, we hope to learn more about these differences and what causes them. This is an observational study conducted in participants' homes and does not require travel. Instead, we will use video calls to talk with children and their parents/guardians about DM1 symptoms and how it affects the child's muscles, heart, and brain. We'll send families an iPad and the other tools they need for the study. During the video call, kids will do some simple activities to see how their body moves and functions. Parents/guardians might need to help their child with some of these activities. After the video visit, we'll get a small blood sample from the child. This can be done at a local lab or even at home. We'll then look at the child's genes in the blood sample to understand how they might be linked to their symptoms. Parents/guardians can chose to have their child's genetic test result returned to them. | Myopathies | À vérifier | Traitement symptomatique | United States | À vérifier |
| CreatineThe objective of this study is to compare two combinations of drugs, minocycline and creatine or celecoxib and creatine, in a phase II trial designed to determine which combination is more effective for ALS. | Parkinson | Phase 3 | À vérifier | United States, Canada | À vérifier |
| The Baby Duchenne Study: Characterizing Developmental and Clinical Outcomes in the First Three Years in Children With Duchenne Muscular DystrophyThe aim of the BABY DUCHENNE study is to evaluate the natural history and characterize the early clinical outcomes in very young children (0-3 years) with Duchenne muscular dystrophy (DMD) identified by newborn screening programs. | Myopathies | À vérifier | À vérifier | United States | À vérifier |
| Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their CaregiversThe purpose of this study is to evaluate the efficacy of Dyadic Life Review (DLR) therapy for reducing caregiver distress, measured by caregiver burden to capture the multifaceted experience of distress, among older adults with advanced cancer and cognitive impairment and their caregivers. | Alzheimer | Non applicable | À vérifier | United States | À vérifier |
| CoQ10The goal of this study is to assess the impact of CoQ10 and GPI 1485 on the progression of Parkinson's disease, in order to determine whether it is reasonable to proceed with further study of either of these agents. | Parkinson | Phase 2 | Neuroprotection + Ralentissement de la progression | United States | À vérifier |
| Vision Training and Learning TaskThis project aims to develop a novel visual training paradigm for use in visually-intact participants and those sufferings from stroke-induced visual impairments. Our task design is built upon theories of statistical learning to reduce the overall training burden while still producing profound improvements to visual abilities. Efficacy will be first established in visually-intact controls before testing in stroke survivors to assess the feasibility of this form of learning in the damaged visual system. | Accident vasculaire cérébral | Non applicable | À vérifier | United States | À vérifier |
| AmlodipineThe purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta. | Myopathies | Phase 1 | À vérifier | À vérifier |
Essais cliniques
8| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Amlodipine | Myopathies | Phase 1 | NCT07075965 | CAP DM1 — Calcium Channel Blocker in Myotonic Dystrophy Type 1 | NOT_YET_RECRUITING |
| Vision Training and Learning Task | Accident vasculaire cérébral | Non applicable | NCT06578117 | Statistical Learning as a Novel Intervention for Cortical Blindness | ACTIVE_NOT_RECRUITING |
| CoQ10 | Parkinson | Phase 2 | NCT00076492 | NINDS Parkinson's Disease Neuroprotection Trial of CoQ10 and GPI 1485 | COMPLETED |
| Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their Caregivers | Alzheimer | Non applicable | NCT07796347 | Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their Caregivers | NOT_YET_RECRUITING |
| The Baby Duchenne Study: Characterizing Developmental and Clinical Outcomes in the First Three Years in Children With Duchenne Muscular Dystrophy | Myopathies | À vérifier | NCT07092540 | The Baby Duchenne Study: Characterizing Developmental and Clinical Outcomes in the First Three Years in Children With Duchenne Muscular Dystrophy | RECRUITING |
| Creatine | Parkinson | Phase 3 | NCT00449865 | NET-PD LS-1 Creatine in Parkinson's Disease | TERMINATED |
| REACH-DM KIDS — Remote Assessments and Genetic Determinants of Congenital and Childhood Myotonic Dystrophy | Myopathies | À vérifier | NCT07630389 | REACH-DM KIDS — Remote Assessments and Genetic Determinants of Congenital and Childhood Myotonic Dystrophy | RECRUITING |
| Minocycline | Parkinson | Phase 2 | NCT00063193 | National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial | COMPLETED |
Publications
13| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Amlodipine | Design-Assisted Chemometric UV Spectrophotometric Determination of Candesartan Cilexetil, Chlorthalidone and Amlodipine Using Principal Component Regression, Partial Least Squares and Genetic Algorithm-Partial Least Squares Models. | Analytical science advances | ||
| Amlodipine | Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases. | Channels (Austin, Tex.) | ||
| Amlodipine | AI-assisted Python automation of mean-centering spectrophotometric methods with comprehensive sustainability assessment. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy | ||
| Minocycline | Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial. | European journal of psychotraumatology | ||
| Minocycline | pH-responsive injectable hydrogel dressing integrating antibacteria, antioxidation, anti-inflammation, and angiogenesis for infected wound healing. | International journal of pharmaceutics: X | ||
| Minocycline | L. (Verbenaceae) attenuates Ischemia-induced olfactory dysfunction by targeting the α7 nAChR allosteric site and mitigating oxidative-inflammatory cascades in the rat olfactory-memory axis. | IBRO neuroscience reports | ||
| Creatine | Real-world creatine supplementation: a large-scale cross-sectional study of use, knowledge, and experiences. | Journal of the International Society of Sports Nutrition | ||
| Creatine | Delaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition. | Journal of the International Society of Sports Nutrition | ||
| Creatine | Shuxin oral liquid attenuates isoproterenol-induced myocardial fibrosis in rats: Association with downregulation of the TGF-β/Smad signaling pathway. | Journal of ethnopharmacology | ||
| Minocycline | Tolerability, Drug Utilization Pattern and Effectiveness of Minocycline Oral Formulations in India: A Real-World Retrospective Study from Electronic Medical Records. | Drugs - real world outcomes | ||
| Minocycline | Balancing Act: Dual targeting of PhoPQ and QseBC two-component systems in Edwardsiella tarda enhances attenuation but diminishes protective immunity. | Microbial pathogenesis | ||
| Creatine | Metabolomic Insights on Obesity and Diabetes from Feeding Diets Varying in Carbohydrate-Fat Ratios in Zucker Diabetic Fatty (ZDF) and Lean Zucker (Z) Rats. | International journal of molecular sciences | ||
| Creatine | Delayed Serum Creatine Kinase Elevation After Snakebite: Serial Changes and Clinical Correlates of Myotoxicity in a Korean Tertiary-Care Cohort. | Journal of clinical medicine |