University of Louisville — Biomedical Watch V2

Traitements7programmes

Essais4liés

Publications6liées

SourceDBlocale

Traitements

7

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
FOLFIRINOXCompare the efficacy and tolerability of IRE in combination with either FOLFIRINOX or gemcitabine in patients with locally advanced pancreatic cancer.	Cancer	Phase 1	À vérifier	United States	À vérifier
GemcitabineThe goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).	Cancer, Parkinson	Phase 1	À vérifier	United States	À vérifier
Irreversible Electroporation (IRE)Most prostate cancer treatment research in the last decade has been focused on trying to improve quality of life, while maintaining a high level of cancer control. However, the concept of Focal treatment is proposed as an intermediate option between active surveillance and treatment of the whole prostate. Focal ablation aims to efficiently treat the localized cancer while reducing complications related to standard treatments, including the risks of incontinence and impotence. Focal Irreversible Electroporation (IRE) delivered by NanoKnife System is composed of the NanoKnife Generator and NanoKnife Single Electrode Probes. With IRE, an electrical current is delivered between a pair of probes in a series of pulses. These pulses create irreversible pores in cell membranes and lead to cell death which allow for only the tissue between these probes being destroyed. The aim of this study is to analyze the safety and efficacy of transperineal IRE treatments in intermediate risk anteriorly localized prostate cancer patients.	Cancer	Phase 1	À vérifier	United States	À vérifier
Irreversible Electroporation (IRE)Most prostate cancer treatment research in the last decade has been focused on trying to improve quality of life, while maintaining a high level of cancer control. However, the concept of Focal treatment is proposed as an intermediate option between active surveillance and treatment of the whole prostate. Focal ablation aims to efficiently treat the localized cancer while reducing complications related to standard treatments, including the risks of incontinence and impotence. Focal Irreversible Electroporation (IRE) delivered by NanoKnife System is composed of the NanoKnife Generator and NanoKnife Single Electrode Probes. With IRE, an electrical current is delivered between a pair of probes in a series of pulses. These pulses create irreversible pores in cell membranes and lead to cell death which allow for only the tissue between these probes being destroyed. The aim of this study is to analyze the safety and efficacy of transperineal IRE treatments in intermediate risk anteriorly localized prostate cancer patients.	Cancer	Non applicable	À vérifier		À vérifier
Irreversible Electroporation (IRE)Most prostate cancer treatment research in the last decade has been focused on trying to improve quality of life, while maintaining a high level of cancer control. However, the concept of Focal treatment is proposed as an intermediate option between active surveillance and treatment of the whole prostate. Focal ablation aims to efficiently treat the localized cancer while reducing complications related to standard treatments, including the risks of incontinence and impotence. Focal Irreversible Electroporation (IRE) delivered by NanoKnife System is composed of the NanoKnife Generator and NanoKnife Single Electrode Probes. With IRE, an electrical current is delivered between a pair of probes in a series of pulses. These pulses create irreversible pores in cell membranes and lead to cell death which allow for only the tissue between these probes being destroyed. The aim of this study is to analyze the safety and efficacy of transperineal IRE treatments in intermediate risk anteriorly localized prostate cancer patients.	Cancer	Non applicable	À vérifier	Netherlands	À vérifier
GemcitabineThe goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).	Cancer	Phase 2	À vérifier	Germany	À vérifier
Irreversible Electroporation (IRE)Most prostate cancer treatment research in the last decade has been focused on trying to improve quality of life, while maintaining a high level of cancer control. However, the concept of Focal treatment is proposed as an intermediate option between active surveillance and treatment of the whole prostate. Focal ablation aims to efficiently treat the localized cancer while reducing complications related to standard treatments, including the risks of incontinence and impotence. Focal Irreversible Electroporation (IRE) delivered by NanoKnife System is composed of the NanoKnife Generator and NanoKnife Single Electrode Probes. With IRE, an electrical current is delivered between a pair of probes in a series of pulses. These pulses create irreversible pores in cell membranes and lead to cell death which allow for only the tissue between these probes being destroyed. The aim of this study is to analyze the safety and efficacy of transperineal IRE treatments in intermediate risk anteriorly localized prostate cancer patients.	Cancer	Phase 1	À vérifier	United States	À vérifier

Essais cliniques

4

Molécule	Indication / population	Phase	NCT	Titre	Statut
Irreversible Electroporation (IRE)	Cancer	Phase 1	NCT03484299	Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma	RECRUITING
Gemcitabine	Cancer	Phase 2	NCT06440993	Durvalumab + Intraductal Radiofrequency Ablation (ID-RFA) in Extra- and Intrahepatic Cholangiocarcinoma	RECRUITING
Irreversible Electroporation (IRE)	Cancer	Non applicable	NCT02791503	CROSSFIRE Trial: Comparing the Efficacy of Irreversible Electroporation With Radiotherapy	COMPLETED
Irreversible Electroporation (IRE)	Cancer	Non applicable	NCT05512663	Safety and Efficacy Evaluation of Transperineal Irreversible Electroporation (IRE) of Anterior Prostate Cancer	UNKNOWN

Publications

6

Molécule	Indication / population	Titre	Journal	Date
Irreversible Electroporation (IRE)		Prostate imaging after focal ablation scoring after irreversible electroporation treatment in localized prostate cancer: Diagnostic accuracy and inter-reader agreement.	European journal of radiology
Irreversible Electroporation (IRE)		Contrast-enhanced ultrasound as a problem-solving tool and irreversible electroporation for a perivascular/peribiliary segment IVs colorectal liver metastasis: a case report.	Radiology case reports
Irreversible Electroporation (IRE)		Oncologic and functional outcomes of novel focal therapy methods for low-risk to intermediate-risk prostate cancer.	Current opinion in urology
Gemcitabine		Stress-specific 14-3-3-client modules in digestive cancers: an evidence-graded review of adaptive survival and therapy resistance.	Cancer biology & therapy
Gemcitabine		Cost-effectiveness analysis of liposomal Irinotecan in combination with oxaliplatin, 5-fluorouracil and leucovorin (NALIRIFOX) for the first-line treatment of adult patients with metastatic adenocarcinoma of the pancreas in Greece.	Expert review of pharmacoeconomics & outcomes research
Gemcitabine		Rosmarinic Acid Sensitizes Ovarian Cancer Cells to Gemcitabine Through Oxidative Stress-Associated Apoptotic and Antiproliferative Responses.	International journal of molecular sciences