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Ohio State University Comprehensive Cancer Center
Traitements, essais et publications liés.
Traitements11programmes
Essais8liés
Publications23liées
SourceDBlocale
Traitements
11| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| Breast Cancer SurgeryThis study will evaluate the efficacy and non-inferiority of a non-surgical approach for the treatment of patients with locally advanced breast cancer. | Cancer | Phase 1/2 | À vérifier | United States | À vérifier |
| MRIThe cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology. Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy). | Cancer, Épilepsie, Migraine, Myopathies, Sclérose latérale amyotrophique, SEP | Phase 1/2 | Remyélinisation | United States | À vérifier |
| Neoadjuvant ChemotherapyThis study will evaluate the efficacy and non-inferiority of a non-surgical approach for the treatment of patients with locally advanced breast cancer. | Cancer | Phase 1/2 | À vérifier | United States | À vérifier |
| radiation therapyThis phase II trial studies nab-paclitaxel (paclitaxel albumin-stabilized nanoparticle formulation) and carboplatin followed by response-based local therapy in treating patients with stage III or IV human papillomavirus (HPV)-related oropharyngeal cancer. Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, carboplatin, hydroxyurea, fluorouracil, paclitaxel, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them spreading. Radiation therapy uses high energy x rays to kill tumor cells. Giving nab-paclitaxel and carboplatin before chemoradiation may make the tumor smaller and reduce the amount of chemotherapy and radiation therapy needed. Assigning chemotherapy and radiation therapy based on response (response-based therapy) and giving patients who are responding well lower doses of treatment may help reduce the occurrence of side effects. | Cancer | Phase 1/2 | À vérifier | United States | À vérifier |
| MRIThe cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology. Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy). | Myopathies | À vérifier | Remyélinisation | France | À vérifier |
| MRIThe cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology. Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy). | Épilepsie | À vérifier | Remyélinisation | United States | À vérifier |
| MRIThe cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology. Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy). | Migraine | Non applicable | Remyélinisation | United States | À vérifier |
| MRIThe cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology. Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy). | Sclérose latérale amyotrophique | À vérifier | Remyélinisation | United Kingdom | À vérifier |
| MRIThe cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology. Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy). | SEP | Non applicable | Remyélinisation | Spain | À vérifier |
| MRIThe cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology. Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy). | Cancer | Non applicable | Remyélinisation | Brazil | À vérifier |
| Neoadjuvant ChemotherapyThis study will evaluate the efficacy and non-inferiority of a non-surgical approach for the treatment of patients with locally advanced breast cancer. | Cancer | Phase 1/2 | À vérifier | United States | À vérifier |
Essais cliniques
8| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Neoadjuvant Chemotherapy | Cancer | Phase 1/2 | NCT07217990 | NoCUT-BC — Neoadjuvant Complete Response Customized Treatment Approach for Definitive Management of Breast Cancer | NOT_YET_RECRUITING |
| MRI | Cancer | Non applicable | NCT02798796 | BREAST-MRI — Brazilian Randomized Study - Impact of MRI for Breast Cancer | COMPLETED |
| MRI | SEP | Non applicable | NCT07037966 | Advancing Portable Brain Imaging: The NextMRI Project's Role in Revolutionizing Diagnostic MRI | COMPLETED |
| MRI | Sclérose latérale amyotrophique | À vérifier | NCT07818772 | 7T Imaging Pilot-study in Patients With Motor Neuron Disease to Find Non-Invasive Disease Imaging Biomarkers | RECRUITING |
| Biospecimen Collection | Cancer | À vérifier | NCT07795411 | Prospective Multiomic Analysis in Small-Cell Lung Cancer | NOT_YET_RECRUITING |
| MRI | Migraine | Non applicable | NCT05654012 | Migraine in Adolescents | RECRUITING |
| MRI | Épilepsie | À vérifier | NCT02107989 | Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database | RECRUITING |
| MRI | Myopathies | À vérifier | NCT04656210 | Myotonic Dystrophy - Vascular and Cognition | ACTIVE_NOT_RECRUITING |
Publications
23| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| radiation therapy | Immunogenicity of neoantigens from hepatocellular carcinoma patients treated with a combined radioimmunotherapy. | Oncoimmunology | ||
| radiation therapy | Local delivery of SBRT and IL-12 to murine PDAC tumors modulates hematopoiesis. | Oncoimmunology | ||
| radiation therapy | Autonomous radiotherapy planning via agentic orchestration using a multimodal TPS-integrated compound AI platform. | Machine learning. Health | ||
| MRI | Brain iron deposition mediates cognitive impairment in COPD: A possible imaging marker linking systemic inflammation to neurodegeneration. | Pulmonology | ||
| MRI | Extraperitoneal Single-Port Robotic-Assisted Radical Cystectomy with Orthotopic Ne-obladder: Technique and Surgical Considerations. | International braz j urol : official journal of the Brazilian Society of Urology | ||
| MRI | New pulse sequence for improving cardiac black-blood and PSIR MRI quality in cases of arrhythmia. | Magnetic resonance letters | ||
| radiation therapy | Current Approaches and Emerging Strategies in the Treatment of Peritoneal Carcinomatosis. | International journal of molecular sciences | ||
| radiation therapy | Patients with cardiac implantable electronic devices undergoing radiation therapy for cancer or magnetic resonance imaging. | Kardiologia polska | ||
| MRI | Deep learning segmentation with uncertainty quantification for spinal tuberculosis on fat-suppressed T2-weighted MRI. | Frontiers in physiology | ||
| MRI | Validation of open-source deep learning segmentation tools for automated glioma volumetry: a narrative review of Dice scores, workflow efficiency, and clinical RANO 2.0 implementation. | Frontiers in neurology | ||
| radiation therapy | A human iPSC-derived 3D spinal cord organoid model to study radiation-induced neural injury. | Stem cells translational medicine | ||
| radiation therapy | Tumefactive demyelinating disorders as neoplasm mimics: description of a typical case and literature review. | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | ||
| radiation therapy | ESTRO clinical practice guideline on high-dose thoracic reirradiation for non-small cell lung cancer. | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology | ||
| radiation therapy | RAS signaling at the crossroads of radioresistance and tumor immunity. | Journal for immunotherapy of cancer | ||
| radiation therapy | Effects of dose heterogeneity on response and toxicity after Y-SIRT for HCC. | European journal of nuclear medicine and molecular imaging | ||
| MRI | Standardized Acquisition of Fetal Cardiac Cine MRI: A Practical Guide. | Circulation. Cardiovascular imaging | ||
| MRI | Leukocyte Telomere Length and Cross-Sectional and Longitudinal Variations in Gray Matter Volume and Cortical Thickness. | Brain and behavior | ||
| MRI | Limited Contribution of T Relaxation to GluCEST MRI Signal Differences Across Four Rat Models with Distinct Pathophysiological Features. | Molecular imaging and biology | ||
| MRI | Outcomes of Neoadjuvant Radiotherapy Followed by Robotic Radical Prostatectomy in High-Risk Locally Advanced Prostate Cancer: A Prospective Pilot Study. | Annals of surgical oncology | ||
| radiation therapy | AI-surrogate structure and dose correlation for left anterior descending artery in lung stereotactic body radiotherapy. | Journal of applied clinical medical physics | ||
| radiation therapy | Same-day Hyaluronic Acid rectal spacer for TRUS-guided HDR Prostate Brachytherapy: Feasibility and dosimetric outcomes. | Journal of applied clinical medical physics | ||
| radiation therapy | Comparative outcomes of proton and photon therapy in the management of malignant peripheral nerve sheath tumors. | European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society | ||
| radiation therapy | CBCT based online daily adaptive treatment improves target coverage with limited benefit for OAR protection in SBRT prostate cancer. | Radiation oncology (London, England) |