Medical University of Graz — Biomedical Watch V2

Traitements8programmes

Essais4liés

Publications5liées

SourceDBlocale

Traitements

8

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
CardioWatch 287-2 GroupEarly detection of atrial fibrillation detected after stroke (AFDAS) is crucial for secondary stroke prevention, as initiating direct oral anticoagulants (DOACs) can reduce atrial fibrillation (AF)-related stroke risk by up to 60%. In cryptogenic stroke (CS), AFDAS likely represents the most frequent underlying etiology, yet paroxysmal and short-duration AF episodes often elude standard monitoring. The Graz AF Risk Score, implemented across all Neurology Departments in Styria, Austria, stratifies patients into tailored monitoring pathways but remains limited by delays in implantable loop recorder (ILR) implantation, patient refusal, and restricted access to early ambulatory ECG monitoring. The study aims to close diagnostic gaps in the current AF detection pathway by implementing a non-invasive, wrist-worn photoplethysmography (PPG) device (i.e., CardioWatch 287-2 \[CW2\]) for early cardiac rhythm monitoring in CS patients. Methods: CATCH-AF is an investigator-initiated, prospective, longitudinal, multi-center, pre-post interventional study including all CS patients admitted to one of five Styrian Neurology Departments. In the pre-intervention phase, AF detection will follow the established Graz AF Risk Score-based algorithm. In the intervention phase, CardioWatch 287-2 screening will replace Holter-ECG screening in moderate-risk patients and will be used for high-risk patients with delayed or declined ILR implantation. Suspected AF episodes will be confirmed by ECG- based assessment at the discretion of the treating cardiologist. The primary endpoint isAFDAS detection at 3 months; secondary endpoints include AFDAS at 12 months, time to AF detection and DOAC initiation, cerebrovascular event recurrence, cardiovascular death, and all-cause mortality at 3 and 12 months. Data will be collected via REDCap and analyzed using descriptive, univariable, and multivariable regression methods, adjusted for confounders with inverse probability of treatment weighting. The investigators hypothesize that CardioWatch 287-2 implementation will increase early AFDAS detection and reduce diagnostic and therapeutic delays, potentially lowering recurrent cerebrovascular events and mortality over 12 months. CATCH-AF represents the first European, population-wide evaluation of a wrist-worn PPG device integrated into an established AF detection pathway for cryptogenic stroke, aiming to improve early diagnosis, treatment initiation and secondary prevention outcomes.	Accident vasculaire cérébral	Non applicable	À vérifier	Austria	À vérifier
isolated Ultrafiltration (iso-UF)Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients. Intradialytic hypotension (IDH), which is an independent risk factor for mortality, occurs in up to 20% of hemodialysis session and may lead to myocardial stunning and cerebral ischemia resulting in increased white matter lesions, gastrointestinal ischemia and shunt vessel thrombosis. Due to the deleterious effects of IDH during HD, preventive measurements such as limiting interdialytic weight gain are recommended, but frequently fluid and salt restriction are not adhered to, thus increasing dialysis time or frequency of treatments is a common strategy in those patients.	Maladie rénale chronique	Non applicable	À vérifier	Austria	À vérifier
LAACLeft atrial appendage (LAA) occlusion (LAAC) has been introduced to treat patients with indication of oral anticoagulation (OAC) for atrial fibrillation (AF) with contraindication to OAC. This registry aims to document all LAAC procedures in Austria.	Maladie coronarienne	À vérifier	À vérifier	Austria	À vérifier
The Effect of Alcohol on Common Tremor SyndromesThe aim of this interventional study is to compare the response to alcohol in patients with essential tremor (ET), essential tremor plus (ETplus), dystonic tremor (DT), tremor associated with dystonia (TaD) and tremor in Parkinson´s disease (PD). The main question to be answered is: • Is there a difference in the objective alcohol responsiveness of patients with ET, DT, TaD and PD? Participants will receive either vodka with rum-flavoured orange juice with a target blood alcohol of 0.4 ‰ or a non-alcoholic rum-flavoured orange juice (vice versa on the second study day). Before and 30, 60 an 120 minutes after the study drink the participants will undergo a clinical examination of the tremor and accelerometry will be performed. Researchers will compare alcohol and placebo in a randomized cross over way to see if the effect of alcohol on tremor exceeds the placebo effect.	Parkinson	NA	À vérifier	Austria	À vérifier
The Effect of Alcohol on Common Tremor SyndromesThe aim of this interventional study is to compare the response to alcohol in patients with essential tremor (ET), essential tremor plus (ETplus), dystonic tremor (DT), tremor associated with dystonia (TaD) and tremor in Parkinson´s disease (PD). The main question to be answered is: • Is there a difference in the objective alcohol responsiveness of patients with ET, DT, TaD and PD? Participants will receive either vodka with rum-flavoured orange juice with a target blood alcohol of 0.4 ‰ or a non-alcoholic rum-flavoured orange juice (vice versa on the second study day). Before and 30, 60 an 120 minutes after the study drink the participants will undergo a clinical examination of the tremor and accelerometry will be performed. Researchers will compare alcohol and placebo in a randomized cross over way to see if the effect of alcohol on tremor exceeds the placebo effect.	Parkinson	NA	À vérifier	Austria	À vérifier
LAACLeft atrial appendage (LAA) occlusion (LAAC) has been introduced to treat patients with indication of oral anticoagulation (OAC) for atrial fibrillation (AF) with contraindication to OAC. This registry aims to document all LAAC procedures in Austria.	Maladie coronarienne	À vérifier	À vérifier	Austria	À vérifier
isolated Ultrafiltration (iso-UF)Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients. Intradialytic hypotension (IDH), which is an independent risk factor for mortality, occurs in up to 20% of hemodialysis session and may lead to myocardial stunning and cerebral ischemia resulting in increased white matter lesions, gastrointestinal ischemia and shunt vessel thrombosis. Due to the deleterious effects of IDH during HD, preventive measurements such as limiting interdialytic weight gain are recommended, but frequently fluid and salt restriction are not adhered to, thus increasing dialysis time or frequency of treatments is a common strategy in those patients.	Maladie rénale chronique	Non applicable	À vérifier	Austria	À vérifier
CardioWatch 287-2 GroupEarly detection of atrial fibrillation detected after stroke (AFDAS) is crucial for secondary stroke prevention, as initiating direct oral anticoagulants (DOACs) can reduce atrial fibrillation (AF)-related stroke risk by up to 60%. In cryptogenic stroke (CS), AFDAS likely represents the most frequent underlying etiology, yet paroxysmal and short-duration AF episodes often elude standard monitoring. The Graz AF Risk Score, implemented across all Neurology Departments in Styria, Austria, stratifies patients into tailored monitoring pathways but remains limited by delays in implantable loop recorder (ILR) implantation, patient refusal, and restricted access to early ambulatory ECG monitoring. The study aims to close diagnostic gaps in the current AF detection pathway by implementing a non-invasive, wrist-worn photoplethysmography (PPG) device (i.e., CardioWatch 287-2 \[CW2\]) for early cardiac rhythm monitoring in CS patients. Methods: CATCH-AF is an investigator-initiated, prospective, longitudinal, multi-center, pre-post interventional study including all CS patients admitted to one of five Styrian Neurology Departments. In the pre-intervention phase, AF detection will follow the established Graz AF Risk Score-based algorithm. In the intervention phase, CardioWatch 287-2 screening will replace Holter-ECG screening in moderate-risk patients and will be used for high-risk patients with delayed or declined ILR implantation. Suspected AF episodes will be confirmed by ECG- based assessment at the discretion of the treating cardiologist. The primary endpoint isAFDAS detection at 3 months; secondary endpoints include AFDAS at 12 months, time to AF detection and DOAC initiation, cerebrovascular event recurrence, cardiovascular death, and all-cause mortality at 3 and 12 months. Data will be collected via REDCap and analyzed using descriptive, univariable, and multivariable regression methods, adjusted for confounders with inverse probability of treatment weighting. The investigators hypothesize that CardioWatch 287-2 implementation will increase early AFDAS detection and reduce diagnostic and therapeutic delays, potentially lowering recurrent cerebrovascular events and mortality over 12 months. CATCH-AF represents the first European, population-wide evaluation of a wrist-worn PPG device integrated into an established AF detection pathway for cryptogenic stroke, aiming to improve early diagnosis, treatment initiation and secondary prevention outcomes.	Accident vasculaire cérébral	Non applicable	À vérifier	Austria	À vérifier

Essais cliniques

4

Molécule	Indication / population	Phase	NCT	Titre	Statut
CardioWatch 287-2 Group	Accident vasculaire cérébral	Non applicable	NCT07899788	CATCH-AF — CATCH AF - Atrial Fibrillation Detection in Cryptogenic Stroke	NOT_YET_RECRUITING
isolated Ultrafiltration (iso-UF)	Maladie rénale chronique	Non applicable	NCT05642156	ISO-UF — Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis	RECRUITING
LAAC	Maladie coronarienne	À vérifier	NCT03409159	Austrian Left Atrial Appendage Closure Registry	RECRUITING
The Effect of Alcohol on Common Tremor Syndromes	Parkinson	NA	NCT06403280	The Effect of Alcohol on Common Tremor Syndromes	COMPLETED

Publications

5

Molécule	Indication / population	Titre	Journal	Date
isolated Ultrafiltration (iso-UF)		Biochemical characterization and catalytic features of a GH5 endo-β-1,4-mannanase from Aspergillus niger code 1234.	Enzyme and microbial technology
isolated Ultrafiltration (iso-UF)		Camel milk-derived extracellular vesicles using a two-step PEG precipitation strategy.	Analytical biochemistry
The Effect of Alcohol on Common Tremor Syndromes		Associations of ADH1B and ALDH2 genotypes and alcohol flushing with drinking history, withdrawal symptoms, and ICD-10 criteria in Japanese alcohol-dependent men.	Pharmacogenetics and genomics
The Effect of Alcohol on Common Tremor Syndromes		Manifestations of potential xylazine withdrawal: A retrospective cohort study with nested case series.	Drug and alcohol dependence
The Effect of Alcohol on Common Tremor Syndromes		Alcohol withdrawal syndrome in hospitalized patients: a practical review.	European journal of internal medicine