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Chinese PLA General Hospital
Traitements, essais et publications liés.
Traitements17programmes
Essais8liés
Publications30liées
SourceDBlocale
Traitements
17| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| CamrelizumabThis is a Phase II clinical trial for Decitabine plus Camrelizumab resistant/relapsed patients with Hodgkin Lymphoma. The purpose is to evaluate the efficacy and safety of the combination therapy of Chidamide plus Decitabine Plus Camrelizumab. | Cancer | Phase 2 | À vérifier | China | À vérifier |
| ChidamideThis is a Phase II clinical trial for Decitabine plus Camrelizumab resistant/relapsed patients with Hodgkin Lymphoma. The purpose is to evaluate the efficacy and safety of the combination therapy of Chidamide plus Decitabine Plus Camrelizumab. | Cancer | Phase 2 | À vérifier | China | À vérifier |
| CT-guided percutaneous radiofrequency ablationThe objective of this study is to evaluate the outcomes of radiofrequency ablation in the treatment of patients with malignant pulmonary nodules（not exceed 3cm ）who are not suitable candidates for or refuse surgical resection. | Cancer | Non applicable | À vérifier | China | À vérifier |
| DecitabineThis is a Phase II clinical trial for Decitabine plus Camrelizumab resistant/relapsed patients with Hodgkin Lymphoma. The purpose is to evaluate the efficacy and safety of the combination therapy of Chidamide plus Decitabine Plus Camrelizumab. | Cancer | Phase 2 | À vérifier | China | À vérifier |
| Low-Intensity Focused Ultrasound StimulationChronic migraine is a disabling neurological disorder characterized by frequent headache attacks and significant impairment of quality of life. Low-intensity focused ultrasound (LIFUS) is a non-invasive neuromodulation technique that can precisely target deep brain regions. This study aims to evaluate the efficacy, safety, and tolerability of LIFUS targeting the left dorsolateral prefrontal cortex (DLPFC) for preventive treatment of chronic migraine in adults. This is a randomized, single-blind, sham-controlled clinical trial. Eligible participants with chronic migraine will be randomly assigned to receive either active LIFUS stimulation targeting the left DLPFC or sham stimulation. Participants will receive 10 stimulation sessions over 2 weeks and will be followed for 3 months after intervention. The primary outcome is the change in monthly migraine days from baseline to 1 month after intervention. Secondary and exploratory outcomes include headache-related disability, quality of life, psychological assessments, electrophysiological measurements, neuroimaging changes, and safety outcomes. | Migraine | Non applicable | À vérifier | China | À vérifier |
| Microwave Thermal guided by Plan for Microwave Thermal Field systemDevelop an intelligent system based on contrast-enhanced ultrasound and clinical information to help doctors automatically obtain ablation parameters (ablation needle number, ablation needle type, ablation time,ablation power) when preparing to use microwave ablation to treat hepatocellular carcinoma | Cancer | Non applicable | À vérifier | China | À vérifier |
| Rimegepant 75 mg ODTThis is a multicenter, single-arm, open-label Phase 4 study evaluating the safety and tolerability of rimegepant 75 mg orally disintegrating tablet (ODT) for the acute treatment of migraine (with or without aura) in adult patients in India who have had an insufficient response, intolerance, or contraindication to triptans. It will enroll approximately 60 participants. | Migraine | Non applicable | À vérifier | China | À vérifier |
| Sham Low-Intensity Focused Ultrasound StimulationChronic migraine is a disabling neurological disorder characterized by frequent headache attacks and significant impairment of quality of life. Low-intensity focused ultrasound (LIFUS) is a non-invasive neuromodulation technique that can precisely target deep brain regions. This study aims to evaluate the efficacy, safety, and tolerability of LIFUS targeting the left dorsolateral prefrontal cortex (DLPFC) for preventive treatment of chronic migraine in adults. This is a randomized, single-blind, sham-controlled clinical trial. Eligible participants with chronic migraine will be randomly assigned to receive either active LIFUS stimulation targeting the left DLPFC or sham stimulation. Participants will receive 10 stimulation sessions over 2 weeks and will be followed for 3 months after intervention. The primary outcome is the change in monthly migraine days from baseline to 1 month after intervention. Secondary and exploratory outcomes include headache-related disability, quality of life, psychological assessments, electrophysiological measurements, neuroimaging changes, and safety outcomes. | Migraine | Non applicable | À vérifier | China | À vérifier |
| Ultrasound-guided Serratus Anterior Plane Block with Normal SalineCoronary artery bypass surgery is an important treatment method for severe coronary heart disease. Among them, minimally invasive bypass surgery, although having less trauma, requires a small incision on the left chest. During the operation, the ribs need to be opened and the muscles of the chest wall pulled, which is prone to causing intercostal nerve damage. Therefore, many patients still experience severe incision pain and chest wall pain after the surgery. This study adopted the "Serratus Anterior Plane Block", which is a regional anesthesia technique. The doctor will inject the anesthetic drug into the gap near the pectoralis major muscle (a muscle located on the side of the chest) under ultrasound guidance. This technique can effectively block the nerves that transmit pain signals, thereby providing good analgesic effects for the anterior lateral chest wall and helping patients alleviate postoperative pain. | Maladie coronarienne | Non applicable | Traitement symptomatique | À vérifier | |
| Ultrasound-guided Serratus Anterior Plane Block with RopivacaineCoronary artery bypass surgery is an important treatment method for severe coronary heart disease. Among them, minimally invasive bypass surgery, although having less trauma, requires a small incision on the left chest. During the operation, the ribs need to be opened and the muscles of the chest wall pulled, which is prone to causing intercostal nerve damage. Therefore, many patients still experience severe incision pain and chest wall pain after the surgery. This study adopted the "Serratus Anterior Plane Block", which is a regional anesthesia technique. The doctor will inject the anesthetic drug into the gap near the pectoralis major muscle (a muscle located on the side of the chest) under ultrasound guidance. This technique can effectively block the nerves that transmit pain signals, thereby providing good analgesic effects for the anterior lateral chest wall and helping patients alleviate postoperative pain. | Maladie coronarienne | Non applicable | Traitement symptomatique | À vérifier | |
| ChidamideThis is a Phase II clinical trial for Decitabine plus Camrelizumab resistant/relapsed patients with Hodgkin Lymphoma. The purpose is to evaluate the efficacy and safety of the combination therapy of Chidamide plus Decitabine Plus Camrelizumab. | Cancer | Phase 2 | À vérifier | China | À vérifier |
| Rimegepant 75 mg ODTThis is a multicenter, single-arm, open-label Phase 4 study evaluating the safety and tolerability of rimegepant 75 mg orally disintegrating tablet (ODT) for the acute treatment of migraine (with or without aura) in adult patients in India who have had an insufficient response, intolerance, or contraindication to triptans. It will enroll approximately 60 participants. | Migraine | Phase 4 | À vérifier | India | À vérifier |
| CT-guided percutaneous radiofrequency ablationThe objective of this study is to evaluate the outcomes of radiofrequency ablation in the treatment of patients with malignant pulmonary nodules（not exceed 3cm ）who are not suitable candidates for or refuse surgical resection. | Cancer | Non applicable | À vérifier | China | À vérifier |
| Low-Intensity Focused Ultrasound StimulationChronic migraine is a disabling neurological disorder characterized by frequent headache attacks and significant impairment of quality of life. Low-intensity focused ultrasound (LIFUS) is a non-invasive neuromodulation technique that can precisely target deep brain regions. This study aims to evaluate the efficacy, safety, and tolerability of LIFUS targeting the left dorsolateral prefrontal cortex (DLPFC) for preventive treatment of chronic migraine in adults. This is a randomized, single-blind, sham-controlled clinical trial. Eligible participants with chronic migraine will be randomly assigned to receive either active LIFUS stimulation targeting the left DLPFC or sham stimulation. Participants will receive 10 stimulation sessions over 2 weeks and will be followed for 3 months after intervention. The primary outcome is the change in monthly migraine days from baseline to 1 month after intervention. Secondary and exploratory outcomes include headache-related disability, quality of life, psychological assessments, electrophysiological measurements, neuroimaging changes, and safety outcomes. | Migraine | Non applicable | À vérifier | China | À vérifier |
| Microwave Thermal guided by Plan for Microwave Thermal Field systemDevelop an intelligent system based on contrast-enhanced ultrasound and clinical information to help doctors automatically obtain ablation parameters (ablation needle number, ablation needle type, ablation time,ablation power) when preparing to use microwave ablation to treat hepatocellular carcinoma | Cancer | Non applicable | À vérifier | China | À vérifier |
| Ultrasound-guided Serratus Anterior Plane Block with RopivacaineCoronary artery bypass surgery is an important treatment method for severe coronary heart disease. Among them, minimally invasive bypass surgery, although having less trauma, requires a small incision on the left chest. During the operation, the ribs need to be opened and the muscles of the chest wall pulled, which is prone to causing intercostal nerve damage. Therefore, many patients still experience severe incision pain and chest wall pain after the surgery. This study adopted the "Serratus Anterior Plane Block", which is a regional anesthesia technique. The doctor will inject the anesthetic drug into the gap near the pectoralis major muscle (a muscle located on the side of the chest) under ultrasound guidance. This technique can effectively block the nerves that transmit pain signals, thereby providing good analgesic effects for the anterior lateral chest wall and helping patients alleviate postoperative pain. | Maladie coronarienne | Non applicable | Traitement symptomatique | À vérifier | |
| Rimegepant 75 mg ODTThis is a multicenter, single-arm, open-label Phase 4 study evaluating the safety and tolerability of rimegepant 75 mg orally disintegrating tablet (ODT) for the acute treatment of migraine (with or without aura) in adult patients in India who have had an insufficient response, intolerance, or contraindication to triptans. It will enroll approximately 60 participants. | Migraine | Non applicable | À vérifier | China | À vérifier |
Essais cliniques
8| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Rimegepant 75 mg ODT | Migraine | Non applicable | NCT07918053 | NIGHTCAP — A Prospective Study of Rimegepant for Short-term Preventive Treatment of Night-shift-related Migraine in Healthcare Professionals | NOT_YET_RECRUITING |
| Ultrasound-guided Serratus Anterior Plane Block with Ropivacaine | Maladie coronarienne | Non applicable | NCT07877532 | Serratus Anterior Plane Block for Recovery After Minimally Invasive CABG | NOT_YET_RECRUITING |
| Microwave Thermal guided by Plan for Microwave Thermal Field system | Cancer | Non applicable | NCT05270642 | Plan for Microwave Thermal Field | UNKNOWN |
| Low-Intensity Focused Ultrasound Stimulation | Migraine | Non applicable | NCT07857109 | Low-Intensity Focused Ultrasound Targeting the Dorsolateral Prefrontal Cortex for Preventive Treatment of Chronic Migraine | NOT_YET_RECRUITING |
| CT-guided percutaneous radiofrequency ablation | Cancer | Non applicable | NCT02629978 | Radiofrequency Ablation of Malignant Pulmonary Nodules | UNKNOWN |
| Microwave Ablation | Cancer | Non applicable | NCT04197960 | Microwave Ablation and Surgical Resection for Micropapillary Thyroid Carcinoma | COMPLETED |
| Rimegepant 75 mg ODT | Migraine | Phase 4 | NCT07685769 | A Study to Find Out if the Medicine Called Rimegepant is Safe for Adults in India | RECRUITING |
| Chidamide | Cancer | Phase 2 | NCT04233294 | Addition of Chidamide to the Combination Treatment of Decitabine Plus Camrelizumab in Combination Treatment Resistant/Relapsed Patients With Classical Hodgkin Lymphoma | UNKNOWN |
Publications
30| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Microwave Thermal guided by Plan for Microwave Thermal Field system | Quantum Photothermal Self-Monitoring Fiber Probes for In Vivo Photothermal Therapy. | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | ||
| Rimegepant 75 mg ODT | A randomized open-label study to evaluate the effectiveness and safety of once-daily rimegepant 75 mg orally disintegrating tablet for the short-term preventive treatment of fasting-triggered headache in individuals with migraine. | Cephalalgia : an international journal of headache | ||
| Rimegepant 75 mg ODT | Rimegepant for acute treatment of migraine in triptan-unsuitable adults: A randomized, double-blind, placebo-controlled phase 4 trial. | Cephalalgia : an international journal of headache | ||
| Rimegepant 75 mg ODT | A phase 1, multicenter, open-label study to evaluate the pharmacokinetics, safety, and tolerability of a single dose of rimegepant in children (aged ≥6 to <12 years) with a history of migraine. | Headache | ||
| Decitabine | Myelodysplastic Syndromes: 2026 Update on Diagnosis, Risk-Stratification and Management. | American journal of hematology | ||
| Decitabine | Defining a Therapeutic Window for Venetoclax in Post-Transplant Maintenance Therapy for High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndromes. | Hematological oncology | ||
| Decitabine | A survival prognostic model for high-risk myelodysplastic syndrome patients treated with decitabine. | Hematology (Amsterdam, Netherlands) | ||
| Camrelizumab | Focused ultrasound ablation surgery combined with immune checkpoint inhibition in driver-gene wild-type NSCLC with liver metastasis: a feasibility study. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group | ||
| Camrelizumab | Cost-effectiveness of adjuvant therapy with camrelizumab in high-risk locoregionally advanced nasopharyngeal carcinoma: from the perspective of the Chinese healthcare system. | Annals of medicine | ||
| Chidamide | Senescent Cancer-Associated Fibroblasts Drive Early-Stage Lymph Node Metastasis in Pancreatic Cancer through Lactate-Mediated Metabolic-Epigenetic Rewiring. | Cancer discovery | ||
| Chidamide | Spatial proteogenomic profiling uncovers sensitization strategies for antibody-drug conjugate in HER2-positive breast cancer. | Cell reports. Medicine | ||
| Chidamide | Deubiquitinases in lung cancer: Oncogenic mechanisms, metabolic reprogramming, immune evasion, and therapeutic targeting. | Pathology, research and practice | ||
| Decitabine | DNA Methyltransferase Inhibitors, Decitabine and Guadecitabine Overcome Immune-Checkpoint Blockade Resistance and Achieve Tumor Regression in the E0771 and 4T1 Murine Models of Triple-Negative Breast Cancer. | Cancers | ||
| Camrelizumab | HAIC-Based Combination Therapy for Advanced Hepatocellular Carcinoma with Vp4 Portal Vein Tumor Thrombus and Child-Pugh B Liver Function: A Case Report. | Journal of hepatocellular carcinoma | ||
| Camrelizumab | Induction chemoimmunotherapy versus radiotherapy alone for inoperable esophageal squamous cell carcinoma: a real-world study. | Frontiers in immunology | ||
| Chidamide | Low-dose chidamide maintenance therapy following allogeneic hematopoietic cell transplantation in T-cell acute lymphoblastic leukemia or lymphomas: a phase II, open-label, multicenter, single-arm trial. | The Lancet regional health. Western Pacific | ||
| Chidamide | Acute lymphoblastic leukemia presenting as myocardial infiltration mimicking hypertrophic cardiomyopathy: a case report. | Frontiers in oncology | ||
| Chidamide | Chidamide‑augmented BEAM conditioning and maintenance in first-remission T‑cell lymphoma: a single‑arm phase 2 experience. | Bone marrow transplantation | ||
| Decitabine | Gastrointestinal adverse reactions and metabolism-nutrition disorders associated with hypomethylating agents: a pharmacovigilance study with exploratory mechanistic analysis. | Frontiers in nutrition | ||
| Decitabine | Successful allogeneic hematopoietic stem cell transplantation in children with myeloid malignancies secondary to GATA2 deficiency using decitabine-containing busulfan conditioning. | Bone marrow transplantation | ||
| Camrelizumab | Camrelizumab combined with chemotherapy as postoperative adjuvant therapy after radical surgery for cervical cancer patients with pathologically positive lymph nodes: a prospective multicenter phase II clinical trial. | Journal of gynecologic oncology | ||
| Chidamide | Low-Dose Chidamide Maintenance Therapy After Hematopoietic Stem Cell Transplantation for T-Cell Acute Lymphoblastic Leukemia: A Case Series. | Hematological oncology | ||
| Camrelizumab | Efficacy at a cost: camrelizumab and famitinib within the expanding landscape of combination therapies. | Gynecology and pelvic medicine | ||
| Camrelizumab | Immune checkpoint inhibitor integration in locoregionally advanced nasopharyngeal carcinoma: a prospective evidence synthesis on efficacy, safety, and therapeutic optimization. | Frontiers in immunology | ||
| Chidamide | Dual resistance to asparaginase and PD-1 blockade in extranodal natural killer/T-cell lymphoma: dismal outcomes from a multicenter cohort. | Haematologica | ||
| Chidamide | MRD-driven HDACi-based therapy post-transplant: a real-world study in high-risk acute myeloid leukemia. | Annals of hematology | ||
| Decitabine | Identification of FOXK1 and SEMA7A as key genes associated with mA-related programmed cell death in diabetic retinopathy. | Hereditas | ||
| Decitabine | Ten-day decitabine vs "3+7" in patients with AML aged ≥60 years: long-term results of the randomized phase 3 EORTC trial AML21. | Blood neoplasia | ||
| Camrelizumab | Clinical Efficacy of Modified San'ao Decoction and Erchen Decoction for Esophageal Dysphagia (Shi Bi) with Phlegm-Dampness and Blood Stasis Syndrome. | Journal of visualized experiments : JoVE | ||
| Camrelizumab | Real-world efficacy and safety of PD-1 inhibitors in patients living with HIV and cancer: a retrospective cohort study. | Frontiers in oncology |