Beth Israel Deaconess Medical Center

Traitements18programmes

Essais8liés

Publications22liées

SourceDBlocale

Traitements

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
DC Stimulator (Transcranial Direct Current Stimulator)The purpose of this study is to determine whether a painless and noninvasive procedure called Transcranial Direct Current Stimulation (tDCS) can be an effective therapy for the treatment of migraine and migraine-associated pain. Stimulation of the motor cortex with tDCS has already been shown to relieve pain in patients with other chronic pain syndromes, including traumatic spinal cord injury and fibromyalgia. Patients with migraine are usually extremely sensitive to pain. A treatment that targets the areas of the brain that are related to the experience of pain may also help decrease pain in patients with migraine. Pain control with this localized approach may help avoid the problems due to pain medications that affect all organs in the body. We hypothesize that 10 sessions of Transcranial Direct Current Stimulation (tDCS) applied over the area of the brain that controls pain and motor function will decrease pain and headache frequency in patients with migraine.	Migraine	NA	Traitement symptomatique	United States	À vérifier
DexrazoxaneThis trial is to evaluate if dexrazoxane is safer and more effective than liposomal doxorubicin in preventing heart failure events in participants with diffuse large B-cell lymphoma (DLBCL) undergoing either standard of care R-CHOP or pola-R-CHP treatment regiments. The names of the study drugs involved in this study are: * Dexrazoxane (a type of Topoisomerase II Inhibitor) * Liposomal Doxorubicin (a type of Topoisomerase II Inhibitor) * Standard of care R-CHOP treatment regimen (Cyclophosphamide, doxorubicin, vincristine, prednisone, rituximab) * Standard of care pola-R-CHP treatment regimen: Cyclophosphamide, doxorubicin, polatuzumab vedotin-piiq, prednisone, rituximab	Insuffisance cardiaque	Phase 2	À vérifier	United States	À vérifier
DoxorubicinThe goal of this clinical study is to find out how the study drug, sacituzumab govitecan (SG) works in participants with endometrial cancer who have received prior treatment with platinum-based chemotherapy and immunotherapy, versus the treatment of physician's choice (TPC). The primary objectives of this study are to evaluate the effect of SG compared to TPC on progression-free survival (PFS) as assessed by blinded independent central review (BICR) and overall survival (OS).	Cancer, Insuffisance cardiaque, Parkinson, SEP	Phase 2	Ralentissement de la progression	United States	À vérifier
Emgality 120 MG in 1 ML Prefilled SyringeThe purpose of this study is to understand better the mechanisms of action of calcitonin gene related peptide (CGRP) targeted monoclonal antibodies in migraine prevention. Specifically, the protocol will allow the investigators to determine whether the main site of action of this novel and recently-approved class of migraine prophylactic drugs act inside or outside the brain and if so, where.	Migraine	Phase 4	À vérifier	United States	À vérifier
Innovative Measures of Speech and Swallowing Dysfunction in Neurological DisordersThis study is evaluating the use of two painless, non-invasive technologies in the assessment of muscle health over time in both healthy volunteers and patients who have diseases that affect the nervous system.	Myasthénie	À vérifier	Traitement symptomatique	United States	À vérifier
IV acetaminophenOur objective is to find an effective prophylactic intervention by evaluating IV acetaminophen's impact in reducing the frequency of postoperative delirium, one of the most common and detrimental complications of cardiac surgery in older adults.	Maladie coronarienne	Phase 3	À vérifier	United States	À vérifier
Mind Body Intervention for Chronic Migraine HeadachesThe goal of this exploratory study is to test a mind-body interventional approach for the treatment of chronic migraines. The main goal is to obtain feasibility information on the protocol which has been used in other similar conditions. We will also evaluate multiple measurement tools in order to optimize a follow-up pilot study evaluating the impact of the protocol on migraines.	Migraine	Non applicable	À vérifier	United States	À vérifier
sham stimulationAttaining goals or rewards commonly entails response costs. In light of cost and benefits, how do participants decide what effort should be put in to give it a shot? Figuratively, you may "go with your gut", but the literal contribution of the gut-brain axis in allocating effort is poorly understood to date. Here, the investigators propose to investigate non-invasive transcutaneous vagal nerve stimulation (tVNS) as a potential modulator of energy metabolism and response vigor. Since the neural mechanisms causing the diverse cognitive and behavioral effects of the stimulation remain largely elusive, the investigators will use computational modeling of instrumental behavior and determine the primary metabolic effects of the stimulation. The investigators hypothesize that tVNS will lead to activation of afferent targets in the brain. In turn, the elicited brain activation is expected to mediate the cognitive effects of the stimulation. This may affect both sides of the utility equation because anti-depressive effects may correspond to boosting the benefit of effort whereas anti-nociceptive effects may reduce perceived costs of effort. Collectively, dissecting the cognitive effects of non-invasive tVNS in healthy individuals may facilitate the more widespread use as a treatment in mental disorders that are characterized by metabolic alterations such as depression.	Accident vasculaire cérébral, Migraine, SEP	Non applicable	À vérifier	United States	À vérifier
transcranial random noise stimulation (tRNS)This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymous loss of conscious vision termed hemianopsia, the loss of one half of the visual field. The goal of this project is to elaborate and refine a rehabilitation protocol for VFD participants. It is hypothesized that visual restoration training using moving stimuli coupled with noninvasive current stimulation on the visual cortex will promote and speed up recovery of visual abilities within the blind field in VFD participants. Moreover, it is expected that visual recovery positively correlates with reduction of the blind field, as measured with traditional visual perimetry: the Humphrey visual field test or an eye-tracker based visual perimetry implemented in a virtual reality (VR) headset. Finally, although results will vary among participants depending on the extent and severity of the cortical lesion, it is expected that a bigger increase in neural response to moving stimuli in the blind visual field in cortical motion area, for those participants who will show the largest behavioral improvement after training. The overarching goals for the study are as follows: Group 1a will test the basic effects of transcranial random noise stimulation (tRNS) coupled with visual training in stroke cohorts, including (i) both chronic/subacute ischemic and chronic hemorrhagic VFD stroke participants, and (ii) longitudinal testing up to 6 months post-treatment. Group 1b will test the effects of transcranial tRNS coupled with visual training on a Virtual Reality (VR) device in stroke cohorts, including both chronic/subacute ischemic and chronic hemorrhagic VFD stroke participants. Group 2 will examine the effects of tRNS alone, without visual training, also including chronic and subacute VFD stroke participants and longitudinal testing.	Accident vasculaire cérébral	Non applicable	À vérifier	United States	À vérifier
VincristineResearchers are looking for new ways to treat follicular lymphoma (FL). A standard (usual) treatment for FL includes a targeted therapy called rituximab and chemotherapy. In this study, researchers want to learn if giving a study medicine called MK-1045 and rituximab can treat FL. MK-1045 is a type of treatment called immunotherapy. The goals of this study are to learn: * About the safety of MK-1045 and rituximab, and if people tolerate them when given together * If people who receive MK-1045 and rituximab have the cancer go away * If people who receive MK-1045 and rituximab live longer without their cancer getting worse compared to those who receive standard treatment (rituximab and chemotherapy)	Cancer, Insuffisance cardiaque, SEP	Phase 2	À vérifier	United States	À vérifier
Innovative Measures of Speech and Swallowing Dysfunction in Neurological DisordersThis study is evaluating the use of two painless, non-invasive technologies in the assessment of muscle health over time in both healthy volunteers and patients who have diseases that affect the nervous system.	Myasthénie	À vérifier	Traitement symptomatique	United States	À vérifier
DC Stimulator (Transcranial Direct Current Stimulator)The purpose of this study is to determine whether a painless and noninvasive procedure called Transcranial Direct Current Stimulation (tDCS) can be an effective therapy for the treatment of migraine and migraine-associated pain. Stimulation of the motor cortex with tDCS has already been shown to relieve pain in patients with other chronic pain syndromes, including traumatic spinal cord injury and fibromyalgia. Patients with migraine are usually extremely sensitive to pain. A treatment that targets the areas of the brain that are related to the experience of pain may also help decrease pain in patients with migraine. Pain control with this localized approach may help avoid the problems due to pain medications that affect all organs in the body. We hypothesize that 10 sessions of Transcranial Direct Current Stimulation (tDCS) applied over the area of the brain that controls pain and motor function will decrease pain and headache frequency in patients with migraine.	Migraine	NA	Traitement symptomatique	United States	À vérifier
Emgality 120 MG in 1 ML Prefilled SyringeThe purpose of this study is to understand better the mechanisms of action of calcitonin gene related peptide (CGRP) targeted monoclonal antibodies in migraine prevention. Specifically, the protocol will allow the investigators to determine whether the main site of action of this novel and recently-approved class of migraine prophylactic drugs act inside or outside the brain and if so, where.	Migraine	Phase 4	À vérifier	United States	À vérifier
Mind Body Intervention for Chronic Migraine HeadachesThe goal of this exploratory study is to test a mind-body interventional approach for the treatment of chronic migraines. The main goal is to obtain feasibility information on the protocol which has been used in other similar conditions. We will also evaluate multiple measurement tools in order to optimize a follow-up pilot study evaluating the impact of the protocol on migraines.	Migraine	Non applicable	À vérifier	United States	À vérifier
sham stimulationAttaining goals or rewards commonly entails response costs. In light of cost and benefits, how do participants decide what effort should be put in to give it a shot? Figuratively, you may "go with your gut", but the literal contribution of the gut-brain axis in allocating effort is poorly understood to date. Here, the investigators propose to investigate non-invasive transcutaneous vagal nerve stimulation (tVNS) as a potential modulator of energy metabolism and response vigor. Since the neural mechanisms causing the diverse cognitive and behavioral effects of the stimulation remain largely elusive, the investigators will use computational modeling of instrumental behavior and determine the primary metabolic effects of the stimulation. The investigators hypothesize that tVNS will lead to activation of afferent targets in the brain. In turn, the elicited brain activation is expected to mediate the cognitive effects of the stimulation. This may affect both sides of the utility equation because anti-depressive effects may correspond to boosting the benefit of effort whereas anti-nociceptive effects may reduce perceived costs of effort. Collectively, dissecting the cognitive effects of non-invasive tVNS in healthy individuals may facilitate the more widespread use as a treatment in mental disorders that are characterized by metabolic alterations such as depression.	SEP	Non applicable	À vérifier	United States	À vérifier
IV acetaminophenOur objective is to find an effective prophylactic intervention by evaluating IV acetaminophen's impact in reducing the frequency of postoperative delirium, one of the most common and detrimental complications of cardiac surgery in older adults.	Maladie coronarienne	Phase 3	À vérifier	United States	À vérifier
DexrazoxaneThis trial is to evaluate if dexrazoxane is safer and more effective than liposomal doxorubicin in preventing heart failure events in participants with diffuse large B-cell lymphoma (DLBCL) undergoing either standard of care R-CHOP or pola-R-CHP treatment regiments. The names of the study drugs involved in this study are: * Dexrazoxane (a type of Topoisomerase II Inhibitor) * Liposomal Doxorubicin (a type of Topoisomerase II Inhibitor) * Standard of care R-CHOP treatment regimen (Cyclophosphamide, doxorubicin, vincristine, prednisone, rituximab) * Standard of care pola-R-CHP treatment regimen: Cyclophosphamide, doxorubicin, polatuzumab vedotin-piiq, prednisone, rituximab	Insuffisance cardiaque	Phase 2	À vérifier	United States	À vérifier
transcranial random noise stimulation (tRNS)This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymous loss of conscious vision termed hemianopsia, the loss of one half of the visual field. The goal of this project is to elaborate and refine a rehabilitation protocol for VFD participants. It is hypothesized that visual restoration training using moving stimuli coupled with noninvasive current stimulation on the visual cortex will promote and speed up recovery of visual abilities within the blind field in VFD participants. Moreover, it is expected that visual recovery positively correlates with reduction of the blind field, as measured with traditional visual perimetry: the Humphrey visual field test or an eye-tracker based visual perimetry implemented in a virtual reality (VR) headset. Finally, although results will vary among participants depending on the extent and severity of the cortical lesion, it is expected that a bigger increase in neural response to moving stimuli in the blind visual field in cortical motion area, for those participants who will show the largest behavioral improvement after training. The overarching goals for the study are as follows: Group 1a will test the basic effects of transcranial random noise stimulation (tRNS) coupled with visual training in stroke cohorts, including (i) both chronic/subacute ischemic and chronic hemorrhagic VFD stroke participants, and (ii) longitudinal testing up to 6 months post-treatment. Group 1b will test the effects of transcranial tRNS coupled with visual training on a Virtual Reality (VR) device in stroke cohorts, including both chronic/subacute ischemic and chronic hemorrhagic VFD stroke participants. Group 2 will examine the effects of tRNS alone, without visual training, also including chronic and subacute VFD stroke participants and longitudinal testing.	Accident vasculaire cérébral	Non applicable	À vérifier	United States	À vérifier

Essais cliniques

Molécule	Indication / population	Phase	NCT	Titre	Statut
transcranial random noise stimulation (tRNS)	Accident vasculaire cérébral	Non applicable	NCT05085210	Improving Visual Field Deficits With Noninvasive Brain Stimulation	ACTIVE_NOT_RECRUITING
Dexrazoxane	Insuffisance cardiaque	Phase 2	NCT07654426	The CARDIOPROTECT Trial	NOT_YET_RECRUITING
IV acetaminophen	Maladie coronarienne	Phase 3	NCT04093219	PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients	COMPLETED
sham stimulation	SEP	Non applicable	NCT04437498	VNS mTBI — Vagal Nerve Stimulation in mTBI	RECRUITING
Mind Body Intervention for Chronic Migraine Headaches	Migraine	Non applicable	NCT06690060	Mind Body Intervention for Chronic Migraine Headaches	RECRUITING
Emgality 120 MG in 1 ML Prefilled Syringe	Migraine	Phase 4	NCT04271202	Novel Insight Into Migraine Pathophysiolgy and Galcanezumab Mechanisms of Action	COMPLETED
DC Stimulator (Transcranial Direct Current Stimulator)	Migraine	NA	NCT00521196	Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)	COMPLETED
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders	Myasthénie	À vérifier	NCT02118805	Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders	COMPLETED

Publications

Molécule	Titre	Journal
Vincristine	Analysis of the efficacy and safety of the IVD/EM maintenance regimen as post-remission treatment for adult patients with T-cell lymphoblastic lymphoma/leukemia.	Leukemia research
Vincristine	Interim Positron Emission Tomography-Guided Dose-Adapted Residual Site Radiation Therapy Improves Survival in Diffuse Large B-Cell Lymphoma Patients With Partial Metabolic Response After R-CHOP: A Retrospective Cohort Analysis.	Advances in radiation oncology
Doxorubicin	Liposome-mediated delivery of a ruthenium-based metallodrug to overcome cisplatin resistance in osteosarcoma.	Drug delivery
Doxorubicin	Nanocarrier-mediated targeting of chemotherapy-induced DPP4 enhances T cell infiltration and improves cancer immunochemotherapy.	Bioactive materials
Doxorubicin	Integrating spectrum-effect relationship, network pharmacology and multi-omics to decipher the mechanism of Cybister chinensis Motschulsky against chronic kidney disease.	Journal of ethnopharmacology
sham stimulation	Transcranial direct current stimulation enhances cognitive performance and modulates QEEG beta- and theta-band power in patients undergoing whole-brain radiotherapy.	IBRO neuroscience reports
Doxorubicin	RETRACTION: Doxorubicin-loaded methoxy-intercalated kaolinite as a repackaging of doxorubicin for an enhanced breast cancer treatment:andinvestigation (2025 36 025101).	Nanotechnology
Doxorubicin	Therapeutic Efficacy of Metronomic Doxorubicin and Low Dose of Gamma Radiation on Breast Cancer Model.	Cell biochemistry and function
DC Stimulator (Transcranial Direct Current Stimulator)	In-Ear Transcranial Alternating Current Stimulation: Auditory Perception and Side Effects Depend on Electrode Montage, Frequency, and Direct Current-Offset.	Neuromodulation : journal of the International Neuromodulation Society
DC Stimulator (Transcranial Direct Current Stimulator)	Remotely Supervised Home-Based tDCS in Treatment-Resistant Depression: Feasibility, Effectiveness and EEG Biomarkers of Response.	Psychiatry research
sham stimulation	Automated intermittent olfactory stimulation to reduce apnea in preterm infants: results of the PREMODEUR randomized clinical trial.	European journal of pediatrics
sham stimulation	Corticospinal Excitability After Continuous and Intermittent Theta Burst Stimulation Applied on the Lateral Cerebellum: A Study on Healthy Individuals.	Noro psikiyatri arsivi
Doxorubicin	A clinical data- and AI-supported engineered fusion vesicle system for enhanced tumor-targeted drug delivery and immunochemotherapeutic synergy.	Journal of controlled release : official journal of the Controlled Release Society
Doxorubicin	Successful Sequential Multimodal Therapy for Lingual Rhabdomyosarcoma in a Young Adult: Case Report.	Case reports in oncological medicine
Doxorubicin	Anticancer effects of alpha-helical peptide epinecidin-1 and its variants in combination with doxorubicin.	Medical oncology (Northwood, London, England)
DC Stimulator (Transcranial Direct Current Stimulator)	Reducing state anxiety with alpha-frequency transcranial alternating current stimulation.	Journal of affective disorders
DC Stimulator (Transcranial Direct Current Stimulator)	Adjunctive transcranial DC stimulation in the management of refractory drug-resistant focal epilepsy in POLG mitochondrial disease: A case series.	Seizure
Doxorubicin	Evaluation of the protective effects of Artemisia dracunculus L. against doxorubicin-induced chronic cardio-toxicity in rat.	Fitoterapia
Doxorubicin	Synchronous rectal cancer and extranodal NK/T-cell lymphoma, nasal type: A case report.	Medicine
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders	Management of chronic closed lock.	The British journal of oral & maxillofacial surgery
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders	Respiratory-Swallow Training and Variable Practice in Parkinson's Disease: A Clinical Trial Pilot Study.	Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)
Doxorubicin	Sustainable gold nanoparticles using Jania rubens, targeted therapeutic potential in prostate cancer and mechanistic insights via GO/KEGG pathway analysis.	Scientific reports