Beni-Suef University — Biomedical Watch V2

Traitements12programmes

Essais8liés

Publications3liées

SourceDBlocale

Traitements

12

Molécule	Indication / population	Phase	Objectif	Pays	Résultat
Doxapram HydrochlorideDoxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous oxide or benzodiazepines over dosage. Value of theophylline to stimulate the respiratory neuronal network has been examined by previous studies and increases the activity of respiratory muscles, including the intercostal , transversus abdominis muscles and the diaphragm, it also has bronchodilator and anti-inflammatory effects.	SEP	Non applicable	Immunomodulation	Egypt	À vérifier
Greater Occipital Nerve Block (GONB)Chronic migraine is a debilitating neurological disorder that significantly affects patients' daily functioning, mental health, and quality of life. Management typically includes acute and preventive treatments, but effectiveness can be limited due to medication overuse or delayed onset of action. OnabotulinumtoxinA injections provide proven long-term preventive benefits, while Greater Occipital Nerve (GON) block offers rapid but short-term relief. Although both treatments are used individually, evidence on the combined effect is limited. This randomized controlled trial aims to evaluate the efficacy and safety of combining OnabotulinumtoxinA injections with GON block, assessing improvements in headache frequency, severity, and patient quality of life compared to single therapy.	Migraine	Non applicable	À vérifier	Egypt	À vérifier
Intraureteral AminophyllineThis multicenter randomized controlled trial will evaluate whether preoperative tamsulosin, intraureteral aminophylline, or their combination can improve ureteral access during primary retrograde intrarenal surgery for renal stones. Adult patients with unilateral renal stones measuring 2 cm or less and planned placement of a 10/12 Fr ureteral access sheath will be randomly assigned to one of four groups in a 2x2 factorial design. Participants will receive either tamsulosin or placebo for 7 days before surgery and either intraureteral aminophylline or intraureteral placebo during the procedure. The main outcome will be successful first-attempt placement of the planned 10/12 Fr ureteral access sheath after study solution instillation, without active ureteral dilatation, sheath downsizing, prestenting with deferred surgery, or abandonment of the procedure due to access failure.	SEP	Phase 2	À vérifier	Egypt	À vérifier
Intravesical AminophyllineAcute calculous anuria is a urological emergency caused by ureteral stone obstruction in a solitary functioning kidney or bilateral ureteral obstruction. Urgent decompression of the upper urinary tract is required to restore urine drainage and prevent further renal impairment. This prospective randomized double-blind controlled trial will evaluate whether intravesical aminophylline can facilitate urgent retrograde ureteral stenting in adult patients with acute calculous anuria due to ureteral stones. Eligible patients will be randomly assigned to receive either intravesical aminophylline diluted in normal saline or placebo saline before attempted retrograde Double-J ureteral stent placement. The primary outcome is technical success, defined as successful placement of a Double-J ureteral stent across the obstructing stone without the need for percutaneous nephrostomy. Secondary outcomes include stenting time, intraoperative complications, renal function recovery, postoperative pain, analgesic requirement, and the need for alternative drainage.	SEP	Phase 2	Traitement symptomatique	Egypt	À vérifier
IV iron sucroseThe aim of this interventional study is to assess the effectiveness of oral lactoferrin in improving hemoglobin levels and correcting iron deficiency anemia in patients with end-stage renal disease (ESRD) on dialysis and also evaluate the impact of lactoferrin on bone health by measuring serum calcium and phosphate and other bone health indicators. The participants will be divided into 3 groups as follow * The Lactoferrin group will receive treatment of oral lactoferrin at a dose of 100 mg twice daily alongside erythropoiesis-stimulating agent (ESA) therapy for three months. * The IV Iron group will receive IV Iron therapy with ESA for the same duration * The Lactoferrin + IV Iron group will receive both oral lactoferrin at a dose of 100 mg twice daily and IV Iron therapy alongside erythropoiesis-stimulating agent (ESA) therapy for three months.	Maladie rénale chronique	Phase 2	À vérifier	Egypt	À vérifier
Mechanism-Based Cervical Rehabilitation for Chronic MigraineTo investigate the effectiveness of mechanism-based cervical sensorimotor rehabilitation on cervical muscle activation, cervical proprioception, and migraine burden.	Migraine	Non applicable	À vérifier		À vérifier
TamsulosinThis multicenter randomized controlled trial will evaluate whether preoperative tamsulosin, intraureteral aminophylline, or their combination can improve ureteral access during primary retrograde intrarenal surgery for renal stones. Adult patients with unilateral renal stones measuring 2 cm or less and planned placement of a 10/12 Fr ureteral access sheath will be randomly assigned to one of four groups in a 2x2 factorial design. Participants will receive either tamsulosin or placebo for 7 days before surgery and either intraureteral aminophylline or intraureteral placebo during the procedure. The main outcome will be successful first-attempt placement of the planned 10/12 Fr ureteral access sheath after study solution instillation, without active ureteral dilatation, sheath downsizing, prestenting with deferred surgery, or abandonment of the procedure due to access failure.	SEP	Phase 2	À vérifier	Egypt	À vérifier
Mechanism-Based Cervical Rehabilitation for Chronic MigraineTo investigate the effectiveness of mechanism-based cervical sensorimotor rehabilitation on cervical muscle activation, cervical proprioception, and migraine burden.	Migraine	Non applicable	À vérifier		À vérifier
Doxapram HydrochlorideDoxapram is licensed for drug-induced post-anesthesia respiratory depression , arousal effect and return airway protective reflexes caused by barbiturates, volatile anesthetics, nitrous oxide or benzodiazepines over dosage. Value of theophylline to stimulate the respiratory neuronal network has been examined by previous studies and increases the activity of respiratory muscles, including the intercostal , transversus abdominis muscles and the diaphragm, it also has bronchodilator and anti-inflammatory effects.	SEP	Non applicable	Immunomodulation	Egypt	À vérifier
Intravesical AminophyllineAcute calculous anuria is a urological emergency caused by ureteral stone obstruction in a solitary functioning kidney or bilateral ureteral obstruction. Urgent decompression of the upper urinary tract is required to restore urine drainage and prevent further renal impairment. This prospective randomized double-blind controlled trial will evaluate whether intravesical aminophylline can facilitate urgent retrograde ureteral stenting in adult patients with acute calculous anuria due to ureteral stones. Eligible patients will be randomly assigned to receive either intravesical aminophylline diluted in normal saline or placebo saline before attempted retrograde Double-J ureteral stent placement. The primary outcome is technical success, defined as successful placement of a Double-J ureteral stent across the obstructing stone without the need for percutaneous nephrostomy. Secondary outcomes include stenting time, intraoperative complications, renal function recovery, postoperative pain, analgesic requirement, and the need for alternative drainage.	SEP	Phase 2	Traitement symptomatique	Egypt	À vérifier
TamsulosinThis multicenter randomized controlled trial will evaluate whether preoperative tamsulosin, intraureteral aminophylline, or their combination can improve ureteral access during primary retrograde intrarenal surgery for renal stones. Adult patients with unilateral renal stones measuring 2 cm or less and planned placement of a 10/12 Fr ureteral access sheath will be randomly assigned to one of four groups in a 2x2 factorial design. Participants will receive either tamsulosin or placebo for 7 days before surgery and either intraureteral aminophylline or intraureteral placebo during the procedure. The main outcome will be successful first-attempt placement of the planned 10/12 Fr ureteral access sheath after study solution instillation, without active ureteral dilatation, sheath downsizing, prestenting with deferred surgery, or abandonment of the procedure due to access failure.	SEP	Phase 2	À vérifier	Egypt	À vérifier
IV iron sucroseThe aim of this interventional study is to assess the effectiveness of oral lactoferrin in improving hemoglobin levels and correcting iron deficiency anemia in patients with end-stage renal disease (ESRD) on dialysis and also evaluate the impact of lactoferrin on bone health by measuring serum calcium and phosphate and other bone health indicators. The participants will be divided into 3 groups as follow * The Lactoferrin group will receive treatment of oral lactoferrin at a dose of 100 mg twice daily alongside erythropoiesis-stimulating agent (ESA) therapy for three months. * The IV Iron group will receive IV Iron therapy with ESA for the same duration * The Lactoferrin + IV Iron group will receive both oral lactoferrin at a dose of 100 mg twice daily and IV Iron therapy alongside erythropoiesis-stimulating agent (ESA) therapy for three months.	Maladie rénale chronique	Phase 2	À vérifier	Egypt	À vérifier

Essais cliniques

8

Molécule	Indication / population	Phase	NCT	Titre	Statut
IV iron sucrose	Maladie rénale chronique	Phase 2	NCT07706582	Management of Iron Deficiency Anemia in Hemodialysis Patients	ACTIVE_NOT_RECRUITING
Tamsulosin	SEP	Phase 2	NCT07623876	TAM-AMIN-UAS — Tamsulosin and Intraureteral Aminophylline for Ureteral Access During RIRS	RECRUITING
Intravesical Aminophylline	SEP	Phase 2	NCT07617948	Intravesical Aminophylline for Urgent Ureteral Stenting in Acute Calculous Anuria	RECRUITING
Aminophylline	SEP	Phase 1	NCT04151381	The Effect of Preoperative Aminophylline	UNKNOWN
Doxapram Hydrochloride	SEP	Non applicable	NCT03894189	The Effect of Doxapram Versus Theophylline on Diaphragmatic Function	UNKNOWN
Dexmedetomidine	Migraine	Non applicable	NCT07769255	Effect of Nebulized Dexmedetomidine on Central Sensitization and Chronification in Migraine	RECRUITING
Mechanism-Based Cervical Rehabilitation for Chronic Migraine	Migraine	Non applicable	NCT07762690	Mechanism-Based Cervical Rehabilitation for Chronic Migraine	NOT_YET_RECRUITING
OnabotulinumtoxinA	Migraine	Non applicable	NCT07535723	Botulinum Toxin and/or Greater Occipital Nerve Block for Patients With Chronic Migraine	NOT_YET_RECRUITING

Publications

3

Molécule	Indication / population	Titre	Journal	Date
Mechanism-Based Cervical Rehabilitation for Chronic Migraine		Common Mechanisms in Migraine, Migraine-Related Neck Pain, and Low Back Pain: Implications for Treatment.	Pain and therapy
Greater Occipital Nerve Block (GONB)		Assessing the effectiveness of greater occipital nerve block in chronic migraine: a systematic review and meta-analysis.	BMC neurology
Greater Occipital Nerve Block (GONB)		Comparison of the Effectiveness of Greater Occipital Nerve Block and Botulinum Toxin Type A in Chronic Migraine: An Exploratory Pilot Study From a Tertiary Care Centre in a Resource-Limited Setting.	Cureus