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Ain Shams University
Traitements, essais et publications liés.
Traitements26programmes
Essais11liés
Publications19liées
SourceDBlocale
Traitements
26| Molécule | Indication / population | Phase | Objectif | Pays | Résultat |
|---|---|---|---|---|---|
| Amlodipine tabletThe goal of this clinical trial is to learn if Ramipril works better than Amlodipine to reduce endothelial dysfunction in pediatric patients (aged 5-18 years) with end-stage kidney disease undergoing maintenance hemodialysis and diagnosed with hypertension. It will also learn about the safety, efficacy, and impact on quality of life of both drugs. The main questions it aims to answer are: * Does Ramipril lower asymmetric dimethylarginine (ADMA) levels-a marker of endothelial dysfunction-more effectively than Amlodipine? * Does Ramipril preserve Fetuin-A levels-a marker of vascular calcification-better than Amlodipine? * How effectively do Ramipril and Amlodipine control blood pressure and improve disease-specific quality of life? * What side effects or medical problems do participants experience while taking Ramipril versus Amlodipine? Researchers will compare Ramipril to Amlodipine to see if Ramipril exerts superior protective effects on vascular health and endothelial function beyond blood pressure reduction. Participants will: * Stop taking previous antihypertensive medications (ACE inhibitors or calcium channel blockers) for a 2-week washout period prior to baseline testing * Take either Ramipril or Amlodipine daily for 3 months * Continue standard hemodialysis sessions (3 times per week, 3-4 hours per session) * Provide pre-dialysis blood samples at baseline and after 3 months of treatment * Complete the Pediatric Quality of Life Inventory (PedsQL™ 3.0 ESRD) questionnaire at baseline and after 3-month * Undergo regular blood pressure checks, clinical monitoring, and weekly phone check-ins to monitor safety and potential side effects | Maladie rénale chronique | Phase 3 | À vérifier | À vérifier | |
| Brachiobasilic arteriovenous fistulaThe study aimed to compare the incidence of postoperative venous hypertension between side-to-side (STS) and end-to-side (ETS) brachiobasilic arteriovenous fistulae. | Hypertension | Non applicable | À vérifier | Egypt | À vérifier |
| Brachiobasilic arteriovenous fistula followed by basilic vein superficialization.The study aimed to compare the incidence of postoperative venous hypertension between side-to-side (STS) and end-to-side (ETS) brachiobasilic arteriovenous fistulae. | Hypertension | Non applicable | À vérifier | Egypt | À vérifier |
| BupivacaineThis multicenter, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the efficacy of repeated bilateral greater occipital nerve (GON) blockade in patients with chronic migraine and chronic tension-type headache. Greater occipital nerve blockade has been widely used as an interventional treatment for chronic headache disorders; however, evidence regarding its differential efficacy across chronic headache phenotypes remains limited. Participants diagnosed with chronic migraine or chronic tension-type headache according to the International Headache Society criteria were randomized to receive bilateral GON blockade with 0.5% bupivacaine or placebo (0.9% saline). Injections were administered weekly during the first month and monthly during the following two months, resulting in a total of six injections over a three-month treatment period. The primary outcome measure is the change in monthly headache frequency from baseline to Month 1. Secondary outcomes include changes in headache intensity, headache duration, disability scores, and other clinical headache parameters during follow-up. | Épilepsie, Migraine, Myopathies | Phase 4 | À vérifier | Egypt | À vérifier |
| Caffeine (200 mg)Caffeine extracted from green tea to abort acute attack of Migraine | Migraine | Phase 4 | À vérifier | Egypt | À vérifier |
| Effects of Curcumin-Piperine Supplementation in FibromyalgiaThe goal of this clinical trail is to evaluate the effectiveness and safety of curcumin-piperine supplementation in patients with fibromyalgia over 3 months compared to placebo. Participants will: Be randomly assigned to receive either curcumin and piperine supplements or a placebo. Attend scheduled clinic visits for clinical assessments and blood sample collection. Complete study questionnaires before and after treatment time frame. The primary question the study aim to answer is: Does Curcumin-piperine supplementation reduce pain intensity by Visual Analog Scale (VAS), compared with placebo? The secondary questions this study aims to answer are: Does supplementation improve fibromyalgia disease impact and quality of life? Does supplementation improve inflammatory biomarkers and oxidative stress? Does supplementation improve insulin resistance? Is curcumin and piperine supplementation safe and well tolerated? | Myopathies | Phase 2 | Neuroprotection + Immunomodulation + Traitement symptomatique | Egypt | À vérifier |
| NSAID (Nonsteroidal anti-inflammatory drugs)Caffeine extracted from green tea to abort acute attack of Migraine | Migraine | Phase 4 | Immunomodulation | Egypt | À vérifier |
| Paracetamol (acetaminophen)Caffeine extracted from green tea to abort acute attack of Migraine | Migraine | Phase 4 | À vérifier | Egypt | À vérifier |
| Pericapsular nerve group (PENG) blockThe goal of this clinical trial is to compare two regimens of the pericapsular nerve group (PENG) block, an ultrasound-guided injection of local anaesthetic targeting the nerves supplying the front of the hip joint, for postoperative pain relief and quadriceps muscle function in patients undergoing primary unilateral total hip arthroplasty under spinal anaesthesia. The PENG block was originally proposed as a motor-sparing technique. However, the standard 20 mL volume can spread to the femoral nerve and cause quadriceps weakness. Reducing the injected volume may limit this spread and better preserve quadriceps strength, but smaller volumes risk shorter analgesic duration. Adding dexamethasone to a low-volume injection may compensate for the reduced volume. The main questions this trial aims to answer are: * Does a low-volume PENG block (10 mL bupivacaine 0.25%) with 4 mg dexamethasone differ from a standard-volume PENG block (20 mL bupivacaine 0.25%) in the time to first rescue analgesia? * Does it differ in the incidence and severity of quadriceps weakness on the operated side? Researchers will compare: * Group A (standard-volume PENG block): 20 mL bupivacaine 0.25%. * Group B (low-volume PENG block with dexamethasone): 5 mL bupivacaine 0.5% plus 4 mL normal saline plus 4 mg dexamethasone in 1 mL, giving 10 mL of bupivacaine 0.25%. Participants will: * Receive spinal anaesthesia with heavy bupivacaine 0.5% and fentanyl. * Be randomly allocated to Group A or Group B using computer-generated random numbers. * Receive the PENG block under ultrasound guidance, performed by an anaesthesiologist expert in regional anaesthesia. * Receive intravenous paracetamol 1 g every 8 hours, with intravenous nalbuphine 5 mg as rescue analgesia when the pain score (NRS) is 4 or more. * Be assessed by an anaesthesiologist blinded to group allocation for pain scores at rest and on movement at 2, 6, 12 and 24 hours; quadriceps strength (MRC scale and straight leg raise) at 6, 12 and 24 hours compared with the preoperative baseline; total opioid consumption over the first 24 hours; and time to first ambulation within the first 24 hours. The primary outcome is the time from completion of the PENG block to the first administration of rescue analgesia, recorded over the first 24 hours postoperatively. The study will be conducted at Ain Shams University Hospitals (El Demerdash Hospital) and will include 60 patients (30 per group), aged 50 to 70 years, ASA physical status I or II. | Myopathies | Phase 4 | Traitement symptomatique | Egypt | À vérifier |
| Ramipril tabletThe goal of this clinical trial is to learn if Ramipril works better than Amlodipine to reduce endothelial dysfunction in pediatric patients (aged 5-18 years) with end-stage kidney disease undergoing maintenance hemodialysis and diagnosed with hypertension. It will also learn about the safety, efficacy, and impact on quality of life of both drugs. The main questions it aims to answer are: * Does Ramipril lower asymmetric dimethylarginine (ADMA) levels-a marker of endothelial dysfunction-more effectively than Amlodipine? * Does Ramipril preserve Fetuin-A levels-a marker of vascular calcification-better than Amlodipine? * How effectively do Ramipril and Amlodipine control blood pressure and improve disease-specific quality of life? * What side effects or medical problems do participants experience while taking Ramipril versus Amlodipine? Researchers will compare Ramipril to Amlodipine to see if Ramipril exerts superior protective effects on vascular health and endothelial function beyond blood pressure reduction. Participants will: * Stop taking previous antihypertensive medications (ACE inhibitors or calcium channel blockers) for a 2-week washout period prior to baseline testing * Take either Ramipril or Amlodipine daily for 3 months * Continue standard hemodialysis sessions (3 times per week, 3-4 hours per session) * Provide pre-dialysis blood samples at baseline and after 3 months of treatment * Complete the Pediatric Quality of Life Inventory (PedsQL™ 3.0 ESRD) questionnaire at baseline and after 3-month * Undergo regular blood pressure checks, clinical monitoring, and weekly phone check-ins to monitor safety and potential side effects | Maladie rénale chronique | Phase 3 | À vérifier | À vérifier | |
| renal biopsyTo investigate the possible role of TGF-β expression in renal biopsy and it's relation with fibrosis, activity and chronicity indices | Lupus | Non applicable | À vérifier | Egypt | À vérifier |
| Sequential teflon dilator usage prior to ureteric access sheath placement in flexible uretroscopyin this study we are going to evaluate the efficacy of intra-ureteric aminophylline instillation in facilitating ureteric access sheath placement prior to flexible ureteroscopy in reducing ureteric injury rates. | SEP | Non applicable | À vérifier | Egypt | À vérifier |
| trans nasal sphenopalatine ganglion blockThe purpose of the study is to compare Sphenopalatine ganglion block (SPGB) and aminophylline in the efficacy and safety management of PDPH. | SEP | Phase 4 | À vérifier | Egypt | À vérifier |
| triptansCaffeine extracted from green tea to abort acute attack of Migraine | Migraine | Phase 4 | À vérifier | Egypt | À vérifier |
| ultrasound guided Greater occipital nerve blockTo investigate the efficacy of Ultrasound guided Stellate Ganglion block in chronic resistant migraine patients in comparison to Greater Occipital Nerve Block correlating its effect to serum CGRP level. | Migraine | NA | À vérifier | Egypt | À vérifier |
| Ultrasound guided Stellate ganglion blockTo investigate the efficacy of Ultrasound guided Stellate Ganglion block in chronic resistant migraine patients in comparison to Greater Occipital Nerve Block correlating its effect to serum CGRP level. | Migraine | NA | À vérifier | Egypt | À vérifier |
| Usage of Aminophylline prior to ureteric dilatation in Flexible uretroscopyin this study we are going to evaluate the efficacy of intra-ureteric aminophylline instillation in facilitating ureteric access sheath placement prior to flexible ureteroscopy in reducing ureteric injury rates. | SEP | Non applicable | À vérifier | Egypt | À vérifier |
| ultrasound guided Greater occipital nerve blockTo investigate the efficacy of Ultrasound guided Stellate Ganglion block in chronic resistant migraine patients in comparison to Greater Occipital Nerve Block correlating its effect to serum CGRP level. | Migraine | NA | À vérifier | Egypt | À vérifier |
| Caffeine (200 mg)Caffeine extracted from green tea to abort acute attack of Migraine | Migraine | Phase 4 | À vérifier | Egypt | À vérifier |
| Effects of Curcumin-Piperine Supplementation in FibromyalgiaThe goal of this clinical trail is to evaluate the effectiveness and safety of curcumin-piperine supplementation in patients with fibromyalgia over 3 months compared to placebo. Participants will: Be randomly assigned to receive either curcumin and piperine supplements or a placebo. Attend scheduled clinic visits for clinical assessments and blood sample collection. Complete study questionnaires before and after treatment time frame. The primary question the study aim to answer is: Does Curcumin-piperine supplementation reduce pain intensity by Visual Analog Scale (VAS), compared with placebo? The secondary questions this study aims to answer are: Does supplementation improve fibromyalgia disease impact and quality of life? Does supplementation improve inflammatory biomarkers and oxidative stress? Does supplementation improve insulin resistance? Is curcumin and piperine supplementation safe and well tolerated? | Myopathies | Phase 2 | Neuroprotection + Immunomodulation + Traitement symptomatique | Egypt | À vérifier |
| BupivacaineThis multicenter, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the efficacy of repeated bilateral greater occipital nerve (GON) blockade in patients with chronic migraine and chronic tension-type headache. Greater occipital nerve blockade has been widely used as an interventional treatment for chronic headache disorders; however, evidence regarding its differential efficacy across chronic headache phenotypes remains limited. Participants diagnosed with chronic migraine or chronic tension-type headache according to the International Headache Society criteria were randomized to receive bilateral GON blockade with 0.5% bupivacaine or placebo (0.9% saline). Injections were administered weekly during the first month and monthly during the following two months, resulting in a total of six injections over a three-month treatment period. The primary outcome measure is the change in monthly headache frequency from baseline to Month 1. Secondary outcomes include changes in headache intensity, headache duration, disability scores, and other clinical headache parameters during follow-up. | Migraine | Non applicable | À vérifier | Turkey (Türkiye) | À vérifier |
| renal biopsyTo investigate the possible role of TGF-β expression in renal biopsy and it's relation with fibrosis, activity and chronicity indices | Lupus | Non applicable | À vérifier | Egypt | À vérifier |
| Usage of Aminophylline prior to ureteric dilatation in Flexible uretroscopyin this study we are going to evaluate the efficacy of intra-ureteric aminophylline instillation in facilitating ureteric access sheath placement prior to flexible ureteroscopy in reducing ureteric injury rates. | SEP | Non applicable | À vérifier | Egypt | À vérifier |
| Pericapsular nerve group (PENG) blockThe goal of this clinical trial is to compare two regimens of the pericapsular nerve group (PENG) block, an ultrasound-guided injection of local anaesthetic targeting the nerves supplying the front of the hip joint, for postoperative pain relief and quadriceps muscle function in patients undergoing primary unilateral total hip arthroplasty under spinal anaesthesia. The PENG block was originally proposed as a motor-sparing technique. However, the standard 20 mL volume can spread to the femoral nerve and cause quadriceps weakness. Reducing the injected volume may limit this spread and better preserve quadriceps strength, but smaller volumes risk shorter analgesic duration. Adding dexamethasone to a low-volume injection may compensate for the reduced volume. The main questions this trial aims to answer are: * Does a low-volume PENG block (10 mL bupivacaine 0.25%) with 4 mg dexamethasone differ from a standard-volume PENG block (20 mL bupivacaine 0.25%) in the time to first rescue analgesia? * Does it differ in the incidence and severity of quadriceps weakness on the operated side? Researchers will compare: * Group A (standard-volume PENG block): 20 mL bupivacaine 0.25%. * Group B (low-volume PENG block with dexamethasone): 5 mL bupivacaine 0.5% plus 4 mL normal saline plus 4 mg dexamethasone in 1 mL, giving 10 mL of bupivacaine 0.25%. Participants will: * Receive spinal anaesthesia with heavy bupivacaine 0.5% and fentanyl. * Be randomly allocated to Group A or Group B using computer-generated random numbers. * Receive the PENG block under ultrasound guidance, performed by an anaesthesiologist expert in regional anaesthesia. * Receive intravenous paracetamol 1 g every 8 hours, with intravenous nalbuphine 5 mg as rescue analgesia when the pain score (NRS) is 4 or more. * Be assessed by an anaesthesiologist blinded to group allocation for pain scores at rest and on movement at 2, 6, 12 and 24 hours; quadriceps strength (MRC scale and straight leg raise) at 6, 12 and 24 hours compared with the preoperative baseline; total opioid consumption over the first 24 hours; and time to first ambulation within the first 24 hours. The primary outcome is the time from completion of the PENG block to the first administration of rescue analgesia, recorded over the first 24 hours postoperatively. The study will be conducted at Ain Shams University Hospitals (El Demerdash Hospital) and will include 60 patients (30 per group), aged 50 to 70 years, ASA physical status I or II. | Myopathies | Phase 4 | Traitement symptomatique | Egypt | À vérifier |
| Brachiobasilic arteriovenous fistula followed by basilic vein superficialization.The study aimed to compare the incidence of postoperative venous hypertension between side-to-side (STS) and end-to-side (ETS) brachiobasilic arteriovenous fistulae. | Hypertension | Non applicable | À vérifier | Egypt | À vérifier |
| Ramipril tabletThe goal of this clinical trial is to learn if Ramipril works better than Amlodipine to reduce endothelial dysfunction in pediatric patients (aged 5-18 years) with end-stage kidney disease undergoing maintenance hemodialysis and diagnosed with hypertension. It will also learn about the safety, efficacy, and impact on quality of life of both drugs. The main questions it aims to answer are: * Does Ramipril lower asymmetric dimethylarginine (ADMA) levels-a marker of endothelial dysfunction-more effectively than Amlodipine? * Does Ramipril preserve Fetuin-A levels-a marker of vascular calcification-better than Amlodipine? * How effectively do Ramipril and Amlodipine control blood pressure and improve disease-specific quality of life? * What side effects or medical problems do participants experience while taking Ramipril versus Amlodipine? Researchers will compare Ramipril to Amlodipine to see if Ramipril exerts superior protective effects on vascular health and endothelial function beyond blood pressure reduction. Participants will: * Stop taking previous antihypertensive medications (ACE inhibitors or calcium channel blockers) for a 2-week washout period prior to baseline testing * Take either Ramipril or Amlodipine daily for 3 months * Continue standard hemodialysis sessions (3 times per week, 3-4 hours per session) * Provide pre-dialysis blood samples at baseline and after 3 months of treatment * Complete the Pediatric Quality of Life Inventory (PedsQL™ 3.0 ESRD) questionnaire at baseline and after 3-month * Undergo regular blood pressure checks, clinical monitoring, and weekly phone check-ins to monitor safety and potential side effects | Maladie rénale chronique | Phase 3 | À vérifier | À vérifier |
Essais cliniques
11| Molécule | Indication / population | Phase | NCT | Titre | Statut |
|---|---|---|---|---|---|
| Ramipril tablet | Maladie rénale chronique | Phase 3 | NCT07879560 | ADMA /PedsQL — Ramipril vs. Amlodipine in Pediatric Hemodialysis Patients | NOT_YET_RECRUITING |
| Brachiobasilic arteriovenous fistula followed by basilic vein superficialization. | Hypertension | Non applicable | NCT07879027 | Incidence of Venous Hypertension in Side-to-Side Versus End-to-Side Brachiobasilic Fistulae | COMPLETED |
| Pericapsular nerve group (PENG) block | Myopathies | Phase 4 | NCT07855341 | Low-Volume Pericapsular Nerve Group (PENG) Block With Dexamethasone vs Standard-Volume PENG Block After Total Hip Arthroplasty | RECRUITING |
| Usage of Aminophylline prior to ureteric dilatation in Flexible uretroscopy | SEP | Non applicable | NCT06830577 | Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure | RECRUITING |
| renal biopsy | Lupus | Non applicable | NCT07823556 | The Role of Transforming Growth Factor- Beta (TGF- β) Expression in Renal Biopsy of Lupus Nephritis Patients | ACTIVE_NOT_RECRUITING |
| Aminophylline | SEP | Phase 4 | NCT05552404 | Postdural Puncture Headache Relief With Aminophylline and SPGB | COMPLETED |
| Melatonin | Lupus | Phase 2/3 | NCT07721324 | SLE — Effect of Melatonin Administration on Systemic Lupus Erythematosus Patients | NOT_YET_RECRUITING |
| Bupivacaine | Migraine | Non applicable | NCT07497646 | GONBLOCK-RCT — Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache | COMPLETED |
| Effects of Curcumin-Piperine Supplementation in Fibromyalgia | Myopathies | Phase 2 | NCT07753018 | Effects of Curcumin-Piperine Supplementation in Fibromyalgia | NOT_YET_RECRUITING |
| Caffeine (200 mg) | Migraine | Phase 4 | NCT07022496 | Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine Attack Using VAS Score Among Patients Attending Headache and Neurology Outpatients Clinic of Ainshams University Hospitals | RECRUITING |
| ultrasound guided Greater occipital nerve block | Migraine | NA | NCT06662461 | Ultrasound Guided Block of Stellate Ganglion Versus Greater Occipital Nerve in Resistant Migraine and Correlation to Calcitonin Gene Related Peptide | RECRUITING |
Publications
19| Molécule | Indication / population | Titre | Journal | Date |
|---|---|---|---|---|
| Ramipril tablet | Aliskiren: a review of its use as monotherapy and as combination therapy in the management of hypertension. | Drugs | ||
| Ramipril tablet | Sexual function among controlled and uncontrolled hypertensive females receiving beta-blockers or ACEI/ARB and thiazides: a prospective randomized controlled study. | Scientific reports | ||
| Amlodipine tablet | A mechanism investigation on the effective strategy for alleviating acute myocardial infarction associated with sleep deprivation. | Naunyn-Schmiedeberg's archives of pharmacology | ||
| Paracetamol (acetaminophen) | From watershed to lagoon: Occurrence and ecological risk of paracetamol in the Segara Anakan coastal ecosystem. | Environmental science and pollution research international | ||
| Paracetamol (acetaminophen) | Paracetamol-induced hepatic injury following intentional self-poisoning: a case report and therapeutic considerations. | Naunyn-Schmiedeberg's archives of pharmacology | ||
| Paracetamol (acetaminophen) | Metal nanocrystals and nanoclusters with paracetamol passivation and for paracetamol detection: a critical review. | Nanoscale advances | ||
| NSAID (Nonsteroidal anti-inflammatory drugs) | Knowledge About and the Use of Oral Nonsteroidal Anti-inflammatory Drugs Among Patients With Rheumatic Disorders in Saudi Arabia: A Cross-Sectional Study. | Cureus | ||
| NSAID (Nonsteroidal anti-inflammatory drugs) | NSAID (nonsteroidal anti-inflammatory drugs) Induced Stevens Johnson Syndrome in a 50-year-old woman: A case study. | Toxicology reports | ||
| NSAID (Nonsteroidal anti-inflammatory drugs) | Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Use Is Associated With an Increased Risk of Femoral Osteonecrosis in Migraine Patients: A Retrospective, TriNetX Database-Based Study. | Cureus | ||
| triptans | Current Clinical Evidence on Nose-to-Brain Drug Delivery. | Drug discovery today | ||
| triptans | Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships. | Annals of medicine | ||
| Caffeine (200 mg) | Design and rationale of TROCADERO: A TRial Of Caffeine to Alleviate DyspnEa Related to ticagrelOr. | American heart journal | ||
| Caffeine (200 mg) | A full-spectrum aqueous extract of black cardamom () improves focus/alertness and executive function: a randomized, double-blinded, placebo- and active-controlled, comparative study in healthy working-class participants. | Frontiers in neuroscience | ||
| Ultrasound guided Stellate ganglion block | Ultrasound-guided stellate ganglion block for refractory sympathetically mediated arrhythmia following acute myocardial infarction: a tutorial and examples. | Frontiers in cardiovascular medicine | ||
| Ultrasound guided Stellate ganglion block | Preoperative Ultrasound-Guided Stellate Ganglion Block for Prevention of Postoperative Sore Throat After Thoracic Surgery: Study Protocol for a Randomized Controlled Trial. | Journal of pain research | ||
| ultrasound guided Greater occipital nerve block | Chronic migraine prophylaxis: Comparative study between ultrasound-guided greater occipital nerve block and medical treatment. | Clinical neurology and neurosurgery | ||
| Ultrasound guided Stellate ganglion block | Ultrasound-Guided Stellate Ganglion Block in Fibromyalgia: A Randomized, Single-Center, Single-Blind, Sham-Controlled Trial. | Pain research & management | ||
| ultrasound guided Greater occipital nerve block | Ultrasound-Guided Greater Occipital Nerve Block Across Headache Phenotypes: Outcomes and Determinants of Response in a Prospective Cohort. | Pain and therapy | ||
| ultrasound guided Greater occipital nerve block | Post-dural Puncture Headache During Bacteraemia: Successful Management With Combined Sphenopalatine Ganglion and Greater Occipital Nerve Blocks. | Cureus |