Fiche traitement
Hyaluronic Acid
Instituto Portugues da Face • Myopathies
Suivi actif
Phase 4
Résumé
Hyaluronic Acid est développé par Instituto Portugues da Face. Le traitement est actuellement en Phase 4. Il est associé à Myopathies. Son objectif thérapeutique principal est Traitement symptomatique. Le statut actuel est : suivi actif.
À vérifier
Traitement symptomatique
Phase 4
Instituto Portugues da Face
Portugal
This study examined whether adding ropivacaine, a local anesthetic, to platelet-rich plasma and hyaluronic acid reduces pain during the first week after temporomandibular joint (jaw joint) arthrocentesis. Arthrocentesis is a procedure that flushes the joint. Thirty adults were randomly assigned to receive either ropivacaine or saline in addition to platelet-rich plasma and hyaluronic acid. Participants rated their pain daily after the procedure.
2026-11-09
Début phase actuelle
Non disponible dans les sources synchronisées
Timeline clinique
Phase 4
Début phase actuelle
Non disponible dans les sources synchronisées
Préclinique
Phase 1
Phase 2
Phase 3
Approuvé
Objectif scientifique de l’étude
classification automatique vérifiable
Traitement symptomatique
Confiance automatique : 87%
Ce pourcentage n’est pas une probabilité de succès clinique.
Il mesure uniquement la force de la classification automatique de l’objectif scientifique. Le calcul part de 45 points, ajoute 7 points par unité de poids du mot-clé le plus fortement détecté, puis est plafonné à 95 %. Exemple : un score maximal de 2 donne 45 + (2 × 7) = 59 %.
Indices détectés : symptom → Traitement symptomatique, pain → Traitement symptomatique
Ce score est heuristique et doit être vérifié dans le protocole ou une publication.
Description affichée depuis l’essai compatible NCT05817162, afin d’éviter le mélange entre plusieurs indications d’une même molécule.
Aucune incohérence majeure détectée entre la maladie, l’objectif et la description.
Transparence et qualité de la fiche
données vérifiablesClassificationCohérente automatiquement
Confiance de la fiche100 %
Source principaleSource officielle ou publication indexée
Dernière vérification2026-11-09
Anomalies détectées0
Validation humaineValidation humaine non effectuée
Donnée issue d’une source
Donnée normalisée automatiquement
Interprétation algorithmique
Classification scientifique multi-axes
ne pas confondre statut et résultatÉtat de l’étudeTerminée
Disponibilité des résultatsRésultats à vérifier
InterprétationImpossible à déterminer
Niveau de preuveNon évaluable
Un essai terminé n’est pas nécessairement positif. Un essai arrêté n’est classé comme échec scientifique que lorsqu’un résultat ou une raison explicite le confirme.
Indicateurs factuels
sans score subjectifPhase enregistréePhase 4
Études associées5
Publications associées26
Statut consolidéSuivi actif
Aucune chance de succès, note d’innovation, potentiel thérapeutique ou probabilité de commercialisation n’est calculé tant qu’un modèle validé et des données suffisantes ne sont pas disponibles.
Historique factuel de la molécule
42 événement(s) daté(s)Cette liste reprend uniquement les dates trouvées dans les registres et publications liés. Elle ne constitue pas une prévision.
| Date | Événement | Source |
|---|---|---|
| 2017-10-09 | Début de l’étudeNCT03350217 | Registre d’essai clinique |
| 2018-04-18 | Début de l’étudeNCT03984955 | Registre d’essai clinique |
| 2019-01-07 | Fin de l’étude prévue / enregistréeNCT03350217 | Registre d’essai clinique |
| 2023-04-01 | Début de l’étudeNCT05817162 | Registre d’essai clinique |
| 2024-11-04 | Fin de l’étude prévue / enregistréeNCT05817162 | Registre d’essai clinique |
| 2025-03-28 | Début de l’étudeNCT06718413 | Registre d’essai clinique |
| 2025-07-01 | Début de l’étudeNCT07643402 | Registre d’essai clinique |
| 2026-05-05 | Fin de l’étude prévue / enregistréeNCT07643402 | Registre d’essai clinique |
| 2026-07-08 | PublicationSame-day Hyaluronic Acid rectal spacer for TRUS-guided HDR Prostate Brachytherapy: Feasibility and dosimetric outcomes. | Journal of applied clinical medical physics |
| 2026-07-08 | PublicationTreatments in oral lichen planus: a review. | Frontiers in oral health |
| 2026-07-10 | PublicationAssociation of AbobotulinumtoxinA and Skinbooster for Periorbital Wrinkles: A Randomized, Controlled, Double-Blind, Split-Face Study. | Aesthetic plastic surgery |
| 2026-07-12 | PublicationKartogenin-loaded liposomes coated with alkylated hyaluronic acid for stimulated chondrogenic differentiation. | International journal of pharmaceutics |
| 2026-07-12 | PublicationEffectiveness and safety of intra-articular hyaluronic acid SEMICAL GEL-B CROSS therapy in knee osteoarthritis (SEM-ART1): Study protocol for a randomized, placebo controlled, double-blind, cross-over clinical trial. | PloS one |
| 2026-07-14 | PublicationVitrectomy Status Alters Early Intravitreal Drug Distribution: An Ex Vivo PET-CT Study. | Investigative ophthalmology & visual science |
| 2026-07-14 | PublicationAdvanced on Minimally Invasive Techniques in Facial Rejuvenation: A Comprehensive Review. | World journal of plastic surgery |
| 2026-08-08 | PublicationProceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016. | BMC health services research |
| 2026-08-13 | PublicationArthroscopy-assisted inferior compartment arthrocentesis of the temporomandibular joint. | Oral and maxillofacial surgery |
| 2026-08-13 | PublicationThree once-weekly intra-articular injections of Hylan G-F 20 significantly improve pain relief compared with placebo in patients with chronic idiopathic knee osteoarthritis: a single-centre, evaluator-blinded and patient-blinded, randomized controlled trial. | Drugs in context |
| 2026-08-13 | PublicationEfficacy of Ultra-high and High Molecular Weight Cross-Linked Hyaluronic Acids Compared with Saline in Knee Osteoarthritis: A Randomized Controlled Trial. | JB & JS open access |
| 2026-08-13 | PublicationHyaluronic acid nanoparticle as drug delivery carrier for the treatment of allergic conjunctivitis. | Bio-medical materials and engineering |
| 2026-08-13 | PublicationTracking Changes in Oral Health-Related Quality of Life Before, During, and After Radiotherapy in Tongue Squamous Cell Carcinoma: A Case Series. | Patient preference and adherence |
| 2026-08-13 | PublicationThe STIIM UP Protocol: Exploratory Evaluation of the Potential of Combined Calcium Hydroxyapatite, Hyaluronic Acid, and Botulinum Toxin A in Neck Rejuvenation. | Journal of clinical medicine |
| 2026-08-13 | PublicationPreserving joint healthspan in knee osteoarthritis: a geroscience-guided review of non-surgical therapies and genicular artery embolization. | GeroScience |
| 2026-08-13 | PublicationOrthobiologic injections for hip osteoarthritis: A systematic review of clinical outcomes. | Orthopedic reviews |
| 2026-08-13 | PublicationA tumor microenvironment-responsive calcium overload nanoplatform inducing PANoptosis for enhanced cancer immunotherapy. | Materials today. Bio |
| 2026-08-16 | PublicationTriple-targeted artificial extracellular vesicles for enhanced glioma therapy via synergistic chemomagnetic penetration of the blood-brain barrier. | Colloids and surfaces. B, Biointerfaces |
| 2026-08-16 | PublicationUltrasound-Guided Greater Auricular Nerve Block: A Pilot Study for Pain Management in Post-Auricular Injection. | Aesthetic plastic surgery |
| 2026-08-16 | PublicationCo-assembly of dipeptide and hydrophobic drug in hyaluronic acid through Schiff base reaction for the treatment of osteoarthritis. | Pharmaceutical science advances |
| 2026-08-16 | PublicationCorrigendum to 'Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells' [Biomaterials 72 (2015) 17043]. | Biomaterials |
| 2026-08-16 | PublicationTargeted discovery of anti-skin aging peptides from Camelus bactrianus placenta: Multi-activity screening, network pharmacology, and in vitro validation focusing on MMP-1 inhibition. | Journal of ethnopharmacology |
| 2026-08-16 | PublicationHigh-molecular-weight hyaluronic acid promotes the protective axis of the renin-angiotensin-aldosterone system in human dermal fibroblasts. | Biochemical and biophysical research communications |
| 2026-08-16 | PublicationBridging fibrosis and function: an integrated mechanistic and therapeutic framework for Peyronie's disease and related erectile dysfunction. | Sexual medicine |
| 2026-08-16 | PublicationNanocarrier-mediated targeting of chemotherapy-induced DPP4 enhances T cell infiltration and improves cancer immunochemotherapy. | Bioactive materials |
| 2026-09-14 | Création de l’enregistrementNCT03350217 | Registre d’essai clinique |
| 2026-09-14 | Création de l’enregistrementNCT07643402 | Registre d’essai clinique |
| 2026-10-18 | Création de l’enregistrementNCT06718413 | Registre d’essai clinique |
| 2026-11-09 | Création de l’enregistrementNCT03984955 | Registre d’essai clinique |
| 2026-11-09 | Dernière mise à jour des donnéesHyaluronic Acid | Biomedical Watch |
| 2026-11-15 | Création de l’enregistrementNCT05817162 | Registre d’essai clinique |
| 2026-11-15 | PublicationEarly Outcome of a Single Peri-Tendinous Hyaluronic Acid Injection for Mid-Portion Non-Insertional Achilles Tendinopathy - A Pilot Study. | Foot (Edinburgh, Scotland) |
| 2028-02-06 | Fin de l’étude prévue / enregistréeNCT03984955 | Registre d’essai clinique |
| 2028-08-31 | Fin de l’étude prévue / enregistréeNCT06718413 | Registre d’essai clinique |
Début phase actuelle
Non disponible dans les sources synchronisées
Essais cliniques liés
5 essai(s)
Début phase actuelle
Non disponible dans les sources synchronisées
| NCT | Titre | Phase | Statut administratif | Pays | Sponsor |
|---|---|---|---|---|---|
| NCT05817162 | Ropivacaine for Jaw Joint Pain After Arthrocentesis With Platelet-Rich Plasma and Hyaluronic Acid | Phase 4 | COMPLETED | Portugal | Instituto Portugues da Face |
| NCT03984955 | CITTE — Comparing Injection Treatments for Tennis Elbow | Non applicable | RECRUITING | United Kingdom | Wrightington, Wigan and Leigh NHS Foundation Trust |
| NCT06718413 | Myofascial Dysfunction in Post Stroke Shoulder Pain | Phase 2 | RECRUITING | United States | Johns Hopkins University |
| NCT03350217 | A Comparison of Eleview Versus Hetastarch as Injectate for EMR | Phase 4 | COMPLETED | United States | Indiana University |
| NCT07643402 | Clinical and Jaw Tracking Assessment Following Intra-articular Injection of PRP and HA in TMJ Disc Displacement With Reduction | Non applicable | COMPLETED | Egypt | Mansoura University |
Publications liées
26 publication(s)Publications liées
26 publication(s)| Titre | PMID | DOI | Journal | Date |
|---|---|---|---|---|
| Early Outcome of a Single Peri-Tendinous Hyaluronic Acid Injection for Mid-Portion Non-Insertional Achilles Tendinopathy - A Pilot Study. Voir source | 33132010 | 10.1016/j.foot.2020.101738 | Foot (Edinburgh, Scotland) | |
| Triple-targeted artificial extracellular vesicles for enhanced glioma therapy via synergistic chemomagnetic penetration of the blood-brain barrier. Voir source | 42090930 | 10.1016/j.colsurfb.2026.115768 | Colloids and surfaces. B, Biointerfaces | |
| Ultrasound-Guided Greater Auricular Nerve Block: A Pilot Study for Pain Management in Post-Auricular Injection. Voir source | 42545492 | 10.1007/s00266-026-06198-z | Aesthetic plastic surgery | |
| Co-assembly of dipeptide and hydrophobic drug in hyaluronic acid through Schiff base reaction for the treatment of osteoarthritis. Voir source | 42438687 | 10.1016/j.pscia.2026.100133 | Pharmaceutical science advances | |
| Corrigendum to 'Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells' [Biomaterials 72 (2015) 17043]. Voir source | 42288431 | 10.1016/j.biomaterials.2026.124378 | Biomaterials | |
| Targeted discovery of anti-skin aging peptides from Camelus bactrianus placenta: Multi-activity screening, network pharmacology, and in vitro validation focusing on MMP-1 inhibition. Voir source | 42302941 | 10.1016/j.jep.2026.122064 | Journal of ethnopharmacology | |
| High-molecular-weight hyaluronic acid promotes the protective axis of the renin-angiotensin-aldosterone system in human dermal fibroblasts. Voir source | 42424931 | 10.1016/j.bbrc.2026.154249 | Biochemical and biophysical research communications | |
| Bridging fibrosis and function: an integrated mechanistic and therapeutic framework for Peyronie's disease and related erectile dysfunction. Voir source | 42592245 | 10.1093/sexmed/qfag070 | Sexual medicine | |
| Nanocarrier-mediated targeting of chemotherapy-induced DPP4 enhances T cell infiltration and improves cancer immunochemotherapy. Voir source | 42592018 | 10.1016/j.bioactmat.2026.07.053 | Bioactive materials | |
| Arthroscopy-assisted inferior compartment arthrocentesis of the temporomandibular joint. Voir source | 42530686 | 10.1007/s10006-026-01610-z | Oral and maxillofacial surgery | |
| Three once-weekly intra-articular injections of Hylan G-F 20 significantly improve pain relief compared with placebo in patients with chronic idiopathic knee osteoarthritis: a single-centre, evaluator-blinded and patient-blinded, randomized controlled trial. Voir source | 38601838 | 10.7573/dic.2023-11-3 | Drugs in context | |
| Efficacy of Ultra-high and High Molecular Weight Cross-Linked Hyaluronic Acids Compared with Saline in Knee Osteoarthritis: A Randomized Controlled Trial. Voir source | 42099891 | 10.2106/JBJS.OA.25.00341 | JB & JS open access | |
| Hyaluronic acid nanoparticle as drug delivery carrier for the treatment of allergic conjunctivitis. Voir source | 42578876 | 10.1177/09592989261474686 | Bio-medical materials and engineering | |
| Tracking Changes in Oral Health-Related Quality of Life Before, During, and After Radiotherapy in Tongue Squamous Cell Carcinoma: A Case Series. Voir source | 40860599 | 10.2147/PPA.S539093 | Patient preference and adherence | |
| The STIIM UP Protocol: Exploratory Evaluation of the Potential of Combined Calcium Hydroxyapatite, Hyaluronic Acid, and Botulinum Toxin A in Neck Rejuvenation. Voir source | 42590155 | 10.3390/jcm15156052 | Journal of clinical medicine | |
| Preserving joint healthspan in knee osteoarthritis: a geroscience-guided review of non-surgical therapies and genicular artery embolization. Voir source | 42576130 | 10.1007/s11357-026-02467-6 | GeroScience | |
| Orthobiologic injections for hip osteoarthritis: A systematic review of clinical outcomes. Voir source | 41450485 | 10.52965/001c.151461 | Orthopedic reviews | |
| A tumor microenvironment-responsive calcium overload nanoplatform inducing PANoptosis for enhanced cancer immunotherapy. Voir source | 42576991 | 10.1016/j.mtbio.2026.103514 | Materials today. Bio | |
| Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016. Voir source | 27409075 | 10.1186/s12913-016-1423-5 | BMC health services research | |
| Vitrectomy Status Alters Early Intravitreal Drug Distribution: An Ex Vivo PET-CT Study. Voir source | 42446480 | 10.1167/iovs.67.8.36 | Investigative ophthalmology & visual science | |
| Advanced on Minimally Invasive Techniques in Facial Rejuvenation: A Comprehensive Review. Voir source | 42441192 | 10.61882/wjps.15.1.3 | World journal of plastic surgery | |
| Kartogenin-loaded liposomes coated with alkylated hyaluronic acid for stimulated chondrogenic differentiation. Voir source | 42425241 | 10.1016/j.ijpharm.2026.127167 | International journal of pharmaceutics | |
| Effectiveness and safety of intra-articular hyaluronic acid SEMICAL GEL-B CROSS therapy in knee osteoarthritis (SEM-ART1): Study protocol for a randomized, placebo controlled, double-blind, cross-over clinical trial. Voir source | 42424346 | 10.1371/journal.pone.0353120 | PloS one | |
| Association of AbobotulinumtoxinA and Skinbooster for Periorbital Wrinkles: A Randomized, Controlled, Double-Blind, Split-Face Study. Voir source | 42420660 | 10.1007/s00266-026-06059-9 | Aesthetic plastic surgery | |
| Same-day Hyaluronic Acid rectal spacer for TRUS-guided HDR Prostate Brachytherapy: Feasibility and dosimetric outcomes. Voir source | 42418218 | 10.1002/acm2.70701 | Journal of applied clinical medical physics | |
| Treatments in oral lichen planus: a review. Voir source | 42416309 | 10.3389/froh.2026.1713845 | Frontiers in oral health |
Sources officielles
liens de rechercheDernière mise à jour des données : 2026-11-09
Ces sources sont proposées pour vérification. Les informations de la fiche doivent être confirmées dans les registres officiels ou les publications originales.